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Items: 9

1.

Tissue-Specific Oncogenic Activity of KRASA146T.

Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM.

Cancer Discov. 2019 Jun;9(6):738-755. doi: 10.1158/2159-8290.CD-18-1220. Epub 2019 Apr 5.

PMID:
30952657
2.

Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells.

Zhang Q, Jeppesen DK, Higginbotham JN, Demory Beckler M, Poulin EJ, Walsh AJ, Skala MC, McKinley ET, Manning HC, Hight MR, Schulte ML, Watt KR, Ayers GD, Wolf MM, Andrejeva G, Rathmell JC, Franklin JL, Coffey RJ.

Cell Mol Gastroenterol Hepatol. 2018 Jan 31;5(4):627-629.e6. doi: 10.1016/j.jcmgh.2018.01.013. eCollection 2018. No abstract available.

3.

The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile.

Lyons J, Ghazi PC, Starchenko A, Tovaglieri A, Baldwin KR, Poulin EJ, Gierut JJ, Genetti C, Yajnik V, Breault DT, Lauffenburger DA, Haigis KM.

PLoS Biol. 2018 Mar 29;16(3):e2002417. doi: 10.1371/journal.pbio.2002417. eCollection 2018 Mar.

4.

No back seat for a progression event-K-RAS as a therapeutic target in CRC.

Poulin EJ, Haigis KM.

Genes Dev. 2017 Feb 15;31(4):333-335. doi: 10.1101/gad.297630.117. Epub 2017 Mar 17. Review.

5.

Loss of Lrig1 leads to expansion of Brunner glands followed by duodenal adenomas with gastric metaplasia.

Wang Y, Shi C, Lu Y, Poulin EJ, Franklin JL, Coffey RJ.

Am J Pathol. 2015 Apr;185(4):1123-34. doi: 10.1016/j.ajpath.2014.12.014.

6.

Using a new Lrig1 reporter mouse to assess differences between two Lrig1 antibodies in the intestine.

Poulin EJ, Powell AE, Wang Y, Li Y, Franklin JL, Coffey RJ.

Stem Cell Res. 2014 Nov;13(3 Pt A):422-30. doi: 10.1016/j.scr.2014.09.002. Epub 2014 Sep 20.

7.

LRIG1 is a triple threat: ERBB negative regulator, intestinal stem cell marker and tumour suppressor.

Wang Y, Poulin EJ, Coffey RJ.

Br J Cancer. 2013 May 14;108(9):1765-70. doi: 10.1038/bjc.2013.138. Epub 2013 Apr 4. Review.

8.

Myofibroblast keratinocyte growth factor reduces tight junctional integrity and increases claudin-2 levels in polarized Caco-2 cells.

Kim TI, Poulin EJ, Blask E, Bukhalid R, Whitehead RH, Franklin JL, Coffey RJ.

Growth Factors. 2012 Oct;30(5):320-32. Epub 2012 Sep 5.

9.

The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor.

Powell AE, Wang Y, Li Y, Poulin EJ, Means AL, Washington MK, Higginbotham JN, Juchheim A, Prasad N, Levy SE, Guo Y, Shyr Y, Aronow BJ, Haigis KM, Franklin JL, Coffey RJ.

Cell. 2012 Mar 30;149(1):146-58. doi: 10.1016/j.cell.2012.02.042.

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