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Items: 1 to 50 of 239

1.

Personalized Drug Sensitivity Screening for Bladder Cancer Using Conditionally Reprogrammed Patient-derived Cells.

Kettunen K, Boström PJ, Lamminen T, Heinosalo T, West G, Saarinen I, Kaipio K, Rantala J, Albanese C, Poutanen M, Taimen P.

Eur Urol. 2019 Oct;76(4):430-434. doi: 10.1016/j.eururo.2019.06.016. Epub 2019 Jun 28.

2.

Gonadal hormone-dependent vs. -independent effects of kisspeptin signaling in the control of body weight and metabolic homeostasis.

Velasco I, León S, Barroso A, Ruiz-Pino F, Heras V, Torres E, León M, Ruohonen ST, García-Galiano D, Romero-Ruiz A, Sánchez-Garrido MA, Olhsson C, Castellano JM, Roa J, Poutanen M, Pinilla L, Vázquez MJ, Tena-Sempere M.

Metabolism. 2019 Sep;98:84-94. doi: 10.1016/j.metabol.2019.06.007. Epub 2019 Jun 19.

PMID:
31226351
3.

Interleukin-6 in the central amygdala is bioactive and co-localised with glucagon-like peptide-1 receptor.

Anesten F, Dalmau Gasull A, Richard JE, Farkas I, Mishra D, Taing L, Zhang F, Poutanen M, Palsdottir V, Liposits Z, Skibicka KP, Jansson JO.

J Neuroendocrinol. 2019 Jun;31(6):e12722. doi: 10.1111/jne.12722. Epub 2019 May 23.

4.

Biology and clinical relevance of Hydroxysteroid (17beta) dehydrogenase enzymes.

Poutanen M, Penning TM.

Mol Cell Endocrinol. 2019 Jun 1;489:1-2. doi: 10.1016/j.mce.2019.04.008. Epub 2019 Apr 13. No abstract available.

PMID:
30991077
5.

Applying mass spectrometric methods to study androgen biosynthesis and metabolism in prostate cancer.

Knuuttila M, Hämäläinen E, Poutanen M.

J Mol Endocrinol. 2019 May 1;62(4):R255-R267. doi: 10.1530/JME-18-0150. Review.

PMID:
30917337
6.

GLP-1-, but not GDF-15-, receptor activation increases the number of IL-6-expressing cells in the external lateral parabrachial nucleus.

Anesten F, Mishra D, Dalmau Gasull A, Engström-Ruud L, Bellman J, Pálsdóttir V, Zhang FP, Trapp S, Skibicka KP, Poutanen M, Jansson JO.

Neuroendocrinology. 2019 Mar 20. doi: 10.1159/000499693. [Epub ahead of print]

PMID:
30889580
7.

Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction.

Zhang FP, Malinen M, Mehmood A, Lehtiniemi T, Jääskeläinen T, Niskanen EA, Korhonen H, Laiho A, Elo LL, Ohlsson C, Kotaja N, Poutanen M, Sipilä P, Palvimo JJ.

Nat Commun. 2019 Feb 15;10(1):777. doi: 10.1038/s41467-019-08730-z.

8.

Simultaneous analysis by LC-MS/MS of 22 ketosteroids with hydroxylamine derivatization and underivatized estradiol from human plasma, serum and prostate tissue.

Häkkinen MR, Murtola T, Voutilainen R, Poutanen M, Linnanen T, Koskivuori J, Lakka T, Jääskeläinen J, Auriola S.

J Pharm Biomed Anal. 2019 Feb 5;164:642-652. doi: 10.1016/j.jpba.2018.11.035. Epub 2018 Nov 16.

PMID:
30472582
9.

Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling.

Roa J, Barroso A, Ruiz-Pino F, Vázquez MJ, Seoane-Collazo P, Martínez-Sanchez N, García-Galiano D, Ilhan T, Pineda R, León S, Manfredi-Lozano M, Heras V, Poutanen M, Castellano JM, Gaytan F, Diéguez C, Pinilla L, López M, Tena-Sempere M.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10758-E10767. doi: 10.1073/pnas.1802053115. Epub 2018 Oct 22.

10.

Decidualization of Human Endometrial Stromal Fibroblasts is a Multiphasic Process Involving Distinct Transcriptional Programs.

Rytkönen KT, Erkenbrack EM, Poutanen M, Elo LL, Pavlicev M, Wagner GP.

Reprod Sci. 2019 Mar;26(3):323-336. doi: 10.1177/1933719118802056. Epub 2018 Oct 11.

PMID:
30309298
11.

Adrenals Contribute to Growth of Castration-Resistant VCaP Prostate Cancer Xenografts.

Huhtaniemi R, Oksala R, Knuuttila M, Mehmood A, Aho E, Laajala TD, Nicorici D, Aittokallio T, Laiho A, Elo L, Ohlsson C, Kallio P, Mäkelä S, Mustonen MVJ, Sipilä P, Poutanen M.

Am J Pathol. 2018 Dec;188(12):2890-2901. doi: 10.1016/j.ajpath.2018.07.029. Epub 2018 Sep 28.

PMID:
30273606
12.

Androgen receptor SUMOylation regulates bone mass in male mice.

Wu J, Movérare-Skrtic S, Zhang FP, Koskela A, Tuukkanen J, Palvimo JJ, Sipilä P, Poutanen M, Ohlsson C.

Mol Cell Endocrinol. 2019 Jan 5;479:117-122. doi: 10.1016/j.mce.2018.09.008. Epub 2018 Sep 24.

13.

Role of hydroxysteroid (17beta) dehydrogenase type 1 in reproductive tissues and hormone-dependent diseases.

Heinosalo T, Saarinen N, Poutanen M.

Mol Cell Endocrinol. 2019 Jun 1;489:9-31. doi: 10.1016/j.mce.2018.08.004. Epub 2018 Aug 25. Review.

PMID:
30149044
14.

Hyperthyroidism and Papillary Thyroid Carcinoma in Thyrotropin Receptor D633H Mutant Mice.

Jaeschke H, Undeutsch H, Patyra K, Löf C, Eszlinger M, Khalil M, Jännäri M, Makkonen K, Toppari J, Zhang FP, Poutanen M, Paschke R, Kero J.

Thyroid. 2018 Oct;28(10):1372-1386. doi: 10.1089/thy.2018.0041.

PMID:
30132406
15.

NLRP3 in somatic non-immune cells of rodent and primate testes.

Walenta L, Schmid N, Schwarzer JU, Köhn FM, Urbanski HF, Behr R, Strauss L, Poutanen M, Mayerhofer A.

Reproduction. 2018 Sep;156(3):231-238. doi: 10.1530/REP-18-0111. Epub 2018 Jun 15.

16.

Insights into the role of androgen receptor in human testicular peritubular cells.

Mayer C, Adam M, Walenta L, Schmid N, Heikelä H, Schubert K, Flenkenthaler F, Dietrich KG, Gruschka S, Arnold GJ, Fröhlich T, Schwarzer JU, Köhn FM, Strauss L, Welter H, Poutanen M, Mayerhofer A.

Andrology. 2018 Sep;6(5):756-765. doi: 10.1111/andr.12509. Epub 2018 Jun 5.

17.

Partial thyrocyte-specific Gαs deficiency leads to rapid-onset hypothyroidism, hyperplasia, and papillary thyroid carcinoma-like lesions in mice.

Patyra K, Jaeschke H, Löf C, Jännäri M, Ruohonen ST, Undeutsch H, Khalil M, Kero A, Poutanen M, Toppari J, Chen M, Weinstein LS, Paschke R, Kero J.

FASEB J. 2018 May 25:fj201800211R. doi: 10.1096/fj.201800211R. [Epub ahead of print]

PMID:
29799790
18.

Preface.

Poutanen M, Tena-Sempere M.

Best Pract Res Clin Endocrinol Metab. 2018 Jun;32(3):215-218. doi: 10.1016/j.beem.2018.05.001. No abstract available.

PMID:
29779577
19.

Intratumoral androgen levels are linked to TMPRSS2-ERG fusion in prostate cancer.

Knuuttila M, Mehmood A, Mäki-Jouppila J, Ryberg H, Taimen P, Knaapila J, Ettala O, Boström PJ, Ohlsson C, Venäläinen MS, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M.

Endocr Relat Cancer. 2018 Sep;25(9):807-819. doi: 10.1530/ERC-18-0148. Epub 2018 May 17.

PMID:
29773553
20.

Thermal Isomerization of Hydroxyazobenzenes as a Platform for Vapor Sensing.

Poutanen M, Ahmed Z, Rautkari L, Ikkala O, Priimagi A.

ACS Macro Lett. 2018 Mar 20;7(3):381-386. doi: 10.1021/acsmacrolett.8b00093. Epub 2018 Mar 10.

21.

Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult mice.

Ohlsson C, Henning P, Nilsson KH, Wu J, Gustafsson KL, Sjögren K, Törnqvist A, Koskela A, Zhang FP, Lagerquist MK, Poutanen M, Tuukkanen J, Lerner UH, Movérare-Skrtic S.

J Endocrinol. 2018 May;237(2):113-122. doi: 10.1530/JOE-18-0020. Epub 2018 Mar 12.

22.

Block Copolymer Micelles for Photonic Fluids and Crystals.

Poutanen M, Guidetti G, Gröschel TI, Borisov OV, Vignolini S, Ikkala O, Gröschel AH.

ACS Nano. 2018 Apr 24;12(4):3149-3158. doi: 10.1021/acsnano.7b09070. Epub 2018 Mar 15.

PMID:
29498830
23.

Secreted frizzled-related protein 2 (SFRP2) expression promotes lesion proliferation via canonical WNT signaling and indicates lesion borders in extraovarian endometriosis.

Heinosalo T, Gabriel M, Kallio L, Adhikari P, Huhtinen K, Laajala TD, Kaikkonen E, Mehmood A, Suvitie P, Kujari H, Aittokallio T, Perheentupa A, Poutanen M.

Hum Reprod. 2018 May 1;33(5):817-831. doi: 10.1093/humrep/dey026.

PMID:
29462326
24.

Analysis by LC-MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue.

Häkkinen MR, Heinosalo T, Saarinen N, Linnanen T, Voutilainen R, Lakka T, Jääskeläinen J, Poutanen M, Auriola S.

J Pharm Biomed Anal. 2018 Apr 15;152:165-172. doi: 10.1016/j.jpba.2018.01.034. Epub 2018 Jan 31.

PMID:
29414008
25.

WNT16 overexpression partly protects against glucocorticoid-induced bone loss.

Ohlsson C, Nilsson KH, Henning P, Wu J, Gustafsson KL, Poutanen M, Lerner UH, Movérare-Skrtic S.

Am J Physiol Endocrinol Metab. 2018 Jun 1;314(6):E597-E604. doi: 10.1152/ajpendo.00292.2017. Epub 2018 Feb 6.

26.

Hydroxysteroid (17β) dehydrogenase 13 deficiency triggers hepatic steatosis and inflammation in mice.

Adam M, Heikelä H, Sobolewski C, Portius D, Mäki-Jouppila J, Mehmood A, Adhikari P, Esposito I, Elo LL, Zhang FP, Ruohonen ST, Strauss L, Foti M, Poutanen M.

FASEB J. 2018 Jun;32(6):3434-3447. doi: 10.1096/fj.201700914R. Epub 2018 Jan 31.

PMID:
29401633
27.

Hydroxysteroid (17β) dehydrogenase 1 expressed by Sertoli cells contributes to steroid synthesis and is required for male fertility.

Hakkarainen J, Zhang FP, Jokela H, Mayerhofer A, Behr R, Cisneros-Montalvo S, Nurmio M, Toppari J, Ohlsson C, Kotaja N, Sipilä P, Poutanen M.

FASEB J. 2018 Jun;32(6):3229-3241. doi: 10.1096/fj.201700921R. Epub 2018 Jan 24.

PMID:
29401623
28.

HSD17B1 expression induces inflammation-aided rupture of mammary gland myoepithelium.

Järvensivu P, Heinosalo T, Hakkarainen J, Kronqvist P, Saarinen N, Poutanen M.

Endocr Relat Cancer. 2018 Apr;25(4):393-406. doi: 10.1530/ERC-17-0476. Epub 2018 Jan 25.

PMID:
29371331
29.

The Expression of HSD17B12 Is Associated with COX-2 Expression and Is Increased in High-Grade Epithelial Ovarian Cancer.

Kemiläinen H, Huhtinen K, Auranen A, Carpén O, Strauss L, Poutanen M.

Oncology. 2018;94(4):233-242. doi: 10.1159/000485624. Epub 2018 Jan 12.

PMID:
29324448
30.

Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria.

Hilander T, Zhou XL, Konovalova S, Zhang FP, Euro L, Chilov D, Poutanen M, Chihade J, Wang ED, Tyynismaa H.

Nucleic Acids Res. 2018 Jan 25;46(2):849-860. doi: 10.1093/nar/gkx1231.

31.

Deleting the mouse Hsd17b1 gene results in a hypomorphic Naglu allele and a phenotype mimicking a lysosomal storage disease.

Jokela H, Hakkarainen J, Kätkänaho L, Pakarinen P, Ruohonen ST, Tena-Sempere M, Zhang FP, Poutanen M.

Sci Rep. 2017 Nov 27;7(1):16406. doi: 10.1038/s41598-017-16618-5.

32.

Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts.

Knuuttila M, Mehmood A, Huhtaniemi R, Yatkin E, Häkkinen MR, Oksala R, Laajala TD, Ryberg H, Handelsman DJ, Aittokallio T, Auriola S, Ohlsson C, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M.

Am J Pathol. 2018 Jan;188(1):216-228. doi: 10.1016/j.ajpath.2017.08.036. Epub 2017 Nov 7.

PMID:
29126837
33.

Maternal expression of the histone demethylase Kdm4a is crucial for pre-implantation development.

Sankar A, Kooistra SM, Gonzalez JM, Ohlsson C, Poutanen M, Helin K.

Development. 2017 Sep 15;144(18):3264-3277. doi: 10.1242/dev.155473. Epub 2017 Aug 21.

34.

In Vivo Expression of miR-32 Induces Proliferation in Prostate Epithelium.

Latonen L, Scaravilli M, Gillen A, Hartikainen S, Zhang FP, Ruusuvuori P, Kujala P, Poutanen M, Visakorpi T.

Am J Pathol. 2017 Nov;187(11):2546-2557. doi: 10.1016/j.ajpath.2017.07.012. Epub 2017 Aug 19.

PMID:
28827140
35.

Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty.

Elo T, Lindfors PH, Lan Q, Voutilainen M, Trela E, Ohlsson C, Huh SH, Ornitz DM, Poutanen M, Howard BA, Mikkola ML.

Sci Rep. 2017 Jul 11;7(1):5049. doi: 10.1038/s41598-017-04637-1.

36.

Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male mice.

Ohlsson C, Hammarstedt A, Vandenput L, Saarinen N, Ryberg H, Windahl SH, Farman HH, Jansson JO, Movérare-Skrtic S, Smith U, Zhang FP, Poutanen M, Hedjazifar S, Sjögren K.

Am J Physiol Endocrinol Metab. 2017 Oct 1;313(4):E450-E462. doi: 10.1152/ajpendo.00093.2017. Epub 2017 Jun 27.

37.

Matched preclinical designs for improved translatability.

Aittokallio T, Scherer A, Poutanen M, Freedman LP.

Sci Transl Med. 2017 May 10;9(389). pii: eaal4101. doi: 10.1126/scitranslmed.aal4101.

PMID:
28490671
38.

Defects in chondrocyte maturation and secondary ossification in mouse knee joint epiphyses due to Snorc deficiency.

Heinonen J, Zhang FP, Surmann-Schmitt C, Honkala S, Stock M, Poutanen M, Säämänen AM.

Osteoarthritis Cartilage. 2017 Jul;25(7):1132-1142. doi: 10.1016/j.joca.2017.03.010. Epub 2017 Mar 18.

39.

Generation of membrane-bound catechol-O-methyl transferase deficient mice with disctinct sex dependent behavioral phenotype.

Tammimaki A, Aonurm-Helm A, Zhang FP, Poutanen M, Duran-Torres G, Garcia-Horsman A, Mannisto PT.

J Physiol Pharmacol. 2016 Dec;67(6):827-842.

40.

Efficient Light-Induced Phase Transitions in Halogen-Bonded Liquid Crystals.

Fernandez-Palacio F, Poutanen M, Saccone M, Siiskonen A, Terraneo G, Resnati G, Ikkala O, Metrangolo P, Priimagi A.

Chem Mater. 2016 Nov 22;28(22):8314-8321. Epub 2016 Oct 6.

41.

Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cells.

Mayer C, Adam M, Glashauser L, Dietrich K, Schwarzer JU, Köhn FM, Strauss L, Welter H, Poutanen M, Mayerhofer A.

Sci Rep. 2016 Nov 16;6:37128. doi: 10.1038/srep37128.

42.

A Nanoparticle-Lectin Immunoassay Improves Discrimination of Serum CA125 from Malignant and Benign Sources.

Gidwani K, Huhtinen K, Kekki H, van Vliet S, Hynninen J, Koivuviita N, Perheentupa A, Poutanen M, Auranen A, Grenman S, Lamminmäki U, Carpen O, van Kooyk Y, Pettersson K.

Clin Chem. 2016 Oct;62(10):1390-400. doi: 10.1373/clinchem.2016.257691. Epub 2016 Aug 18.

43.

The Hydroxysteroid (17β) Dehydrogenase Family Gene HSD17B12 Is Involved in the Prostaglandin Synthesis Pathway, the Ovarian Function, and Regulation of Fertility.

Kemiläinen H, Adam M, Mäki-Jouppila J, Damdimopoulou P, Damdimopoulos AE, Kere J, Hovatta O, Laajala TD, Aittokallio T, Adamski J, Ryberg H, Ohlsson C, Strauss L, Poutanen M.

Endocrinology. 2016 Oct;157(10):3719-3730. Epub 2016 Aug 4.

PMID:
27490311
44.

Optimized design and analysis of preclinical intervention studies in vivo.

Laajala TD, Jumppanen M, Huhtaniemi R, Fey V, Kaur A, Knuuttila M, Aho E, Oksala R, Westermarck J, Mäkelä S, Poutanen M, Aittokallio T.

Sci Rep. 2016 Aug 2;6:30723. doi: 10.1038/srep30723.

45.

Stress-activated miR-21/miR-21* in hepatocytes promotes lipid and glucose metabolic disorders associated with high-fat diet consumption.

Calo N, Ramadori P, Sobolewski C, Romero Y, Maeder C, Fournier M, Rantakari P, Zhang FP, Poutanen M, Dufour JF, Humar B, Nef S, Foti M.

Gut. 2016 Nov;65(11):1871-1881. doi: 10.1136/gutjnl-2015-310822. Epub 2016 May 24.

46.

Hyperprolactinemia induced by hCG leads to metabolic disturbances in female mice.

Ratner LD, Stevens G, Bonaventura MM, Lux-Lantos VA, Poutanen M, Calandra RS, Huhtaniemi IT, Rulli SB.

J Endocrinol. 2016 Jul;230(1):157-69. doi: 10.1530/JOE-15-0528. Epub 2016 May 6.

PMID:
27154336
47.

From pure compounds to complex exposure: Effects of dietary cadmium and lignans on estrogen, epidermal growth factor receptor, and mitogen activated protein kinase signaling in vivo.

Ali I, Hurmerinta T, Nurmi T, Berglund M, Rüegg J, Poutanen M, Halldin K, Mäkelä S, Damdimopoulou P.

Toxicol Lett. 2016 Jun 24;253:27-35. doi: 10.1016/j.toxlet.2016.04.020. Epub 2016 Apr 22.

PMID:
27108949
48.

Fam3c modulates osteogenic cell differentiation and affects bone volume and cortical bone mineral density.

Määttä JA, Bendre A, Laanti M, Büki KG, Rantakari P, Tervola P, Saarimäki J, Poutanen M, Härkönen P, Väänänen K.

Bonekey Rep. 2016 Apr 6;5:787. doi: 10.1038/bonekey.2016.14. eCollection 2016.

49.

Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding.

Björkgren I, Alvarez L, Blank N, Balbach M, Turunen H, Laajala TD, Toivanen J, Krutskikh A, Wahlberg N, Huhtaniemi I, Poutanen M, Wachten D, Sipilä P.

Mol Cell Endocrinol. 2016 May 15;427:143-54. doi: 10.1016/j.mce.2016.03.013. Epub 2016 Mar 14.

PMID:
26987518
50.

Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse.

Vehmas AP, Adam M, Laajala TD, Kastenmüller G, Prehn C, Rozman J, Ohlsson C, Fuchs H, Hrabě de Angelis M, Gailus-Durner V, Elo LL, Aittokallio T, Adamski J, Corthals G, Poutanen M, Strauss L.

J Proteomics. 2016 Feb 5;133:66-75. doi: 10.1016/j.jprot.2015.12.009. Epub 2015 Dec 9.

PMID:
26691839

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