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Items: 17


Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.

Miller MM, Banville J, Friends TJ, Gagnon M, Hangeland JJ, Lavallée JF, Martel A, O'Grady H, Rémillard R, Ruediger E, Tremblay F, Posy SL, Allegretto NJ, Guarino VR, Harden DG, Harper TW, Hartl K, Josephs J, Malmstrom S, Watson C, Yang Y, Zhang G, Wong P, Yang J, Bouvier M, Seiffert DA, Wexler RR, Lawrence RM, Priestley ES, Marinier A.

J Med Chem. 2019 Aug 22;62(16):7400-7416. doi: 10.1021/acs.jmedchem.9b00186. Epub 2019 Aug 5.


Improving Accuracy, Diversity, and Speed with Prime Macrocycle Conformational Sampling.

Sindhikara D, Spronk SA, Day T, Borrelli K, Cheney DL, Posy SL.

J Chem Inf Model. 2017 Aug 28;57(8):1881-1894. doi: 10.1021/acs.jcim.7b00052. Epub 2017 Aug 8.


Building homogeneous time-resolved fluorescence resonance energy transfer assays for characterization of bivalent inhibitors of an inhibitor of apoptosis protein target.

Chaudhry C, Davis J, Zhang Y, Posy S, Lei M, Shen H, Yan C, Devaux B, Zhang L, Blat Y, Metzler W, Borzilleri RM, Talbott RL.

Anal Biochem. 2016 Mar 15;497:8-17. doi: 10.1016/j.ab.2015.11.026. Epub 2015 Dec 30.


Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer.

Zhang Y, Seigal BA, Terrett NK, Talbott RL, Fargnoli J, Naglich JG, Chaudhry C, Posy SL, Vuppugalla R, Cornelius G, Lei M, Wang C, Zhang Y, Schmidt RJ, Wei DD, Miller MM, Allen MP, Li L, Carter PH, Vite GD, Borzilleri RM.

ACS Med Chem Lett. 2015 May 27;6(7):770-5. doi: 10.1021/acsmedchemlett.5b00091. eCollection 2015 Jul 9.


The discovery of macrocyclic XIAP antagonists from a DNA-programmed chemistry library, and their optimization to give lead compounds with in vivo antitumor activity.

Seigal BA, Connors WH, Fraley A, Borzilleri RM, Carter PH, Emanuel SL, Fargnoli J, Kim K, Lei M, Naglich JG, Pokross ME, Posy SL, Shen H, Surti N, Talbott R, Zhang Y, Terrett NK.

J Med Chem. 2015 Mar 26;58(6):2855-61. doi: 10.1021/jm501892g. Epub 2015 Mar 12.


Discovery of tetrahydroisoquinoline-based bivalent heterodimeric IAP antagonists.

Kim KS, Zhang L, Williams D, Perez HL, Stang E, Borzilleri RM, Posy S, Lei M, Chaudhry C, Emanuel S, Talbott R.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):5022-9. doi: 10.1016/j.bmcl.2014.09.022. Epub 2014 Sep 16.


Ligand placement based on prior structures: the guided ligand-replacement method.

Klei HE, Moriarty NW, Echols N, Terwilliger TC, Baldwin ET, Pokross M, Posy S, Adams PD.

Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):134-43. doi: 10.1107/S1399004713030071. Epub 2013 Dec 25.


3D matched pairs: integrating ligand- and structure-based knowledge for ligand design and receptor annotation.

Posy SL, Claus BL, Pokross ME, Johnson SR.

J Chem Inf Model. 2013 Jul 22;53(7):1576-88. doi: 10.1021/ci400201k. Epub 2013 Jul 10.


Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins.

Vendome J, Posy S, Jin X, Bahna F, Ahlsen G, Shapiro L, Honig B.

Nat Struct Mol Biol. 2011 Jun;18(6):693-700. doi: 10.1038/nsmb.2051. Epub 2011 May 15.


Trends in kinase selectivity: insights for target class-focused library screening.

Posy SL, Hermsmeier MA, Vaccaro W, Ott KH, Todderud G, Lippy JS, Trainor GL, Loughney DA, Johnson SR.

J Med Chem. 2011 Jan 13;54(1):54-66. doi: 10.1021/jm101195a. Epub 2010 Dec 3.


T-cadherin structures reveal a novel adhesive binding mechanism.

Ciatto C, Bahna F, Zampieri N, VanSteenhouse HC, Katsamba PS, Ahlsen G, Harrison OJ, Brasch J, Jin X, Posy S, Vendome J, Ranscht B, Jessell TM, Honig B, Shapiro L.

Nat Struct Mol Biol. 2010 Mar;17(3):339-47. doi: 10.1038/nsmb.1781. Epub 2010 Feb 28.


Linking molecular affinity and cellular specificity in cadherin-mediated adhesion.

Katsamba P, Carroll K, Ahlsen G, Bahna F, Vendome J, Posy S, Rajebhosale M, Price S, Jessell TM, Ben-Shaul A, Shapiro L, Honig BH.

Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11594-9. doi: 10.1073/pnas.0905349106. Epub 2009 Jun 24.


Sequence and structural determinants of strand swapping in cadherin domains: do all cadherins bind through the same adhesive interface?

Posy S, Shapiro L, Honig B.

J Mol Biol. 2008 May 9;378(4):954-68. doi: 10.1016/j.jmb.2008.02.063. Epub 2008 Mar 4.


Crystal structure of the extracellular cholinesterase-like domain from neuroligin-2.

Koehnke J, Jin X, Budreck EC, Posy S, Scheiffele P, Honig B, Shapiro L.

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1873-8. doi: 10.1073/pnas.0711701105. Epub 2008 Feb 4.


Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases.

Ortiz CO, Etchberger JF, Posy SL, Frøkjaer-Jensen C, Lockery S, Honig B, Hobert O.

Genetics. 2006 May;173(1):131-49. Epub 2006 Mar 17.


Specificity of cell-cell adhesion by classical cadherins: Critical role for low-affinity dimerization through beta-strand swapping.

Chen CP, Posy S, Ben-Shaul A, Shapiro L, Honig BH.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8531-6. Epub 2005 Jun 3.


On the role of structural information in remote homology detection and sequence alignment: new methods using hybrid sequence profiles.

Tang CL, Xie L, Koh IY, Posy S, Alexov E, Honig B.

J Mol Biol. 2003 Dec 12;334(5):1043-62.


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