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Items: 1 to 50 of 158

1.

Single-Cell Transcriptional Profiling of Aortic Endothelium Identifies a Hierarchy from Endovascular Progenitors to Differentiated Cells.

Lukowski SW, Patel J, Andersen SB, Sim SL, Wong HY, Tay J, Winkler I, Powell JE, Khosrotehrani K.

Cell Rep. 2019 May 28;27(9):2748-2758.e3. doi: 10.1016/j.celrep.2019.04.102.

2.

Comprehensive Multiple eQTL Detection and Its Application to GWAS Interpretation.

Zeng B, Lloyd-Jones LR, Montgomery GW, Metspalu A, Esko T, Franke L, Vosa U, Claringbould A, Brigham KL, Quyyumi AA, Idaghdour Y, Yang J, Visscher PM, Powell JE, Gibson G.

Genetics. 2019 Jul;212(3):905-918. doi: 10.1534/genetics.119.302091. Epub 2019 May 22.

PMID:
31123039
3.

Action 3:30R: Results of a Cluster Randomised Feasibility Study of a Revised Teaching Assistant-Led Extracurricular Physical Activity Intervention for 8 to 10 Year Olds.

Jago R, Tibbitts B, Sanderson E, Bird EL, Porter A, Metcalfe C, Powell JE, Gillett D, Sebire SJ.

Int J Environ Res Public Health. 2019 Jan 6;16(1). pii: E131. doi: 10.3390/ijerph16010131.

4.

Identification of 55,000 Replicated DNA Methylation QTL.

McRae AF, Marioni RE, Shah S, Yang J, Powell JE, Harris SE, Gibson J, Henders AK, Bowdler L, Painter JN, Murphy L, Martin NG, Starr JM, Wray NR, Deary IJ, Visscher PM, Montgomery GW.

Sci Rep. 2018 Dec 4;8(1):17605. doi: 10.1038/s41598-018-35871-w.

5.

Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation.

Friedman CE, Nguyen Q, Lukowski SW, Helfer A, Chiu HS, Miklas J, Levy S, Suo S, Han JJ, Osteil P, Peng G, Jing N, Baillie GJ, Senabouth A, Christ AN, Bruxner TJ, Murry CE, Wong ES, Ding J, Wang Y, Hudson J, Ruohola-Baker H, Bar-Joseph Z, Tam PPL, Powell JE, Palpant NJ.

Cell Stem Cell. 2018 Oct 4;23(4):586-598.e8. doi: 10.1016/j.stem.2018.09.009.

PMID:
30290179
6.

Single-Cell Profiling Identifies Key Pathways Expressed by iPSCs Cultured in Different Commercial Media.

Daniszewski M, Nguyen Q, Chy HS, Singh V, Crombie DE, Kulkarni T, Liang HH, Sivakumaran P, Lidgerwood GE, Hernández D, Conquest A, Rooney LA, Chevalier S, Andersen SB, Senabouth A, Vickers JC, Mackey DA, Craig JE, Laslett AL, Hewitt AW, Powell JE, Pébay A.

iScience. 2018 Sep 28;7:30-39. doi: 10.1016/j.isci.2018.08.016. Epub 2018 Aug 23.

7.

Transcriptomics and single-cell RNA-sequencing.

Chambers DC, Carew AM, Lukowski SW, Powell JE.

Respirology. 2019 Jan;24(1):29-36. doi: 10.1111/resp.13412. Epub 2018 Sep 28. Review.

8.

Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome.

Fung JN, Mortlock S, Girling JE, Holdsworth-Carson SJ, Teh WT, Zhu Z, Lukowski SW, McKinnon BD, McRae A, Yang J, Healey M, Powell JE, Rogers PAW, Montgomery GW.

Sci Rep. 2018 Jul 30;8(1):11424. doi: 10.1038/s41598-018-29462-y.

9.

Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.

MacGregor S, Ong JS, An J, Han X, Zhou T, Siggs OM, Law MH, Souzeau E, Sharma S, Lynn DJ, Beesley J, Sheldrick B, Mills RA, Landers J, Ruddle JB, Graham SL, Healey PR, White AJR, Casson RJ, Best S, Grigg JR, Goldberg I, Powell JE, Whiteman DC, Radford-Smith GL, Martin NG, Montgomery GW, Burdon KP, Mackey DA, Gharahkhani P, Craig JE, Hewitt AW.

Nat Genet. 2018 Aug;50(8):1067-1071. doi: 10.1038/s41588-018-0176-y. Epub 2018 Jul 27.

PMID:
30054594
10.

Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes.

Ramnath D, Irvine KM, Lukowski SW, Horsfall LU, Loh Z, Clouston AD, Patel PJ, Fagan KJ, Iyer A, Lampe G, Stow JL, Schroder K, Fairlie DP, Powell JE, Powell EE, Sweet MJ.

JCI Insight. 2018 Jul 26;3(14). pii: 120274. doi: 10.1172/jci.insight.120274. eCollection 2018 Jul 26.

11.

Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis.

De Smit E, Lukowski SW, Anderson L, Senabouth A, Dauyey K, Song S, Wyse B, Wheeler L, Chen CY, Cao K, Wong Ten Yuen A, Shuey N, Clarke L, Lopez Sanchez I, Hung SSC, Pébay A, Mackey DA, Brown MA, Hewitt AW, Powell JE.

BMC Med Genomics. 2018 Jul 23;11(1):61. doi: 10.1186/s12920-018-0376-4.

12.

Modulation of the honey bee queen microbiota: Effects of early social contact.

Powell JE, Eiri D, Moran NA, Rangel J.

PLoS One. 2018 Jul 12;13(7):e0200527. doi: 10.1371/journal.pone.0200527. eCollection 2018.

13.

Detection of HPV E7 Transcription at Single-Cell Resolution in Epidermis.

Lukowski SW, Tuong ZK, Noske K, Senabouth A, Nguyen QH, Andersen SB, Soyer HP, Frazer IH, Powell JE.

J Invest Dermatol. 2018 Dec;138(12):2558-2567. doi: 10.1016/j.jid.2018.06.169. Epub 2018 Jun 30.

PMID:
29964033
14.

Trans-eQTLs identified in whole blood have limited influence on complex disease biology.

Yap CX, Lloyd-Jones L, Holloway A, Smartt P, Wray NR, Gratten J, Powell JE.

Eur J Hum Genet. 2018 Sep;26(9):1361-1368. doi: 10.1038/s41431-018-0174-7. Epub 2018 Jun 11.

PMID:
29891877
15.

Single-cell RNA-seq of human induced pluripotent stem cells reveals cellular heterogeneity and cell state transitions between subpopulations.

Nguyen QH, Lukowski SW, Chiu HS, Senabouth A, Bruxner TJC, Christ AN, Palpant NJ, Powell JE.

Genome Res. 2018 Jul;28(7):1053-1066. doi: 10.1101/gr.223925.117. Epub 2018 May 11.

16.

Signatures of negative selection in the genetic architecture of human complex traits.

Zeng J, de Vlaming R, Wu Y, Robinson MR, Lloyd-Jones LR, Yengo L, Yap CX, Xue A, Sidorenko J, McRae AF, Powell JE, Montgomery GW, Metspalu A, Esko T, Gibson G, Wray NR, Visscher PM, Yang J.

Nat Genet. 2018 May;50(5):746-753. doi: 10.1038/s41588-018-0101-4. Epub 2018 Apr 16.

PMID:
29662166
17.

Genetic Engineering of Bee Gut Microbiome Bacteria with a Toolkit for Modular Assembly of Broad-Host-Range Plasmids.

Leonard SP, Perutka J, Powell JE, Geng P, Richhart DD, Byrom M, Kar S, Davies BW, Ellington AD, Moran NA, Barrick JE.

ACS Synth Biol. 2018 May 18;7(5):1279-1290. doi: 10.1021/acssynbio.7b00399. Epub 2018 Apr 13.

18.

Single cell RNA sequencing of stem cell-derived retinal ganglion cells.

Daniszewski M, Senabouth A, Nguyen QH, Crombie DE, Lukowski SW, Kulkarni T, Sluch VM, Jabbari JS, Chamling X, Zack DJ, Pébay A, Powell JE, Hewitt AW.

Sci Data. 2018 Feb 13;5:180013. doi: 10.1038/sdata.2018.13.

19.

MHC-Dependent Mate Selection within 872 Spousal Pairs of European Ancestry from the Health and Retirement Study.

Qiao Z, Powell JE, Evans DM.

Genes (Basel). 2018 Jan 22;9(1). pii: E53. doi: 10.3390/genes9010053.

20.

Human iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks.

Nayler SP, Powell JE, Vanichkina DP, Korn O, Wells CA, Kanjhan R, Sun J, Taft RJ, Lavin MF, Wolvetang EJ.

Front Cell Neurosci. 2017 Oct 13;11:321. doi: 10.3389/fncel.2017.00321. eCollection 2017.

21.

Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood.

Lukowski SW, Lloyd-Jones LR, Holloway A, Kirsten H, Hemani G, Yang J, Small K, Zhao J, Metspalu A, Dermitzakis ET, Gibson G, Spector TD, Thiery J, Scholz M, Montgomery GW, Esko T, Visscher PM, Powell JE.

Nat Commun. 2017 Sep 7;8(1):483. doi: 10.1038/s41467-017-00473-z.

22.

Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data.

Robins C, McRae AF, Powell JE, Wiener HW, Aslibekyan S, Kennedy EM, Absher DM, Arnett DK, Montgomery GW, Visscher PM, Cutler DJ, Conneely KN.

Genetics. 2017 Dec;207(4):1547-1560. doi: 10.1534/genetics.117.300217. Epub 2017 Aug 30.

23.

Novel insight into the origin of the growth dynamics of sauropod dinosaurs.

Cerda IA, Chinsamy A, Pol D, Apaldetti C, Otero A, Powell JE, Martínez RN.

PLoS One. 2017 Jun 27;12(6):e0179707. doi: 10.1371/journal.pone.0179707. eCollection 2017.

24.

Constraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression.

Zeng B, Lloyd-Jones LR, Holloway A, Marigorta UM, Metspalu A, Montgomery GW, Esko T, Brigham KL, Quyyumi AA, Idaghdour Y, Yang J, Visscher PM, Powell JE, Gibson G.

G3 (Bethesda). 2017 Aug 7;7(8):2533-2544. doi: 10.1534/g3.117.043752.

25.

Honeybee gut microbiota promotes host weight gain via bacterial metabolism and hormonal signaling.

Zheng H, Powell JE, Steele MI, Dietrich C, Moran NA.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4775-4780. doi: 10.1073/pnas.1701819114. Epub 2017 Apr 18.

26.

The genetic regulation of transcription in human endometrial tissue.

Fung JN, Girling JE, Lukowski SW, Sapkota Y, Wallace L, Holdsworth-Carson SJ, Henders AK, Healey M, Rogers PAW, Powell JE, Montgomery GW.

Hum Reprod. 2017 Apr 1;32(4):893-904. doi: 10.1093/humrep/dex006.

PMID:
28177073
27.

Endometriosis risk alleles at 1p36.12 act through inverse regulation of CDC42 and LINC00339.

Powell JE, Fung JN, Shakhbazov K, Sapkota Y, Cloonan N, Hemani G, Hillman KM, Kaufmann S, Luong HT, Bowdler L, Painter JN, Holdsworth-Carson SJ, Visscher PM, Dinger ME, Healey M, Nyholt DR, French JD, Edwards SL, Rogers PA, Montgomery GW.

Hum Mol Genet. 2016 Nov 15;25(22):5046-5058. doi: 10.1093/hmg/ddw320.

PMID:
28171565
28.

The Genetic Architecture of Gene Expression in Peripheral Blood.

Lloyd-Jones LR, Holloway A, McRae A, Yang J, Small K, Zhao J, Zeng B, Bakshi A, Metspalu A, Dermitzakis M, Gibson G, Spector T, Montgomery G, Esko T, Visscher PM, Powell JE.

Am J Hum Genet. 2017 Feb 2;100(2):371. doi: 10.1016/j.ajhg.2017.01.026. No abstract available.

29.

The Genetic Architecture of Gene Expression in Peripheral Blood.

Lloyd-Jones LR, Holloway A, McRae A, Yang J, Small K, Zhao J, Zeng B, Bakshi A, Metspalu A, Dermitzakis M, Gibson G, Spector T, Montgomery G, Esko T, Visscher PM, Powell JE.

Am J Hum Genet. 2017 Feb 2;100(2):228-237. doi: 10.1016/j.ajhg.2016.12.008. Epub 2017 Jan 5. Erratum in: Am J Hum Genet. 2017 Feb 2;100(2):371.

30.

Genome-wide analysis of blood gene expression in migraine implicates immune-inflammatory pathways.

Gerring ZF, Powell JE, Montgomery GW, Nyholt DR.

Cephalalgia. 2018 Feb;38(2):292-303. doi: 10.1177/0333102416686769. Epub 2017 Jan 6.

PMID:
28058943
31.

Autosomal genetic control of human gene expression does not differ across the sexes.

Kassam I, Lloyd-Jones L, Holloway A, Small KS, Zeng B, Bakshi A, Metspalu A, Gibson G, Spector TD, Esko T, Montgomery GW, Powell JE, Yang J, Visscher PM, McRae AF.

Genome Biol. 2016 Dec 1;17(1):248.

32.

Genome-wide screen identifies host colonization determinants in a bacterial gut symbiont.

Powell JE, Leonard SP, Kwong WK, Engel P, Moran NA.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13887-13892. Epub 2016 Nov 14.

33.

Evidence for mitochondrial genetic control of autosomal gene expression.

Kassam I, Qi T, Lloyd-Jones L, Holloway A, Jan Bonder M, Henders AK, Martin NG, Powell JE, Franke L, Montgomery GW, Visscher PM, McRae AF.

Hum Mol Genet. 2016 Dec 15;25(24):5332-5338. doi: 10.1093/hmg/ddw347.

34.

AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo.

Hung SS, Chrysostomou V, Li F, Lim JK, Wang JH, Powell JE, Tu L, Daniszewski M, Lo C, Wong RC, Crowston JG, Pébay A, King AE, Bui BV, Liu GS, Hewitt AW.

Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3470-6. doi: 10.1167/iovs.16-19316.

PMID:
27367513
35.

Bristol Girls Dance Project: a cluster randomised controlled trial of an after-school dance programme to increase physical activity among 11- to 12-year-old girls.

Jago R, Edwards MJ, Sebire SJ, Bird EL, Tomkinson K, Kesten JM, Banfield K, May T, Cooper AR, Blair PS, Powell JE.

Southampton (UK): NIHR Journals Library; 2016 May.

36.

Using self-determination theory to promote adolescent girls' physical activity: Exploring the theoretical fidelity of the Bristol Girls Dance Project.

Sebire SJ, Kesten JM, Edwards MJ, May T, Banfield K, Tomkinson K, Blair PS, Bird EL, Powell JE, Jago R.

Psychol Sport Exerc. 2016 May;24:100-110.

37.

Process evaluation of the Bristol girls dance project.

Sebire SJ, Edwards MJ, Kesten JM, May T, Banfield KJ, Bird EL, Tomkinson K, Blair P, Powell JE, Jago R.

BMC Public Health. 2016 Apr 21;16:349. doi: 10.1186/s12889-016-3010-4.

38.

Shared genetic control of expression and methylation in peripheral blood.

Shakhbazov K, Powell JE, Hemani G, Henders AK, Martin NG, Visscher PM, Montgomery GW, McRae AF.

BMC Genomics. 2016 Apr 6;17:278. doi: 10.1186/s12864-016-2498-4.

39.

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets.

Zhu Z, Zhang F, Hu H, Bakshi A, Robinson MR, Powell JE, Montgomery GW, Goddard ME, Wray NR, Visscher PM, Yang J.

Nat Genet. 2016 May;48(5):481-7. doi: 10.1038/ng.3538. Epub 2016 Mar 28.

PMID:
27019110
40.

Endometrial vezatin and its association with endometriosis risk.

Holdsworth-Carson SJ, Fung JN, Luong HT, Sapkota Y, Bowdler LM, Wallace L, Teh WT, Powell JE, Girling JE, Healey M, Montgomery GW, Rogers PA.

Hum Reprod. 2016 May;31(5):999-1013. doi: 10.1093/humrep/dew047. Epub 2016 Mar 22.

PMID:
27005890
41.
42.

Does family-centred neonatal discharge planning reduce healthcare usage? A before and after study in South West England.

Ingram JC, Powell JE, Blair PS, Pontin D, Redshaw M, Manns S, Beasant L, Burden H, Johnson D, Rose C, Fleming PJ.

BMJ Open. 2016 Mar 10;6(3):e010752. doi: 10.1136/bmjopen-2015-010752.

43.

Blood gene expression studies in migraine: Potential and caveats.

Gerring Z, Rodriguez-Acevedo AJ, Powell JE, Griffiths LR, Montgomery GW, Nyholt DR.

Cephalalgia. 2016 Jun;36(7):669-78. doi: 10.1177/0333102416628463. Epub 2016 Feb 9. Review.

PMID:
26862113
44.

The low EOMES/TBX21 molecular phenotype in multiple sclerosis reflects CD56+ cell dysregulation and is affected by immunomodulatory therapies.

McKay FC, Gatt PN, Fewings N, Parnell GP, Schibeci SD, Basuki MA, Powell JE, Goldinger A, Fabis-Pedrini MJ, Kermode AG, Burke T, Vucic S, Stewart GJ, Booth DR.

Clin Immunol. 2016 Feb;163:96-107. doi: 10.1016/j.clim.2015.12.015. Epub 2016 Jan 4.

PMID:
26762769
45.

Lessons learnt from the Bristol Girls Dance Project cluster RCT: implications for designing and implementing after-school physical activity interventions.

Edwards MJ, May T, Kesten JM, Banfield K, Bird EL, Powell JE, Sebire SJ, Jago R.

BMJ Open. 2016 Jan 8;6(1):e010036. doi: 10.1136/bmjopen-2015-010036.

46.

Correction: Collagen Sequence Analysis of the Extinct Giant Ground Sloths Lestodon and Megatherium.

Buckley M, Fariña RA, Lawless C, Tambusso PS, Varela L, Carlini AA, Powell JE, Martinez JG.

PLoS One. 2015 Dec 7;10(12):e0144793. doi: 10.1371/journal.pone.0144793. eCollection 2015. No abstract available.

47.

Collagen Sequence Analysis of the Extinct Giant Ground Sloths Lestodon and Megatherium.

Buckley M, Fariña RA, Lawless C, Tambusso PS, Varela L, Carlini AA, Powell JE, Martinez JG.

PLoS One. 2015 Nov 5;10(11):e0139611. doi: 10.1371/journal.pone.0139611. eCollection 2015. Erratum in: PLoS One. 2015;10(12):e0144793.

48.

Effect and cost of an after-school dance programme on the physical activity of 11-12 year old girls: The Bristol Girls Dance Project, a school-based cluster randomised controlled trial.

Jago R, Edwards MJ, Sebire SJ, Tomkinson K, Bird EL, Banfield K, May T, Kesten JM, Cooper AR, Powell JE, Blair PS.

Int J Behav Nutr Phys Act. 2015 Oct 6;12:128. doi: 10.1186/s12966-015-0289-y.

49.

Population genetic differentiation of height and body mass index across Europe.

Robinson MR, Hemani G, Medina-Gomez C, Mezzavilla M, Esko T, Shakhbazov K, Powell JE, Vinkhuyzen A, Berndt SI, Gustafsson S, Justice AE, Kahali B, Locke AE, Pers TH, Vedantam S, Wood AR, van Rheenen W, Andreassen OA, Gasparini P, Metspalu A, Berg LH, Veldink JH, Rivadeneira F, Werge TM, Abecasis GR, Boomsma DI, Chasman DI, de Geus EJ, Frayling TM, Hirschhorn JN, Hottenga JJ, Ingelsson E, Loos RJ, Magnusson PK, Martin NG, Montgomery GW, North KE, Pedersen NL, Spector TD, Speliotes EK, Goddard ME, Yang J, Visscher PM.

Nat Genet. 2015 Nov;47(11):1357-62. doi: 10.1038/ng.3401. Epub 2015 Sep 14.

50.

Evidence-based intervention for preschool children with primary speech and language impairments: Child Talk – an exploratory mixed-methods study.

Roulstone SE, Marshall JE, Powell GG, Goldbart J, Wren YE, Coad J, Daykin N, Powell JE, Lascelles L, Hollingworth W, Emond A, Peters TJ, Pollock JI, Fernandes C, Moultrie J, Harding SA, Morgan L, Hambly HF, Parker NK, Coad RA.

Southampton (UK): NIHR Journals Library; 2015 Aug.

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