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Items: 15


CDK7 inhibition suppresses Castration-Resistant Prostate Cancer through MED1 inactivation.

Rasool RU, Natesan R, Deng Q, Aras S, Lal P, Sander Effron S, Mitchell-Velasquez E, Posimo JM, Carskadon S, Baca SC, Pomerantz MM, Siddiqui J, Schwartz LE, Lee DJ, Palanisamy N, Narla G, Den RB, Freedman ML, Brady DC, Asangani IA.

Cancer Discov. 2019 Aug 29. pii: CD-19-0189. doi: 10.1158/2159-8290.CD-19-0189. [Epub ahead of print]


Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism.

Chung CY, Posimo JM, Lee S, Tsang T, Davis JM, Brady DC, Chang CJ.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18285-18294. doi: 10.1073/pnas.1904610116. Epub 2019 Aug 26.


Copper chaperone ATOX1 is required for MAPK signaling and growth in BRAF mutation-positive melanoma.

Kim YJ, Bond GJ, Tsang T, Posimo JM, Busino L, Brady DC.

Metallomics. 2019 Aug 1;11(8):1430-1440. doi: 10.1039/c9mt00042a. Epub 2019 Jul 18.


YAP1 enhances NF-κB-dependent and independent effects on clock-mediated unfolded protein responses and autophagy in sarcoma.

Rivera-Reyes A, Ye S, E Marino G, Egolf S, E Ciotti G, Chor S, Liu Y, Posimo JM, Park PMC, Pak K, Babichev Y, Sostre-Colón J, Tameire F, Leli NM, Koumenis C, C Brady D, Mancuso A, Weber K, Gladdy R, Qi J, Eisinger-Mathason TSK.

Cell Death Dis. 2018 Oct 31;9(11):1108. doi: 10.1038/s41419-018-1142-4.


Synergistic stress exacerbation in hippocampal neurons: Evidence favoring the dual-hit hypothesis of neurodegeneration.

Heinemann SD, Posimo JM, Mason DM, Hutchison DF, Leak RK.

Hippocampus. 2016 Aug;26(8):980-94. doi: 10.1002/hipo.22580. Epub 2016 Mar 29.


Astrocytes Surviving Severe Stress Can Still Protect Neighboring Neurons from Proteotoxic Injury.

Gleixner AM, Posimo JM, Pant DB, Henderson MP, Leak RK.

Mol Neurobiol. 2016 Sep;53(7):4939-60. doi: 10.1007/s12035-015-9427-4. Epub 2015 Sep 15.


Heat shock protein defenses in the neocortex and allocortex of the telencephalon.

Posimo JM, Weilnau JN, Gleixner AM, Broeren MT, Weiland NL, Brodsky JL, Wipf P, Leak RK.

Neurobiol Aging. 2015 May;36(5):1924-37. doi: 10.1016/j.neurobiolaging.2015.02.011. Epub 2015 Feb 18.


Heat shock protein responses to aging and proteotoxicity in the olfactory bulb.

Crum TS, Gleixner AM, Posimo JM, Mason DM, Broeren MT, Heinemann SD, Wipf P, Brodsky JL, Leak RK.

J Neurochem. 2015 Jun;133(6):780-794. doi: 10.1111/jnc.13041. Epub 2015 Mar 5.


Impact of aging on heat shock protein expression in the substantia nigra and striatum of the female rat.

Gleixner AM, Pulugulla SH, Pant DB, Posimo JM, Crum TS, Leak RK.

Cell Tissue Res. 2014 Jul;357(1):43-54. doi: 10.1007/s00441-014-1852-6. Epub 2014 Apr 11.


Viability assays for cells in culture.

Posimo JM, Unnithan AS, Gleixner AM, Choi HJ, Jiang Y, Pulugulla SH, Leak RK.

J Vis Exp. 2014 Jan 20;(83):e50645. doi: 10.3791/50645.


N-acetyl cysteine prevents synergistic, severe toxicity from two hits of oxidative stress.

Unnithan AS, Jiang Y, Rumble JL, Pulugulla SH, Posimo JM, Gleixner AM, Leak RK.

Neurosci Lett. 2014 Feb 7;560:71-6. doi: 10.1016/j.neulet.2013.12.023. Epub 2013 Dec 18.


N-Acetyl cysteine blunts proteotoxicity in a heat shock protein-dependent manner.

Jiang Y, Rumble JL, Gleixner AM, Unnithan AS, Pulugulla SH, Posimo JM, Choi HJ, Crum TS, Pant DB, Leak RK.

Neuroscience. 2013;255:19-32. doi: 10.1016/j.neuroscience.2013.09.049. Epub 2013 Oct 3.


Neocortex and allocortex respond differentially to cellular stress in vitro and aging in vivo.

Posimo JM, Titler AM, Choi HJ, Unnithan AS, Leak RK.

PLoS One. 2013;8(3):e58596. doi: 10.1371/journal.pone.0058596. Epub 2013 Mar 11.


Astrocyte plasticity revealed by adaptations to severe proteotoxic stress.

Titler AM, Posimo JM, Leak RK.

Cell Tissue Res. 2013 Jun;352(3):427-43. doi: 10.1007/s00441-013-1571-4. Epub 2013 Feb 19.


Rescue from a two hit, high-throughput model of neurodegeneration with N-acetyl cysteine.

Unnithan AS, Choi HJ, Titler AM, Posimo JM, Leak RK.

Neurochem Int. 2012 Aug;61(3):356-68. doi: 10.1016/j.neuint.2012.06.001. Epub 2012 Jun 9.


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