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Items: 1 to 50 of 51

1.

Distinct functions for the membrane-proximal ectodomain region (MPER) of HIV-1 gp41 in cell-free and cell-cell viral transmission and cell-cell fusion.

Narasimhulu VGS, Bellamy-McIntyre AK, Laumaea AE, Lay CS, Harrison DN, King HAD, Drummer HE, Poumbourios P.

J Biol Chem. 2018 Apr 20;293(16):6099-6120. doi: 10.1074/jbc.RA117.000537. Epub 2018 Mar 1.

PMID:
29496992
2.

Escape of Hepatitis C Virus from Epitope I Neutralization Increases Sensitivity of Other Neutralization Epitopes.

Gu J, Hardy J, Boo I, Vietheer P, McCaffrey K, Alhammad Y, Chopra A, Gaudieri S, Poumbourios P, Coulibaly F, Drummer HE.

J Virol. 2018 Apr 13;92(9). pii: e02066-17. doi: 10.1128/JVI.02066-17. Print 2018 May 1.

3.

An Optimized Hepatitis C Virus E2 Glycoprotein Core Adopts a Functional Homodimer That Efficiently Blocks Virus Entry.

McCaffrey K, Boo I, Owczarek CM, Hardy MP, Perugini MA, Fabri L, Scotney P, Poumbourios P, Drummer HE.

J Virol. 2017 Feb 14;91(5). pii: e01668-16. doi: 10.1128/JVI.01668-16. Print 2017 Mar 1.

4.

The core domain of hepatitis C virus glycoprotein E2 generates potent cross-neutralizing antibodies in guinea pigs.

Vietheer PT, Boo I, Gu J, McCaffrey K, Edwards S, Owczarek C, Hardy MP, Fabri L, Center RJ, Poumbourios P, Drummer HE.

Hepatology. 2017 Apr;65(4):1117-1131. doi: 10.1002/hep.28989. Epub 2017 Feb 14.

5.

Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region.

Alhammad Y, Gu J, Boo I, Harrison D, McCaffrey K, Vietheer PT, Edwards S, Quinn C, Coulibaly F, Poumbourios P, Drummer HE.

J Virol. 2015 Dec;89(24):12245-61. doi: 10.1128/JVI.02070-15. Epub 2015 Sep 16.

6.

Longitudinal Sequence and Functional Evolution within Glycoprotein E2 in Hepatitis C Virus Genotype 3a Infection.

Alhammad YM, Maharajh S, Butcher R, Eden JS, White PA, Poumbourios P, Drummer HE.

PLoS One. 2015 May 13;10(5):e0126397. doi: 10.1371/journal.pone.0126397. eCollection 2015.

7.

Forced virus evolution reveals functional crosstalk between the disulfide bonded region and membrane proximal ectodomain region of HIV-1 gp41.

Khasawneh AI, Laumaea A, Harrison DN, Bellamy-McIntyre AK, Drummer HE, Poumbourios P.

Retrovirology. 2013 Apr 23;10:44. doi: 10.1186/1742-4690-10-44.

8.

Allosteric modulation of the HIV-1 gp120-gp41 association site by adjacent gp120 variable region 1 (V1) N-glycans linked to neutralization sensitivity.

Drummer HE, Hill MK, Maerz AL, Wood S, Ramsland PA, Mak J, Poumbourios P.

PLoS Pathog. 2013;9(4):e1003218. doi: 10.1371/journal.ppat.1003218. Epub 2013 Apr 4.

9.

Role of conserved cysteine residues in hepatitis C virus glycoprotein e2 folding and function.

McCaffrey K, Boo I, Tewierek K, Edmunds ML, Poumbourios P, Drummer HE.

J Virol. 2012 Apr;86(7):3961-74. doi: 10.1128/JVI.05396-11. Epub 2012 Jan 25.

10.

Distinct roles in folding, CD81 receptor binding and viral entry for conserved histidine residues of hepatitis C virus glycoprotein E1 and E2.

Boo I, teWierik K, Douam F, Lavillette D, Poumbourios P, Drummer HE.

Biochem J. 2012 Apr 1;443(1):85-94. doi: 10.1042/BJ20110868.

PMID:
22240035
11.

Role for the terminal clasp of HIV-1 gp41 glycoprotein in the initiation of membrane fusion.

Lay CS, Ludlow LE, Stapleton D, Bellamy-McIntyre AK, Ramsland PA, Drummer HE, Poumbourios P.

J Biol Chem. 2011 Dec 2;286(48):41331-43. doi: 10.1074/jbc.M111.299826. Epub 2011 Oct 5.

12.

Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 contain reduced cysteine residues essential for virus entry.

Fraser J, Boo I, Poumbourios P, Drummer HE.

J Biol Chem. 2011 Sep 16;286(37):31984-92. doi: 10.1074/jbc.M111.269605. Epub 2011 Jul 15.

13.

The variable regions of hepatitis C virus glycoprotein E2 have an essential structural role in glycoprotein assembly and virion infectivity.

McCaffrey K, Gouklani H, Boo I, Poumbourios P, Drummer HE.

J Gen Virol. 2011 Jan;92(Pt 1):112-21. doi: 10.1099/vir.0.026385-0. Epub 2010 Oct 6.

PMID:
20926639
14.

An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes.

Sterjovski J, Roche M, Churchill MJ, Ellett A, Farrugia W, Gray LR, Cowley D, Poumbourios P, Lee B, Wesselingh SL, Cunningham AL, Ramsland PA, Gorry PR.

Virology. 2010 Sep 1;404(2):269-78. doi: 10.1016/j.virol.2010.05.006. Epub 2010 Jun 8.

15.

Role for the disulfide-bonded region of human immunodeficiency virus type 1 gp41 in receptor-triggered activation of membrane fusion function.

Bellamy-McIntyre AK, Bär S, Ludlow L, Drummer HE, Poumbourios P.

Biochem Biophys Res Commun. 2010 Apr 16;394(4):904-8. doi: 10.1016/j.bbrc.2010.03.071. Epub 2010 Mar 15.

PMID:
20230797
16.

Tissue-specific sequence alterations in the human immunodeficiency virus type 1 envelope favoring CCR5 usage contribute to persistence of dual-tropic virus in the brain.

Gray L, Roche M, Churchill MJ, Sterjovski J, Ellett A, Poumbourios P, Sherieff S, Wang B, Saksena N, Purcell DF, Wesselingh S, Cunningham AL, Brew BJ, Gabuzda D, Gorry PR.

J Virol. 2009 Jun;83(11):5430-41. doi: 10.1128/JVI.02648-08. Epub 2009 Mar 25. Erratum in: J Virol. 2009 Aug;83(15):7794. Sheffief, Shameem [corrected to Sherieff, Shameem].

17.
18.

Expression and characterization of a minimal hepatitis C virus glycoprotein E2 core domain that retains CD81 binding.

McCaffrey K, Boo I, Poumbourios P, Drummer HE.

J Virol. 2007 Sep;81(17):9584-90. Epub 2007 Jun 20.

19.

An N-terminal glycine-rich sequence contributes to retrovirus trimer of hairpins stability.

Wilson KA, Maerz AL, Bär S, Drummer HE, Poumbourios P.

Biochem Biophys Res Commun. 2007 Aug 10;359(4):1037-43. Epub 2007 Jun 11.

PMID:
17577584
20.

Functional links between the fusion peptide-proximal polar segment and membrane-proximal region of human immunodeficiency virus gp41 in distinct phases of membrane fusion.

Bellamy-McIntyre AK, Lay CS, Baär S, Maerz AL, Talbo GH, Drummer HE, Poumbourios P.

J Biol Chem. 2007 Aug 10;282(32):23104-16. Epub 2007 May 25.

21.
22.
23.

Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5delta32 allele.

Gray L, Churchill MJ, Keane N, Sterjovski J, Ellett AM, Purcell DF, Poumbourios P, Kol C, Wang B, Saksena NK, Wesselingh SL, Price P, French M, Gabuzda D, Gorry PR.

J Virol. 2006 Apr;80(7):3684-91.

25.

Determinants of CD81 dimerization and interaction with hepatitis C virus glycoprotein E2.

Drummer HE, Wilson KA, Poumbourios P.

Biochem Biophys Res Commun. 2005 Mar 4;328(1):251-7.

PMID:
15670777
26.
28.

Functional evolution of the HIV-1 envelope glycoprotein 120 association site of glycoprotein 41.

Poumbourios P, Maerz AL, Drummer HE.

J Biol Chem. 2003 Oct 24;278(43):42149-60. Epub 2003 Aug 15.

29.
30.

Cell surface expression of functional hepatitis C virus E1 and E2 glycoproteins.

Drummer HE, Maerz A, Poumbourios P.

FEBS Lett. 2003 Jul 10;546(2-3):385-90.

31.
32.

Disulfide exchange in domain 2 of CD4 is required for entry of HIV-1.

Matthias LJ, Yam PT, Jiang XM, Vandegraaff N, Li P, Poumbourios P, Donoghue N, Hogg PJ.

Nat Immunol. 2002 Aug;3(8):727-32. Epub 2002 Jul 1.

PMID:
12089508
35.

Functional implications of the human T-lymphotropic virus type 1 transmembrane glycoprotein helical hairpin structure.

Maerz AL, Center RJ, Kemp BE, Kobe B, Poumbourios P.

J Virol. 2000 Jul;74(14):6614-21.

36.

Evolutionary conservation of the membrane fusion machine.

Poumbourios P, Center RJ, Wilson KA, Kemp BE, Kobe B.

IUBMB Life. 1999 Aug;48(2):151-6. Review.

38.

Crystallization of a trimeric human T cell leukemia virus type 1 gp21 ectodomain fragment as a chimera with maltose-binding protein.

Center RJ, Kobe B, Wilson KA, Teh T, Howlett GJ, Kemp BE, Poumbourios P.

Protein Sci. 1998 Jul;7(7):1612-9.

39.

Efficacy of fusion peptide homologs in blocking cell lysis and HIV-induced fusion.

Silburn KA, McPhee DA, Maerz AL, Poumbourios P, Whittaker RG, Kirkpatrick A, Reilly WG, Manthey MK, Curtain CC.

AIDS Res Hum Retroviruses. 1998 Mar 20;14(5):385-92.

PMID:
9546797
40.

Mutation-directed chemical cross-linking of human immunodeficiency virus type 1 gp41 oligomers.

McInerney TL, El Ahmar W, Kemp BE, Poumbourios P.

J Virol. 1998 Feb;72(2):1523-33.

41.
42.
43.

Determinants of human immunodeficiency virus type 1 envelope glycoprotein oligomeric structure.

Poumbourios P, el Ahmar W, McPhee DA, Kemp BE.

J Virol. 1995 Feb;69(2):1209-18.

44.

Synthetic peptides representing sequences within gp41 of HIV as immunogens for murine T- and B-cell responses.

Brown LE, White DO, Agius C, Kemp BE, Yatzakis N, Poumbourios P, McPhee DA, Jackson DC.

Arch Virol. 1995;140(4):635-54.

PMID:
7540829
45.

Studies on the antibody response of mice and humans after immunization with potential influenza virus A (H1N1) vaccines.

Poumbourios P, Oxford JS, Jackson DC.

Immunol Cell Biol. 1993 Feb;71 ( Pt 1):13-25.

PMID:
7679664
46.
47.

N-terminal residues 105-117 of HIV-1 gp120 are not involved in CD4 binding.

el Ahmar W, Poumbourios P, McPhee DA, Kemp BE.

AIDS Res Hum Retroviruses. 1991 Oct;7(10):855-8.

PMID:
1720631
48.
49.

The stoichiometry of binding between monoclonal antibody molecules and the hemagglutinin of influenza virus.

Poumbourios P, Brown LE, White DO, Jackson DC.

Virology. 1990 Dec;179(2):768-76.

PMID:
1700542
50.

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