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Recent Advances in Pathology: the 2019 Annual Review Issue of The Journal of Pathology.

Herrington CS, Poulsom R, Coates PJ.

J Pathol. 2019 Apr;247(5):535-538. doi: 10.1002/path.5255.


Separation of Dual Oxidase 2 and Lactoperoxidase Expression in Intestinal Crypts and Species Differences May Limit Hydrogen Peroxide Scavenging During Mucosal Healing in Mice and Humans.

Rigoni A, Poulsom R, Jeffery R, Mehta S, Lewis A, Yau C, Giannoulatou E, Feakins R, Lindsay JO, Colombo MP, Silver A.

Inflamm Bowel Dis. 2017 Dec 19;24(1):136-148. doi: 10.1093/ibd/izx024.


GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions.

Bustos V, Nolan ÁM, Nijhuis A, Harvey H, Parker A, Poulsom R, McBryan J, Thomas W, Silver A, Harvey BJ.

Oncotarget. 2017 Sep 6;8(48):84258-84275. doi: 10.18632/oncotarget.20653. eCollection 2017 Oct 13.


Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines.

Scudamore CL, Soilleux EJ, Karp NA, Smith K, Poulsom R, Herrington CS, Day MJ, Brayton CF, Bolon B, Whitelaw B, White ES, Everitt JI, Arends MJ.

J Pathol. 2016 Jan;238(2):359-67. doi: 10.1002/path.4642. Epub 2015 Nov 28. Review.


BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling.

Urban BC, Collard TJ, Eagle CJ, Southern SL, Greenhough A, Hamdollah-Zadeh M, Ghosh A, Poulsom R, Paraskeva C, Silver A, Williams AC.

Gut. 2016 Jul;65(7):1151-64. doi: 10.1136/gutjnl-2014-308270. Epub 2015 Jun 1.


Low-dose TNF augments fracture healing in normal and osteoporotic bone by up-regulating the innate immune response.

Chan JK, Glass GE, Ersek A, Freidin A, Williams GA, Gowers K, Espirito Santo AI, Jeffery R, Otto WR, Poulsom R, Feldmann M, Rankin SM, Horwood NJ, Nanchahal J.

EMBO Mol Med. 2015 May;7(5):547-61. doi: 10.15252/emmm.201404487.


Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.

Davis H, Irshad S, Bansal M, Rafferty H, Boitsova T, Bardella C, Jaeger E, Lewis A, Freeman-Mills L, Giner FC, Rodenas-Cuadrado P, Mallappa S, Clark S, Thomas H, Jeffery R, Poulsom R, Rodriguez-Justo M, Novelli M, Chetty R, Silver A, Sansom OJ, Greten FR, Wang LM, East JE, Tomlinson I, Leedham SJ.

Nat Med. 2015 Jan;21(1):62-70. doi: 10.1038/nm.3750. Epub 2014 Dec 1.


Epidermal growth factor attenuates tubular necrosis following mercuric chloride damage by regeneration of indigenous, not bone marrow-derived cells.

Yen TH, Alison MR, Goodlad RA, Otto WR, Jeffery R, Cook HT, Wright NA, Poulsom R.

J Cell Mol Med. 2015 Feb;19(2):463-73. doi: 10.1111/jcmm.12478. Epub 2014 Nov 11.


Fibroblast growth factor receptor (FGFR) gene amplifications are rare events in bladder cancer.

Fischbach A, Rogler A, Erber R, Stoehr R, Poulsom R, Heidenreich A, Schneevoigt BS, Hauke S, Hartmann A, Knuechel R, Veeck J, Gaisa NT.

Histopathology. 2015 Apr;66(5):639-49. doi: 10.1111/his.12473. Epub 2015 Jan 12.


In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts.

Nijhuis A, Biancheri P, Lewis A, Bishop CL, Giuffrida P, Chan C, Feakins R, Poulsom R, Di Sabatino A, Corazza GR, MacDonald TT, Lindsay JO, Silver AR.

Clin Sci (Lond). 2014 Sep;127(5):341-50. doi: 10.1042/CS20140048.


The stem cell organisation, and the proliferative and gene expression profile of Barrett's epithelium, replicates pyloric-type gastric glands.

Lavery DL, Nicholson AM, Poulsom R, Jeffery R, Hussain A, Gay LJ, Jankowski JA, Zeki SS, Barr H, Harrison R, Going J, Kadirkamanathan S, Davis P, Underwood T, Novelli MR, Rodriguez-Justo M, Shepherd N, Jansen M, Wright NA, McDonald SA.

Gut. 2014 Dec;63(12):1854-63. doi: 10.1136/gutjnl-2013-306508. Epub 2014 Feb 18.


DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid.

MacFie TS, Poulsom R, Parker A, Warnes G, Boitsova T, Nijhuis A, Suraweera N, Poehlmann A, Szary J, Feakins R, Jeffery R, Harper RW, Jubb AM, Lindsay JO, Silver A.

Inflamm Bowel Dis. 2014 Mar;20(3):514-24. doi: 10.1097/01.MIB.0000442012.45038.0e. Erratum in: Inflamm Bowel Dis. 2014 Apr;20(4):775.


Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors.

Teixeira VH, Nadarajan P, Graham TA, Pipinikas CP, Brown JM, Falzon M, Nye E, Poulsom R, Lawrence D, Wright NA, McDonald S, Giangreco A, Simons BD, Janes SM.

Elife. 2013 Oct 22;2:e00966. doi: 10.7554/eLife.00966.


Identifying the origin and phenotype of cells in tumor xenografts.

Jeffery R, Seedhar P, Poulsom R.

Methods Mol Biol. 2014;1070:235-45. doi: 10.1007/978-1-4614-8244-4_18.


Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.

Humphries A, Cereser B, Gay LJ, Miller DS, Das B, Gutteridge A, Elia G, Nye E, Jeffery R, Poulsom R, Novelli MR, Rodriguez-Justo M, McDonald SA, Wright NA, Graham TA.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2490-9. doi: 10.1073/pnas.1220353110. Epub 2013 Jun 13.


Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.

Barker N, Rookmaaker MB, Kujala P, Ng A, Leushacke M, Snippert H, van de Wetering M, Tan S, Van Es JH, Huch M, Poulsom R, Verhaar MC, Peters PJ, Clevers H.

Cell Rep. 2012 Sep 27;2(3):540-52. doi: 10.1016/j.celrep.2012.08.018. Epub 2012 Sep 20.


Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation.

Radulescu S, Ridgway RA, Cordero J, Athineos D, Salgueiro P, Poulsom R, Neumann J, Jung A, Patel S, Woodgett J, Barker N, Pritchard DM, Oien K, Sansom OJ.

Oncogene. 2013 Apr 18;32(16):2048-57. doi: 10.1038/onc.2012.224. Epub 2012 Jun 4.


Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.

Wong VW, Stange DE, Page ME, Buczacki S, Wabik A, Itami S, van de Wetering M, Poulsom R, Wright NA, Trotter MW, Watt FM, Winton DJ, Clevers H, Jensen KB.

Nat Cell Biol. 2012 Mar 4;14(4):401-8. doi: 10.1038/ncb2464.


Trefoil factor family peptides in normal and diseased human pancreas.

Guppy NJ, El-Bahrawy ME, Kocher HM, Fritsch K, Qureshi YA, Poulsom R, Jeffery RE, Wright NA, Otto WR, Alison MR.

Pancreas. 2012 Aug;41(6):888-96. doi: 10.1097/MPA.0b013e31823c9ec5.


Bone marrow-derived cells contribute to cerulein-induced pancreatic fibrosis in the mouse.

Lin WR, Inatomi O, Lee CY, Kallis YN, Otto WR, Jeffery R, Poulsom R, Alison MR.

Int J Exp Pathol. 2012 Apr;93(2):130-8. doi: 10.1111/j.1365-2613.2011.00804.x. Epub 2012 Jan 27.


The ailing gut: a therapeutic role for bone marrow cells?

Alison MR, Lin WR, Lee CY, Poulsom R, Wright NA, Otto WR.

Transplantation. 2012 Mar 27;93(6):565-71. doi: 10.1097/TP.0b013e3182419893. Review.


Activation of the BMP4 pathway and early expression of CDX2 characterize non-specialized columnar metaplasia in a human model of Barrett's esophagus.

Castillo D, Puig S, Iglesias M, Seoane A, de Bolós C, Munitiz V, Parrilla P, Comerma L, Poulsom R, Krishnadath KK, Grande L, Pera M.

J Gastrointest Surg. 2012 Feb;16(2):227-37; discussion 237. doi: 10.1007/s11605-011-1758-5. Epub 2011 Nov 11.


Bone marrow cells in murine colitis: multi-signal analysis confirms pericryptal myofibroblast engraftment without epithelial involvement.

Lee CY, Jeffery R, Hutchinson G, Alison MR, Poulsom R, Wright NA, Otto WR.

PLoS One. 2011;6(10):e26082. doi: 10.1371/journal.pone.0026082. Epub 2011 Oct 13.


Distinct roles for S100a8 in early embryo development and in the maternal deciduum.

Baker JR, Jeffery R, May RD, Mathies M, Spencer-Dene B, Poulsom R, Hogg N.

Dev Dyn. 2011 Sep;240(9):2194-203. doi: 10.1002/dvdy.22709.


The C-terminus of Apc does not influence intestinal adenoma development or progression.

Lewis A, Davis H, Deheragoda M, Pollard P, Nye E, Jeffery R, Segditsas S, East P, Poulsom R, Stamp G, Wright N, Tomlinson I.

J Pathol. 2012 Jan;226(1):73-83. doi: 10.1002/path.2972. Epub 2011 Oct 18.


Omnis cellula e cellula revisited: cell biology as the foundation of pathology.

Wright NA, Poulsom R.

J Pathol. 2012 Jan;226(2):145-7. doi: 10.1002/path.3030.


Clonal architecture of human prostatic epithelium in benign and malignant conditions.

Gaisa NT, Graham TA, McDonald SA, Poulsom R, Heidenreich A, Jakse G, Knuechel R, Wright NA.

J Pathol. 2011 Oct;225(2):172-80. doi: 10.1002/path.2959. Epub 2011 Aug 24.


DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.

Li JL, Sainson RC, Oon CE, Turley H, Leek R, Sheldon H, Bridges E, Shi W, Snell C, Bowden ET, Wu H, Chowdhury PS, Russell AJ, Montgomery CP, Poulsom R, Harris AL.

Cancer Res. 2011 Sep 15;71(18):6073-83. doi: 10.1158/0008-5472.CAN-11-1704. Epub 2011 Jul 29.


The human urothelium consists of multiple clonal units, each maintained by a stem cell.

Gaisa NT, Graham TA, McDonald SA, Cañadillas-Lopez S, Poulsom R, Heidenreich A, Jakse G, Tadrous PJ, Knuechel R, Wright NA.

J Pathol. 2011 Oct;225(2):163-71. doi: 10.1002/path.2945. Epub 2011 Jul 8.


Experimental models of renal disease.

Poulsom R.

Int J Exp Pathol. 2011 Jun;92(3):141-2. doi: 10.1111/j.1365-2613.2011.00776.x.


PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.

Sakthianandeswaren A, Christie M, D'Andreti C, Tsui C, Jorissen RN, Li S, Fleming NI, Gibbs P, Lipton L, Malaterre J, Ramsay RG, Phesse TJ, Ernst M, Jeffery RE, Poulsom R, Leedham SJ, Segditsas S, Tomlinson IP, Bernhard OK, Simpson RJ, Walker F, Faux MC, Church N, Catimel B, Flanagan DJ, Vincan E, Sieber OM.

Cancer Res. 2011 May 15;71(10):3709-19. doi: 10.1158/0008-5472.CAN-10-2342. Epub 2011 May 10.


Elevation of WNT5A expression in polyp formation in Lkb1+/- mice and Peutz-Jeghers syndrome.

Lai C, Robinson J, Clark S, Stamp G, Poulsom R, Silver A.

J Pathol. 2011 Apr;223(5):584-92. doi: 10.1002/path.2835. Epub 2011 Feb 21.


The Journal of Pathology's approach to publication ethics and misconduct.

Hall PA, Wixon J, Poulsom R.

J Pathol. 2011 Mar;223(4):447-9. doi: 10.1002/path.2843.


T cells reactive with HLA-A*0201 peptides from the histone demethylase JARID1B are found in the circulation of breast cancer patients.

Coleman JA, Correa I, Cooper L, Bohnenkamp HR, Poulsom R, Burchell JM, Taylor-Papadimitriou J.

Int J Cancer. 2011 May 1;128(9):2114-24. doi: 10.1002/ijc.25792. Epub 2011 Feb 11.


Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis.

Ashrafian H, O'Flaherty L, Adam J, Steeples V, Chung YL, East P, Vanharanta S, Lehtonen H, Nye E, Hatipoglu E, Miranda M, Howarth K, Shukla D, Troy H, Griffiths J, Spencer-Dene B, Yusuf M, Volpi E, Maxwell PH, Stamp G, Poulsom R, Pugh CW, Costa B, Bardella C, Di Renzo MF, Kotlikoff MI, Launonen V, Aaltonen L, El-Bahrawy M, Tomlinson I, Pollard PJ.

Cancer Res. 2010 Nov 15;70(22):9153-65. doi: 10.1158/0008-5472.CAN-10-1949. Epub 2010 Oct 26.


Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5.

Lewis A, Segditsas S, Deheragoda M, Pollard P, Jeffery R, Nye E, Lockstone H, Davis H, Clark S, Stamp G, Poulsom R, Wright N, Tomlinson I.

Gut. 2010 Dec;59(12):1680-6. doi: 10.1136/gut.2009.193680. Epub 2010 Oct 6.


CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer.

Ripka S, Neesse A, Riedel J, Bug E, Aigner A, Poulsom R, Fulda S, Neoptolemos J, Greenhalf W, Barth P, Gress TM, Michl P.

Gut. 2010 Aug;59(8):1101-10. doi: 10.1136/gut.2009.189720. Epub 2010 May 4.


More developments at The Journal of Pathology.

Hall PA, Poulsom R, Taylor J, Wixon J.

J Pathol. 2010 May;221(1):1-2. doi: 10.1002/path.2709.


Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.

Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, van Es JH, Sato T, Stange DE, Begthel H, van den Born M, Danenberg E, van den Brink S, Korving J, Abo A, Peters PJ, Wright N, Poulsom R, Clevers H.

Cell Stem Cell. 2010 Jan 8;6(1):25-36. doi: 10.1016/j.stem.2009.11.013.


An introduction to genes, genomes and disease.

Hall PA, Reis-Filho JS, Tomlinson IP, Poulsom R.

J Pathol. 2010 Jan;220(2):109-13. doi: 10.1002/path.2652.


The fibroblast growth factor receptor inhibitor PD173074 blocks small cell lung cancer growth in vitro and in vivo.

Pardo OE, Latigo J, Jeffery RE, Nye E, Poulsom R, Spencer-Dene B, Lemoine NR, Stamp GW, Aboagye EO, Seckl MJ.

Cancer Res. 2009 Nov 15;69(22):8645-51. doi: 10.1158/0008-5472.CAN-09-1576. Epub 2009 Nov 10.


The Journal of Pathology 2008 Jeremy Jass Prize for Research Excellence in Pathology.

Hall PA, Poulsom R, Coates PJ, Du MQ, Hogendoorn PC, Jones LJ, Ladanyi M, Murray GI, Niedobitek G.

J Pathol. 2009 Dec;219(4):393-5. doi: 10.1002/path.2634.


Targeted induction of endoplasmic reticulum stress induces cartilage pathology.

Rajpar MH, McDermott B, Kung L, Eardley R, Knowles L, Heeran M, Thornton DJ, Wilson R, Bateman JF, Poulsom R, Arvan P, Kadler KE, Briggs MD, Boot-Handford RP.

PLoS Genet. 2009 Oct;5(10):e1000691. doi: 10.1371/journal.pgen.1000691. Epub 2009 Oct 16.


How does The Journal of Pathology deal with conflict of interest?

Hall PA, Poulsom R, Wixon J.

J Pathol. 2009 Dec;219(4):396-9. doi: 10.1002/path.2621.


Human cord blood CD133+ stem cells transplanted to nod-scid mice provide conditions for regeneration of olfactory neuroepithelium after permanent damage induced by dichlobenil.

Franceschini V, Bettini S, Pifferi S, Rosellini A, Menini A, Saccardi R, Ognio E, Jeffery R, Poulsom R, Revoltella RP.

Stem Cells. 2009 Apr;27(4):825-35. doi: 10.1002/stem.11.


The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.

Pollard P, Deheragoda M, Segditsas S, Lewis A, Rowan A, Howarth K, Willis L, Nye E, McCart A, Mandir N, Silver A, Goodlad R, Stamp G, Cockman M, East P, Spencer-Dene B, Poulsom R, Wright N, Tomlinson I.

Gastroenterology. 2009 Jun;136(7):2204-2213.e1-13. doi: 10.1053/j.gastro.2009.02.058. Epub 2009 Feb 25.


Parietal epithelial cells regenerate podocytes.

Poulsom R, Little MH.

J Am Soc Nephrol. 2009 Feb;20(2):231-3. doi: 10.1681/ASN.2008121279. Epub 2009 Jan 28. No abstract available.


Sources of adult hepatic stem cells: haematopoietic.

Jeffery R, Poulsom R, Alison MR.

Methods Mol Biol. 2009;481:141-54. doi: 10.1007/978-1-59745-201-4_12. Review.


mRNA expression profiling of phyllodes tumours of the breast: identification of genes important in the development of borderline and malignant phyllodes tumours.

Jones AM, Mitter R, Poulsom R, Gillett C, Hanby AM, Tomlinson IP, Sawyer EJ; Phyllodes Tumour Consortium.

J Pathol. 2008 Dec;216(4):408-17. doi: 10.1002/path.2439.


Cochlear repair by transplantation of human cord blood CD133+ cells to nod-scid mice made deaf with kanamycin and noise.

Revoltella RP, Papini S, Rosellini A, Michelini M, Franceschini V, Ciorba A, Bertolaso L, Magosso S, Hatzopoulos S, Lorito G, Giordano P, Simoni E, Ognio E, Cilli M, Saccardi R, Urbani S, Jeffery R, Poulsom R, Martini A.

Cell Transplant. 2008;17(6):665-78.


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