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Items: 1 to 50 of 92


High-Fat Diets Alter the Modulatory Effects of Xenobiotics on Cytochrome P450 Activities.

Sadler NC, Webb-Robertson BM, Clauss TR, Pounds JG, Corley R, Wright AT.

Chem Res Toxicol. 2018 May 21;31(5):308-318. doi: 10.1021/acs.chemrestox.8b00008. Epub 2018 May 4.


Metabolite Signatures in Hydrophilic Extracts of Mouse Lungs Exposed to Cigarette Smoke Revealed by 1H NMR Metabolomics Investigation.

Jz H, X W, J F, Bj R, Km W, Sc T, Jg P, Ra C, M L, M H.

Metabolomics (Los Angel). 2015 Jun;5(2). pii: 143. Epub 2015 May 12.


Susceptibility to quantum dot induced lung inflammation differs widely among the Collaborative Cross founder mouse strains.

Scoville DK, White CC, Botta D, McConnachie LA, Zadworny ME, Schmuck SC, Hu X, Gao X, Yu J, Dills RL, Sheppard L, Delaney MA, Griffith WC, Beyer RP, Zangar RC, Pounds JG, Faustman EM, Kavanagh TJ.

Toxicol Appl Pharmacol. 2015 Dec 1;289(2):240-50. doi: 10.1016/j.taap.2015.09.019. Epub 2015 Oct 21.


Review, evaluation, and discussion of the challenges of missing value imputation for mass spectrometry-based label-free global proteomics.

Webb-Robertson BJ, Wiberg HK, Matzke MM, Brown JN, Wang J, McDermott JE, Smith RD, Rodland KD, Metz TO, Pounds JG, Waters KM.

J Proteome Res. 2015 May 1;14(5):1993-2001. doi: 10.1021/pr501138h. Epub 2015 Apr 22. Review.


Bayesian proteoform modeling improves protein quantification of global proteomic measurements.

Webb-Robertson BJ, Matzke MM, Datta S, Payne SH, Kang J, Bramer LM, Nicora CD, Shukla AK, Metz TO, Rodland KD, Smith RD, Tardiff MF, McDermott JE, Pounds JG, Waters KM.

Mol Cell Proteomics. 2014 Dec;13(12):3639-46. doi: 10.1074/mcp.M113.030932.


Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routes.

Teeguarden JG, Mikheev VB, Minard KR, Forsythe WC, Wang W, Sharma G, Karin N, Tilton SC, Waters KM, Asgharian B, Price OR, Pounds JG, Thrall BD.

Part Fibre Toxicol. 2014 Sep 30;11:46. doi: 10.1186/s12989-014-0046-4.


Bayesian Proteoform Modeling Improves Protein Quantification of Global Proteomic Measurements.

Webb-Robertson BJ, Matzke MM, Datta S, Payne SH, Kang J, Bramer LM, Nicora CD, Shukla AK, Metz TO, Rodland KD, Smith RD, Tardiff MF, McDermott JE, Pounds JG, Waters KM.

Mol Cell Proteomics. 2014 Aug 16. pii: mcp.O113.030932. [Epub ahead of print]


A halotyrosine antibody that detects increased protein modifications in asthma patients.

Jin H, Hallstrand TS, Daly DS, Matzke MM, Nair P, Bigelow DJ, Pounds JG, Zangar RC.

J Immunol Methods. 2014 Jan 31;403(1-2):17-25. doi: 10.1016/j.jim.2013.11.013. Epub 2013 Dec 2.


A semiautomated framework for integrating expert knowledge into disease marker identification.

Wang J, Webb-Robertson BJ, Matzke MM, Varnum SM, Brown JN, Riensche RM, Adkins JN, Jacobs JM, Hoidal JR, Scholand MB, Pounds JG, Blackburn MR, Rodland KD, McDermott JE.

Dis Markers. 2013;35(5):513-23. doi: 10.1155/2013/613529. Epub 2013 Oct 10.


Dysregulation of macrophage activation profiles by engineered nanoparticles.

Kodali V, Littke MH, Tilton SC, Teeguarden JG, Shi L, Frevert CW, Wang W, Pounds JG, Thrall BD.

ACS Nano. 2013 Aug 27;7(8):6997-7010. doi: 10.1021/nn402145t. Epub 2013 Jul 9.


Impaired transcriptional response of the murine heart to cigarette smoke in the setting of high fat diet and obesity.

Tilton SC, Karin NJ, Webb-Robertson BJ, Waters KM, Mikheev V, Lee KM, Corley RA, Pounds JG, Bigelow DJ.

Chem Res Toxicol. 2013 Jul 15;26(7):1034-42. doi: 10.1021/tx400078b. Epub 2013 Jun 20.


Sequential projection pursuit principal component analysis--dealing with missing data associated with new -omics technologies.

Webb-Robertson BJ, Matzke MM, Metz TO, McDermott JE, Walker H, Rodland KD, Pounds JG, Waters KM.

Biotechniques. 2013 Mar;54(3):165-8. doi: 10.2144/000113978.


Preparation and Characterization Challenges to Understanding Environmental and Biological Impacts of Nanoparticles.

Karakoti AS, Munusamy P, Hostetler K, Kodali V, Kuchibhatla S, Orr G, Pounds JG, Teeguarden JG, Thrall BD, Baer DR.

Surf Interface Anal. 2012 Aug;44(5):882-889. Epub 2012 Apr 17.


Diet-induced obesity reprograms the inflammatory response of the murine lung to inhaled endotoxin.

Tilton SC, Waters KM, Karin NJ, Webb-Robertson BJ, Zangar RC, Lee KM, Bigelow DJ, Pounds JG, Corley RA.

Toxicol Appl Pharmacol. 2013 Mar 1;267(2):137-48. doi: 10.1016/j.taap.2012.12.020. Epub 2013 Jan 7.


A comparative analysis of computational approaches to relative protein quantification using peptide peak intensities in label-free LC-MS proteomics experiments.

Matzke MM, Brown JN, Gritsenko MA, Metz TO, Pounds JG, Rodland KD, Shukla AK, Smith RD, Waters KM, McDermott JE, Webb-Robertson BJ.

Proteomics. 2013 Feb;13(3-4):493-503. doi: 10.1002/pmic.201200269. Epub 2012 Nov 8. Review.


Proteomic analysis of bronchoalveolar lavage fluid proteins from mice infected with Francisella tularensis ssp. novicida.

Varnum SM, Webb-Robertson BJ, Pounds JG, Moore RJ, Smith RD, Frevert CW, Skerrett SJ, Wunschel D.

J Proteome Res. 2012 Jul 6;11(7):3690-703. doi: 10.1021/pr3001767. Epub 2012 Jun 22.


Electrochemical immunoassay of cotinine in serum based on nanoparticle probe and immunochromatographic strip.

Nian H, Wang J, Wu H, Lo JG, Chiu KH, Pounds JG, Lin Y.

Anal Chim Acta. 2012 Feb 3;713:50-5. doi: 10.1016/j.aca.2011.11.028. Epub 2011 Nov 22.


A statistical selection strategy for normalization procedures in LC-MS proteomics experiments through dataset-dependent ranking of normalization scaling factors.

Webb-Robertson BJ, Matzke MM, Jacobs JM, Pounds JG, Waters KM.

Proteomics. 2011 Dec;11(24):4736-41. doi: 10.1002/pmic.201100078. Epub 2011 Nov 17.


t⁴ workshop report. Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials.

Silbergeld EK, Contreras EQ, Hartung T, Hirsch C, Hogberg H, Jachak AC, Jordan W, Landsiedel R, Morris J, Patri A, Pounds JG, de Vizcaya Ruiz A, Shvedova A, Tanguay R, Tatarazako N, van Vliet E, Walker NJ, Wiesner M, Wilcox N, Zurlo J.

ALTEX. 2011;28(3):236-41.


Aerosolized ZnO nanoparticles induce toxicity in alveolar type II epithelial cells at the air-liquid interface.

Xie Y, Williams NG, Tolic A, Chrisler WB, Teeguarden JG, Maddux BL, Pounds JG, Laskin A, Orr G.

Toxicol Sci. 2012 Feb;125(2):450-61. doi: 10.1093/toxsci/kfr251. Epub 2011 Sep 28.


Quantitative proteomics analysis of adsorbed plasma proteins classifies nanoparticles with different surface properties and size.

Zhang H, Burnum KE, Luna ML, Petritis BO, Kim JS, Qian WJ, Moore RJ, Heredia-Langner A, Webb-Robertson BJ, Thrall BD, Camp DG 2nd, Smith RD, Pounds JG, Liu T.

Proteomics. 2011 Dec;11(23):4569-77. doi: 10.1002/pmic.201100037. Epub 2011 Nov 4.


Improved quality control processing of peptide-centric LC-MS proteomics data.

Matzke MM, Waters KM, Metz TO, Jacobs JM, Sims AC, Baric RS, Pounds JG, Webb-Robertson BJ.

Bioinformatics. 2011 Oct 15;27(20):2866-72. doi: 10.1093/bioinformatics/btr479. Epub 2011 Aug 18.


Smoking, COPD, and 3-nitrotyrosine levels of plasma proteins.

Jin H, Webb-Robertson BJ, Peterson ES, Tan R, Bigelow DJ, Scholand MB, Hoidal JR, Pounds JG, Zangar RC.

Environ Health Perspect. 2011 Sep;119(9):1314-20. doi: 10.1289/ehp.1103745. Epub 2011 Jun 6.


Testing in EHS: What is the Current Status of Experimentation?

Baer DR, Karakoti AS, Munusamy P, Thrall BD, Pounds JG, Teeguarden JG, Amonette JE, Orr G, Tratnyek PG, Nurmi JT.

Proc IEEE Conf Nanotechnol. 2011:18-19.


Comparative proteomics and pulmonary toxicity of instilled single-walled carbon nanotubes, crocidolite asbestos, and ultrafine carbon black in mice.

Teeguarden JG, Webb-Robertson BJ, Waters KM, Murray AR, Kisin ER, Varnum SM, Jacobs JM, Pounds JG, Zanger RC, Shvedova AA.

Toxicol Sci. 2011 Mar;120(1):123-35. doi: 10.1093/toxsci/kfq363. Epub 2010 Dec 6.


ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies.

Hinderliter PM, Minard KR, Orr G, Chrisler WB, Thrall BD, Pounds JG, Teeguarden JG.

Part Fibre Toxicol. 2010 Nov 30;7(1):36. doi: 10.1186/1743-8977-7-36.


Combined statistical analyses of peptide intensities and peptide occurrences improves identification of significant peptides from MS-based proteomics data.

Webb-Robertson BJ, McCue LA, Waters KM, Matzke MM, Jacobs JM, Metz TO, Varnum SM, Pounds JG.

J Proteome Res. 2010 Nov 5;9(11):5748-56. doi: 10.1021/pr1005247. Epub 2010 Oct 8.


Rapid and sensitive detection of protein biomarker using a portable fluorescence biosensor based on quantum dots and a lateral flow test strip.

Li Z, Wang Y, Wang J, Tang Z, Pounds JG, Lin Y.

Anal Chem. 2010 Aug 15;82(16):7008-14. doi: 10.1021/ac101405a.


Proteomic biomarkers in plasma that differentiate rapid and slow decline in lung function in adult cigarette smokers with chronic obstructive pulmonary disease (COPD).

Rana GS, York TP, Edmiston JS, Zedler BK, Pounds JG, Adkins JN, Varnum SM, Smith RD, Liu Z, Li G, Webb BT, Murrelle EL, Flora JW.

Anal Bioanal Chem. 2010 Jul;397(5):1809-19. doi: 10.1007/s00216-010-3742-4. Epub 2010 May 5. Erratum in: Anal Bioanal Chem. 2010 Sep;398(2):1133. Varnum, Susan M [added].


Sensitive immunoassays of nitrated fibrinogen in human biofluids.

Tang Z, Wu H, Du D, Wang J, Wang H, Qian WJ, Bigelow DJ, Pounds JG, Smith RD, Lin Y.

Talanta. 2010 Jun 15;81(4-5):1662-9. doi: 10.1016/j.talanta.2010.03.022. Epub 2010 Mar 19.


(1)H nuclear magnetic resonance metabolomics analysis identifies novel urinary biomarkers for lung function.

McClay JL, Adkins DE, Isern NG, O'Connell TM, Wooten JB, Zedler BK, Dasika MS, Webb BT, Webb-Robertson BJ, Pounds JG, Murrelle EL, Leppert MF, van den Oord EJ.

J Proteome Res. 2010 Jun 4;9(6):3083-90. doi: 10.1021/pr1000048.


Endogenous 3,4-dihydroxyphenylalanine and dopaquinone modifications on protein tyrosine: links to mitochondrially derived oxidative stress via hydroxyl radical.

Zhang X, Monroe ME, Chen B, Chin MH, Heibeck TH, Schepmoes AA, Yang F, Petritis BO, Camp DG 2nd, Pounds JG, Jacobs JM, Smith DJ, Bigelow DJ, Smith RD, Qian WJ.

Mol Cell Proteomics. 2010 Jun;9(6):1199-208. doi: 10.1074/mcp.M900321-MCP200. Epub 2010 Feb 2.


Syndecan-1 mediates the coupling of positively charged submicrometer amorphous silica particles with actin filaments across the alveolar epithelial cell membrane.

Orr G, Panther DJ, Cassens KJ, Phillips JL, Tarasevich BJ, Pounds JG.

Toxicol Appl Pharmacol. 2009 Apr 15;236(2):210-20. doi: 10.1016/j.taap.2009.01.022. Epub 2009 Feb 6.


A Bayesian integration model of high-throughput proteomics and metabolomics data for improved early detection of microbial infections.

Webb-Robertson BJ, McCue LA, Beagley N, McDermott JE, Wunschel DS, Varnum SM, Hu JZ, Isern NG, Buchko GW, Mcateer K, Pounds JG, Skerrett SJ, Liggitt D, Frevert CW.

Pac Symp Biocomput. 2009:451-63.


Macrophage responses to silica nanoparticles are highly conserved across particle sizes.

Waters KM, Masiello LM, Zangar RC, Tarasevich BJ, Karin NJ, Quesenberry RD, Bandyopadhyay S, Teeguarden JG, Pounds JG, Thrall BD.

Toxicol Sci. 2009 Feb;107(2):553-69. doi: 10.1093/toxsci/kfn250. Epub 2008 Dec 10.


Problems in determination of skeletal lead burden in archaeological samples: an example from the First African Baptist Church population.

Wittmers LE Jr, Aufderheide AC, Pounds JG, Jones KW, Angel JL.

Am J Phys Anthropol. 2008 Aug;136(4):379-86. doi: 10.1002/ajpa.20819.


Characterization of the mouse bronchoalveolar lavage proteome by micro-capillary LC-FTICR mass spectrometry.

Pounds JG, Flora JW, Adkins JN, Lee KM, Rana GS, Sengupta T, Smith RD, McKinney WJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Mar 15;864(1-2):95-101. doi: 10.1016/j.jchromb.2008.01.044. Epub 2008 Feb 14.


Submicrometer and nanoscale inorganic particles exploit the actin machinery to be propelled along microvilli-like structures into alveolar cells.

Orr G, Panther DJ, Phillips JL, Tarasevich BJ, Dohnalkova A, Hu D, Teeguarden JG, Pounds JG.

ACS Nano. 2007 Dec;1(5):463-75. doi: 10.1021/nn700149r.


Particokinetics in vitro: dosimetry considerations for in vitro nanoparticle toxicity assessments.

Teeguarden JG, Hinderliter PM, Orr G, Thrall BD, Pounds JG.

Toxicol Sci. 2007 Feb;95(2):300-12. Epub 2006 Nov 10. Review. Erratum in: Toxicol Sci. 2007 Jun;97(2):614.


Data merging for integrated microarray and proteomic analysis.

Waters KM, Pounds JG, Thrall BD.

Brief Funct Genomic Proteomic. 2006 Dec;5(4):261-72. Epub 2006 May 10. Review.


A proteomic study of the HUPO Plasma Proteome Project's pilot samples using an accurate mass and time tag strategy.

Adkins JN, Monroe ME, Auberry KJ, Shen Y, Jacobs JM, Camp DG 2nd, Vitzthum F, Rodland KD, Zangar RC, Smith RD, Pounds JG.

Proteomics. 2005 Aug;5(13):3454-66.


A study of spectral integration and normalization in NMR-based metabonomic analyses.

Webb-Robertson BJ, Lowry DF, Jarman KH, Harbo SJ, Meng QR, Fuciarelli AF, Pounds JG, Lee KM.

J Pharm Biomed Anal. 2005 Sep 15;39(3-4):830-6.


Interactive toxicity of simple chemical mixtures of cadmium, mercury, methylmercury and trimethyltin: model-dependent responses.

Pounds JG, Haider J, Chen DG, Mumtaz M.

Environ Toxicol Pharmacol. 2004 Nov;18(2):101-13. doi: 10.1016/j.etap.2004.05.012.


The human plasma proteome: a nonredundant list developed by combination of four separate sources.

Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A.

Mol Cell Proteomics. 2004 Apr;3(4):311-26. Epub 2004 Jan 12.


Proteomic characterization of nipple aspirate fluid: identification of potential biomarkers of breast cancer.

Varnum SM, Covington CC, Woodbury RL, Petritis K, Kangas LJ, Abdullah MS, Pounds JG, Smith RD, Zangar RC.

Breast Cancer Res Treat. 2003 Jul;80(1):87-97.


Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry.

Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG.

Mol Cell Proteomics. 2002 Dec;1(12):947-55.


Arsenite disrupts mitosis and induces apoptosis in SV40-transformed human skin fibroblasts.

States JC, Reiners JJ Jr, Pounds JG, Kaplan DJ, Beauerle BD, McNeely SC, Mathieu P, McCabe MJ Jr.

Toxicol Appl Pharmacol. 2002 Apr 15;180(2):83-91. Erratum in: Toxicol Appl Pharmacol 2002 Sep 1;183(2):152.


Protein kinase C does not mediate the inhibitory action of lead on vitamin D3-dependent production of osteocalcin in osteoblastic bone cells.

Guity P, McCabe MJ Jr, Pitts DK, Santini RP, Pounds JG.

Toxicol Appl Pharmacol. 2002 Jan 15;178(2):109-16.


Estimation of cumulative lead releases (lead flux) from the maternal skeleton during pregnancy and lactation.

Gulson BL, Pounds JG, Mushak P, Thomas BJ, Gray B, Korsch MJ.

J Lab Clin Med. 1999 Dec;134(6):631-40.


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