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Items: 11


Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs.

O'Byrne S, Elliott N, Rice S, Buck G, Fordham N, Garnett C, Godfrey L, Crump NT, Wright G, Inglott S, Hua P, Psaila B, Povinelli B, Knapp DJHF, Agraz-Doblas A, Bueno C, Varela I, Bennett P, Koohy H, Watt SM, Karadimitris A, Mead AJ, Ancliff P, Vyas P, Menendez P, Milne TA, Roberts I, Roy A.

Blood. 2019 Sep 26;134(13):1059-1071. doi: 10.1182/blood.2019001289. Epub 2019 Aug 5.


Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation.

Di Genua C, Norfo R, Rodriguez-Meira A, Wen WX, Drissen R, Booth CAG, Povinelli B, Repapi E, Gray N, Carrelha J, Kettyle LM, Jamieson L, Neo WH, Thongjuea S, Nerlov C, Mead AJ.

Haematologica. 2019 Nov;104(11):2215-2224. doi: 10.3324/haematol.2018.205351. Epub 2019 Apr 11.


Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing.

Rodriguez-Meira A, Buck G, Clark SA, Povinelli BJ, Alcolea V, Louka E, McGowan S, Hamblin A, Sousos N, Barkas N, Giustacchini A, Psaila B, Jacobsen SEW, Thongjuea S, Mead AJ.

Mol Cell. 2019 Mar 21;73(6):1292-1305.e8. doi: 10.1016/j.molcel.2019.01.009. Epub 2019 Feb 12.


Single cell analysis of normal and leukemic hematopoiesis.

Povinelli BJ, Rodriguez-Meira A, Mead AJ.

Mol Aspects Med. 2018 Feb;59:85-94. doi: 10.1016/j.mam.2017.08.006. Epub 2017 Sep 8. Review.


Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia.

Giustacchini A, Thongjuea S, Barkas N, Woll PS, Povinelli BJ, Booth CAG, Sopp P, Norfo R, Rodriguez-Meira A, Ashley N, Jamieson L, Vyas P, Anderson K, Segerstolpe Å, Qian H, Olsson-Strömberg U, Mustjoki S, Sandberg R, Jacobsen SEW, Mead AJ.

Nat Med. 2017 Jun;23(6):692-702. doi: 10.1038/nm.4336. Epub 2017 May 15.


Standard sub-thermoneutral caging temperature influences radiosensitivity of hematopoietic stem and progenitor cells.

Povinelli BJ, Kokolus KM, Eng JW, Dougher CW, Curtin L, Capitano ML, Sailsbury-Ruf CT, Repasky EA, Nemeth MJ.

PLoS One. 2015 Mar 20;10(3):e0120078. doi: 10.1371/journal.pone.0120078. eCollection 2015.


Related-to-receptor tyrosine kinase receptor regulates hematopoietic stem and progenitor sensitivity to myelosuppressive injury in mice.

Povinelli BJ, Srivastava P, Nemeth MJ.

Exp Hematol. 2015 Mar;43(3):243-252.e1. doi: 10.1016/j.exphem.2014.10.014. Epub 2014 Nov 11.


Pharmacological targeting of β-catenin in normal karyotype acute myeloid leukemia blasts.

Griffiths EA, Golding MC, Srivastava P, Povinelli BJ, James SR, Ford LA, Wetzler M, Wang ES, Nemeth MJ.

Haematologica. 2015 Feb;100(2):e49-52. doi: 10.3324/haematol.2014.113118. Epub 2014 Nov 7. No abstract available.


The Thoc1 encoded ribonucleoprotein is required for myeloid progenitor cell homeostasis in the adult mouse.

Pitzonka L, Ullas S, Chinnam M, Povinelli BJ, Fisher DT, Golding M, Appenheimer MM, Nemeth MJ, Evans S, Goodrich DW.

PLoS One. 2014 May 15;9(5):e97628. doi: 10.1371/journal.pone.0097628. eCollection 2014.


Stressful presentations: mild cold stress in laboratory mice influences phenotype of dendritic cells in naïve and tumor-bearing mice.

Kokolus KM, Spangler HM, Povinelli BJ, Farren MR, Lee KP, Repasky EA.

Front Immunol. 2014 Feb 10;5:23. doi: 10.3389/fimmu.2014.00023. eCollection 2014.


Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor.

Povinelli BJ, Nemeth MJ.

Stem Cells. 2014 Jan;32(1):105-15. doi: 10.1002/stem.1513.

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