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NOTUM inhibition increases endocortical bone formation and bone strength.

Brommage R, Liu J, Vogel P, Mseeh F, Thompson AY, Potter DG, Shadoan MK, Hansen GM, Jeter-Jones S, Cui J, Bright D, Bardenhagen JP, Doree DD, Movérare-Skrtic S, Nilsson KH, Henning P, Lerner UH, Ohlsson C, Sands AT, Tarver JE, Powell DR, Zambrowicz B, Liu Q.

Bone Res. 2019 Jan 8;7:2. doi: 10.1038/s41413-018-0038-3. eCollection 2019.


A Randomized Trial to Evaluate the Effect of Toric Versus Spherical Contact Lenses on Vision and Eyestrain.

Berntsen DA, Cox SM, Bickle KM, Mathew JH, Powell DR, Seidman SH, Little BK, Lorenz KO, Nichols JJ.

Eye Contact Lens. 2019 Jan;45(1):28-33. doi: 10.1097/ICL.0000000000000528.


Clinical factors associated with contact lens dropout.

Pucker AD, Jones-Jordan LA, Marx S, Powell DR, Kwan JT, Srinivasan S, Sickenberger W, Jones L; Contact Lens Assessment of Symptomatic Subjects (CLASS) Study Group.

Cont Lens Anterior Eye. 2018 Dec 8. pii: S1367-0484(18)30880-4. doi: 10.1016/j.clae.2018.12.002. [Epub ahead of print]


A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling.

Koch B, Barugahare AA, Lo TL, Huang C, Schittenhelm RB, Powell DR, Beilharz TH, Traven A.

Cell Rep. 2018 Nov 20;25(8):2244-2258.e7. doi: 10.1016/j.celrep.2018.10.080.


The Intercellular Tight Junction and Spontaneous Coronary Artery Dissection.

Fahey JK, Williams SM, Tyagi S, Powell DR, Hallab JC, Chahal G, Ramialison MSM, White AJ.

J Am Coll Cardiol. 2018 Oct 2;72(14):1752-1753. doi: 10.1016/j.jacc.2018.07.040. No abstract available.


A novel role for Lyl1 in primitive erythropoiesis.

Chiu SK, Saw J, Huang Y, Sonderegger SE, Wong NC, Powell DR, Beck D, Pimanda JE, Tremblay CS, Curtis DJ.

Development. 2018 Oct 11;145(19). pii: dev162990. doi: 10.1242/dev.162990.


Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells.

Tremblay CS, Saw J, Chiu SK, Wong NC, Tsyganov K, Ghotb S, Graham AN, Yan F, Guirguis AA, Sonderegger SE, Lee N, Kalitsis P, Reynolds J, Ting SB, Powell DR, Jane SM, Curtis DJ.

Nat Commun. 2018 Aug 30;9(1):3535. doi: 10.1038/s41467-018-06021-7.


Anion Complexation Studies of 3-Nitrophenyl-Substituted Tripodal Thiourea Receptor: A Naked-Eye Detection of Sulfate via Fluoride Displacement Assay.

Emami Khansari M, Hasan MH, Johnson CR, Williams NA, Wong BM, Powell DR, Tandon R, Hossain MA.

ACS Omega. 2017 Dec 31;2(12):9057-9066. doi: 10.1021/acsomega.7b01485. Epub 2017 Dec 18.


Wolbachia enhances insect-specific flavivirus infection in Aedes aegypti mosquitoes.

Amuzu HE, Tsyganov K, Koh C, Herbert RI, Powell DR, McGraw EA.

Ecol Evol. 2018 May 8;8(11):5441-5454. doi: 10.1002/ece3.4066. eCollection 2018 Jun.


Functional and genomic characterisation of a xenograft model system for the study of metastasis in triple-negative breast cancer.

Johnstone CN, Pattison AD, Gorringe KL, Harrison PF, Powell DR, Lock P, Baloyan D, Ernst M, Stewart AG, Beilharz TH, Anderson RL.

Dis Model Mech. 2018 May 29;11(5). pii: dmm032250. doi: 10.1242/dmm.032250.


Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection.

Tucey TM, Verma J, Harrison PF, Snelgrove SL, Lo TL, Scherer AK, Barugahare AA, Powell DR, Wheeler RT, Hickey MJ, Beilharz TH, Naderer T, Traven A.

Cell Metab. 2018 May 1;27(5):988-1006.e7. doi: 10.1016/j.cmet.2018.03.019.


Galactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung Cancer.

Kennedy EM, Powell DR, Li Z, Bell JSK, Barwick BG, Feng H, McCrary MR, Dwivedi B, Kowalski J, Dynan WS, Conneely KN, Vertino PM.

Sci Rep. 2018 Apr 30;8(1):6709. doi: 10.1038/s41598-018-24755-8.


Concurrent Host-Pathogen Transcriptional Responses in a Clostridium perfringens Murine Myonecrosis Infection.

Low LY, Harrison PF, Gould J, Powell DR, Choo JM, Forster SC, Chapman R, Gearing LJ, Cheung JK, Hertzog P, Rood JI.

MBio. 2018 Mar 27;9(2). pii: e00473-18. doi: 10.1128/mBio.00473-18.


Choosing Wisely Canada recommendations.

Powell DR.

Can Fam Physician. 2018 Mar;64(3):198. No abstract available.


Lewis Acid Activation of the Ferrous Heme-NO Fragment toward the N-N Coupling Reaction with NO To Generate N2O.

Abucayon EG, Khade RL, Powell DR, Zhang Y, Richter-Addo GB.

J Am Chem Soc. 2018 Mar 28;140(12):4204-4207. doi: 10.1021/jacs.7b13681. Epub 2018 Mar 15.


Determination of the small RNA GcvB regulon in the Gram-negative bacterial pathogen Pasteurella multocida and identification of the GcvB seed binding region.

Gulliver EL, Wright A, Lucas DD, Mégroz M, Kleifeld O, Schittenhelm RB, Powell DR, Seemann T, Bulitta JB, Harper M, Boyce JD.

RNA. 2018 May;24(5):704-720. doi: 10.1261/rna.063248.117. Epub 2018 Feb 12.


Highly selective and sensitive macrocycle-based dinuclear foldamer for fluorometric and colorimetric sensing of citrate in water.

Rhaman MM, Hasan MH, Alamgir A, Xu L, Powell DR, Wong BM, Tandon R, Hossain MA.

Sci Rep. 2018 Jan 10;8(1):286. doi: 10.1038/s41598-017-18322-w.


Supramolecular Assembly of Uridine Monophosphate (UMP) and Thymidine Monophosphate (TMP) with a Dinuclear Copper(II) Receptor.

Rhaman MM, Powell DR, Hossain MA.

ACS Omega. 2017 Nov 30;2(11):7803-7811. doi: 10.1021/acsomega.7b01293. Epub 2017 Nov 10.


Cell Type of Origin Dictates the Route to Pluripotency.

Nefzger CM, Rossello FJ, Chen J, Liu X, Knaupp AS, Firas J, Paynter JM, Pflueger J, Buckberry S, Lim SM, Williams B, Alaei S, Faye-Chauhan K, Petretto E, Nilsson SK, Lister R, Ramialison M, Powell DR, Rackham OJL, Polo JM.

Cell Rep. 2017 Dec 5;21(10):2649-2660. doi: 10.1016/j.celrep.2017.11.029.


An Ideal C3-Symmetric Sulfate Complex: Molecular Recognition of Oxoanions by m-Nitrophenyl- and Pentafluorophenyl-Functionalized Hexaurea Receptors.

Portis B, Mirchi A, Emami Khansari M, Pramanik A, Johnson CR, Powell DR, Leszczynski J, Hossain MA.

ACS Omega. 2017 Sep 30;2(9):5840-5849. doi: 10.1021/acsomega.7b01115. Epub 2017 Sep 18.


Efficacy of Toric Contact Lenses in Fitting and Patient-Reported Outcomes in Contact Lens Wearers.

Cox SM, Berntsen DA, Bickle KM, Mathew JH, Powell DR, Little BK, Lorenz KO, Nichols JJ.

Eye Contact Lens. 2018 Sep;44 Suppl 1:S296-S299. doi: 10.1097/ICL.0000000000000418.


De novo transcriptome assembly for the spiny mouse (Acomys cahirinus).

Mamrot J, Legaie R, Ellery SJ, Wilson T, Seemann T, Powell DR, Gardner DK, Walker DW, Temple-Smith P, Papenfuss AT, Dickinson H.

Sci Rep. 2017 Aug 21;7(1):8996. doi: 10.1038/s41598-017-09334-7.


Carbon-Nitrogen and Nitrogen-Nitrogen Bond Formation from Nucleophilic Attack at Coordinated Nitrosyls in Fe and Ru Heme Models.

Abucayon EG, Powell DR, Richter-Addo GB.

J Am Chem Soc. 2017 Jul 19;139(28):9495-9498. doi: 10.1021/jacs.7b05209. Epub 2017 Jul 5.


LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice.

Powell DR, Smith MG, Doree DD, Harris AL, Greer J, DaCosta CM, Thompson A, Jeter-Jones S, Xiong W, Carson KG, Goodwin NC, Harrison BA, Rawlins DB, Strobel ED, Gopinathan S, Wilson A, Mseeh F, Zambrowicz B, Ding ZM.

J Pharmacol Exp Ther. 2017 Jul;362(1):85-97. doi: 10.1124/jpet.117.240820. Epub 2017 Apr 25.


Schiff base thorium(iv) and uranium(iv) chloro complexes: synthesis, substitution and oxidation chemistry.

Stobbe BC, Powell DR, Thomson RK.

Dalton Trans. 2017 Apr 11;46(15):4888-4892. doi: 10.1039/c7dt00580f.


Correction to Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-Anthropoidal Mammalian Microbiomes.

Motley JL, Stamps BW, Mitchell CA, Thompson AT, Cross J, You J, Powell DR, Stevenson BS, Cichewicz RH.

J Nat Prod. 2017 Apr 28;80(4):1233. doi: 10.1021/acs.jnatprod.7b00234. Epub 2017 Mar 24. No abstract available.


Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-anthropoidal Mammalian Microbiomes.

Motley JL, Stamps BW, Mitchell CA, Thompson AT, Cross J, You J, Powell DR, Stevenson BS, Cichewicz RH.

J Nat Prod. 2017 Mar 24;80(3):598-608. doi: 10.1021/acs.jnatprod.6b00772. Epub 2016 Nov 21. Erratum in: J Nat Prod. 2017 Apr 28;80(4):1233.


Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes.

Goodwin NC, Ding ZM, Harrison BA, Strobel ED, Harris AL, Smith M, Thompson AY, Xiong W, Mseeh F, Bruce DJ, Diaz D, Gopinathan S, Li L, O'Neill E, Thiel M, Wilson AG, Carson KG, Powell DR, Rawlins DB.

J Med Chem. 2017 Jan 26;60(2):710-721. doi: 10.1021/acs.jmedchem.6b01541. Epub 2017 Jan 17.


Over or under: hydride attack at the metal versus the coordinated nitrosyl ligand in ferric nitrosyl porphyrins.

Abucayon EG, Khade RL, Powell DR, Shaw MJ, Zhang Y, Richter-Addo GB.

Dalton Trans. 2016 Nov 15;45(45):18259-18266.


Synthesis and Characterization of Copper Complexes with CuICuI, Cu1.5Cu1.5m and CuIICuII Core Structures Supported by a Flexible Dipyridylamide Ligand.

McMoran EP, Powell DR, Perez F, Rowe GT, Yang L.

Inorg Chem. 2016 Nov 7;55(21):11462-11472. Epub 2016 Oct 26.


Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion.

Syring KE, Boortz KA, Oeser JK, Ustione A, Platt KA, Shadoan MK, McGuinness OP, Piston DW, Powell DR, O'Brien RM.

Endocrinology. 2016 Dec;157(12):4534-4541. Epub 2016 Oct 18.


Chlorination of 1-Carba-closo-dodecaborate and 1-Ammonio-closo-dodecaborate Anions.

Saleh M, Powell DR, Wehmschulte RJ.

Inorg Chem. 2016 Oct 5. [Epub ahead of print]


Dapagliflozin Binds Specifically to Sodium-Glucose Cotransporter 2 in the Proximal Renal Tubule.

Ghezzi C, Yu AS, Hirayama BA, Kepe V, Liu J, Scafoglio C, Powell DR, Huang SC, Satyamurthy N, Barrio JR, Wright EM.

J Am Soc Nephrol. 2017 Mar;28(3):802-810. doi: 10.1681/ASN.2016050510. Epub 2016 Sep 12.


Haplotyping the human leukocyte antigen system from single chromosomes.

Murphy NM, Burton M, Powell DR, Rossello FJ, Cooper D, Chopra A, Hsieh MJ, Sayer DC, Gordon L, Pertile MD, Tait BD, Irving HR, Pouton CW.

Sci Rep. 2016 Jul 27;6:30381. doi: 10.1038/srep30381.


Effect of Buffer Conditions and Organic Cosolvents on the Rate of Strain-Promoted Azide-Alkyne Cycloaddition.

Davis DL, Price EK, Aderibigbe SO, Larkin MX, Barlow ED, Chen R, Ford LC, Gray ZT, Gren SH, Jin Y, Keddington KS, Kent AD, Kim D, Lewis A, Marrouche RS, O'Dair MK, Powell DR, Scadden MH, Session CB, Tao J, Trieu J, Whiteford KN, Yuan Z, Yun G, Zhu J, Heemstra JM.

J Org Chem. 2016 Aug 5;81(15):6816-9. doi: 10.1021/acs.joc.6b01112. Epub 2016 Jul 14.


Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque.

Powell DR, Gay JP, Smith M, Wilganowski N, Harris A, Holland A, Reyes M, Kirkham L, Kirkpatrick LL, Zambrowicz B, Hansen G, Platt KA, van Sligtenhorst I, Ding ZM, Desai U.

Diabetes Metab Syndr Obes. 2016 Jun 22;9:185-99. doi: 10.2147/DMSO.S106653. eCollection 2016.


Revisiting the physiological roles of SGLTs and GLUTs using positron emission tomography in mice.

Sala-Rabanal M, Hirayama BA, Ghezzi C, Liu J, Huang SC, Kepe V, Koepsell H, Yu A, Powell DR, Thorens B, Wright EM, Barrio JR.

J Physiol. 2016 Aug 1;594(15):4425-38. doi: 10.1113/JP271904. Epub 2016 May 10.


Dentin Dysplasia in Notum Knockout Mice.

Vogel P, Read RW, Hansen GM, Powell DR, Kantaputra PN, Zambrowicz B, Brommage R.

Vet Pathol. 2016 Jul;53(4):853-62. doi: 10.1177/0300985815626778. Epub 2016 Feb 29.


A Versatile Strategy for Isolating a Highly Enriched Population of Intestinal Stem Cells.

Nefzger CM, Jardé T, Rossello FJ, Horvay K, Knaupp AS, Powell DR, Chen J, Abud HE, Polo JM.

Stem Cell Reports. 2016 Mar 8;6(3):321-9. doi: 10.1016/j.stemcr.2016.01.014. Epub 2016 Feb 25.


Crystal structure of bis(bis{(E)-[(6-{(E)-[(4-fluorobenzyl)imino]methyl}pyridin-2-yl)methylidene](4-fluorophenyl)amine}nickel(II)) tetra-bromide nona-hydrate.

Basaran I, Rhaman MM, Powell DR, Hossain MA.

Acta Crystallogr E Crystallogr Commun. 2015 Nov 21;71(Pt 12):m226-7. doi: 10.1107/S2056989015021519. eCollection 2015 Dec 1.


Segregation of Naturally Occurring Mitochondrial DNA Variants in a Mini-Pig Model.

Cagnone G, Tsai TS, Srirattana K, Rossello F, Powell DR, Rohrer G, Cree L, Trounce IA, St John JC.

Genetics. 2016 Mar;202(3):931-44. doi: 10.1534/genetics.115.181321. Epub 2016 Jan 27.


Texas Native Plants Yield Compounds with Cytotoxic Activities against Prostate Cancer Cells.

Shaffer CV, Cai S, Peng J, Robles AJ, Hartley RM, Powell DR, Du L, Cichewicz RH, Mooberry SL.

J Nat Prod. 2016 Mar 25;79(3):531-40. doi: 10.1021/acs.jnatprod.5b00908. Epub 2016 Jan 19.


PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia.

Guirguis AA, Slape CI, Failla LM, Saw J, Tremblay CS, Powell DR, Rossello F, Wei A, Strasser A, Curtis DJ.

Cell Death Differ. 2016 Jun;23(6):1049-59. doi: 10.1038/cdd.2015.159. Epub 2016 Jan 8.


Identification of Compounds with Efficacy against Malaria Parasites from Common North American Plants.

Cai S, Risinger AL, Nair S, Peng J, Anderson TJ, Du L, Powell DR, Mooberry SL, Cichewicz RH.

J Nat Prod. 2016 Mar 25;79(3):490-8. doi: 10.1021/acs.jnatprod.5b00874. Epub 2015 Dec 21.


Neutrophils in the Tumor Microenvironment.

Powell DR, Huttenlocher A.

Trends Immunol. 2016 Jan;37(1):41-52. doi: 10.1016/ Epub 2015 Dec 14. Review.


Hydride Attack on a Coordinated Ferric Nitrosyl: Experimental and DFT Evidence for the Formation of a Heme Model-HNO Derivative.

Abucayon EG, Khade RL, Powell DR, Zhang Y, Richter-Addo GB.

J Am Chem Soc. 2016 Jan 13;138(1):104-7. doi: 10.1021/jacs.5b12008. Epub 2015 Dec 23.


Six-coordinate ferric porphyrins containing bidentate N-t-butyl-N-nitrosohydroxylaminato ligands: structure, magnetism, IR spectroelectrochemisty, and reactivity.

Xu N, Christian JH, Dalal NS, Abucayon EG, Lingafelt C, Powell DR, Richter-Addo GB.

Dalton Trans. 2015 Dec 14;44(46):20121-30. doi: 10.1039/c5dt03074a.


A bridged di-iron porphyrin hyponitrite complex as a model for biological N2O production from hyponitrite.

Xu N, Abucayon EG, Powell DR, Richter-Addo GB.

Nitric Oxide. 2016 Jan 30;52:16-20. doi: 10.1016/j.niox.2015.10.005. Epub 2015 Oct 31.


Integration of Posttranscriptional Gene Networks into Metabolic Adaptation and Biofilm Maturation in Candida albicans.

Verma-Gaur J, Qu Y, Harrison PF, Lo TL, Quenault T, Dagley MJ, Bellousoff M, Powell DR, Beilharz TH, Traven A.

PLoS Genet. 2015 Oct 16;11(10):e1005590. doi: 10.1371/journal.pgen.1005590. eCollection 2015 Oct.


Crystal structure of N-(2-{[2,6-bis-(2,2,2-tri-fluoro-acetamido)-phen-yl]disulfan-yl}-3-(2,2,2-tri-fluoro-acetamido)-phen-yl)-2,2,2-tri-fluoro-acetamide.

Awasabisah D, Powell DR, Richter-Addo GB.

Acta Crystallogr E Crystallogr Commun. 2015 Aug 6;71(Pt 9):o639-40. doi: 10.1107/S2056989015014231. eCollection 2015 Sep 1.

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