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In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned.

Lipponen A, Natunen T, Hujo M, Ciszek R, Hämäläinen E, Tohka J, Hiltunen M, Paananen J, Poulsen D, Kansanen E, Ekolle Ndode-Ekane X, Levonen AL, Pitkänen A.

Int J Mol Sci. 2019 Oct 29;20(21). pii: E5395. doi: 10.3390/ijms20215395.


A Systematic Review and Meta-Analysis of Nature-Based Mindfulness: Effects of Moving Mindfulness Training into an Outdoor Natural Setting.

Djernis D, Lerstrup I, Poulsen D, Stigsdotter U, Dahlgaard J, O'Toole M.

Int J Environ Res Public Health. 2019 Sep 2;16(17). pii: E3202. doi: 10.3390/ijerph16173202.


Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury.

McGuire MJ, Gertz SM, McCutcheon JD, Richardson CR, Poulsen DJ.

J Vis Exp. 2019 Jun 21;(148). doi: 10.3791/59637.


Visualization of thalamic calcium influx with quantitative susceptibility mapping as a potential imaging biomarker for repeated mild traumatic brain injury.

Schweser F, Kyyriäinen J, Preda M, Pitkänen A, Toffolo K, Poulsen A, Donahue K, Levy B, Poulsen D.

Neuroimage. 2019 Oct 15;200:250-258. doi: 10.1016/j.neuroimage.2019.06.024. Epub 2019 Jun 12.


Psycho-Physiological Stress Recovery in Outdoor Nature-Based Interventions: A Systematic Review of the Past Eight Years of Research.

Corazon SS, Sidenius U, Poulsen DV, Gramkow MC, Stigsdotter UK.

Int J Environ Res Public Health. 2019 May 16;16(10). pii: E1711. doi: 10.3390/ijerph16101711.


Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies.

Karttunen J, Heiskanen M, Lipponen A, Poulsen D, Pitkänen A.

Int J Mol Sci. 2019 Mar 13;20(6). pii: E1259. doi: 10.3390/ijms20061259. Review.


Post-Occupancy Evaluation of a Crisis Shelter Garden and Application of Findings Through the Use of a Participatory Design Process.

Lygum VL, Poulsen DV, Djernis D, Djernis HG, Sidenius U, Stigsdotter UK.

HERD. 2019 Jul;12(3):153-167. doi: 10.1177/1937586718812444. Epub 2018 Nov 22.


The Tree Is My Anchor: A Pilot Study on the Treatment of BED through Nature-Based Therapy.

Corazon SS, Sidenius U, Vammen KS, Klinker SE, Stigsdotter UK, Poulsen DV.

Int J Environ Res Public Health. 2018 Nov 8;15(11). pii: E2486. doi: 10.3390/ijerph15112486.


Pediatric traumatic brain injury and ocular injury.

Gise R, Truong T, Poulsen DM, Soliman Y, Parsikia A, Mbekeani JN.

J AAPOS. 2018 Dec;22(6):421-425.e3. doi: 10.1016/j.jaapos.2018.07.351. Epub 2018 Oct 17.


Convulsive seizures and EEG spikes after lateral fluid-percussion injury in the rat.

Smith D, Rau T, Poulsen A, MacWilliams Z, Patterson D, Kelly W, Poulsen D.

Epilepsy Res. 2018 Nov;147:87-94. doi: 10.1016/j.eplepsyres.2018.09.005. Epub 2018 Sep 17.


Circulating microRNAs as biomarkers in traumatic brain injury.

Toffolo K, Osei J, Kelly W, Poulsen A, Donahue K, Wang J, Hunter M, Bard J, Wang J, Poulsen D.

Neuropharmacology. 2019 Feb;145(Pt B):199-208. doi: 10.1016/j.neuropharm.2018.08.028. Epub 2018 Sep 7. Review.


"That Guy, Is He Really Sick at All?" An Analysis of How Veterans with PTSD Experience Nature-Based Therapy.

Poulsen DV, Stigsdotter UK, Davidsen AS.

Healthcare (Basel). 2018 Jun 14;6(2). pii: E64. doi: 10.3390/healthcare6020064.


Thymosin beta 4 induces significant changes in the plasma miRNA profile following severe traumatic brain injury in the rat lateral fluid percussion injury model.

Osei J, Kelly W, Toffolo K, Donahue K, Levy B, Bard J, Wang J, Levy E, Nowak N, Poulsen D.

Expert Opin Biol Ther. 2018 Jul;18(sup1):159-164. doi: 10.1080/14712598.2018.1484102.


Effects of Intraborehole Flow on Purging and Sampling Long-Screened or Open Wells.

Poulsen DL, Cook PG, Simmons CT, McCallum JL, Dogramaci S.

Ground Water. 2019 Mar;57(2):269-278. doi: 10.1111/gwat.12797. Epub 2018 Jun 13.


IonStar enables high-precision, low-missing-data proteomics quantification in large biological cohorts.

Shen X, Shen S, Li J, Hu Q, Nie L, Tu C, Wang X, Poulsen DJ, Orsburn BC, Wang J, Qu J.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):E4767-E4776. doi: 10.1073/pnas.1800541115. Epub 2018 May 9.


Intracranial pressure changes after mild traumatic brain injury: a systematic review.

Haider MN, Leddy JJ, Hinds AL, Aronoff N, Rein D, Poulsen D, Willer BS.

Brain Inj. 2018;32(7):809-815. doi: 10.1080/02699052.2018.1469045. Epub 2018 Apr 27.


A Long-Term Follow-Up of the Efficacy of Nature-Based Therapy for Adults Suffering from Stress-Related Illnesses on Levels of Healthcare Consumption and Sick-Leave Absence: A Randomized Controlled Trial.

Corazon SS, Nyed PK, Sidenius U, Poulsen DV, Stigsdotter UK.

Int J Environ Res Public Health. 2018 Jan 15;15(1). pii: E137. doi: 10.3390/ijerph15010137.


Health-Promoting Nature Access for People with Mobility Impairments: A Systematic Review.

Zhang G, Poulsen DV, Lygum VL, Corazon SS, Gramkow MC, Stigsdotter UK.

Int J Environ Res Public Health. 2017 Jun 29;14(7). pii: E703. doi: 10.3390/ijerph14070703. Review.


Etiology of optic atrophy: a prospective observational study from Saudi Arabia.

Mbekeani JN, Fattah MA, Poulsen DM, Hazzaa SA, Dababo MA, Eldali A, Ahmed M.

Ann Saudi Med. 2017 May-Jun;37(3):232-239. doi: 10.5144/0256-4947.2017.232.


'Everything just seems much more right in nature': How veterans with post-traumatic stress disorder experience nature-based activities in a forest therapy garden.

Poulsen DV, Stigsdotter UK, Djernis D, Sidenius U.

Health Psychol Open. 2016 Mar 31;3(1):2055102916637090. doi: 10.1177/2055102916637090. eCollection 2016 Jan.


Recent advances in the treatment of corneal ectasia with intrastromal corneal ring segments.

Poulsen DM, Kang JJ.

Curr Opin Ophthalmol. 2015 Jul;26(4):273-7. doi: 10.1097/ICU.0000000000000163. Review.


GLT1 overexpression in SOD1(G93A) mouse cervical spinal cord does not preserve diaphragm function or extend disease.

Li K, Hala TJ, Seetharam S, Poulsen DJ, Wright MC, Lepore AC.

Neurobiol Dis. 2015 Jun;78:12-23. doi: 10.1016/j.nbd.2015.03.010. Epub 2015 Mar 25.


The neuroprotective potential of low-dose methamphetamine in preclinical models of stroke and traumatic brain injury.

Rau T, Ziemniak J, Poulsen D.

Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jan 4;64:231-6. doi: 10.1016/j.pnpbp.2015.02.013. Epub 2015 Feb 25. Review.


Transplantation of glial progenitors that overexpress glutamate transporter GLT1 preserves diaphragm function following cervical SCI.

Li K, Javed E, Hala TJ, Sannie D, Regan KA, Maragakis NJ, Wright MC, Poulsen DJ, Lepore AC.

Mol Ther. 2015 Mar;23(3):533-48. doi: 10.1038/mt.2014.236. Epub 2014 Dec 10.


Overexpression of the astrocyte glutamate transporter GLT1 exacerbates phrenic motor neuron degeneration, diaphragm compromise, and forelimb motor dysfunction following cervical contusion spinal cord injury.

Li K, Nicaise C, Sannie D, Hala TJ, Javed E, Parker JL, Putatunda R, Regan KA, Suain V, Brion JP, Rhoderick F, Wright MC, Poulsen DJ, Lepore AC.

J Neurosci. 2014 May 28;34(22):7622-38. doi: 10.1523/JNEUROSCI.4690-13.2014.


Hilar mossy cells provide the first glutamatergic synapses to adult-born dentate granule cells.

Chancey JH, Poulsen DJ, Wadiche JI, Overstreet-Wadiche L.

J Neurosci. 2014 Feb 5;34(6):2349-54. doi: 10.1523/JNEUROSCI.3620-13.2014.


Phenoxybenzamine is neuroprotective in a rat model of severe traumatic brain injury.

Rau TF, Kothiwal A, Rova A, Rhoderick JF, Poulsen DJ.

Int J Mol Sci. 2014 Jan 20;15(1):1402-17. doi: 10.3390/ijms15011402.


Administration of low dose methamphetamine 12 h after a severe traumatic brain injury prevents neurological dysfunction and cognitive impairment in rats.

Rau TF, Kothiwal AS, Rova AR, Brooks DM, Rhoderick JF, Poulsen AJ, Hutchinson J, Poulsen DJ.

Exp Neurol. 2014 Mar;253:31-40. doi: 10.1016/j.expneurol.2013.12.001. Epub 2013 Dec 11.


Overexpression of adenosine kinase in cortical astrocytes and focal neocortical epilepsy in mice.

Shen HY, Sun H, Hanthorn MM, Zhi Z, Lan JQ, Poulsen DJ, Wang RK, Boison D.

J Neurosurg. 2014 Mar;120(3):628-38. doi: 10.3171/2013.10.JNS13918. Epub 2013 Nov 22.


Ursodiol and colorectal cancer or dysplasia risk in primary sclerosing cholangitis and inflammatory bowel disease: a meta-analysis.

Hansen JD, Kumar S, Lo WK, Poulsen DM, Halai UA, Tater KC.

Dig Dis Sci. 2013 Nov;58(11):3079-87. doi: 10.1007/s10620-013-2772-0. Epub 2013 Jul 30. Review.


MRI of neuronal recovery after low-dose methamphetamine treatment of traumatic brain injury in rats.

Ding GL, Chopp M, Poulsen DJ, Li L, Qu C, Li Q, Nejad-Davarani SP, Budaj JS, Wu H, Mahmood A, Jiang Q.

PLoS One. 2013 Apr 18;8(4):e61241. doi: 10.1371/journal.pone.0061241. Print 2013.


Oxygen glucose deprivation in rat hippocampal slice cultures results in alterations in carnitine homeostasis and mitochondrial dysfunction.

Rau TF, Lu Q, Sharma S, Sun X, Leary G, Beckman ML, Hou Y, Wainwright MS, Kavanaugh M, Poulsen DJ, Black SM.

PLoS One. 2012;7(9):e40881. doi: 10.1371/journal.pone.0040881. Epub 2012 Sep 11.


Treatment with low-dose methamphetamine improves behavioral and cognitive function after severe traumatic brain injury.

Rau TF, Kothiwal AS, Rova AR, Brooks DM, Poulsen DJ.

J Trauma Acute Care Surg. 2012 Aug;73(2 Suppl 1):S165-72. doi: 10.1097/TA.0b013e318260896a.


Increased NADPH oxidase-derived superoxide is involved in the neuronal cell death induced by hypoxia-ischemia in neonatal hippocampal slice cultures.

Lu Q, Wainwright MS, Harris VA, Aggarwal S, Hou Y, Rau T, Poulsen DJ, Black SM.

Free Radic Biol Med. 2012 Sep 1;53(5):1139-51. doi: 10.1016/j.freeradbiomed.2012.06.012. Epub 2012 Jun 19.


Increased p38 mitogen-activated protein kinase signaling is involved in the oxidative stress associated with oxygen and glucose deprivation in neonatal hippocampal slice cultures.

Lu Q, Rau TF, Harris V, Johnson M, Poulsen DJ, Black SM.

Eur J Neurosci. 2011 Oct;34(7):1093-101. doi: 10.1111/j.1460-9568.2011.07786.x. Epub 2011 Sep 21.


Concurrent validity and reliability of clinical evaluation of the single leg squat.

Poulsen DR, James CR.

Physiother Theory Pract. 2011 Nov;27(8):586-94. doi: 10.3109/09593985.2011.552539. Epub 2011 Jul 31.


Low dose methamphetamine mediates neuroprotection through a PI3K-AKT pathway.

Rau TF, Kothiwal A, Zhang L, Ulatowski S, Jacobson S, Brooks DM, Cardozo-Pelaez F, Chopp M, Poulsen DJ.

Neuropharmacology. 2011 Sep;61(4):677-86. doi: 10.1016/j.neuropharm.2011.05.010. Epub 2011 May 27.


Adenosine kinase determines the degree of brain injury after ischemic stroke in mice.

Shen HY, Lusardi TA, Williams-Karnesky RL, Lan JQ, Poulsen DJ, Boison D.

J Cereb Blood Flow Metab. 2011 Jul;31(7):1648-59. doi: 10.1038/jcbfm.2011.30. Epub 2011 Mar 23.


Adenosine kinase as a target for therapeutic antisense strategies in epilepsy.

Theofilas P, Brar S, Stewart KA, Shen HY, Sandau US, Poulsen D, Boison D.

Epilepsia. 2011 Mar;52(3):589-601. doi: 10.1111/j.1528-1167.2010.02947.x. Epub 2011 Jan 28.


Functionalization, self-assembly, and photoswitching quenching for azobenzene derivatives adsorbed on Au(111).

Cho J, Berbil-Bautista L, Levy N, Poulsen D, Fréchet JM, Crommie MF.

J Chem Phys. 2010 Dec 21;133(23):234707. doi: 10.1063/1.3519557.


Quinacridone-based molecular donors for solution processed bulk-heterojunction organic solar cells.

Chen JJ, Chen TL, Kim B, Poulsen DA, Mynar JL, Fréchet JM, Ma B.

ACS Appl Mater Interfaces. 2010 Sep;2(9):2679-86. doi: 10.1021/am100523g.


Determination of photoswitching dynamics through chiral mapping of single molecules using a scanning tunneling microscope.

Comstock MJ, Strubbe DA, Berbil-Bautista L, Levy N, Cho J, Poulsen D, Fréchet JM, Louie SG, Crommie MF.

Phys Rev Lett. 2010 Apr 30;104(17):178301. Epub 2010 Apr 28.


Site isolation of emitters within cross-linked polymer nanoparticles for white electroluminescence.

Gao H, Poulsen DA, Ma B, Unruh DA, Zhao X, Millstone JE, Fréchet JM.

Nano Lett. 2010 Apr 14;10(4):1440-4. doi: 10.1021/nl100347p.


Site isolation in phosphorescent bichromophoric block copolymers designed for white electroluminescence.

Poulsen DA, Kim BJ, Ma B, Zonte CS, Fréchet JM.

Adv Mater. 2010 Jan 5;22(1):77-82. doi: 10.1002/adma.200901453. No abstract available.


Small-molecule-directed nanoparticle assembly towards stimuli-responsive nanocomposites.

Zhao Y, Thorkelsson K, Mastroianni AJ, Schilling T, Luther JM, Rancatore BJ, Matsunaga K, Jinnai H, Wu Y, Poulsen D, Fréchet JM, Alivisatos AP, Xu T.

Nat Mater. 2009 Dec;8(12):979-85. doi: 10.1038/nmat2565. Epub 2009 Oct 18.


Adenoviral and AAV-mediated gene transfer to the inner ear: role of serotype, promoter, and viral load on in vivo and in vitro infection efficiencies.

Luebke AE, Rova C, Von Doersten PG, Poulsen DJ.

Adv Otorhinolaryngol. 2009;66:87-98. doi: 10.1159/000218209. Epub 2009 Jun 2. Review.


Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1.

Yang Y, Gozen O, Watkins A, Lorenzini I, Lepore A, Gao Y, Vidensky S, Brennan J, Poulsen D, Won Park J, Li Jeon N, Robinson MB, Rothstein JD.

Neuron. 2009 Mar 26;61(6):880-94. doi: 10.1016/j.neuron.2009.02.010.


Self-patterned molecular photoswitching in nanoscale surface assemblies.

Levy N, Comstock MJ, Cho J, Berbil-Bautista L, Kirakosian A, Lauterwasser F, Poulsen DA, Fréchet JM, Crommie MF.

Nano Lett. 2009 Mar;9(3):935-9. doi: 10.1021/nl802632g.


Selective overexpression of excitatory amino acid transporter 2 (EAAT2) in astrocytes enhances neuroprotection from moderate but not severe hypoxia-ischemia.

Weller ML, Stone IM, Goss A, Rau T, Rova C, Poulsen DJ.

Neuroscience. 2008 Sep 9;155(4):1204-11. doi: 10.1016/j.neuroscience.2008.05.059. Epub 2008 Jun 17.

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