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Targeting metabolism to regulate immune responses in autoimmunity and cancer.

Patel CH, Leone RD, Horton MR, Powell JD.

Nat Rev Drug Discov. 2019 Jul 30. doi: 10.1038/s41573-019-0032-5. [Epub ahead of print] Review.


An integrated experimental-computational approach for predicting virulence in New Zealand white rabbits and humans following inhalation exposure to Bacillus anthracis spores.

Hess BM, Thomas DG, Weber TJ, Hutchison JR, Straub TM, Bruckner-Lea CJ, Powell JD, Kabilan S, Corley RA.

PLoS One. 2019 Jul 1;14(7):e0219160. doi: 10.1371/journal.pone.0219160. eCollection 2019.


Rapid nondestructive measurement of bacterial cultures with 3D interferometric imaging.

Larimer C, Brann MR, Powell JD, Marshall MJ, Suter JD, Addleman RS.

Sci Rep. 2019 May 30;9(1):8055. doi: 10.1038/s41598-019-43839-7.


Inhibition of glutamine metabolism accelerates resolution of acute lung injury.

Vigeland CL, Beggs HS, Collins SL, Chan-Li Y, Powell JD, Doerschuk CM, Horton MR.

Physiol Rep. 2019 Mar;7(5):e14019. doi: 10.14814/phy2.14019.


An avian influenza virus A(H7N9) reassortant that recently emerged in the United States with low pathogenic phenotype does not efficiently infect swine.

Powell JD, Abente EJ, Torchetti MK, Killian ML, Vincent AL.

Influenza Other Respir Viruses. 2019 May;13(3):288-291. doi: 10.1111/irv.12631. Epub 2019 Feb 13.


PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress.

Ranek MJ, Kokkonen-Simon KM, Chen A, Dunkerly-Eyring BL, Vera MP, Oeing CU, Patel CH, Nakamura T, Zhu G, Bedja D, Sasaki M, Holewinski RJ, Van Eyk JE, Powell JD, Lee DI, Kass DA.

Nature. 2019 Feb;566(7743):264-269. doi: 10.1038/s41586-019-0895-y. Epub 2019 Jan 30.


Peeking under the Hood of Naive T Cells.

Xu W, Powell JD.

Cell Metab. 2018 Dec 4;28(6):801-802. doi: 10.1016/j.cmet.2018.11.008.


MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice.

Riggle BA, Sinharay S, Schreiber-Stainthorp W, Munasinghe JP, Maric D, Prchalova E, Slusher BS, Powell JD, Miller LH, Pierce SK, Hammoud DA.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033. doi: 10.1073/pnas.1812909115. Epub 2018 Dec 4.


A phase II study of temsirolimus and liposomal doxorubicin for patients with recurrent and refractory bone and soft tissue sarcomas.

Trucco MM, Meyer CF, Thornton KA, Shah P, Chen AR, Wilky BA, Carrera-Haro MA, Boyer LC, Ferreira MF, Shafique U, Powell JD, Loeb DM.

Clin Sarcoma Res. 2018 Nov 5;8:21. doi: 10.1186/s13569-018-0107-9. eCollection 2018.


Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models.

Leone RD, Sun IM, Oh MH, Sun IH, Wen J, Englert J, Powell JD.

Cancer Immunol Immunother. 2018 Aug;67(8):1271-1284. doi: 10.1007/s00262-018-2186-0. Epub 2018 Jun 19.


mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells.

Sun IH, Oh MH, Zhao L, Patel CH, Arwood ML, Xu W, Tam AJ, Blosser RL, Wen J, Powell JD.

J Immunol. 2018 Jul 15;201(2):481-492. doi: 10.4049/jimmunol.1701477. Epub 2018 Jun 8.


Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.

Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, Zhang L, Powell JD, Dang CV.

Cell. 2018 Jun 28;174(1):72-87.e32. doi: 10.1016/j.cell.2018.05.009. Epub 2018 May 31.


Intentional overdose of the novel anti-epileptic drug eslicarbazepine presenting with recurrent seizures and ventricular dysrhythmias.

Thompson J, Powell JD, Ovakim DH.

CJEM. 2018 Oct;20(S2):S44-S47. doi: 10.1017/cem.2017.401. Epub 2017 Sep 18.


mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages.

Oh MH, Collins SL, Sun IH, Tam AJ, Patel CH, Arwood ML, Chan-Li Y, Powell JD, Horton MR.

Cell Rep. 2017 Sep 5;20(10):2439-2454. doi: 10.1016/j.celrep.2017.08.046.


Influenza-Omics and the Host Response: Recent Advances and Future Prospects.

Powell JD, Waters KM.

Pathogens. 2017 Jun 10;6(2). pii: E25. doi: 10.3390/pathogens6020025. Review.


Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease.

Patel CH, Powell JD.

Curr Opin Immunol. 2017 Jun;46:82-88. doi: 10.1016/j.coi.2017.04.006. Epub 2017 May 15. Review.


mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation.

Chornoguz O, Hagan RS, Haile A, Arwood ML, Gamper CJ, Banerjee A, Powell JD.

J Immunol. 2017 May 15;198(10):3939-3948. doi: 10.4049/jimmunol.1601078. Epub 2017 Apr 19.


mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis.

Hallowell RW, Collins SL, Craig JM, Zhang Y, Oh M, Illei PB, Chan-Li Y, Vigeland CL, Mitzner W, Scott AL, Powell JD, Horton MR.

Nat Commun. 2017 Jan 27;8:14208. doi: 10.1038/ncomms14208.


Murine Full-thickness Skin Transplantation.

Cheng CH, Lee CF, Fryer M, Furtmüller GJ, Oh B, Powell JD, Brandacher G.

J Vis Exp. 2017 Jan 2;(119). doi: 10.3791/55105.


Targeting Metabolism as a Novel Therapeutic Approach to Autoimmunity, Inflammation, and Transplantation.

Bettencourt IA, Powell JD.

J Immunol. 2017 Feb 1;198(3):999-1005. doi: 10.4049/jimmunol.1601318. Review.


The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment.

Williams JB, Horton BL, Zheng Y, Duan Y, Powell JD, Gajewski TF.

J Exp Med. 2017 Feb;214(2):381-400. doi: 10.1084/jem.20160485. Epub 2017 Jan 23.


Warburg meets epigenetics.

Patel CH, Powell JD.

Science. 2016 Oct 28;354(6311):419-420. No abstract available.


An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor.

Hsiao PY, Kalin JH, Sun IH, Amin MN, Lo YC, Chiang MJ, Giddens J, Sysa-Shah P, Gabrielson K, Wang LX, Powell JD, Cole PA.

Chembiochem. 2016 Oct 17;17(20):1951-1960. doi: 10.1002/cbic.201600337. Epub 2016 Aug 26.


Deletion of mTORC1 Activity in CD4+ T Cells Is Associated with Lung Fibrosis and Increased γδ T Cells.

Vigeland CL, Collins SL, Chan-Li Y, Hughes AH, Oh MH, Powell JD, Horton MR.

PLoS One. 2016 Sep 20;11(9):e0163288. doi: 10.1371/journal.pone.0163288. eCollection 2016.


De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation.

Ladle BH, Li KP, Phillips MJ, Pucsek AB, Haile A, Powell JD, Jaffee EM, Hildeman DA, Gamper CJ.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10631-6. doi: 10.1073/pnas.1524490113. Epub 2016 Aug 31.


Leucine Metabolism in T Cell Activation: mTOR Signaling and Beyond.

Ananieva EA, Powell JD, Hutson SM.

Adv Nutr. 2016 Jul 15;7(4):798S-805S. doi: 10.3945/an.115.011221. Print 2016 Jul. Review.


Hunger Pains: Stimulating the Appetite of the Immune System for Cancer.

Englert JM, Powell JD.

Cancer Cell. 2016 Jul 11;30(1):13-15. doi: 10.1016/j.ccell.2016.06.019.


A cytometry microparticle platform approach for screening tobacco microRNA changes after agrobacterium delivery.

Powell JD, Chen Q, Mason HS.

J Microbiol Methods. 2016 Aug;127:230-235. doi: 10.1016/j.mimet.2016.06.023. Epub 2016 Jun 23.


Vaccinia vaccine-based immunotherapy arrests and reverses established pulmonary fibrosis.

Collins SL, Chan-Li Y, Oh M, Vigeland CL, Limjunyawong N, Mitzner W, Powell JD, Horton MR.

JCI Insight. 2016 Apr 7;1(4):e83116.


The landscape of viral proteomics and its potential to impact human health.

Oxford KL, Wendler JP, McDermott JE, White Iii RA, Powell JD, Jacobs JM, Adkins JN, Waters KM.

Expert Rev Proteomics. 2016 Jun;13(6):579-91. doi: 10.1080/14789450.2016.1184091. Epub 2016 May 26. Review.


Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells.

Sadtler K, Estrellas K, Allen BW, Wolf MT, Fan H, Tam AJ, Patel CH, Luber BS, Wang H, Wagner KR, Powell JD, Housseau F, Pardoll DM, Elisseeff JH.

Science. 2016 Apr 15;352(6283):366-70. doi: 10.1126/science.aad9272.


Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation.

Pollizzi KN, Sun IH, Patel CH, Lo YC, Oh MH, Waickman AT, Tam AJ, Blosser RL, Wen J, Delgoffe GM, Powell JD.

Nat Immunol. 2016 Jun;17(6):704-11. doi: 10.1038/ni.3438. Epub 2016 Apr 11.


The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment.

Sharma MD, Shinde R, McGaha TL, Huang L, Holmgaard RB, Wolchok JD, Mautino MR, Celis E, Sharpe AH, Francisco LM, Powell JD, Yagita H, Mellor AL, Blazar BR, Munn DH.

Sci Adv. 2015 Nov 6;1(10):e1500845. doi: 10.1126/sciadv.1500845. eCollection 2015 Nov.


Preventing Allograft Rejection by Targeting Immune Metabolism.

Lee CF, Lo YC, Cheng CH, Furtmüller GJ, Oh B, Andrade-Oliveira V, Thomas AG, Bowman CE, Slusher BS, Wolfgang MJ, Brandacher G, Powell JD.

Cell Rep. 2015 Oct 27;13(4):760-770. doi: 10.1016/j.celrep.2015.09.036. Epub 2015 Oct 17.


Targeting glutamine metabolism rescues mice from late-stage cerebral malaria.

Gordon EB, Hart GT, Tran TM, Waisberg M, Akkaya M, Kim AS, Hamilton SE, Pena M, Yazew T, Qi CF, Lee CF, Lo YC, Miller LH, Powell JD, Pierce SK.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13075-80. doi: 10.1073/pnas.1516544112. Epub 2015 Oct 5.


Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion.

Delgoffe GM, Powell JD.

Mol Immunol. 2015 Dec;68(2 Pt C):492-6. doi: 10.1016/j.molimm.2015.07.026. Review.


Patient-Reported Outcome Instruments for Physical Symptoms Among Patients Receiving Maintenance Dialysis: A Systematic Review.

Flythe JE, Powell JD, Poulton CJ, Westreich KD, Handler L, Reeve BB, Carey TS.

Am J Kidney Dis. 2015 Dec;66(6):1033-46. doi: 10.1053/j.ajkd.2015.05.020. Epub 2015 Jul 23. Review.


Dysregulated Macrophages Are Present in Bleomycin-Induced Murine Laryngotracheal Stenosis.

Hillel AT, Samad I, Ma G, Ding D, Sadtler K, Powell JD, Lane AP, Horton MR.

Otolaryngol Head Neck Surg. 2015 Aug;153(2):244-50. doi: 10.1177/0194599815589106. Epub 2015 Jun 17.


Bacillus anthracis spores germinate extracellularly at air-liquid interface in an in vitro lung model under serum-free conditions.

Powell JD, Hutchison JR, Hess BM, Straub TM.

J Appl Microbiol. 2015 Sep;119(3):711-23. doi: 10.1111/jam.12872. Epub 2015 Jul 30.


A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy.

Leone RD, Lo YC, Powell JD.

Comput Struct Biotechnol J. 2015 Apr 8;13:265-72. doi: 10.1016/j.csbj.2015.03.008. eCollection 2015. Review.


mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation.

Pollizzi KN, Patel CH, Sun IH, Oh MH, Waickman AT, Wen J, Delgoffe GM, Powell JD.

J Clin Invest. 2015 May;125(5):2090-108. doi: 10.1172/JCI77746. Epub 2015 Apr 20.


Something in the air: hyperoxic conditioning of the tumor microenvironment for enhanced immunotherapy.

Leone RD, Horton MR, Powell JD.

Cancer Cell. 2015 Apr 13;27(4):435-6. doi: 10.1016/j.ccell.2015.03.014.


Cellular size as a means of tracking mTOR activity and cell fate of CD4+ T cells upon antigen recognition.

Pollizzi KN, Waickman AT, Patel CH, Sun IH, Powell JD.

PLoS One. 2015 Apr 7;10(4):e0121710. doi: 10.1371/journal.pone.0121710. eCollection 2015.


Rapamycin inhibits human laryngotracheal stenosis-derived fibroblast proliferation, metabolism, and function in vitro.

Namba DR, Ma G, Samad I, Ding D, Pandian V, Powell JD, Horton MR, Hillel AT.

Otolaryngol Head Neck Surg. 2015 May;152(5):881-8. doi: 10.1177/0194599815573708. Epub 2015 Mar 9.


Sugar, fat, and protein: new insights into what T cells crave.

Delgoffe GM, Powell JD.

Curr Opin Immunol. 2015 Apr;33:49-54. doi: 10.1016/j.coi.2015.01.015. Epub 2015 Feb 6. Review.


Regulation of T cells by mTOR: the known knowns and the known unknowns.

Pollizzi KN, Powell JD.

Trends Immunol. 2015 Jan;36(1):13-20. doi: 10.1016/ Epub 2014 Dec 16. Review.


Construction of an in vitro primary lung co-culture platform derived from New Zealand white rabbits.

Powell JD, Hess BM, Hutchison JR, Straub TM.

In Vitro Cell Dev Biol Anim. 2015 May;51(5):433-40. doi: 10.1007/s11626-014-9853-z. Epub 2014 Dec 10. No abstract available.


Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger.

Prevot N, Pyaram K, Bischoff E, Sen JM, Powell JD, Chang CH.

J Immunol. 2015 Jan 1;194(1):223-30. doi: 10.4049/jimmunol.1401985. Epub 2014 Nov 17.


Polymerase discordance in novel swine influenza H3N2v constellations is tolerated in swine but not human respiratory epithelial cells.

Powell JD, Dlugolenski D, Nagy T, Gabbard J, Lee C, Tompkins SM, Tripp RA.

PLoS One. 2014 Oct 16;9(10):e110264. doi: 10.1371/journal.pone.0110264. eCollection 2014.


Single-agent GVHD prophylaxis with posttransplantation cyclophosphamide after myeloablative, HLA-matched BMT for AML, ALL, and MDS.

Kanakry CG, Tsai HL, Bolaños-Meade J, Smith BD, Gojo I, Kanakry JA, Kasamon YL, Gladstone DE, Matsui W, Borrello I, Huff CA, Swinnen LJ, Powell JD, Pratz KW, DeZern AE, Showel MM, McDevitt MA, Brodsky RA, Levis MJ, Ambinder RF, Fuchs EJ, Rosner GL, Jones RJ, Luznik L.

Blood. 2014 Dec 11;124(25):3817-27. doi: 10.1182/blood-2014-07-587477. Epub 2014 Oct 14.

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