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Items: 1 to 50 of 93

1.

Evolutionary emergence of Hairless as a novel component of the Notch signaling pathway.

Miller SW, Movsesyan A, Zhang S, Fernández R, Posakony JW.

Elife. 2019 Sep 23;8. pii: e48115. doi: 10.7554/eLife.48115.

2.

Lateral inhibition: Two modes of non-autonomous negative autoregulation by neuralized.

Miller SW, Posakony JW.

PLoS Genet. 2018 Jul 20;14(7):e1007528. doi: 10.1371/journal.pgen.1007528. eCollection 2018 Jul.

3.

Automated tools for comparative sequence analysis of genic regions using the GenePalette application.

Smith AF, Posakony JW, Rebeiz M.

Dev Biol. 2017 Sep 1;429(1):158-164. doi: 10.1016/j.ydbio.2017.06.033. Epub 2017 Jun 30.

4.

Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway.

Pattabhi S, Wilkins CR, Dong R, Knoll ML, Posakony J, Kaiser S, Mire CE, Wang ML, Ireton RC, Geisbert TW, Bedard KM, Iadonato SP, Loo YM, Gale M Jr.

J Virol. 2015 Dec 16;90(5):2372-87. doi: 10.1128/JVI.02202-15.

5.

Neural precursor-specific expression of multiple Drosophila genes is driven by dual enhancer modules with overlapping function.

Miller SW, Rebeiz M, Atanasov JE, Posakony JW.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17194-9. doi: 10.1073/pnas.1415308111. Epub 2014 Nov 17.

6.

An enhancer composed of interlocking submodules controls transcriptional autoregulation of suppressor of hairless.

Liu F, Posakony JW.

Dev Cell. 2014 Apr 14;29(1):88-101. doi: 10.1016/j.devcel.2014.02.005.

7.

Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors.

Mahajan SS, Scian M, Sripathy S, Posakony J, Lao U, Loe TK, Leko V, Thalhofer A, Schuler AD, Bedalov A, Simon JA.

J Med Chem. 2014 Apr 24;57(8):3283-94. doi: 10.1021/jm4018064. Epub 2014 Apr 15.

8.

Glucosamine and glucosamine-6-phosphate derivatives: catalytic cofactor analogues for the glmS ribozyme.

Posakony JJ, Ferré-D'Amaré AR.

J Org Chem. 2013 May 17;78(10):4730-43. doi: 10.1021/jo400192e. Epub 2013 Apr 30.

9.

Role of architecture in the function and specificity of two Notch-regulated transcriptional enhancer modules.

Liu F, Posakony JW.

PLoS Genet. 2012 Jul;8(7):e1002796. doi: 10.1371/journal.pgen.1002796. Epub 2012 Jul 5.

10.

Ancestral and conserved cis-regulatory architectures in developmental control genes.

Rebeiz M, Castro B, Liu F, Yue F, Posakony JW.

Dev Biol. 2012 Feb 15;362(2):282-94. doi: 10.1016/j.ydbio.2011.12.011. Epub 2011 Dec 13.

11.

Identification of hunchback cis-regulatory DNA conferring temporal expression in neuroblasts and neurons.

Hirono K, Margolis JS, Posakony JW, Doe CQ.

Gene Expr Patterns. 2012 Jan-Feb;12(1-2):11-7. doi: 10.1016/j.gep.2011.10.001. Epub 2011 Oct 20.

12.

A cis-regulatory map of the Drosophila genome.

Nègre N, Brown CD, Ma L, Bristow CA, Miller SW, Wagner U, Kheradpour P, Eaton ML, Loriaux P, Sealfon R, Li Z, Ishii H, Spokony RF, Chen J, Hwang L, Cheng C, Auburn RP, Davis MB, Domanus M, Shah PK, Morrison CA, Zieba J, Suchy S, Senderowicz L, Victorsen A, Bild NA, Grundstad AJ, Hanley D, MacAlpine DM, Mannervik M, Venken K, Bellen H, White R, Gerstein M, Russell S, Grossman RL, Ren B, Posakony JW, Kellis M, White KP.

Nature. 2011 Mar 24;471(7339):527-31. doi: 10.1038/nature09990.

13.

Dinoxin B, a withanolide from Datura inoxia leaves with specific cytotoxic activities.

Vermillion K, Holguin FO, Berhow MA, Richins RD, Redhouse T, O'Connell MA, Posakony J, Mahajan SS, Kelly SM, Simon JA.

J Nat Prod. 2011 Feb 25;74(2):267-71. doi: 10.1021/np1004714. Epub 2011 Jan 31.

14.

Experimental selection of hypoxia-tolerant Drosophila melanogaster.

Zhou D, Udpa N, Gersten M, Visk DW, Bashir A, Xue J, Frazer KA, Posakony JW, Subramaniam S, Bafna V, Haddad GG.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2349-54. doi: 10.1073/pnas.1010643108. Epub 2011 Jan 24.

15.

Identification of functional elements and regulatory circuits by Drosophila modENCODE.

modENCODE Consortium, Roy S, Ernst J, Kharchenko PV, Kheradpour P, Negre N, Eaton ML, Landolin JM, Bristow CA, Ma L, Lin MF, Washietl S, Arshinoff BI, Ay F, Meyer PE, Robine N, Washington NL, Di Stefano L, Berezikov E, Brown CD, Candeias R, Carlson JW, Carr A, Jungreis I, Marbach D, Sealfon R, Tolstorukov MY, Will S, Alekseyenko AA, Artieri C, Booth BW, Brooks AN, Dai Q, Davis CA, Duff MO, Feng X, Gorchakov AA, Gu T, Henikoff JG, Kapranov P, Li R, MacAlpine HK, Malone J, Minoda A, Nordman J, Okamura K, Perry M, Powell SK, Riddle NC, Sakai A, Samsonova A, Sandler JE, Schwartz YB, Sher N, Spokony R, Sturgill D, van Baren M, Wan KH, Yang L, Yu C, Feingold E, Good P, Guyer M, Lowdon R, Ahmad K, Andrews J, Berger B, Brenner SE, Brent MR, Cherbas L, Elgin SC, Gingeras TR, Grossman R, Hoskins RA, Kaufman TC, Kent W, Kuroda MI, Orr-Weaver T, Perrimon N, Pirrotta V, Posakony JW, Ren B, Russell S, Cherbas P, Graveley BR, Lewis S, Micklem G, Oliver B, Park PJ, Celniker SE, Henikoff S, Karpen GH, Lai EC, MacAlpine DM, Stein LD, White KP, Kellis M.

Science. 2010 Dec 24;330(6012):1787-97. doi: 10.1126/science.1198374. Epub 2010 Dec 22.

16.

Notch regulates numb: integration of conditional and autonomous cell fate specification.

Rebeiz M, Miller SW, Posakony JW.

Development. 2011 Jan;138(2):215-25. doi: 10.1242/dev.050161. Epub 2010 Dec 9.

17.

Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta.

Fontana JR, Posakony JW.

Dev Biol. 2009 Sep 15;333(2):373-85. doi: 10.1016/j.ydbio.2009.06.039. Epub 2009 Jul 4.

18.

Complex interplay of three transcription factors in controlling the tormogen differentiation program of Drosophila mechanoreceptors.

Miller SW, Avidor-Reiss T, Polyanovsky A, Posakony JW.

Dev Biol. 2009 May 15;329(2):386-99. doi: 10.1016/j.ydbio.2009.02.009. Epub 2009 Feb 20.

19.

Identification of CDK2 substrates in human cell lysates.

Chi Y, Welcker M, Hizli AA, Posakony JJ, Aebersold R, Clurman BE.

Genome Biol. 2008 Oct 13;9(10):R149. doi: 10.1186/gb-2008-9-10-r149.

20.

Upd/Jak/STAT signaling represses wg transcription to allow initiation of morphogenetic furrow in Drosophila eye development.

Tsai YC, Yao JG, Chen PH, Posakony JW, Barolo S, Kim J, Sun YH.

Dev Biol. 2007 Jun 15;306(2):760-71. Epub 2007 Apr 18.

21.

KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging.

Ocorr K, Reeves NL, Wessells RJ, Fink M, Chen HS, Akasaka T, Yasuda S, Metzger JM, Giles W, Posakony JW, Bodmer R.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3943-8. Epub 2007 Feb 28.

22.

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.

Heltweg B, Gatbonton T, Schuler AD, Posakony J, Li H, Goehle S, Kollipara R, Depinho RA, Gu Y, Simon JA, Bedalov A.

Cancer Res. 2006 Apr 15;66(8):4368-77.

23.

Composition and Antimicrobial Activity of Anemopsis californica leaf oil.

Medina AL, Lucero ME, Holguin FO, Estell RE, Posakony JJ, Simon J, O'Connell MA.

J Agric Food Chem. 2005 Nov 2;53(22):8694-8.

PMID:
16248573
24.

Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless.

Castro B, Barolo S, Bailey AM, Posakony JW.

Development. 2005 Aug;132(15):3333-44. Epub 2005 Jun 23.

25.

Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma.

Bonham M, Posakony J, Coleman I, Montgomery B, Simon J, Nelson PS.

Clin Cancer Res. 2005 May 15;11(10):3905-14.

26.

An ancient transcriptional regulatory linkage.

Rebeiz M, Stone T, Posakony JW.

Dev Biol. 2005 May 15;281(2):299-308.

27.
28.

Identification and characterization of Sir2 inhibitors through phenotypic assays in yeast.

Posakony J, Hirao M, Bedalov A.

Comb Chem High Throughput Screen. 2004 Nov;7(7):661-8. Review.

PMID:
15578928
29.
30.

Inhibitors of Sir2: evaluation of splitomicin analogues.

Posakony J, Hirao M, Stevens S, Simon JA, Bedalov A.

J Med Chem. 2004 May 6;47(10):2635-44.

PMID:
15115404
31.

New Drosophila transgenic reporters: insulated P-element vectors expressing fast-maturing RFP.

Barolo S, Castro B, Posakony JW.

Biotechniques. 2004 Mar;36(3):436-40, 442.

32.

Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast.

Hirao M, Posakony J, Nelson M, Hruby H, Jung M, Simon JA, Bedalov A.

J Biol Chem. 2003 Dec 26;278(52):52773-82. Epub 2003 Oct 8.

33.

NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae.

Bedalov A, Hirao M, Posakony J, Nelson M, Simon JA.

Mol Cell Biol. 2003 Oct;23(19):7044-54.

34.
35.

New routes to N-alkylated cyclic sulfamidates.

Posakony JJ, Grierson JR, Tewson TJ.

J Org Chem. 2002 Jul 26;67(15):5164-9.

PMID:
12126401
36.
37.

Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling.

Barolo S, Posakony JW.

Genes Dev. 2002 May 15;16(10):1167-81. Review. No abstract available.

38.
39.

A notch-independent activity of suppressor of hairless is required for normal mechanoreceptor physiology.

Barolo S, Walker RG, Polyanovsky AD, Freschi G, Keil T, Posakony JW.

Cell. 2000 Dec 8;103(6):957-69.

40.

GFP and beta-galactosidase transformation vectors for promoter/enhancer analysis in Drosophila.

Barolo S, Carver LA, Posakony JW.

Biotechniques. 2000 Oct;29(4):726, 728, 730, 732. No abstract available.

41.
42.
44.

An essential role for the Drosophila Pax2 homolog in the differentiation of adult sensory organs.

Kavaler J, Fu W, Duan H, Noll M, Posakony JW.

Development. 1999 May;126(10):2261-72.

45.

Birds on a wire and tiling the inner ear.

Posakony JW.

Nat Genet. 1999 Mar;21(3):253-4. No abstract available.

PMID:
10080171
46.
47.

Regulation of Drosophila neurogenesis by RNA:RNA duplexes?

Lai EC, Posakony JW.

Cell. 1998 Jun 26;93(7):1103-4. No abstract available.

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