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Items: 1 to 50 of 132

1.

Isolation of LMX1a Ventral Midbrain Progenitors Improves the Safety and Predictability of Human Pluripotent Stem Cell-Derived Neural Transplants in Parkinsonian Disease.

de Luzy IR, Niclis JC, Gantner CW, Kauhausen JA, Hunt CPJ, Ermine C, Pouton CW, Thompson LH, Parish CL.

J Neurosci. 2019 Nov 27;39(48):9521-9531. doi: 10.1523/JNEUROSCI.1160-19.2019. Epub 2019 Oct 22.

PMID:
31641054
2.

Local inflammation alters the lung disposition of a drug loaded pegylated liposome after pulmonary dosing to rats.

Haque S, Feeney O, Meeusen E, Boyd BJ, McIntosh MP, Pouton CW, Whittaker M, Kaminskas LM.

J Control Release. 2019 Aug 10;307:32-43. doi: 10.1016/j.jconrel.2019.05.043. Epub 2019 May 29.

PMID:
31152749
3.

Unlocking the full potential of lipid-based formulations using lipophilic salt/ionic liquid forms.

Williams HD, Ford L, Igonin A, Shan Z, Botti P, Morgen MM, Hu G, Pouton CW, Scammells PJ, Porter CJH, Benameur H.

Adv Drug Deliv Rev. 2019 Mar 1;142:75-90. doi: 10.1016/j.addr.2019.05.008. Epub 2019 May 29. Review.

PMID:
31150666
4.

Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs.

Vithani K, Jannin V, Pouton CW, Boyd BJ.

Adv Drug Deliv Rev. 2019 Mar 1;142:16-34. doi: 10.1016/j.addr.2019.01.008. Epub 2019 Jan 21. Review.

PMID:
30677448
5.

Suggested Procedures for the Reproducible Synthesis of Poly(d,l-lactide-co-glycolide) Nanoparticles Using the Emulsification Solvent Diffusion Platform.

Haque S, Boyd BJ, McIntosh MP, Pouton CW, Kaminskas LM, Whittaker M.

Curr Nanosci. 2018 Oct;14(5):448-453. doi: 10.2174/1573413714666180313130235.

6.

A Nonionic Polyethylene Oxide (PEO) Surfactant Model: Experimental and Molecular Dynamics Studies of Kolliphor EL.

Suys EJA, Warren DB, Pham AC, Nowell CJ, Clulow AJ, Benameur H, Porter CJH, Pouton CW, Chalmers DK.

J Pharm Sci. 2019 Jan;108(1):193-204. doi: 10.1016/j.xphs.2018.11.028. Epub 2018 Nov 28.

PMID:
30502483
7.

Improvement in the Predicted Partitioning of Alcohol and Polyethylene Oxide Groups Between Water and Octanol (logP) in Molecular Dynamics Simulations.

Warren DB, McPhee E, Birru WA, Benameur H, Chalmers DK, Pouton CW.

J Pharm Sci. 2019 Jan;108(1):214-222. doi: 10.1016/j.xphs.2018.11.016. Epub 2018 Nov 20.

PMID:
30468829
8.

Location of Solvated Probe Molecules Within Nonionic Surfactant Micelles Using Molecular Dynamics.

Warren DB, McPhee E, Birru WA, Benameur H, Chalmers DK, Pouton CW.

J Pharm Sci. 2019 Jan;108(1):205-213. doi: 10.1016/j.xphs.2018.10.055. Epub 2018 Nov 3.

PMID:
30395831
9.

Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations.

Williams HD, Ford L, Han S, Tangso KJ, Lim S, Shackleford DM, Vodak DT, Benameur H, Pouton CW, Scammells PJ, Porter CJH.

Mol Pharm. 2018 Dec 3;15(12):5678-5696. doi: 10.1021/acs.molpharmaceut.8b00858. Epub 2018 Nov 13.

10.

Self-Crosslinking Lipopeptide/DNA/PEGylated Particles: A New Platform for DNA Vaccination Designed for Assembly in Aqueous Solution.

Ho JK, White PJ, Pouton CW.

Mol Ther Nucleic Acids. 2018 Sep 7;12:504-517. doi: 10.1016/j.omtn.2018.05.025. Epub 2018 Jul 18.

11.

Corrigendum: Purification and characterization of adenovirus core protein VII: a histone-like protein that is critical for adenovirus core formation.

Sharma G, Moria N, Williams M, Krishnarjuna B, Pouton CW.

J Gen Virol. 2018 Jun;99(6):860. doi: 10.1099/jgv.0.001078. No abstract available.

PMID:
29855408
12.

Polymeric Precipitation Inhibitors Promote Fenofibrate Supersaturation and Enhance Drug Absorption from a Type IV Lipid-Based Formulation.

Suys EJA, Chalmers DK, Pouton CW, Porter CJH.

Mol Pharm. 2018 Jun 4;15(6):2355-2371. doi: 10.1021/acs.molpharmaceut.8b00206. Epub 2018 May 4.

PMID:
29659287
13.

Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke.

Evans MA, Lim R, Kim HA, Chu HX, Gardiner-Mann CV, Taylor KWE, Chan CT, Brait VH, Lee S, Dinh QN, Vinh A, Phan TG, Srikanth VK, Ma H, Arumugam TV, Fann DY, Poh L, Hunt CPJ, Pouton CW, Haynes JM, Selemidis S, Kwan W, Teo L, Bourne JA, Neumann S, Young S, Gowing EK, Drummond GR, Clarkson AN, Wallace EM, Sobey CG, Broughton BRS.

Stroke. 2018 Mar;49(3):700-709. doi: 10.1161/STROKEAHA.117.019136. Epub 2018 Jan 30.

PMID:
29382802
14.

A comparison of the lung clearance kinetics of solid lipid nanoparticles and liposomes by following the 3H-labelled structural lipids after pulmonary delivery in rats.

Haque S, Whittaker M, McIntosh MP, Pouton CW, Phipps S, Kaminskas LM.

Eur J Pharm Biopharm. 2018 Apr;125:1-12. doi: 10.1016/j.ejpb.2018.01.001. Epub 2018 Jan 5.

PMID:
29309835
15.

Specification of murine ground state pluripotent stem cells to regional neuronal populations.

Alsanie WF, Niclis JC, Hunt CP, De Luzy IR, Penna V, Bye CR, Pouton CW, Haynes J, Firas J, Thompson LH, Parish CL.

Sci Rep. 2017 Nov 22;7(1):16001. doi: 10.1038/s41598-017-16248-x.

16.

Computational Models of the Intestinal Environment. 3. The Impact of Cholesterol Content and pH on Mixed Micelle Colloids.

Suys EJA, Warren DB, Porter CJH, Benameur H, Pouton CW, Chalmers DK.

Mol Pharm. 2017 Nov 6;14(11):3684-3697. doi: 10.1021/acs.molpharmaceut.7b00446. Epub 2017 Oct 5.

PMID:
28980815
17.

A PITX3-EGFP Reporter Line Reveals Connectivity of Dopamine and Non-dopamine Neuronal Subtypes in Grafts Generated from Human Embryonic Stem Cells.

Niclis JC, Gantner CW, Hunt CPJ, Kauhausen JA, Durnall JC, Haynes JM, Pouton CW, Parish CL, Thompson LH.

Stem Cell Reports. 2017 Sep 12;9(3):868-882. doi: 10.1016/j.stemcr.2017.08.002. Epub 2017 Aug 31.

18.

A suicidal strain of Listeria monocytogenes is effective as a DNA vaccine delivery system for oral administration.

Sinha S, Kuo CY, Ho JK, White PJ, Jazayeri JA, Pouton CW.

Vaccine. 2017 Sep 12;35(38):5115-5122. doi: 10.1016/j.vaccine.2017.08.014. Epub 2017 Aug 16.

PMID:
28822642
19.

Purification and characterization of adenovirus core protein VII: a histone-like protein that is critical for adenovirus core formation.

Sharma G, Moria N, Williams M, Krishnarjuna B, Pouton CW.

J Gen Virol. 2017 Jul;98(7):1785-1794. doi: 10.1099/jgv.0.000817. Epub 2017 Jul 8. Erratum in: J Gen Virol. 2018 Jun;99(6):860.

PMID:
28695796
20.

Transformation of Biopharmaceutical Classification System Class I and III Drugs Into Ionic Liquids and Lipophilic Salts for Enhanced Developability Using Lipid Formulations.

Williams HD, Ford L, Lim S, Han S, Baumann J, Sullivan H, Vodak D, Igonin A, Benameur H, Pouton CW, Scammells PJ, Porter CJH.

J Pharm Sci. 2018 Jan;107(1):203-216. doi: 10.1016/j.xphs.2017.05.019. Epub 2017 May 23.

PMID:
28549907
21.

Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents.

Niclis JC, Gantner CW, Alsanie WF, McDougall SJ, Bye CR, Elefanty AG, Stanley EG, Haynes JM, Pouton CW, Thompson LH, Parish CL.

Stem Cells Transl Med. 2017 Mar;6(3):937-948. doi: 10.5966/sctm.2016-0073. Epub 2016 Oct 14.

22.

High Molecular Weight DNA Enrichment with Peptide Nucleic Acid Probes.

Murphy NM, Pouton CW, Irving HR.

Methods Mol Biol. 2017;1551:73-85. doi: 10.1007/978-1-4939-6750-6_4.

PMID:
28138841
23.

Computational Models of the Gastrointestinal Environment. 1. The Effect of Digestion on the Phase Behavior of Intestinal Fluids.

Birru WA, Warren DB, Headey SJ, Benameur H, Porter CJ, Pouton CW, Chalmers DK.

Mol Pharm. 2017 Mar 6;14(3):566-579. doi: 10.1021/acs.molpharmaceut.6b00888. Epub 2017 Feb 15.

PMID:
28099023
24.
25.

Transient Supersaturation Supports Drug Absorption from Lipid-Based Formulations for Short Periods of Time, but Ongoing Solubilization Is Required for Longer Absorption Periods.

Crum MF, Trevaskis NL, Pouton CW, Porter CJ.

Mol Pharm. 2017 Feb 6;14(2):394-405. doi: 10.1021/acs.molpharmaceut.6b00792. Epub 2017 Jan 13.

PMID:
28002666
26.

Computational Models of the Gastrointestinal Environment. 2. Phase Behavior and Drug Solubilization Capacity of a Type I Lipid-Based Drug Formulation after Digestion.

Birru WA, Warren DB, Han S, Benameur H, Porter CJ, Pouton CW, Chalmers DK.

Mol Pharm. 2017 Mar 6;14(3):580-592. doi: 10.1021/acs.molpharmaceut.6b00887. Epub 2017 Feb 15.

PMID:
27936778
27.

Tissue-specific Calibration of Real-time PCR Facilitates Absolute Quantification of Plasmid DNA in Biodistribution Studies.

Ho JK, White PJ, Pouton CW.

Mol Ther Nucleic Acids. 2016 Oct 4;5(10):e371. doi: 10.1038/mtna.2016.79.

28.

Haplotyping the human leukocyte antigen system from single chromosomes.

Murphy NM, Burton M, Powell DR, Rossello FJ, Cooper D, Chopra A, Hsieh MJ, Sayer DC, Gordon L, Pertile MD, Tait BD, Irving HR, Pouton CW.

Sci Rep. 2016 Jul 27;6:30381. doi: 10.1038/srep30381.

29.

50years of oral lipid-based formulations: Provenance, progress and future perspectives.

Feeney OM, Crum MF, McEvoy CL, Trevaskis NL, Williams HD, Pouton CW, Charman WN, Bergström CAS, Porter CJH.

Adv Drug Deliv Rev. 2016 Jun 1;101:167-194. doi: 10.1016/j.addr.2016.04.007. Epub 2016 Apr 16. Review.

PMID:
27089810
30.

Disposition and safety of inhaled biodegradable nanomedicines: Opportunities and challenges.

Haque S, Whittaker MR, McIntosh MP, Pouton CW, Kaminskas LM.

Nanomedicine. 2016 Aug;12(6):1703-24. doi: 10.1016/j.nano.2016.03.002. Epub 2016 Mar 23. Review.

PMID:
27033834
31.

Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination.

Le CP, Nowell CJ, Kim-Fuchs C, Botteri E, Hiller JG, Ismail H, Pimentel MA, Chai MG, Karnezis T, Rotmensz N, Renne G, Gandini S, Pouton CW, Ferrari D, Möller A, Stacker SA, Sloan EK.

Nat Commun. 2016 Mar 1;7:10634. doi: 10.1038/ncomms10634.

32.

A new in vitro lipid digestion - in vivo absorption model to evaluate the mechanisms of drug absorption from lipid-based formulations.

Crum MF, Trevaskis NL, Williams HD, Pouton CW, Porter CJ.

Pharm Res. 2016 Apr;33(4):970-82. doi: 10.1007/s11095-015-1843-7. Epub 2015 Dec 24.

PMID:
26703975
33.

Comparing mouse and human pluripotent stem cell derived cardiac cells: Both systems have advantages for pharmacological and toxicological screening.

Lagerqvist EL, Finnin BA, Elliott DA, Anderson DJ, Wu SM, Pouton CW, Haynes JM.

J Pharmacol Toxicol Methods. 2015 Jul-Aug;74:17-25. doi: 10.1016/j.vascn.2015.04.009. Epub 2015 May 6.

PMID:
25957031
34.

Human pluripotent stem cell derived midbrain PITX3(eGFP/w) neurons: a versatile tool for pharmacological screening and neurodegenerative modeling.

Watmuff B, Hartley BJ, Hunt CP, Fabb SA, Pouton CW, Haynes JM.

Front Cell Neurosci. 2015 Mar 31;9:104. doi: 10.3389/fncel.2015.00104. eCollection 2015.

35.

Toward the establishment of standardized in vitro tests for lipid-based formulations. 5. Lipolysis of representative formulations by gastric lipase.

Bakala-N'Goma JC, Williams HD, Sassene PJ, Kleberg K, Calderone M, Jannin V, Igonin A, Partheil A, Marchaud D, Jule E, Vertommen J, Maio M, Blundell R, Benameur H, Müllertz A, Pouton CW, Porter CJ, Carrière F.

Pharm Res. 2015 Apr;32(4):1279-87. doi: 10.1007/s11095-014-1532-y. Epub 2014 Oct 7.

PMID:
25288015
36.

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 6: effects of varying pancreatin and calcium levels.

Sassene P, Kleberg K, Williams HD, Bakala-N'Goma JC, Carrière F, Calderone M, Jannin V, Igonin A, Partheil A, Marchaud D, Jule E, Vertommen J, Maio M, Blundell R, Benameur H, Porter CJ, Pouton CW, Müllertz A.

AAPS J. 2014 Nov;16(6):1344-57. doi: 10.1208/s12248-014-9672-x. Epub 2014 Oct 2.

37.

An in vitro digestion test that reflects rat intestinal conditions to probe the importance of formulation digestion vs first pass metabolism in Danazol bioavailability from lipid based formulations.

Anby MU, Nguyen TH, Yeap YY, Feeney OM, Williams HD, Benameur H, Pouton CW, Porter CJ.

Mol Pharm. 2014 Nov 3;11(11):4069-83. doi: 10.1021/mp500197b. Epub 2014 Sep 29.

PMID:
25265395
38.

Zinc-finger nuclease enhanced gene targeting in human embryonic stem cells.

Hartley BJ, Fabb SA, Finnin BA, Haynes JM, Pouton CW.

J Vis Exp. 2014 Aug 23;(90):e51764. doi: 10.3791/51764.

39.

'Stealth' lipid-based formulations: poly(ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug.

Feeney OM, Williams HD, Pouton CW, Porter CJ.

J Control Release. 2014 Oct 28;192:219-27. doi: 10.1016/j.jconrel.2014.07.037. Epub 2014 Jul 22.

PMID:
25058571
40.

Digestion of phospholipids after secretion of bile into the duodenum changes the phase behavior of bile components.

Birru WA, Warren DB, Ibrahim A, Williams HD, Benameur H, Porter CJ, Chalmers DK, Pouton CW.

Mol Pharm. 2014 Aug 4;11(8):2825-34. doi: 10.1021/mp500193g. Epub 2014 Jul 16.

PMID:
24987935
41.

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system.

Williams HD, Sassene P, Kleberg K, Calderone M, Igonin A, Jule E, Vertommen J, Blundell R, Benameur H, Müllertz A, Porter CJ, Pouton CW; Communicated on Behalf of the LFCS Consortium.

J Pharm Sci. 2014 Aug;103(8):2441-55. doi: 10.1002/jps.24067. Epub 2014 Jul 1.

PMID:
24985238
42.

SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development.

Skelton RJ, Costa M, Anderson DJ, Bruveris F, Finnin BW, Koutsis K, Arasaratnam D, White AJ, Rafii A, Ng ES, Elefanty AG, Stanley EG, Pouton CW, Haynes JM, Ardehali R, Davis RP, Mummery CL, Elliott DA.

Stem Cell Res. 2014 Jul;13(1):172-9. doi: 10.1016/j.scr.2014.04.016. Epub 2014 May 4.

43.

Human leukocyte antigen haplotype phasing by allele-specific enrichment with peptide nucleic acid probes.

Murphy NM, Pouton CW, Irving HR.

Mol Genet Genomic Med. 2014 May;2(3):245-53. doi: 10.1002/mgg3.65. Epub 2014 Jan 19.

44.

Non-linear increases in danazol exposure with dose in older vs. younger beagle dogs: the potential role of differences in bile salt concentration, thermodynamic activity, and formulation digestion.

Anby MU, Williams HD, Feeney O, Edwards GA, Benameur H, Pouton CW, Porter CJ.

Pharm Res. 2014 Jun;31(6):1536-52. doi: 10.1007/s11095-013-1260-8. Epub 2014 Jan 30.

PMID:
24477676
46.

The synthesis and biological evaluation of multifunctionalised derivatives of noscapine as cytotoxic agents.

Debono AJ, Mistry SJ, Xie J, Muthiah D, Phillips J, Ventura S, Callaghan R, Pouton CW, Capuano B, Scammells PJ.

ChemMedChem. 2014 Feb;9(2):399-410. doi: 10.1002/cmdc.201300395. Epub 2013 Dec 11.

PMID:
24339417
47.

DNA-dependent protein kinase is a context dependent regulator of Lmx1a and midbrain specification.

Hunt CP, Fabb SA, Pouton CW, Haynes JM.

PLoS One. 2013 Oct 23;8(10):e78759. doi: 10.1371/journal.pone.0078759. eCollection 2013.

48.

Glyceride lipid formulations: molecular dynamics modeling of phase behavior during dispersion and molecular interactions between drugs and excipients.

Warren DB, King D, Benameur H, Pouton CW, Chalmers DK.

Pharm Res. 2013 Dec;30(12):3238-53. doi: 10.1007/s11095-013-1206-1. Epub 2013 Oct 3.

PMID:
24092054
49.

Lipid-based formulations and drug supersaturation: harnessing the unique benefits of the lipid digestion/absorption pathway.

Williams HD, Trevaskis NL, Yeap YY, Anby MU, Pouton CW, Porter CJ.

Pharm Res. 2013 Dec;30(12):2976-92. doi: 10.1007/s11095-013-1126-0. Epub 2013 Jul 4. Review.

PMID:
23824582
50.

In vitro assessment of drug-free and fenofibrate-containing lipid formulations using dispersion and digestion testing gives detailed insights into the likely fate of formulations in the intestine.

Devraj R, Williams HD, Warren DB, Mohsin K, Porter CJ, Pouton CW.

Eur J Pharm Sci. 2013 Jul 16;49(4):748-60. doi: 10.1016/j.ejps.2013.04.036. Epub 2013 May 16.

PMID:
23684915

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