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Items: 23


Deletion of Adam6 in Mus musculus leads to male subfertility and deficits in sperm ascent into the oviduct.

Voronina VA, Harris FM, Schmahl J, Galligan C, Oristian D, Zamfirova R, Gong G, Bai Y, Fury W, Rajamani S, Walls JR, Poueymirou WT, Esau L, Gale NW, Auerbach W, Murphy AJ, Macdonald LE.

Biol Reprod. 2019 Mar 1;100(3):686-696. doi: 10.1093/biolre/ioy210.


Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs.

Lai KM, Gong G, Atanasio A, Rojas J, Quispe J, Posca J, White D, Huang M, Fedorova D, Grant C, Miloscio L, Droguett G, Poueymirou WT, Auerbach W, Yancopoulos GD, Frendewey D, Rinn J, Valenzuela DM.

PLoS One. 2015 Apr 24;10(4):e0125522. doi: 10.1371/journal.pone.0125522. eCollection 2015.


Generation of fertile and fecund F0 XY female mice from XY ES cells.

Kuno J, Poueymirou WT, Gong G, Siao CJ, Clarke G, Esau L, Kojak N, Posca J, Atanasio A, Strein J, Yancopoulos GD, Lai KM, DeChiara TM, Frendewey D, Auerbach W, Valenzuela DM.

Transgenic Res. 2015 Feb;24(1):19-29. doi: 10.1007/s11248-014-9815-y. Epub 2014 Aug 3.


Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes.

Macdonald LE, Karow M, Stevens S, Auerbach W, Poueymirou WT, Yasenchak J, Frendewey D, Valenzuela DM, Giallourakis CC, Alt FW, Yancopoulos GD, Murphy AJ.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5147-52. doi: 10.1073/pnas.1323896111. Epub 2014 Mar 25.


Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice.

Murphy AJ, Macdonald LE, Stevens S, Karow M, Dore AT, Pobursky K, Huang TT, Poueymirou WT, Esau L, Meola M, Mikulka W, Krueger P, Fairhurst J, Valenzuela DM, Papadopoulos N, Yancopoulos GD.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5153-8. doi: 10.1073/pnas.1324022111. Epub 2014 Mar 25.


Efficient differentiation and function of human macrophages in humanized CSF-1 mice.

Rathinam C, Poueymirou WT, Rojas J, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rongvaux A, Eynon EE, Manz MG, Flavell RA.

Blood. 2011 Sep 15;118(11):3119-28. doi: 10.1182/blood-2010-12-326926. Epub 2011 Jul 25.


Producing fully ES cell-derived mice from eight-cell stage embryo injections.

DeChiara TM, Poueymirou WT, Auerbach W, Frendewey D, Yancopoulos GD, Valenzuela DM.

Methods Enzymol. 2010;476:285-94. doi: 10.1016/S0076-6879(10)76016-X.


VelociMouse: fully ES cell-derived F0-generation mice obtained from the injection of ES cells into eight-cell-stage embryos.

Dechiara TM, Poueymirou WT, Auerbach W, Frendewey D, Yancopoulos GD, Valenzuela DM.

Methods Mol Biol. 2009;530:311-24. doi: 10.1007/978-1-59745-471-1_16.


F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses.

Poueymirou WT, Auerbach W, Frendewey D, Hickey JF, Escaravage JM, Esau L, Doré AT, Stevens S, Adams NC, Dominguez MG, Gale NW, Yancopoulos GD, DeChiara TM, Valenzuela DM.

Nat Biotechnol. 2007 Jan;25(1):91-9. Epub 2006 Dec 24.


Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5.

Macdonald LE, Wortley KE, Gowen LC, Anderson KD, Murray JD, Poueymirou WT, Simmons MV, Barber D, Valenzuela DM, Economides AN, Wiegand SJ, Yancopoulos GD, Sleeman MW, Murphy AJ.

Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2496-501. Epub 2005 Feb 7.


Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy.

Lai KM, Gonzalez M, Poueymirou WT, Kline WO, Na E, Zlotchenko E, Stitt TN, Economides AN, Yancopoulos GD, Glass DJ.

Mol Cell Biol. 2004 Nov;24(21):9295-304.


High-throughput engineering of the mouse genome coupled with high-resolution expression analysis.

Valenzuela DM, Murphy AJ, Frendewey D, Gale NW, Economides AN, Auerbach W, Poueymirou WT, Adams NC, Rojas J, Yasenchak J, Chernomorsky R, Boucher M, Elsasser AL, Esau L, Zheng J, Griffiths JA, Wang X, Su H, Xue Y, Dominguez MG, Noguera I, Torres R, Macdonald LE, Stewart AF, DeChiara TM, Yancopoulos GD.

Nat Biotechnol. 2003 Jun;21(6):652-9. Epub 2003 May 5.


Identification of ubiquitin ligases required for skeletal muscle atrophy.

Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, Pan ZQ, Valenzuela DM, DeChiara TM, Stitt TN, Yancopoulos GD, Glass DJ.

Science. 2001 Nov 23;294(5547):1704-8. Epub 2001 Oct 25.


Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development.

DeChiara TM, Kimble RB, Poueymirou WT, Rojas J, Masiakowski P, Valenzuela DM, Yancopoulos GD.

Nat Genet. 2000 Mar;24(3):271-4.


The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo.

DeChiara TM, Bowen DC, Valenzuela DM, Simmons MV, Poueymirou WT, Thomas S, Kinetz E, Compton DL, Rojas E, Park JS, Smith C, DiStefano PS, Glass DJ, Burden SJ, Yancopoulos GD.

Cell. 1996 May 17;85(4):501-12.


Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth.

DeChiara TM, Vejsada R, Poueymirou WT, Acheson A, Suri C, Conover JC, Friedman B, McClain J, Pan L, Stahl N, Ip NY, Yancopoulos GD.

Cell. 1995 Oct 20;83(2):313-22.


Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4.

Conover JC, Erickson JT, Katz DM, Bianchi LM, Poueymirou WT, McClain J, Pan L, Helgren M, Ip NY, Boland P, et al.

Nature. 1995 May 18;375(6528):235-8.


Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells.

Conover JC, Ip NY, Poueymirou WT, Bates B, Goldfarb MP, DeChiara TM, Yancopoulos GD.

Development. 1993 Nov;119(3):559-65.


Effects of protein kinase C activators on germinal vesicle breakdown and polar body emission of mouse oocytes.

Bornslaeger EA, Poueymirou WT, Mattei P, Schultz RM.

Exp Cell Res. 1986 Aug;165(2):507-17.


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