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Items: 1 to 50 of 244

1.

Linear and circular CDKN2B-AS1 expression is associated with Inflammatory Bowel Disease and participates in intestinal barrier formation.

Rankin CR, Lokhandwala ZA, Huang R, Pekow J, Pothoulakis C, Padua D.

Life Sci. 2019 Jun 14:116571. doi: 10.1016/j.lfs.2019.116571. [Epub ahead of print]

PMID:
31207308
2.

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR.

Rankin CR, Treger J, Faure-Kumar E, Benhammou J, Anisman-Posner D, Bollinger AE, Pothoulakis C, Padua DM.

J Vis Exp. 2019 Mar 1;(145). doi: 10.3791/59233.

PMID:
30882798
3.

Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis.

Huang J, Kelly CP, Bakirtzi K, Villafuerte Gálvez JA, Lyras D, Mileto SJ, Larcombe S, Xu H, Yang X, Shields KS, Zhu W, Zhang Y, Goldsmith JD, Patel IJ, Hansen J, Huang M, Yla-Herttuala S, Moss AC, Paredes-Sabja D, Pothoulakis C, Shah YM, Wang J, Chen X.

Nat Microbiol. 2019 Feb;4(2):269-279. doi: 10.1038/s41564-018-0300-x. Epub 2018 Dec 3.

PMID:
30510170
4.

Identification of novel mRNAs and lncRNAs associated with mouse experimental colitis and human inflammatory bowel disease.

Rankin CR, Theodorou E, Man Law IK, Rowe L, Kokkotou E, Pekow J, Wang J, Martín MG, Pothoulakis C, Padua D.

Am J Physiol Gastrointest Liver Physiol. 2018 Nov 1;315(5):G722-G733. doi: 10.1152/ajpgi.00077.2018. Epub 2018 Jun 28.

5.

Mesenteric Adipose-derived Stromal Cells From Crohn's Disease Patients Induce Protective Effects in Colonic Epithelial Cells and Mice With Colitis.

Hoffman JM, Sideri A, Ruiz JJ, Stavrakis D, Shih DQ, Turner JR, Pothoulakis C, Karagiannides I.

Cell Mol Gastroenterol Hepatol. 2018 Feb 8;6(1):1-16. doi: 10.1016/j.jcmgh.2018.02.001. eCollection 2018.

6.

Colonic Inhibition of Phosphatase and Tensin Homolog Increases Colitogenic Bacteria, Causing Development of Colitis in Il10-/- Mice.

Mitchell J, Kim SJ, Koukos G, Seelmann A, Veit B, Shepard B, Blumer-Schuette S, Winter HS, Iliopoulos D, Pothoulakis C, Im E, Rhee SH.

Inflamm Bowel Dis. 2018 Jul 12;24(8):1718-1732. doi: 10.1093/ibd/izy124.

PMID:
29788382
7.

Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation.

Videlock EJ, Mahurkar-Joshi S, Hoffman JM, Iliopoulos D, Pothoulakis C, Mayer EA, Chang L.

Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G140-G157. doi: 10.1152/ajpgi.00288.2017. Epub 2018 Mar 22.

PMID:
29565640
8.

MicroRNA-31-3p Is Involved in Substance P (SP)-Associated Inflammation in Human Colonic Epithelial Cells and Experimental Colitis.

Fang K, Law IKM, Padua D, Sideri A, Huang V, Kevil CG, Iliopoulos D, Pothoulakis C.

Am J Pathol. 2018 Mar;188(3):586-599. doi: 10.1016/j.ajpath.2017.10.023. Epub 2017 Dec 16.

9.

Functional role and therapeutic targeting of microRNAs in inflammatory bowel disease.

Soroosh A, Koutsioumpa M, Pothoulakis C, Iliopoulos D.

Am J Physiol Gastrointest Liver Physiol. 2018 Feb 1;314(2):G256-G262. doi: 10.1152/ajpgi.00268.2017. Epub 2017 Nov 16. Review.

10.

Fidaxomicin and OP-1118 Inhibit Clostridium difficile Toxin A- and B-Mediated Inflammatory Responses via Inhibition of NF-κB Activity.

Koon HW, Wang J, Mussatto CC, Ortiz C, Lee EC, Tran DH, Chen X, Kelly CP, Pothoulakis C.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01513-17. doi: 10.1128/AAC.01513-17. Print 2018 Jan.

11.

CRHR2/Ucn2 signaling is a novel regulator of miR-7/YY1/Fas circuitry contributing to reversal of colorectal cancer cell resistance to Fas-mediated apoptosis.

Pothoulakis C, Torre-Rojas M, Duran-Padilla MA, Gevorkian J, Zoras O, Chrysos E, Chalkiadakis G, Baritaki S.

Int J Cancer. 2018 Jan 15;142(2):334-346. doi: 10.1002/ijc.31064. Epub 2017 Oct 12.

12.

Analysis of endogenous lipids during intestinal wound healing.

Lee Y, Choo J, Kim SJ, Heo G, Pothoulakis C, Kim YH, Im E.

PLoS One. 2017 Aug 11;12(8):e0183028. doi: 10.1371/journal.pone.0183028. eCollection 2017.

13.

Role of G protein-coupled receptors-microRNA interactions in gastrointestinal pathophysiology.

Law IKM, Padua DM, Iliopoulos D, Pothoulakis C.

Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G361-G372. doi: 10.1152/ajpgi.00144.2017. Epub 2017 Aug 3. Review.

14.

Endocannabinoids in the gastrointestinal tract.

Lee Y, Jo J, Chung HY, Pothoulakis C, Im E.

Am J Physiol Gastrointest Liver Physiol. 2016 Oct 1;311(4):G655-G666. doi: 10.1152/ajpgi.00294.2015. Epub 2016 Aug 18. Review.

15.

Probiotic Saccharomyces boulardii CNCM I-745 prevents outbreak-associated Clostridium difficile-associated cecal inflammation in hamsters.

Koon HW, Su B, Xu C, Mussatto CC, Tran DH, Lee EC, Ortiz C, Wang J, Lee JE, Ho S, Chen X, Kelly CP, Pothoulakis C.

Am J Physiol Gastrointest Liver Physiol. 2016 Oct 1;311(4):G610-G623. doi: 10.1152/ajpgi.00150.2016. Epub 2016 Aug 11.

16.

A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation.

Padua D, Mahurkar-Joshi S, Law IK, Polytarchou C, Vu JP, Pisegna JR, Shih D, Iliopoulos D, Pothoulakis C.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G446-57. doi: 10.1152/ajpgi.00212.2016. Epub 2016 Aug 4.

17.

Neuropeptide substance P and the immune response.

Mashaghi A, Marmalidou A, Tehrani M, Grace PM, Pothoulakis C, Dana R.

Cell Mol Life Sci. 2016 Nov;73(22):4249-4264. doi: 10.1007/s00018-016-2293-z. Epub 2016 Jun 17. Review.

18.

Neurotensin Promotes the Development of Colitis and Intestinal Angiogenesis via Hif-1α-miR-210 Signaling.

Bakirtzi K, Law IK, Xue X, Iliopoulos D, Shah YM, Pothoulakis C.

J Immunol. 2016 May 15;196(10):4311-21. doi: 10.4049/jimmunol.1501443. Epub 2016 Apr 13.

19.

Identification of a novel interaction between corticotropin releasing hormone (Crh) and macroautophagy.

Giannogonas P, Apostolou A, Manousopoulou A, Theocharis S, Macari SA, Psarras S, Garbis SD, Pothoulakis C, Karalis KP.

Sci Rep. 2016 Mar 18;6:23342. doi: 10.1038/srep23342.

20.

Neurotensin-induced miR-133α expression regulates neurotensin receptor 1 recycling through its downstream target aftiphilin.

Law IK, Jensen D, Bunnett NW, Pothoulakis C.

Sci Rep. 2016 Feb 23;6:22195. doi: 10.1038/srep22195.

21.

Urocortins and CRF receptor type 2 variants in the male rat colon: gene expression and regulation by endotoxin and anti-inflammatory effect.

Yuan PQ, Wu SV, Pothoulakis C, Taché Y.

Am J Physiol Gastrointest Liver Physiol. 2016 Mar 15;310(6):G387-98. doi: 10.1152/ajpgi.00337.2015. Epub 2016 Jan 7.

22.

Genome-wide DNA methylation profiling of peripheral blood mononuclear cells in irritable bowel syndrome.

Mahurkar S, Polytarchou C, Iliopoulos D, Pothoulakis C, Mayer EA, Chang L.

Neurogastroenterol Motil. 2016 Mar;28(3):410-22. doi: 10.1111/nmo.12741. Epub 2015 Dec 16.

23.

The Insect Peptide CopA3 Increases Colonic Epithelial Cell Proliferation and Mucosal Barrier Function to Prevent Inflammatory Responses in the Gut.

Kim DH, Hwang JS, Lee IH, Nam ST, Hong J, Zhang P, Lu LF, Lee J, Seok H, Pothoulakis C, Lamont JT, Kim H.

J Biol Chem. 2016 Feb 12;291(7):3209-23. doi: 10.1074/jbc.M115.682856. Epub 2015 Dec 11.

24.

Identification of a novel substance P (SP)-neurokinin-1 receptor (NK-1R) microRNA-221-5p inflammatory network in human colonic epithelial cells.

Fang K, Sideri A, Law IK, Bakirtzi K, Polytarchou C, Iliopoulos D, Pothoulakis C.

Cell Mol Gastroenterol Hepatol. 2015 Sep 1;1(5):503-515.

25.

Novel approaches to treating Clostridium difficile-associated colitis.

Padua D, Pothoulakis C.

Expert Rev Gastroenterol Hepatol. 2016;10(2):193-204. doi: 10.1586/17474124.2016.1109444. Epub 2015 Dec 7. Review.

26.

Corticotropin-Releasing Hormone Receptor 2 Signaling Promotes Mucosal Repair Responses after Colitis.

Hoffman JM, Baritaki S, Ruiz JJ, Sideri A, Pothoulakis C.

Am J Pathol. 2016 Jan;186(1):134-44. doi: 10.1016/j.ajpath.2015.09.013. Epub 2015 Nov 18.

27.

Substance P mediates pro-inflammatory cytokine release form mesenteric adipocytes in Inflammatory Bowel Disease patients.

Sideri A, Bakirtzi K, Shih DQ, Koon HW, Fleshner P, Arsenescu R, Arsenescu V, Turner JR, Karagiannides I, Pothoulakis C.

Cell Mol Gastroenterol Hepatol. 2015 Jul 1;1(4):420-432.

28.

Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling.

Rodriguez JA, Huerta-Yepez S, Law IK, Baay-Guzman GJ, Tirado-Rodriguez B, Hoffman JM, Iliopoulos D, Hommes DW, Verspaget HW, Chang L, Pothoulakis C, Baritaki S.

Cell Mol Gastroenterol Hepatol. 2015 Nov 1;1(6):610-630.

29.

Corticotropin Releasing Hormone and Urocortin 3 Stimulate Vascular Endothelial Growth Factor Expression through the cAMP/CREB Pathway.

Rhee SH, Ma EL, Lee Y, Taché Y, Pothoulakis C, Im E.

J Biol Chem. 2015 Oct 23;290(43):26194-203. doi: 10.1074/jbc.M115.678979. Epub 2015 Sep 8.

30.

A Novel Peroxisome Proliferator-activated Receptor (PPAR)γ Agonist 2-Hydroxyethyl 5-chloro-4,5-didehydrojasmonate Exerts Anti-Inflammatory Effects in Colitis.

Choo J, Lee Y, Yan XJ, Noh TH, Kim SJ, Son S, Pothoulakis C, Moon HR, Jung JH, Im E.

J Biol Chem. 2015 Oct 16;290(42):25609-19. doi: 10.1074/jbc.M115.673046. Epub 2015 Sep 4.

31.

Identification of Spinal Cord MicroRNA and Gene Signatures in a Model of Chronic Stress-Induced Visceral Hyperalgesia in Rat.

Bradesi S, Karagiannides I, Bakirtzi K, Joshi SM, Koukos G, Iliopoulos D, Pothoulakis C, Mayer EA.

PLoS One. 2015 Jul 29;10(7):e0130938. doi: 10.1371/journal.pone.0130938. eCollection 2015.

32.

MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice.

Polytarchou C, Hommes DW, Palumbo T, Hatziapostolou M, Koutsioumpa M, Koukos G, van der Meulen-de Jong AE, Oikonomopoulos A, van Deen WK, Vorvis C, Serebrennikova OB, Birli E, Choi J, Chang L, Anton PA, Tsichlis PN, Pothoulakis C, Verspaget HW, Iliopoulos D.

Gastroenterology. 2015 Oct;149(4):981-92.e11. doi: 10.1053/j.gastro.2015.05.057. Epub 2015 Jun 6.

34.

A microRNA signature in pediatric ulcerative colitis: deregulation of the miR-4284/CXCL5 pathway in the intestinal epithelium.

Koukos G, Polytarchou C, Kaplan JL, Oikonomopoulos A, Ziring D, Hommes DW, Wahed R, Kokkotou E, Pothoulakis C, Winter HS, Iliopoulos D.

Inflamm Bowel Dis. 2015 May;21(5):996-1005. doi: 10.1097/MIB.0000000000000339.

35.

Anti-fibrogenic effects of the anti-microbial peptide cathelicidin in murine colitis-associated fibrosis.

Yoo JH, Ho S, Tran DH, Cheng M, Bakirtzi K, Kukota Y, Ichikawa R, Su B, Tran DH, Hing TC, Chang I, Shih DQ, Issacson RE, Gallo RL, Fiocchi C, Pothoulakis C, Koon HW.

Cell Mol Gastroenterol Hepatol. 2015 Jan;1(1):55-74.e1.

36.

Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFNγ/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis.

Vilisaar J, Kawabe K, Braitch M, Aram J, Furtun Y, Fahey AJ, Chopra M, Tanasescu R, Tighe PJ, Gran B, Pothoulakis C, Constantinescu CS.

J Neuroimmune Pharmacol. 2015 Sep;10(3):457-67. doi: 10.1007/s11481-015-9589-x. Epub 2015 Feb 18.

37.

Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1.

Sideri A, Stavrakis D, Bowe C, Shih DQ, Fleshner P, Arsenescu V, Arsenescu R, Turner JR, Pothoulakis C, Karagiannides I.

Am J Physiol Gastrointest Liver Physiol. 2015 Apr 1;308(7):G591-604. doi: 10.1152/ajpgi.00269.2014. Epub 2015 Jan 15.

38.

The neurotensin-HIF-1α-VEGFα axis orchestrates hypoxia, colonic inflammation, and intestinal angiogenesis.

Bakirtzi K, West G, Fiocchi C, Law IK, Iliopoulos D, Pothoulakis C.

Am J Pathol. 2014 Dec;184(12):3405-14. doi: 10.1016/j.ajpath.2014.08.015. Epub 2014 Oct 7.

39.

Neurotensin--regulated miR-133α is involved in proinflammatory signalling in human colonic epithelial cells and in experimental colitis.

Law IK, Bakirtzi K, Polytarchou C, Oikonomopoulos A, Hommes D, Iliopoulos D, Pothoulakis C.

Gut. 2015 Jul;64(7):1095-104. doi: 10.1136/gutjnl-2014-307329. Epub 2014 Aug 11.

40.

Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals.

Jensen DD, Halls ML, Murphy JE, Canals M, Cattaruzza F, Poole DP, Lieu T, Koon HW, Pothoulakis C, Bunnett NW.

J Biol Chem. 2014 Jul 18;289(29):20283-94. doi: 10.1074/jbc.M114.578179. Epub 2014 Jun 4.

41.

Fidaxomicin inhibits Clostridium difficile toxin A-mediated enteritis in the mouse ileum.

Koon HW, Ho S, Hing TC, Cheng M, Chen X, Ichikawa Y, Kelly CP, Pothoulakis C.

Antimicrob Agents Chemother. 2014 Aug;58(8):4642-50. doi: 10.1128/AAC.02783-14. Epub 2014 Jun 2.

42.

Disruption of Pten speeds onset and increases severity of spontaneous colitis in Il10(-/-) mice.

Im E, Jung J, Pothoulakis C, Rhee SH.

Gastroenterology. 2014 Sep;147(3):667-679.e10. doi: 10.1053/j.gastro.2014.05.034. Epub 2014 May 29.

43.

Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis.

Shih DQ, Zheng L, Zhang X, Zhang H, Kanazawa Y, Ichikawa R, Wallace KL, Chen J, Pothoulakis C, Koon HW, Targan SR.

Mucosal Immunol. 2014 Nov;7(6):1492-503. doi: 10.1038/mi.2014.37. Epub 2014 May 21.

44.

Chronic unpredictable stress regulates visceral adipocyte-mediated glucose metabolism and inflammatory circuits in male rats.

Karagiannides I, Golovatscka V, Bakirtzi K, Sideri A, Salas M, Stavrakis D, Polytarchou C, Iliopoulos D, Pothoulakis C, Bradesi S.

Physiol Rep. 2014 May 12;2(5):e00284. doi: 10.14814/phy2.284. Print 2014.

45.

Inhibition of vasoactive intestinal polypeptide (VIP) induces resistance to dextran sodium sulfate (DSS)-induced colitis in mice.

Vu JP, Million M, Larauche M, Luong L, Norris J, Waschek JA, Pothoulakis C, Pisegna JR, Germano PM.

J Mol Neurosci. 2014 Jan;52(1):37-47. doi: 10.1007/s12031-013-0205-3. Epub 2014 Jan 7.

46.

Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.

Steinhoff MS, von Mentzer B, Geppetti P, Pothoulakis C, Bunnett NW.

Physiol Rev. 2014 Jan;94(1):265-301. doi: 10.1152/physrev.00031.2013. Review.

47.

Erratum: Sustained TL1A (TNFSF15) expression on both lymphoid and myeloid cells leads to mild spontaneous intestinal inflammation and fibrosis (DOI: 10.1556/EuJMI.3.2013.1.2).

Zheng L, Zhang X, Chen J, Ichikawa R, Wallace K, Pothoulakis C, Koon HW, Targan SR, Shih DQ.

Eur J Microbiol Immunol (Bp). 2013 Jun;3(2):141. doi: 10.1556/EuJMI.3.2013.2.8. Epub 2013 Jun 5. No abstract available.

48.

Silence Please!: siRNA approaches to tighten the intestinal barrier in vivo.

Bakirtzi K, Hoffman JM, Pothoulakis C.

Am J Pathol. 2013 Dec;183(6):1700-1702. doi: 10.1016/j.ajpath.2013.10.001. Epub 2013 Oct 30. No abstract available.

49.

Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes.

Grasberger H, Chang L, Shih W, Presson AP, Sayuk GS, Newberry RD, Karagiannides I, Pothoulakis C, Mayer E, Merchant JL.

Am J Gastroenterol. 2013 Nov;108(11):1766-74. doi: 10.1038/ajg.2013.304. Epub 2013 Sep 24.

50.

MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis.

Koukos G, Polytarchou C, Kaplan JL, Morley-Fletcher A, Gras-Miralles B, Kokkotou E, Baril-Dore M, Pothoulakis C, Winter HS, Iliopoulos D.

Gastroenterology. 2013 Oct;145(4):842-52.e2. doi: 10.1053/j.gastro.2013.07.001. Epub 2013 Jul 12.

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