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Items: 13


Analysis of 7,815 cancer exomes reveals associations between mutational processes and somatic driver mutations.

Poulos RC, Wong YT, Ryan R, Pang H, Wong JWH.

PLoS Genet. 2018 Nov 9;14(11):e1007779. doi: 10.1371/journal.pgen.1007779. [Epub ahead of print]


Disruption of a -35 kb Enhancer Impairs CTCF Binding and MLH1 Expression in Colorectal Cells.

Liu Q, Thoms JAI, Nunez AC, Huang Y, Knezevic K, Packham D, Poulos RC, Williams R, Beck D, Hawkins NJ, Ward RL, Wong JWH, Hesson LB, Sloane MA, Pimanda JE.

Clin Cancer Res. 2018 Sep 15;24(18):4602-4611. doi: 10.1158/1078-0432.CCR-17-3678. Epub 2018 Jun 13.


Finding cancer driver mutations in the era of big data research.

Poulos RC, Wong JWH.

Biophys Rev. 2018 Apr 2. doi: 10.1007/s12551-018-0415-6. [Epub ahead of print] Review.


Proteogenomic analysis prioritises functional single nucleotide variants in cancer samples.

Ma S, Menon R, Poulos RC, Wong JWH.

Oncotarget. 2017 Sep 27;8(56):95841-95852. doi: 10.18632/oncotarget.21339. eCollection 2017 Nov 10.


The interaction between cytosine methylation and processes of DNA replication and repair shape the mutational landscape of cancer genomes.

Poulos RC, Olivier J, Wong JWH.

Nucleic Acids Res. 2017 Jul 27;45(13):7786-7795. doi: 10.1093/nar/gkx463.


The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription.

Wong M, Tee AEL, Milazzo G, Bell JL, Poulos RC, Atmadibrata B, Sun Y, Jing D, Ho N, Ling D, Liu PY, Zhang XD, Hüttelmaier S, Wong JWH, Wang J, Polly P, Perini G, Scarlett CJ, Liu T.

Cancer Res. 2017 May 1;77(9):2522-2533. doi: 10.1158/0008-5472.CAN-16-1663. Epub 2017 Feb 16.


Mutation hotspots in cis-regulatory regions in cancer.

Poulos RC, Wong JW.

Oncoscience. 2016 Nov 23;3(11-12):318-319. doi: 10.18632/oncoscience.325. eCollection 2016. No abstract available.


Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif.

Poulos RC, Thoms JAI, Guan YF, Unnikrishnan A, Pimanda JE, Wong JWH.

Cell Rep. 2016 Dec 13;17(11):2865-2872. doi: 10.1016/j.celrep.2016.11.055.


Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes.

Perera D, Poulos RC, Shah A, Beck D, Pimanda JE, Wong JW.

Nature. 2016 Apr 14;532(7598):259-63. doi: 10.1038/nature17437.


WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.

Sun Y, Bell JL, Carter D, Gherardi S, Poulos RC, Milazzo G, Wong JW, Al-Awar R, Tee AE, Liu PY, Liu B, Atmadibrata B, Wong M, Trahair T, Zhao Q, Shohet JM, Haupt Y, Schulte JH, Brown PJ, Arrowsmith CH, Vedadi M, MacKenzie KL, Hüttelmaier S, Perini G, Marshall GM, Braithwaite A, Liu T.

Cancer Res. 2015 Dec 1;75(23):5143-54. doi: 10.1158/0008-5472.CAN-15-0423. Epub 2015 Oct 15.


The search for cis-regulatory driver mutations in cancer genomes.

Poulos RC, Sloane MA, Hesson LB, Wong JW.

Oncotarget. 2015 Oct 20;6(32):32509-25. doi: 10.18632/oncotarget.5085. Review.


Systematic Screening of Promoter Regions Pinpoints Functional Cis-Regulatory Mutations in a Cutaneous Melanoma Genome.

Poulos RC, Thoms JA, Shah A, Beck D, Pimanda JE, Wong JW.

Mol Cancer Res. 2015 Aug;13(8):1218-26. doi: 10.1158/1541-7786.MCR-15-0146. Epub 2015 Jun 16.


OncoCis: annotation of cis-regulatory mutations in cancer.

Perera D, Chacon D, Thoms JA, Poulos RC, Shlien A, Beck D, Campbell PJ, Pimanda JE, Wong JW.

Genome Biol. 2014;15(10):485.

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