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Items: 28


Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues.

Yoon JS, Kim G, Jarhad DB, Kim HR, Shin YS, Qu S, Sahu PK, Kim HO, Lee HW, Wang SB, Kong YJ, Chang TS, Ogando NS, Kovacikova K, Snijder EJ, Posthuma CC, van Hemert MJ, Jeong LS.

J Med Chem. 2019 Jul 11;62(13):6346-6362. doi: 10.1021/acs.jmedchem.9b00781. Epub 2019 Jun 20.


Adaptive mutations in replicase transmembrane subunits can counteract inhibition of equine arteritis virus RNA synthesis by cyclophilin inhibitors.

de Wilde AH, Boomaars-van der Zanden AL, de Jong AWM, Barcéna M, Snijder EJ, Posthuma CC.

J Virol. 2019 Jun 26. pii: JVI.00490-19. doi: 10.1128/JVI.00490-19. [Epub ahead of print]


Cyclophilins and cyclophilin inhibitors in nidovirus replication.

de Wilde AH, Pham U, Posthuma CC, Snijder EJ.

Virology. 2018 Sep;522:46-55. doi: 10.1016/j.virol.2018.06.011. Epub 2018 Jul 12. Review.


Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture.

de Wilde AH, Zevenhoven-Dobbe JC, Beugeling C, Chatterji U, de Jong D, Gallay P, Szuhai K, Posthuma CC, Snijder EJ.

Virology. 2018 Apr;517:148-156. doi: 10.1016/j.virol.2017.11.022. Epub 2017 Dec 15.


Inducing fluorescence of uranyl acetate as a dual-purpose contrast agent for correlative light-electron microscopy with nanometre precision.

Tuijtel MW, Mulder AA, Posthuma CC, van der Hoeven B, Koster AJ, Bárcena M, Faas FGA, Sharp TH.

Sci Rep. 2017 Sep 5;7(1):10442. doi: 10.1038/s41598-017-10905-x.


Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes.

Posthuma CC, Te Velthuis AJW, Snijder EJ.

Virus Res. 2017 Apr 15;234:58-73. doi: 10.1016/j.virusres.2017.01.023. Epub 2017 Feb 6. Review.


Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model.

de Wilde AH, Falzarano D, Zevenhoven-Dobbe JC, Beugeling C, Fett C, Martellaro C, Posthuma CC, Feldmann H, Perlman S, Snijder EJ.

Virus Res. 2017 Jan 15;228:7-13. doi: 10.1016/j.virusres.2016.11.011. Epub 2016 Nov 10.


Arterivirus RNA-dependent RNA polymerase: Vital enzymatic activity remains elusive.

Lehmann KC, Gorbalenya AE, Snijder EJ, Posthuma CC.

Virology. 2016 Jan;487:68-74. doi: 10.1016/j.virol.2015.10.002. Epub 2015 Oct 23.


Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses.

Lehmann KC, Gulyaeva A, Zevenhoven-Dobbe JC, Janssen GM, Ruben M, Overkleeft HS, van Veelen PA, Samborskiy DV, Kravchenko AA, Leontovich AM, Sidorov IA, Snijder EJ, Posthuma CC, Gorbalenya AE.

Nucleic Acids Res. 2015 Sep 30;43(17):8416-34. doi: 10.1093/nar/gkv838. Epub 2015 Aug 24.


Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity.

Peters HL, Jochmans D, de Wilde AH, Posthuma CC, Snijder EJ, Neyts J, Seley-Radtke KL.

Bioorg Med Chem Lett. 2015 Aug 1;25(15):2923-6. doi: 10.1016/j.bmcl.2015.05.039. Epub 2015 May 23.


Arterivirus nsp12 versus the coronavirus nsp16 2'-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins.

Lehmann KC, Hooghiemstra L, Gulyaeva A, Samborskiy DV, Zevenhoven-Dobbe JC, Snijder EJ, Gorbalenya AE, Posthuma CC.

J Gen Virol. 2015 Sep;96(9):2643-55. doi: 10.1099/vir.0.000209. Epub 2015 Jun 3.


What we know but do not understand about nidovirus helicases.

Lehmann KC, Snijder EJ, Posthuma CC, Gorbalenya AE.

Virus Res. 2015 Apr 16;202:12-32. doi: 10.1016/j.virusres.2014.12.001. Epub 2014 Dec 8. Review.


One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities.

Subissi L, Posthuma CC, Collet A, Zevenhoven-Dobbe JC, Gorbalenya AE, Decroly E, Snijder EJ, Canard B, Imbert I.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):E3900-9. doi: 10.1073/pnas.1323705111. Epub 2014 Sep 2.


Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes.

Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi S, Imbert I, Canard B, Guillemot JC, Lécine P, Pfefferle S, Drosten C, Snijder EJ, Decroly E, Morelli X.

J Biol Chem. 2014 Sep 12;289(37):25783-96. doi: 10.1074/jbc.M114.577353. Epub 2014 Jul 29.


Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.

de Wilde AH, Jochmans D, Posthuma CC, Zevenhoven-Dobbe JC, van Nieuwkoop S, Bestebroer TM, van den Hoogen BG, Neyts J, Snijder EJ.

Antimicrob Agents Chemother. 2014 Aug;58(8):4875-84. doi: 10.1128/AAC.03011-14. Epub 2014 May 19.


Mass spectrometry-based comparative sequence analysis for the genetic monitoring of influenza A(H1N1)pdm09 virus.

Gooskens J, Zevenhoven-Dobbe JC, Claas EC, Kroes AC, Posthuma CC.

PLoS One. 2014 Apr 3;9(4):e92970. doi: 10.1371/journal.pone.0092970. eCollection 2014.


Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase.

Deng Z, Lehmann KC, Li X, Feng C, Wang G, Zhang Q, Qi X, Yu L, Zhang X, Feng W, Wu W, Gong P, Tao Y, Posthuma CC, Snijder EJ, Gorbalenya AE, Chen Z.

Nucleic Acids Res. 2014 Mar;42(5):3464-77. doi: 10.1093/nar/gkt1310. Epub 2013 Dec 24.


MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment.

de Wilde AH, Raj VS, Oudshoorn D, Bestebroer TM, van Nieuwkoop S, Limpens RW, Posthuma CC, van der Meer Y, Bárcena M, Haagmans BL, Snijder EJ, van den Hoogen BG.

J Gen Virol. 2013 Aug;94(Pt 8):1749-60. doi: 10.1099/vir.0.052910-0. Epub 2013 Apr 25.


Structure and genetic analysis of the arterivirus nonstructural protein 7alpha.

Manolaridis I, Gaudin C, Posthuma CC, Zevenhoven-Dobbe JC, Imbert I, Canard B, Kelly G, Tucker PA, Conte MR, Snijder EJ.

J Virol. 2011 Jul;85(14):7449-53. doi: 10.1128/JVI.00255-11. Epub 2011 May 11.


Mass spectrometry-based comparative sequencing to detect ganciclovir resistance in the UL97 gene of human cytomegalovirus.

Posthuma CC, van der Beek MT, van der Blij-de Brouwer CS, van der Heiden PL, Marijt EW, Spaan WJ, Claas EC, Nederstigt C, Vossen AC, Snijder EJ, Kroes AC.

J Clin Virol. 2011 May;51(1):25-30. doi: 10.1016/j.jcv.2011.01.015. Epub 2011 Mar 8.


Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production.

Firth AE, Zevenhoven-Dobbe JC, Wills NM, Go YY, Balasuriya UB, Atkins JF, Snijder EJ, Posthuma CC.

J Gen Virol. 2011 May;92(Pt 5):1097-106. doi: 10.1099/vir.0.029264-0. Epub 2011 Feb 9.


The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle.

Raaben M, Posthuma CC, Verheije MH, te Lintelo EG, Kikkert M, Drijfhout JW, Snijder EJ, Rottier PJ, de Haan CA.

J Virol. 2010 Aug;84(15):7869-79. doi: 10.1128/JVI.00485-10. Epub 2010 May 19.


Formation of the arterivirus replication/transcription complex: a key role for nonstructural protein 3 in the remodeling of intracellular membranes.

Posthuma CC, Pedersen KW, Lu Z, Joosten RG, Roos N, Zevenhoven-Dobbe JC, Snijder EJ.

J Virol. 2008 May;82(9):4480-91. doi: 10.1128/JVI.02756-07. Epub 2008 Feb 27.


An infectious recombinant equine arteritis virus expressing green fluorescent protein from its replicase gene.

van den Born E, Posthuma CC, Knoops K, Snijder EJ.

J Gen Virol. 2007 Apr;88(Pt 4):1196-205.


Site-directed mutagenesis of the Nidovirus replicative endoribonuclease NendoU exerts pleiotropic effects on the arterivirus life cycle.

Posthuma CC, Nedialkova DD, Zevenhoven-Dobbe JC, Blokhuis JH, Gorbalenya AE, Snijder EJ.

J Virol. 2006 Feb;80(4):1653-61.


A complex zinc finger controls the enzymatic activities of nidovirus helicases.

Seybert A, Posthuma CC, van Dinten LC, Snijder EJ, Gorbalenya AE, Ziebuhr J.

J Virol. 2005 Jan;79(2):696-704.

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