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Items: 29

1.

Proteolytic processing and activation of gingipain zymogens secreted by T9SS of Porphyromonas gingivalis.

Veillard F, Sztukowska M, Nowakowska Z, Mizgalska D, Thøgersen IB, Enghild JJ, Bogyo M, Potempa B, Nguyen KA, Potempa J.

Biochimie. 2019 Jun 15. pii: S0300-9084(19)30175-0. doi: 10.1016/j.biochi.2019.06.010. [Epub ahead of print]

PMID:
31212040
2.

Triggering NETosis via protease-activated receptor (PAR)-2 signaling as a mechanism of hijacking neutrophils function for pathogen benefits.

Bryzek D, Ciaston I, Dobosz E, Gasiorek A, Makarska A, Sarna M, Eick S, Puklo M, Lech M, Potempa B, Potempa J, Koziel J.

PLoS Pathog. 2019 May 20;15(5):e1007773. doi: 10.1371/journal.ppat.1007773. eCollection 2019 May.

3.

Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes.

Peters F, Scharfenberg F, Colmorgen C, Armbrust F, Wichert R, Arnold P, Potempa B, Potempa J, Pietrzik CU, Häsler R, Rosenstiel P, Becker-Pauly C.

FASEB J. 2019 Jun;33(6):7490-7504. doi: 10.1096/fj.201802391R. Epub 2019 Mar 27.

PMID:
30916990
4.

Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor.

Guevara T, Rodríguez-Banqueri A, Lasica AM, Ksiazek M, Potempa BA, Potempa J, Gomis-Rüth FX.

Sci Rep. 2019 Mar 20;9(1):4935. doi: 10.1038/s41598-019-41354-3.

5.

Adhesive protein-mediated cross-talk between Candida albicans and Porphyromonas gingivalis in dual species biofilm protects the anaerobic bacterium in unfavorable oxic environment.

Bartnicka D, Karkowska-Kuleta J, Zawrotniak M, Satała D, Michalik K, Zielinska G, Bochenska O, Kozik A, Ciaston I, Koziel J, Dutton LC, Nobbs AH, Potempa B, Baster Z, Rajfur Z, Potempa J, Rapala-Kozik M.

Sci Rep. 2019 Mar 13;9(1):4376. doi: 10.1038/s41598-019-40771-8.

6.

Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.

Dominy SS, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A, Nguyen M, Haditsch U, Raha D, Griffin C, Holsinger LJ, Arastu-Kapur S, Kaba S, Lee A, Ryder MI, Potempa B, Mydel P, Hellvard A, Adamowicz K, Hasturk H, Walker GD, Reynolds EC, Faull RLM, Curtis MA, Dragunow M, Potempa J.

Sci Adv. 2019 Jan 23;5(1):eaau3333. doi: 10.1126/sciadv.aau3333. eCollection 2019 Jan.

7.

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.

Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C.

Cell Rep. 2017 Nov 21;21(8):2090-2103. doi: 10.1016/j.celrep.2017.10.087.

8.

Proteolytic effects of gingipains on trefoil factor family peptides.

Chaiyarit P, Jaresitthikunchai J, Phaonakrop N, Roytrakul S, Potempa B, Potempa J.

Clin Oral Investig. 2018 Mar;22(2):1009-1018. doi: 10.1007/s00784-017-2181-4. Epub 2017 Jul 19.

PMID:
28726036
9.

Inactive Gingipains from P. gingivalis Selectively Skews T Cells toward a Th17 Phenotype in an IL-6 Dependent Manner.

Glowczyk I, Wong A, Potempa B, Babyak O, Lech M, Lamont RJ, Potempa J, Koziel J.

Front Cell Infect Microbiol. 2017 Apr 27;7:140. doi: 10.3389/fcimb.2017.00140. eCollection 2017.

10.

Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome.

Pomowski A, Usón I, Nowakowska Z, Veillard F, Sztukowska MN, Guevara T, Goulas T, Mizgalska D, Nowak M, Potempa B, Huntington JA, Potempa J, Gomis-Rüth FX.

J Biol Chem. 2017 Apr 7;292(14):5724-5735. doi: 10.1074/jbc.M117.776724. Epub 2017 Feb 14.

11.

Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.

Lasica AM, Goulas T, Mizgalska D, Zhou X, de Diego I, Ksiazek M, Madej M, Guo Y, Guevara T, Nowak M, Potempa B, Goel A, Sztukowska M, Prabhakar AT, Bzowska M, Widziolek M, Thøgersen IB, Enghild JJ, Simonian M, Kulczyk AW, Nguyen KA, Potempa J, Gomis-Rüth FX.

Sci Rep. 2016 Nov 24;6:37708. doi: 10.1038/srep37708.

12.

Erratum to: Concentration of antibodies against Porphyromonas gingivalisis increased before the onset of symptoms of rheumatoid arthritis.

Johansson L, Sherina N, Kharlamova N, Potempa B, Larsson B, Israelsson L, Potempa J, Rantapää-Dahlqvist S, Lundberg K.

Arthritis Res Ther. 2016 Nov 4;18(1):257. No abstract available.

13.

Structure of RagB, a major immunodominant outer-membrane surface receptor antigen of Porphyromonas gingivalis.

Goulas T, Garcia-Ferrer I, Hutcherson JA, Potempa BA, Potempa J, Scott DA, Xavier Gomis-Rüth F.

Mol Oral Microbiol. 2016 Dec;31(6):472-485. doi: 10.1111/omi.12140. Epub 2015 Nov 16.

14.

Concentration of antibodies against Porphyromonas gingivalis is increased before the onset of symptoms of rheumatoid arthritis.

Johansson L, Sherina N, Kharlamova N, Potempa B, Larsson B, Israelsson L, Potempa J, Rantapää-Dahlqvist S, Lundberg K.

Arthritis Res Ther. 2016 Sep 7;18:201. doi: 10.1186/s13075-016-1100-4. Erratum in: Arthritis Res Ther. 2016 Nov 4;18(1):257.

15.

Gingipains of Porphyromonas gingivalis Affect the Stability and Function of Serine Protease Inhibitor of Kazal-type 6 (SPINK6), a Tissue Inhibitor of Human Kallikreins.

Plaza K, Kalinska M, Bochenska O, Meyer-Hoffert U, Wu Z, Fischer J, Falkowski K, Sasiadek L, Bielecka E, Potempa B, Kozik A, Potempa J, Kantyka T.

J Biol Chem. 2016 Sep 2;291(36):18753-64. doi: 10.1074/jbc.M116.722942. Epub 2016 Jun 27.

16.

The outer-membrane export signal of Porphyromonas gingivalis type IX secretion system (T9SS) is a conserved C-terminal β-sandwich domain.

de Diego I, Ksiazek M, Mizgalska D, Koneru L, Golik P, Szmigielski B, Nowak M, Nowakowska Z, Potempa B, Houston JA, Enghild JJ, Thøgersen IB, Gao J, Kwan AH, Trewhella J, Dubin G, Gomis-Rüth FX, Nguyen KA, Potempa J.

Sci Rep. 2016 Mar 23;6:23123. doi: 10.1038/srep23123.

17.

Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology.

Kharlamova N, Jiang X, Sherina N, Potempa B, Israelsson L, Quirke AM, Eriksson K, Yucel-Lindberg T, Venables PJ, Potempa J, Alfredsson L, Lundberg K.

Arthritis Rheumatol. 2016 Mar;68(3):604-13. doi: 10.1002/art.39491.

18.

Structural studies of Helix aspersa agglutinin complexed with GalNAc: A lectin that serves as a diagnostic tool.

Pietrzyk AJ, Bujacz A, Mak P, Potempa B, Niedziela T.

Int J Biol Macromol. 2015 Nov;81:1059-68. doi: 10.1016/j.ijbiomac.2015.09.044. Epub 2015 Sep 28.

PMID:
26416237
19.

Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase.

Goulas T, Mizgalska D, Garcia-Ferrer I, Kantyka T, Guevara T, Szmigielski B, Sroka A, Millán C, Usón I, Veillard F, Potempa B, Mydel P, Solà M, Potempa J, Gomis-Rüth FX.

Sci Rep. 2015 Jul 1;5:11969. doi: 10.1038/srep11969.

20.

Purification and characterisation of recombinant His-tagged RgpB gingipain from Porphymonas gingivalis.

Veillard F, Potempa B, Guo Y, Ksiazek M, Sztukowska MN, Houston JA, Koneru L, Nguyen KA, Potempa J.

Biol Chem. 2015 Apr;396(4):377-84. doi: 10.1515/hsz-2014-0304.

21.

Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity.

Bielecka E, Scavenius C, Kantyka T, Jusko M, Mizgalska D, Szmigielski B, Potempa B, Enghild JJ, Prossnitz ER, Blom AM, Potempa J.

J Biol Chem. 2014 Nov 21;289(47):32481-7. doi: 10.1074/jbc.C114.617142. Epub 2014 Oct 16.

22.

Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis.

de Diego I, Veillard F, Sztukowska MN, Guevara T, Potempa B, Pomowski A, Huntington JA, Potempa J, Gomis-Rüth FX.

J Biol Chem. 2014 Nov 14;289(46):32291-302. doi: 10.1074/jbc.M114.602052. Epub 2014 Sep 29.

23.

A pathogenic trace of Tannerella forsythia - shedding of soluble fully active tumor necrosis factor α from the macrophage surface by karilysin.

Bryzek D, Ksiazek M, Bielecka E, Karim AY, Potempa B, Staniec D, Koziel J, Potempa J.

Mol Oral Microbiol. 2014 Dec;29(6):294-306. doi: 10.1111/omi.12080. Epub 2014 Oct 3.

24.

Gingipain aminopeptidase activities in Porphyromonas gingivalis.

Veillard F, Potempa B, Poreba M, Drag M, Potempa J.

Biol Chem. 2012 Dec;393(12):1471-6.

25.

Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases.

Veillard F, Sztukowska M, Mizgalska D, Ksiazek M, Houston J, Potempa B, Enghild JJ, Thogersen IB, Gomis-Rüth FX, Nguyen KA, Potempa J.

Biochim Biophys Acta. 2013 Aug;1830(8):4218-28. doi: 10.1016/j.bbagen.2013.04.005. Epub 2013 Apr 10.

26.

Porphyromonas gingivalis virulence factor gingipain RgpB shows a unique zymogenic mechanism for cysteine peptidases.

de Diego I, Veillard FT, Guevara T, Potempa B, Sztukowska M, Potempa J, Gomis-Rüth FX.

J Biol Chem. 2013 May 17;288(20):14287-96. doi: 10.1074/jbc.M112.444927. Epub 2013 Apr 4.

27.

Cleavage of extracellular matrix in periodontitis: gingipains differentially affect cell adhesion activities of fibronectin and tenascin-C.

Ruggiero S, Cosgarea R, Potempa J, Potempa B, Eick S, Chiquet M.

Biochim Biophys Acta. 2013 Apr;1832(4):517-26. doi: 10.1016/j.bbadis.2013.01.003. Epub 2013 Jan 9.

28.

Neutrophils alter epithelial response to Porphyromonas gingivalis in a gingival crevice model.

Bondy-Carey JL, Galicia J, Bagaitkar J, Potempa JS, Potempa B, Kinane DF, Veillard F, Scott DA.

Mol Oral Microbiol. 2013 Apr;28(2):102-13. doi: 10.1111/omi.12008. Epub 2012 Nov 22.

29.

Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes.

Sztukowska M, Veillard F, Potempa B, Bogyo M, Enghild JJ, Thogersen IB, Nguyen KA, Potempa J.

Biol Chem. 2012 Sep;393(9):971-7. doi: 10.1515/hsz-2012-0175.

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