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Items: 1 to 50 of 416

1.

Gingipains impair attachment of epithelial cell to dental titanium abutment surfaces.

Eick S, Gadzo N, Tacchi M, Sculean A, Potempa J, Stavropoulos A.

J Biomed Mater Res B Appl Biomater. 2019 Feb 14. doi: 10.1002/jbm.b.34345. [Epub ahead of print]

PMID:
30763463
2.

Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.

Dominy SS, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A, Nguyen M, Haditsch U, Raha D, Griffin C, Holsinger LJ, Arastu-Kapur S, Kaba S, Lee A, Ryder MI, Potempa B, Mydel P, Hellvard A, Adamowicz K, Hasturk H, Walker GD, Reynolds EC, Faull RLM, Curtis MA, Dragunow M, Potempa J.

Sci Adv. 2019 Jan 23;5(1):eaau3333. doi: 10.1126/sciadv.aau3333. eCollection 2019 Jan.

3.

Complement Activation as a Helping Hand for Inflammophilic Pathogens and Cancer.

Okrój M, Potempa J.

Front Immunol. 2019 Jan 10;9:3125. doi: 10.3389/fimmu.2018.03125. eCollection 2018. Review.

4.

Structure, function, and inhibition of a genomic/clinical variant of Porphyromonas gingivalis peptidylarginine deiminase.

Bereta G, Goulas T, Madej M, Bielecka E, Solà M, Potempa J, Xavier Gomis-Rüth F.

Protein Sci. 2019 Mar;28(3):478-486. doi: 10.1002/pro.3571. Epub 2019 Jan 30.

PMID:
30638292
5.

Conjugate of Enkephalin and Temporin Peptides as a Novel Therapeutic Agent for Sepsis.

Golda A, Kosikowska-Adamus P, Babyak O, Lech M, Wysocka M, Lesner A, Potempa J, Koziel J.

Bioconjug Chem. 2018 Dec 10. doi: 10.1021/acs.bioconjchem.8b00763. [Epub ahead of print]

PMID:
30525485
6.

Effects of statins on multispecies oral biofilm identify simvastatin as a drug candidate targeting Porphyromonas gingivalis.

Kamińska M, Aliko A, Hellvard A, Bielecka E, Binder V, Marczyk A, Potempa J, Delaleu N, Kantyka T, Mydel P.

J Periodontol. 2018 Dec 2. doi: 10.1002/JPER.18-0179. [Epub ahead of print]

PMID:
30506795
7.

Expression of human and Porphyromonas gingivalis glutaminyl cyclases in periodontitis and rheumatoid arthritis-A pilot study.

Bender P, Egger A, Westermann M, Taudte N, Sculean A, Potempa J, Möller B, Buchholz M, Eick S.

Arch Oral Biol. 2019 Jan;97:223-230. doi: 10.1016/j.archoralbio.2018.10.022. Epub 2018 Oct 28.

PMID:
30399509
8.

Impact of Porphyromonas gingivalis Peptidylarginine Deiminase on Bacterial Biofilm Formation, Epithelial Cell Invasion, and Epithelial Cell Transcriptional Landscape.

Aliko A, Kamińska M, Bergum B, Gawron K, Benedyk M, Lamont RJ, Malicki S, Delaleu N, Potempa J, Mydel P.

Sci Rep. 2018 Sep 20;8(1):14144. doi: 10.1038/s41598-018-32603-y.

9.

Fibroblasts from recurrent fibrotic overgrowths reveal high rate of proliferation in vitro - findings from the study of hereditary and idiopathic gingival fibromatosis.

Gawron K, Łazarz-Bartyzel K, Kowalska A, Bereta G, Nowakowska Z, Plakwicz P, Potempa J, Fertala A, Chomyszyn-Gajewska M.

Connect Tissue Res. 2019 Jan;60(1):29-39. doi: 10.1080/03008207.2018.1517758. Epub 2018 Sep 20.

PMID:
30231645
10.

Periodontal Pathogens and Associated Intrathecal Antibodies in Early Stages of Alzheimer's Disease.

Laugisch O, Johnen A, Maldonado A, Ehmke B, Bürgin W, Olsen I, Potempa J, Sculean A, Duning T, Eick S.

J Alzheimers Dis. 2018;66(1):105-114. doi: 10.3233/JAD-180620.

PMID:
30223397
11.

Aristolochic acid I determine the phenotype and activation of macrophages in acute and chronic kidney disease.

Honarpisheh M, Foresto-Neto O, Steiger S, Kraft F, Koehler P, von Rauchhaupt E, Potempa J, Adamowicz K, Koziel J, Lech M.

Sci Rep. 2018 Aug 15;8(1):12169. doi: 10.1038/s41598-018-30628-x.

12.

TIMP-1 association with collagen type I overproduction in hereditary gingival fibromatosis.

Gawron K, Ochała-Kłos A, Nowakowska Z, Bereta G, Łazarz-Bartyzel K, Grabiec AM, Plakwicz P, Górska R, Fertala A, Chomyszyn-Gajewska M, Potempa J.

Oral Dis. 2018 Nov;24(8):1581-1590. doi: 10.1111/odi.12938. Epub 2018 Aug 14.

PMID:
29989318
13.

Citrullination as a plausible link to periodontitis, rheumatoid arthritis, atherosclerosis and Alzheimer's disease.

Olsen I, Singhrao SK, Potempa J.

J Oral Microbiol. 2018 Jun 22;10(1):1487742. doi: 10.1080/20002297.2018.1487742. eCollection 2018. Review.

14.

Host cell-surface proteins as substrates of gingipains, the main proteases of Porphyromonas gingivalis.

Hočevar K, Potempa J, Turk B.

Biol Chem. 2018 Nov 27;399(12):1353-1361. doi: 10.1515/hsz-2018-0215.

PMID:
29927743
15.

Porphyromonas gingivalis Peptidyl Arginine Deiminase Can Modulate Neutrophil Activity via Infection of Human Dental Stem Cells.

Kriebel K, Hieke C, Engelmann R, Potempa J, Müller-Hilke B, Lang H, Kreikemeyer B.

J Innate Immun. 2018;10(4):264-278. doi: 10.1159/000489020. Epub 2018 Jun 1.

16.

Structural basis for ADP-dependent glucokinase inhibition by 8-bromo-substituted adenosine nucleotide.

Grudnik P, Kamiński MM, Rembacz KP, Kuśka K, Madej M, Potempa J, Dawidowski M, Dubin G.

J Biol Chem. 2018 Jul 13;293(28):11088-11099. doi: 10.1074/jbc.RA117.001562. Epub 2018 May 21.

PMID:
29784881
17.

The activity of bacterial peptidylarginine deiminase is important during formation of dual-species biofilm by periodontal pathogen Porphyromonas gingivalis and opportunistic fungus Candida albicans.

Karkowska-Kuleta J, Bartnicka D, Zawrotniak M, Zielinska G, Kieronska A, Bochenska O, Ciaston I, Koziel J, Potempa J, Baster Z, Rajfur Z, Rapala-Kozik M.

Pathog Dis. 2018 Jun 1;76(4). doi: 10.1093/femspd/fty033.

PMID:
29668945
18.

The Bacteroidetes Q-Rule: Pyroglutamate in Signal Peptidase I Substrates.

Bochtler M, Mizgalska D, Veillard F, Nowak ML, Houston J, Veith P, Reynolds EC, Potempa J.

Front Microbiol. 2018 Mar 1;9:230. doi: 10.3389/fmicb.2018.00230. eCollection 2018.

19.

Unique Substrate Specificity of SplE Serine Protease from Staphylococcus aureus.

Stach N, Kalinska M, Zdzalik M, Kitel R, Karim A, Serwin K, Rut W, Larsen K, Jabaiah A, Firlej M, Wladyka B, Daugherty P, Stennicke H, Drag M, Potempa J, Dubin G.

Structure. 2018 Apr 3;26(4):572-579.e4. doi: 10.1016/j.str.2018.02.008. Epub 2018 Mar 8.

PMID:
29526434
20.

In vivo expression of proteases and protease inhibitor, a serpin, by periodontal pathogens at teeth and implants.

Eckert M, Mizgalska D, Sculean A, Potempa J, Stavropoulos A, Eick S.

Mol Oral Microbiol. 2018 Jun;33(3):240-248. doi: 10.1111/omi.12220. Epub 2018 Apr 17.

PMID:
29498485
21.

A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.

Wong A, Bryzek D, Dobosz E, Scavenius C, Svoboda P, Rapala-Kozik M, Lesner A, Frydrych I, Enghild J, Mydel P, Pohl J, Thompson PR, Potempa J, Koziel J.

J Immunol. 2018 Apr 1;200(7):2327-2340. doi: 10.4049/jimmunol.1701391. Epub 2018 Feb 23.

PMID:
29475987
22.

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.

Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C.

Cell Rep. 2017 Nov 21;21(8):2090-2103. doi: 10.1016/j.celrep.2017.10.087.

23.

Association of Distinct Fine Specificities of Anti-Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotella intermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis.

Schwenzer A, Quirke AM, Marzeda AM, Wong A, Montgomery AB, Sayles HR, Eick S, Gawron K, Chomyszyn-Gajewska M, Łazarz-Bartyzel K, Davis S, Potempa J, Kessler BM, Fischer R, Venables PJ, Payne JB, Mikuls TR, Midwood KS.

Arthritis Rheumatol. 2017 Dec;69(12):2303-2313. doi: 10.1002/art.40227. Epub 2017 Oct 30.

24.

Epigenetic regulation in bacterial infections: targeting histone deacetylases.

Grabiec AM, Potempa J.

Crit Rev Microbiol. 2018 May;44(3):336-350. doi: 10.1080/1040841X.2017.1373063. Epub 2017 Oct 3. Review.

PMID:
28971711
25.

Genes Contributing to Porphyromonas gingivalis Fitness in Abscess and Epithelial Cell Colonization Environments.

Miller DP, Hutcherson JA, Wang Y, Nowakowska ZM, Potempa J, Yoder-Himes DR, Scott DA, Whiteley M, Lamont RJ.

Front Cell Infect Microbiol. 2017 Aug 28;7:378. doi: 10.3389/fcimb.2017.00378. eCollection 2017.

26.

The case for periodontitis in the pathogenesis of rheumatoid arthritis.

Potempa J, Mydel P, Koziel J.

Nat Rev Rheumatol. 2017 Oct;13(10):606-620. doi: 10.1038/nrrheum.2017.132. Epub 2017 Aug 24. Review.

PMID:
28835673
27.

Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis.

Sonesson A, Przybyszewska K, Eriksson S, Mörgelin M, Kjellström S, Davies J, Potempa J, Schmidtchen A.

Sci Rep. 2017 Aug 18;7(1):8689. doi: 10.1038/s41598-017-08046-2.

28.

Proteolytic effects of gingipains on trefoil factor family peptides.

Chaiyarit P, Jaresitthikunchai J, Phaonakrop N, Roytrakul S, Potempa B, Potempa J.

Clin Oral Investig. 2018 Mar;22(2):1009-1018. doi: 10.1007/s00784-017-2181-4. Epub 2017 Jul 19.

PMID:
28726036
29.

Immunomodulatory Molecule IRAK-M Balances Macrophage Polarization and Determines Macrophage Responses during Renal Fibrosis.

Steiger S, Kumar SV, Honarpisheh M, Lorenz G, Günthner R, Romoli S, Gröbmayr R, Susanti HE, Potempa J, Koziel J, Lech M.

J Immunol. 2017 Aug 15;199(4):1440-1452. doi: 10.4049/jimmunol.1601982. Epub 2017 Jul 12.

30.

The Type IX Secretion System (T9SS): Highlights and Recent Insights into Its Structure and Function.

Lasica AM, Ksiazek M, Madej M, Potempa J.

Front Cell Infect Microbiol. 2017 May 26;7:215. doi: 10.3389/fcimb.2017.00215. eCollection 2017. Review.

31.

Manipulation of Neutrophils by Porphyromonas gingivalis in the Development of Periodontitis.

Sochalska M, Potempa J.

Front Cell Infect Microbiol. 2017 May 23;7:197. doi: 10.3389/fcimb.2017.00197. eCollection 2017. Review.

32.

A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.

Goulas T, Ksiazek M, Garcia-Ferrer I, Sochaj-Gregorczyk AM, Waligorska I, Wasylewski M, Potempa J, Gomis-Rüth FX.

J Biol Chem. 2017 Jun 30;292(26):10883-10898. doi: 10.1074/jbc.M117.786533. Epub 2017 May 16.

33.

Inactive Gingipains from P. gingivalis Selectively Skews T Cells toward a Th17 Phenotype in an IL-6 Dependent Manner.

Glowczyk I, Wong A, Potempa B, Babyak O, Lech M, Lamont RJ, Potempa J, Koziel J.

Front Cell Infect Microbiol. 2017 Apr 27;7:140. doi: 10.3389/fcimb.2017.00140. eCollection 2017.

34.

Analysis of mutations in the SOS-1 gene in two Polish families with hereditary gingival fibromatosis.

Gawron K, Bereta G, Nowakowska Z, Łazarz-Bartyzel K, Potempa J, Chomyszyn-Gajewska M, Górska R, Plakwicz P.

Oral Dis. 2017 Oct;23(7):983-989. doi: 10.1111/odi.12684. Epub 2017 May 22.

35.

Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease.

Godlewska U, Brzoza P, Sroka A, Majewski P, Jentsch H, Eckert M, Eick S, Potempa J, Zabel BA, Cichy J.

Front Immunol. 2017 Mar 29;8:353. doi: 10.3389/fimmu.2017.00353. eCollection 2017.

36.

Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome.

Pomowski A, Usón I, Nowakowska Z, Veillard F, Sztukowska MN, Guevara T, Goulas T, Mizgalska D, Nowak M, Potempa B, Huntington JA, Potempa J, Gomis-Rüth FX.

J Biol Chem. 2017 Apr 7;292(14):5724-5735. doi: 10.1074/jbc.M117.776724. Epub 2017 Feb 14.

37.

Relationship between past myocardial infarction, periodontal disease and Porphyromonas gingivalis serum antibodies: A case-control study.

Łysek RP, Szafraniec K, Polak M, Jankowski P, Micek A, Wolfshaut-Wolak R, Czarnecka D, Potempa J, Pająk A.

Cardiol J. 2018;25(3):386-392. doi: 10.5603/CJ.a2017.0015. Epub 2017 Feb 2.

38.

Mirolysin, a LysargiNase from Tannerella forsythia, proteolytically inactivates the human cathelicidin, LL-37.

Koneru L, Ksiazek M, Waligorska I, Straczek A, Lukasik M, Madej M, Thøgersen IB, Enghild JJ, Potempa J.

Biol Chem. 2016 Dec 20. pii: /j/bchm.ahead-of-print/hsz-2016-0267/hsz-2016-0267.xml. doi: 10.1515/hsz-2016-0267. [Epub ahead of print]

39.

Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.

Lasica AM, Goulas T, Mizgalska D, Zhou X, de Diego I, Ksiazek M, Madej M, Guo Y, Guevara T, Nowak M, Potempa B, Goel A, Sztukowska M, Prabhakar AT, Bzowska M, Widziolek M, Thøgersen IB, Enghild JJ, Simonian M, Kulczyk AW, Nguyen KA, Potempa J, Gomis-Rüth FX.

Sci Rep. 2016 Nov 24;6:37708. doi: 10.1038/srep37708.

40.

Erratum to: Concentration of antibodies against Porphyromonas gingivalisis increased before the onset of symptoms of rheumatoid arthritis.

Johansson L, Sherina N, Kharlamova N, Potempa B, Larsson B, Israelsson L, Potempa J, Rantapää-Dahlqvist S, Lundberg K.

Arthritis Res Ther. 2016 Nov 4;18(1):257. No abstract available.

41.

Structure of RagB, a major immunodominant outer-membrane surface receptor antigen of Porphyromonas gingivalis.

Goulas T, Garcia-Ferrer I, Hutcherson JA, Potempa BA, Potempa J, Scott DA, Xavier Gomis-Rüth F.

Mol Oral Microbiol. 2016 Dec;31(6):472-485. doi: 10.1111/omi.12140. Epub 2015 Nov 16.

42.

MCPIP-1, Alias Regnase-1, Controls Epithelial Inflammation by Posttranscriptional Regulation of IL-8 Production.

Dobosz E, Wilamowski M, Lech M, Bugara B, Jura J, Potempa J, Koziel J.

J Innate Immun. 2016;8(6):564-578. Epub 2016 Aug 12.

43.

Zebrafish as a new model to study effects of periodontal pathogens on cardiovascular diseases.

Widziolek M, Prajsnar TK, Tazzyman S, Stafford GP, Potempa J, Murdoch C.

Sci Rep. 2016 Oct 25;6:36023. doi: 10.1038/srep36023.

44.

A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction.

Surmiak E, Twarda-Clapa A, Zak KM, Musielak B, Tomala MD, Kubica K, Grudnik P, Madej M, Jablonski M, Potempa J, Kalinowska-Tluscik J, Dömling A, Dubin G, Holak TA.

ACS Chem Biol. 2016 Dec 16;11(12):3310-3318. Epub 2016 Oct 17.

PMID:
27709883
45.

FACIN, a Double-Edged Sword of the Emerging Periodontal Pathogen Filifactor alocis: A Metabolic Enzyme Moonlighting as a Complement Inhibitor.

Jusko M, Miedziak B, Ermert D, Magda M, King BC, Bielecka E, Riesbeck K, Eick S, Potempa J, Blom AM.

J Immunol. 2016 Oct 15;197(8):3245-3259. Epub 2016 Sep 16.

46.

Gingival Fibromatosis with Significant De Novo Formation of Fibrotic Tissue and a High Rate of Recurrence.

Gawron K, Łazarz-Bartyzel K, Fertala A, Plakwicz P, Potempa J, Chomyszyn-Gajewska M.

Version 2. Am J Case Rep. 2016 Sep 9 [revised 2016 Jan 1];17:655-9. doi: 10.12659/AJCR.899997.

47.

Concentration of antibodies against Porphyromonas gingivalis is increased before the onset of symptoms of rheumatoid arthritis.

Johansson L, Sherina N, Kharlamova N, Potempa B, Larsson B, Israelsson L, Potempa J, Rantapää-Dahlqvist S, Lundberg K.

Arthritis Res Ther. 2016 Sep 7;18:201. doi: 10.1186/s13075-016-1100-4. Erratum in: Arthritis Res Ther. 2016 Nov 4;18(1):257.

48.

Role of OmpA2 surface regions of Porphyromonas gingivalis in host-pathogen interactions with oral epithelial cells.

Naylor KL, Widziolek M, Hunt S, Conolly M, Hicks M, Stafford P, Potempa J, Murdoch C, Douglas CW, Stafford GP.

Microbiologyopen. 2017 Feb;6(1). doi: 10.1002/mbo3.401. Epub 2016 Sep 6.

49.

Gingipains of Porphyromonas gingivalis Affect the Stability and Function of Serine Protease Inhibitor of Kazal-type 6 (SPINK6), a Tissue Inhibitor of Human Kallikreins.

Plaza K, Kalinska M, Bochenska O, Meyer-Hoffert U, Wu Z, Fischer J, Falkowski K, Sasiadek L, Bielecka E, Potempa B, Kozik A, Potempa J, Kantyka T.

J Biol Chem. 2016 Sep 2;291(36):18753-64. doi: 10.1074/jbc.M116.722942. Epub 2016 Jun 27.

50.

Vaccination with recombinant RgpA peptide protects against Porphyromonas gingivalis-induced bone loss.

Wilensky A, Potempa J, Houri-Haddad Y, Shapira L.

J Periodontal Res. 2017 Apr;52(2):285-291. doi: 10.1111/jre.12393. Epub 2016 Jun 10.

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