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Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs.

Fox JM, Moynihan JR, Mott BT, Mazzone JR, Anders NM, Brown PA, Rudek MA, Liu JO, Arav-Boger R, Posner GH, Civin CI, Chen X.

Oncotarget. 2016 Feb 9;7(6):7268-79. doi: 10.18632/oncotarget.6896.


Inhibition of human cytomegalovirus replication by artemisinins: effects mediated through cell cycle modulation.

Roy S, He R, Kapoor A, Forman M, Mazzone JR, Posner GH, Arav-Boger R.

Antimicrob Agents Chemother. 2015 Jul;59(7):3870-9. doi: 10.1128/AAC.00262-15. Epub 2015 Apr 13.


Antimalarial chemotherapy: orally curative artemisinin-derived trioxane dimer esters.

Conyers RC, Mazzone JR, Tripathi AK, Sullivan DJ, Posner GH.

Bioorg Med Chem Lett. 2015 Jan 15;25(2):245-8. doi: 10.1016/j.bmcl.2014.11.064. Epub 2014 Nov 27.


Age- and sex-dependent hormonal modulation of the expression of vitamin D receptor and 25-hydroxyvitamin D 1α hydroxylase in human bone cells.

Somjen D, Katzburg S, Hendel D, Sharon O, Posner GH.

Expert Rev Endocrinol Metab. 2014 May;9(3):283-292. doi: 10.1586/17446651.2014.899897. Epub 2014 Mar 29.


Antimalarial chemotherapy: artemisinin-derived dimer carbonates and thiocarbonates.

Mazzone JR, Conyers RC, Tripathi AK, Sullivan DJ, Posner GH.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2440-3. doi: 10.1016/j.bmcl.2014.04.025. Epub 2014 Apr 16.


A thiazole derivative of artemisinin moderately reduces Toxoplasma gondii cyst burden in infected mice.

Schultz TL, Hencken CP, Woodard LE, Posner GH, Yolken RH, Jones-Brando L, Carruthers VB.

J Parasitol. 2014 Aug;100(4):516-21. doi: 10.1645/13-451.1. Epub 2014 Feb 13.


The survival times of malaria-infected mice are prolonged more by several new two-carbon-linked artemisinin-derived dimer carbamates than by the trioxane antimalarial drug artemether.

Conyers RC, Mazzone JR, Siegler MA, Tripathi AK, Sullivan DJ, Mott BT, Posner GH.

Bioorg Med Chem Lett. 2014 Mar 1;24(5):1285-9. doi: 10.1016/j.bmcl.2014.01.059. Epub 2014 Jan 30.


In vitro combination of anti-cytomegalovirus compounds acting through different targets: role of the slope parameter and insights into mechanisms of Action.

Cai H, Kapoor A, He R, Venkatadri R, Forman M, Posner GH, Arav-Boger R.

Antimicrob Agents Chemother. 2014;58(2):986-94. doi: 10.1128/AAC.01972-13. Epub 2013 Nov 25.


Unique and highly selective anticytomegalovirus activities of artemisinin-derived dimer diphenyl phosphate stem from combination of dimer unit and a diphenyl phosphate moiety.

He R, Forman M, Mott BT, Venkatadri R, Posner GH, Arav-Boger R.

Antimicrob Agents Chemother. 2013 Sep;57(9):4208-14. doi: 10.1128/AAC.00893-13. Epub 2013 Jun 17.


Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study.

Mott BT, He R, Chen X, Fox JM, Civin CI, Arav-Boger R, Posner GH.

Bioorg Med Chem. 2013 Jul 1;21(13):3702-7. doi: 10.1016/j.bmc.2013.04.027. Epub 2013 Apr 22.


Age-dependent responsiveness of human female bone cells to vitamin D analog and PTH.

Somjen D, Katzburg S, Kaye AM, Posner GH.

J Endocrinol Invest. 2013 Feb;36(2):118-22.


Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs.

Mott BT, Tripathi A, Siegler MA, Moore CD, Sullivan DJ, Posner GH.

J Med Chem. 2013 Mar 28;56(6):2630-41. doi: 10.1021/jm400058j. Epub 2013 Mar 7.


A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases().

Mott BT, Cheng KC, Guha R, Kommer VP, Williams DL, Vermeire JJ, Cappello M, Maloney DJ, Rai G, Jadhav A, Simeonov A, Inglese J, Posner GH, Thomas CJ.

Medchemcomm. 2012 Dec;3(12):1505-1511.


Vitamin D less-calcemic analog modulates the expression of estrogen receptors, vitamin D receptor and 1α-hydroxylase 25-hydroxy vitamin D in human thyroid cancer cell lines.

Somjen D, Grafi-Cohen M, Posner GH, Sharon O, Kraiem Z, Stern N.

J Steroid Biochem Mol Biol. 2013 Jul;136:80-2. doi: 10.1016/j.jsbmb.2012.09.015. Epub 2012 Oct 8. Review.


Differential photoprotective effects of 1,25-dihydroxyvitamin D3 and a low calcaemic deltanoid.

Dixon KM, Sequeira VB, Deo SS, Mohan R, Posner GH, Mason RS.

Photochem Photobiol Sci. 2012 Dec;11(12):1825-30. doi: 10.1039/c2pp25208b.


Malaria-infected mice live until at least day 30 after a new artemisinin-derived thioacetal thiocarbonate combined with mefloquine are administered together in a single, low, oral dose.

Jacobine AM, Mazzone JR, Slack RD, Tripathi AK, Sullivan DJ, Posner GH.

J Med Chem. 2012 Sep 13;55(17):7892-9. doi: 10.1021/jm3009986. Epub 2012 Aug 27.


Artemisinin-derived dimer diphenyl phosphate is an irreversible inhibitor of human cytomegalovirus replication.

He R, Park K, Cai H, Kapoor A, Forman M, Mott B, Posner GH, Arav-Boger R.

Antimicrob Agents Chemother. 2012 Jul;56(7):3508-15. doi: 10.1128/AAC.00519-12. Epub 2012 Apr 30.


Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine.

Slack RD, Mott BT, Woodard LE, Tripathi A, Sullivan D, Nenortas E, Girdwood SC, Shapiro TA, Posner GH.

J Med Chem. 2012 Jan 12;55(1):291-6. doi: 10.1021/jm201214d. Epub 2011 Dec 15. Erratum in: J Med Chem. 2012 Feb 23;55(4):1788. Triphati, Abhai [corrected to Tripathi, Abhai].


An artemisinin-derived dimer has highly potent anti-cytomegalovirus (CMV) and anti-cancer activities.

He R, Mott BT, Rosenthal AS, Genna DT, Posner GH, Arav-Boger R.

PLoS One. 2011;6(8):e24334. doi: 10.1371/journal.pone.0024334. Epub 2011 Aug 31.


Cyanocuprates convert carboxylic acids directly into ketones.

Genna DT, Posner GH.

Org Lett. 2011 Oct 7;13(19):5358-61. doi: 10.1021/ol202237j. Epub 2011 Sep 6.


Three-component, one-flask synthesis of rhodanines (thiazolidinones).

Jacobine AM, Posner GH.

J Org Chem. 2011 Oct 7;76(19):8121-5. doi: 10.1021/jo201561t. Epub 2011 Aug 31.


Mutual interaction of special phytoestrogenic compounds, their synthetic carboxy-derivatives and the less-calcemic vitamin D analog activities in human derived female cultured osteoblasts.

Somjen D, Katzburg S, Sharon O, Posner GH, Jaccard N, Hendel D, Tamir S, Vaya J.

J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):351-7. doi: 10.1016/j.jsbmb.2011.07.003. Epub 2011 Jul 23.


Highly stereocontrolled and regiocontrolled syntheses of 2,3,4-trisubstituted alkanoates and lactones.

Hencken CP, Genna DT, Siegler MA, Posner GH.

J Org Chem. 2011 Jun 17;76(12):5149-55. doi: 10.1021/jo200795f. Epub 2011 May 20.


Recombinant luciferase-expressing human cytomegalovirus (CMV) for evaluation of CMV inhibitors.

He R, Sandford G, Hayward GS, Burns WH, Posner GH, Forman M, Arav-Boger R.

Virol J. 2011 Jan 26;8:40. doi: 10.1186/1743-422X-8-40.


Vitamin D metabolites and analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cell line.

Somjen D, Katzburg S, Grafi-Cohen M, Knoll E, Sharon O, Posner GH.

J Steroid Biochem Mol Biol. 2011 Jan;123(1-2):85-9. doi: 10.1016/j.jsbmb.2010.11.010. Epub 2010 Nov 24.


A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice.

Moon DK, Tripathi A, Sullivan D, Siegler MA, Parkin S, Posner GH.

Bioorg Med Chem Lett. 2011 May 1;21(9):2773-5. doi: 10.1016/j.bmcl.2010.09.123. Epub 2010 Sep 29.


α-Chloro-β,γ-ethylenic esters: enantiocontrolled synthesis and substitutions.

Genna DT, Hencken CP, Siegler MA, Posner GH.

Org Lett. 2010 Oct 15;12(20):4694-7. doi: 10.1021/ol102142a.


The effects of native and synthetic estrogenic compounds as well as vitamin D less-calcemic analogs on adipocytes content in rat bone marrow.

Somjen D, Katzburg S, Kohen F, Gayer B, Posner GH, Yoles I, Livne E.

J Endocrinol Invest. 2011 Feb;34(2):106-10. doi: 10.3275/7108. Epub 2010 Jun 11.


Apc(MIN) modulation of vitamin D secosteroid growth control.

Xu H, Posner GH, Stevenson M, Campbell FC.

Carcinogenesis. 2010 Aug;31(8):1434-41. doi: 10.1093/carcin/bgq098. Epub 2010 May 20.


Asymmetric, organocatalytic, three-step synthesis of alpha-hydroxy-(E)-beta,gamma-unsaturated esters.

Hess LC, Posner GH.

Org Lett. 2010 May 7;12(9):2120-2. doi: 10.1021/ol100615j.


Thiazole, oxadiazole, and carboxamide derivatives of artemisinin are highly selective and potent inhibitors of Toxoplasma gondii.

Hencken CP, Jones-Brando L, Bordón C, Stohler R, Mott BT, Yolken R, Posner GH, Woodard LE.

J Med Chem. 2010 May 13;53(9):3594-601. doi: 10.1021/jm901857d.


Vitamin D analogues targeting CYP24 in chronic kidney disease.

Posner GH, Helvig C, Cuerrier D, Collop D, Kharebov A, Ryder K, Epps T, Petkovich M.

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):13-9. doi: 10.1016/j.jsbmb.2010.03.065. Epub 2010 Mar 27.


Vitamin D analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cells.

Somjen D, Katzburg S, Knoll E, Sharon O, Posner GH, Stern N.

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):265-7. doi: 10.1016/j.jsbmb.2010.03.047. Epub 2010 Mar 20.


The response of creatine kinase specific activity in rat pituitary to estrogenic compounds and vitamin d less-calcemic analogs.

Somjen D, Mirsky N, Tamir S, Vaya J, Posner GH, Kaye AM.

Int J Cell Biol. 2009;2009:273651. doi: 10.1155/2009/273651. Epub 2009 Sep 10.


Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine.

Woodard LE, Mott BT, Singhal V, Kumar N, Shapiro TA, Posner GH.

Pharmaceuticals (Basel). 2009 Dec 21;2(3):228-235.


Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose.

Woodard LE, Chang W, Chen X, Liu JO, Shapiro TA, Posner GH.

J Med Chem. 2009 Dec 10;52(23):7458-62. doi: 10.1021/jm9005934.


'Novel alkyl side chain sulfone 1alpha,25-dihydroxyvitamin D3 analogs: a comparison of in vitro antiproliferative activities and in vivo calcemic activities'.

Usera AR, Dolan P, Kensler TW, Posner GH.

Bioorg Med Chem. 2009 Aug 1;17(15):5627-31. doi: 10.1016/j.bmc.2009.06.033. Epub 2009 Jun 21.


Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.

Rosenthal AS, Chen X, Liu JO, West DC, Hergenrother PJ, Shapiro TA, Posner GH.

J Med Chem. 2009 Feb 26;52(4):1198-203. doi: 10.1021/jm801484v.


Vitamin D receptor modulates the neoplastic phenotype through antagonistic growth regulatory signals.

Xu H, McCann M, Zhang Z, Posner GH, Bingham V, El-Tanani M, Campbell FC.

Mol Carcinog. 2009 Aug;48(8):758-72. doi: 10.1002/mc.20520.


Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent.

Hartwig CL, Rosenthal AS, D'Angelo J, Griffin CE, Posner GH, Cooper RA.

Biochem Pharmacol. 2009 Feb 1;77(3):322-36. doi: 10.1016/j.bcp.2008.10.015. Epub 2008 Oct 19.


Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle.

D'Angelo JG, Bordón C, Posner GH, Yolken R, Jones-Brando L.

J Antimicrob Chemother. 2009 Jan;63(1):146-50. doi: 10.1093/jac/dkn451. Epub 2008 Nov 6.


Asymmetric, organocatalytic, three-step synthesis of gamma-hydroxy-(E)-alpha,beta-unsaturated sulfones and esters.

Petersen KS, Posner GH.

Org Lett. 2008 Oct 16;10(20):4685-7. doi: 10.1021/ol8020513. Epub 2008 Sep 24.


Effect of artemisinins and other endoperoxides on nitric oxide-related signaling pathway in RAW 264.7 mouse macrophage cells.

Konkimalla VB, Blunder M, Korn B, Soomro SA, Jansen H, Chang W, Posner GH, Bauer R, Efferth T.

Nitric Oxide. 2008 Sep;19(2):184-91. doi: 10.1016/j.niox.2008.04.008. Epub 2008 Apr 22.


Electronically stabilized versions of the antimalarial acetal trioxanes artemether and artesunate.

Posner GH, Maio WA, Kalinda AS.

Bioorg Med Chem. 2008 May 1;16(9):5247-53. doi: 10.1016/j.bmc.2008.03.010. Epub 2008 Mar 6.


Malaria-infected mice are cured by oral administration of new artemisinin derivatives.

Posner GH, Chang W, Hess L, Woodard L, Sinishtaj S, Usera AR, Maio W, Rosenthal AS, Kalinda AS, D'Angelo JG, Petersen KS, Stohler R, Chollet J, Santo-Tomas J, Snyder C, Rottmann M, Wittlin S, Brun R, Shapiro TA.

J Med Chem. 2008 Feb 28;51(4):1035-42. doi: 10.1021/jm701168h. Epub 2008 Jan 31.


Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1 alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation.

Petersen KS, Dolan PM, Kensler TW, Peleg S, Posner GH.

J Med Chem. 2007 Nov 15;50(23):5824-32. Epub 2007 Oct 9.


Cyclopentanone ring expansion leading to functionalized delta-lactams: short synthesis of simple sedum alkaloids.

Maio WA, Sinishtaj S, Posner GH.

Org Lett. 2007 Jul 5;9(14):2673-6. Epub 2007 Jun 12.


Antiproliferative, low-calcemic, fluorinated sulfone analogs of 1alpha,25-dihydroxyvitamin D3: chemical synthesis and biological evaluation.

Usera AR, Dolan PM, Kensler TW, Posner GH.

Bioorg Med Chem. 2007 Aug 15;15(16):5509-18. Epub 2007 May 25.

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