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Items: 28

1.

Publisher Correction: Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours.

Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K.

Nat Cell Biol. 2018 Oct;20(10):1228. doi: 10.1038/s41556-018-0184-2.

PMID:
30089842
2.

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours.

Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K.

Nat Cell Biol. 2018 Jul;20(7):775-781. doi: 10.1038/s41556-018-0118-z. Epub 2018 Jun 25. Erratum in: Nat Cell Biol. 2018 Oct;20(10):1228.

3.

Leveraging the iron-starvation response to promote ferroptosis.

Alvarez SW, Possemato R.

Oncotarget. 2018 Feb 3;9(13):10830-10831. doi: 10.18632/oncotarget.24395. eCollection 2018 Feb 16. No abstract available.

4.

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.

Minton DR, Nam M, McLaughlin DJ, Shin J, Bayraktar EC, Alvarez SW, Sviderskiy VO, Papagiannakopoulos T, Sabatini DM, Birsoy K, Possemato R.

Mol Cell. 2018 Feb 15;69(4):610-621.e5. doi: 10.1016/j.molcel.2018.01.024.

5.

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis.

Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato R.

Nature. 2017 Nov 30;551(7682):639-643. doi: 10.1038/nature24637. Epub 2017 Nov 22.

6.

Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.

Vaeth M, Maus M, Klein-Hessling S, Freinkman E, Yang J, Eckstein M, Cameron S, Turvey SE, Serfling E, Berberich-Siebelt F, Possemato R, Feske S.

Immunity. 2017 Oct 17;47(4):664-679.e6. doi: 10.1016/j.immuni.2017.09.003. Epub 2017 Oct 11.

7.

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.

Sayin VI, LeBoeuf SE, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou AM, Ubriaco J, Muir A, Karagiannis D, Morris PJ, Thomas CJ, Possemato R, Vander Heiden MG, Papagiannakopoulos T.

Elife. 2017 Oct 2;6. pii: e28083. doi: 10.7554/eLife.28083.

8.

Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu MR, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM.

Nat Chem Biol. 2016 Jul 19;12(8):656. doi: 10.1038/nchembio0816-656. No abstract available.

PMID:
27434767
9.

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM.

Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. Erratum in: Nat Chem Biol. 2016 Jul 19;12 (8):656.

10.

Amino acid management in cancer.

Tsun ZY, Possemato R.

Semin Cell Dev Biol. 2015 Jul;43:22-32. doi: 10.1016/j.semcdb.2015.08.002. Epub 2015 Aug 12. Review.

11.

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.

Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM.

Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8.

12.

Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening.

Strohecker AM, Joshi S, Possemato R, Abraham RT, Sabatini DM, White E.

Oncogene. 2015 Nov 5;34(45):5662-76. doi: 10.1038/onc.2015.23. Epub 2015 Mar 16.

13.

Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM.

Cell. 2014 Aug 28;158(5):1094-1109. doi: 10.1016/j.cell.2014.07.032.

14.

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

Birsoy K, Possemato R, Lorbeer FK, Bayraktar EC, Thiru P, Yucel B, Wang T, Chen WW, Clish CB, Sabatini DM.

Nature. 2014 Apr 3;508(7494):108-12. doi: 10.1038/nature13110. Epub 2014 Mar 16.

15.

A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM.

Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14.

16.

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.

Birsoy K, Wang T, Possemato R, Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y, Peterson TR, Carette JE, Brummelkamp TR, Clish CB, Sabatini DM.

Nat Genet. 2013 Jan;45(1):104-8. doi: 10.1038/ng.2471. Epub 2012 Dec 2.

17.

Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts.

Nguyen CL, Possemato R, Bauerlein EL, Xie A, Scully R, Hahn WC.

Mol Cell Biol. 2012 Oct;32(19):3963-77. doi: 10.1128/MCB.00436-12. Epub 2012 Jul 30.

18.

Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson.

Birsoy K, Sabatini DM, Possemato R.

Nat Med. 2012 Jul 6;18(7):1022-3. doi: 10.1038/nm.2870. No abstract available.

PMID:
22772555
19.

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.

Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM.

Nature. 2011 Aug 18;476(7360):346-50. doi: 10.1038/nature10350.

20.

Maintenance of tumor initiating cells of defined genetic composition by nucleostemin.

Okamoto N, Yasukawa M, Nguyen C, Kasim V, Maida Y, Possemato R, Shibata T, Ligon KL, Fukami K, Hahn WC, Masutomi K.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20388-93. doi: 10.1073/pnas.1015171108. Epub 2011 Jul 5.

21.

An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA.

Maida Y, Yasukawa M, Furuuchi M, Lassmann T, Possemato R, Okamoto N, Kasim V, Hayashizaki Y, Hahn WC, Masutomi K.

Nature. 2009 Sep 10;461(7261):230-5. doi: 10.1038/nature08283. Epub 2009 Aug 23.

22.

Suppression of hPOT1 in diploid human cells results in an hTERT-dependent alteration of telomere length dynamics.

Possemato R, Timmons JC, Bauerlein EL, Wada N, Baldwin A, Masutomi K, Hahn WC.

Mol Cancer Res. 2008 Oct;6(10):1582-93. doi: 10.1158/1541-7786.MCR-08-0070.

23.

Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicity.

Chen W, Arroyo JD, Timmons JC, Possemato R, Hahn WC.

Cancer Res. 2005 Sep 15;65(18):8183-92.

24.

The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

Masutomi K, Possemato R, Wong JM, Currier JL, Tothova Z, Manola JB, Ganesan S, Lansdorp PM, Collins K, Hahn WC.

Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8222-7. Epub 2005 May 31.

25.

Identification of specific PP2A complexes involved in human cell transformation.

Chen W, Possemato R, Campbell KT, Plattner CA, Pallas DC, Hahn WC.

Cancer Cell. 2004 Feb;5(2):127-36.

26.

T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells.

Lugo-Villarino G, Maldonado-Lopez R, Possemato R, Penaranda C, Glimcher LH.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7749-54. Epub 2003 Jun 11.

27.

Flp recombinase regulated lacZ expression at the ROSA26 locus.

Possemato R, Eggan K, Moeller BJ, Jaenisch R, Jackson-Grusby L.

Genesis. 2002 Feb;32(2):184-6. No abstract available.

PMID:
11857816
28.

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation.

Jackson-Grusby L, Beard C, Possemato R, Tudor M, Fambrough D, Csankovszki G, Dausman J, Lee P, Wilson C, Lander E, Jaenisch R.

Nat Genet. 2001 Jan;27(1):31-9.

PMID:
11137995

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