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Items: 1 to 50 of 319

1.

Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice.

Bruce DJ, Peterson CD, Kitto KF, Akgün E, Lazzaroni S, Portoghese PS, Fairbanks CA, Wilcox GL.

Anesthesiology. 2019 Sep;131(3):649-663. doi: 10.1097/ALN.0000000000002840.

PMID:
31343460
2.

Targeting MOR-mGluR5 heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5.

Shueb SS, Erb SJ, Lunzer MM, Speltz R, Harding-Rose C, Akgün E, Simone DA, Portoghese PS.

Neuropharmacology. 2019 Dec 1;160:107690. doi: 10.1016/j.neuropharm.2019.107690. Epub 2019 Jul 1.

PMID:
31271770
3.

Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling.

Zhang X, Peng Y, Grace PM, Metcalf MD, Kwilasz AJ, Wang Y, Zhang T, Wu S, Selfridge BR, Portoghese PS, Rice KC, Watkins LR, Hutchinson MR, Wang X.

FASEB J. 2019 Aug;33(8):9577-9587. doi: 10.1096/fj.201900173RRR. Epub 2019 Jun 4.

4.

The bivalent ligand MCC22 potently attenuates hyperalgesia in a mouse model of cisplatin-evoked neuropathic pain without tolerance or reward.

Cataldo G, Erb SJ, Lunzer MM, Luong N, Akgün E, Portoghese PS, Olson JK, Simone DA.

Neuropharmacology. 2019 Nov 1;158:107598. doi: 10.1016/j.neuropharm.2019.04.004. Epub 2019 Apr 7.

PMID:
30970233
5.

Combined Glia Inhibition and Opioid Receptor Agonism Afford Highly Potent Analgesics without Tolerance.

Akgün E, Lunzer MM, Portoghese PS.

ACS Chem Neurosci. 2019 Apr 17;10(4):2004-2011. doi: 10.1021/acschemneuro.8b00323. Epub 2018 Aug 24.

PMID:
30110531
6.

A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance.

Dutta R, Lunzer MM, Auger JL, Akgün E, Portoghese PS, Binstadt BA.

Arthritis Res Ther. 2018 Jul 27;20(1):154. doi: 10.1186/s13075-018-1661-5.

7.

Bivalent ligand MCC22 potently attenuates nociception in a murine model of sickle cell disease.

Cataldo G, Lunzer MM, Olson JK, Akgün E, Belcher JD, Vercellotti GM, Portoghese PS, Simone DA.

Pain. 2018 Jul;159(7):1382-1391. doi: 10.1097/j.pain.0000000000001225.

8.

Bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice.

Peterson CD, Kitto KF, Akgün E, Lunzer MM, Riedl MS, Vulchanova L, Wilcox GL, Portoghese PS, Fairbanks CA.

Pain. 2017 Dec;158(12):2431-2441. doi: 10.1097/j.pain.0000000000001050.

9.

Heteromer Induction: An Approach to Unique Pharmacology?

Portoghese PS, Akgün E, Lunzer MM.

ACS Chem Neurosci. 2017 Mar 15;8(3):426-428. doi: 10.1021/acschemneuro.7b00002. Epub 2017 Jan 31.

PMID:
28139906
10.

Modulation of musculoskeletal hyperalgesia by brown adipose tissue activity in mice.

Goudie-DeAngelis EM, Abdelhamid RE, Nunez MG, Kissel CL, Kovács KJ, Portoghese PS, Larson AA.

Pain. 2016 Nov;157(11):2561-2570.

11.

Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5).

Akgün E, Javed MI, Lunzer MM, Powers MD, Sham YY, Watanabe Y, Portoghese PS.

J Med Chem. 2015 Nov 12;58(21):8647-57. doi: 10.1021/acs.jmedchem.5b01245. Epub 2015 Oct 20.

12.

Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model.

Smeester BA, Lunzer MM, Akgün E, Beitz AJ, Portoghese PS.

Eur J Pharmacol. 2014 Nov 15;743:48-52. doi: 10.1016/j.ejphar.2014.09.008. Epub 2014 Sep 17.

13.

Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects.

Le Naour M, Lunzer MM, Powers MD, Kalyuzhny AE, Benneyworth MA, Thomas MJ, Portoghese PS.

J Med Chem. 2014 Aug 14;57(15):6383-92. doi: 10.1021/jm500159d. Epub 2014 Jul 18.

14.

Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception.

Akgün E, Javed MI, Lunzer MM, Smeester BA, Beitz AJ, Portoghese PS.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11595-9. doi: 10.1073/pnas.1305461110. Epub 2013 Jun 24.

15.

Bivalent ligands that target μ opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance.

Le Naour M, Akgün E, Yekkirala A, Lunzer MM, Powers MD, Kalyuzhny AE, Portoghese PS.

J Med Chem. 2013 Jul 11;56(13):5505-13. doi: 10.1021/jm4005219. Epub 2013 Jun 20.

16.

An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands.

Yekkirala AS, Kalyuzhny AE, Portoghese PS.

ACS Chem Biol. 2013 Jul 19;8(7):1412-6. doi: 10.1021/cb400113d. Epub 2013 May 17.

17.

Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens.

Pravetoni M, Le Naour M, Tucker AM, Harmon TM, Hawley TM, Portoghese PS, Pentel PR.

J Med Chem. 2013 Feb 14;56(3):915-23. doi: 10.1021/jm3013745. Epub 2013 Jan 15.

18.

Clinically employed opioid analgesics produce antinociception via μ-δ opioid receptor heteromers in Rhesus monkeys.

Yekkirala AS, Banks ML, Lunzer MM, Negus SS, Rice KC, Portoghese PS.

ACS Chem Neurosci. 2012 Sep 19;3(9):720-7. Epub 2012 Jul 5.

19.

The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors.

Metcalf MD, Yekkirala AS, Powers MD, Kitto KF, Fairbanks CA, Wilcox GL, Portoghese PS.

ACS Chem Neurosci. 2012 Jul 18;3(7):505-9. doi: 10.1021/cn3000394. Epub 2012 May 22.

20.

Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats.

Pravetoni M, Raleigh MD, Le Naour M, Tucker AM, Harmon TM, Jones JM, Birnbaum AK, Portoghese PS, Pentel PR.

Vaccine. 2012 Jun 29;30(31):4617-24. doi: 10.1016/j.vaccine.2012.04.101. Epub 2012 May 11.

21.

Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor.

Cawston EE, Lam PC, Harikumar KG, Dong M, Ball AM, Augustine ML, Akgün E, Portoghese PS, Orry A, Abagyan R, Sexton PM, Miller LJ.

J Biol Chem. 2012 May 25;287(22):18618-35. doi: 10.1074/jbc.M111.335646. Epub 2012 Mar 30.

22.

An oxycodone conjugate vaccine elicits drug-specific antibodies that reduce oxycodone distribution to brain and hot-plate analgesia.

Pravetoni M, Le Naour M, Harmon TM, Tucker AM, Portoghese PS, Pentel PR.

J Pharmacol Exp Ther. 2012 Apr;341(1):225-32. doi: 10.1124/jpet.111.189506. Epub 2012 Jan 18.

23.

MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys.

Aceto MD, Harris LS, Negus SS, Banks ML, Hughes LD, Akgün E, Portoghese PS.

Int J Med Chem. 2012;2012:327257. doi: 10.1155/2012/327257. Epub 2012 Apr 29.

24.

Opioid activity of spinally selective analogues of N-naphthoyl-β-naltrexamine in HEK-293 cells and mice.

Le Naour M, Lunzer MM, Powers MD, Portoghese PS.

J Med Chem. 2012 Jan 26;55(2):670-7. doi: 10.1021/jm200902v. Epub 2012 Jan 5.

25.

Allosteric interactions between δ and κ opioid receptors in peripheral sensory neurons.

Berg KA, Rowan MP, Gupta A, Sanchez TA, Silva M, Gomes I, McGuire BA, Portoghese PS, Hargreaves KM, Devi LA, Clarke WP.

Mol Pharmacol. 2012 Feb;81(2):264-72. doi: 10.1124/mol.111.072702. Epub 2011 Nov 9.

26.

My farewell to the Journal of Medicinal Chemistry.

Portoghese PS.

J Med Chem. 2011 Dec 22;54(24):8235. doi: 10.1021/jm201370n. Epub 2011 Nov 9. No abstract available.

PMID:
22070537
27.

The FEMA GRAS assessment of aliphatic and aromatic terpene hydrocarbons used as flavor ingredients.

Adams TB, Gavin CL, McGowen MM, Waddell WJ, Cohen SM, Feron VJ, Marnett LJ, Munro IC, Portoghese PS, Rietjens IM, Smith RL.

Food Chem Toxicol. 2011 Oct;49(10):2471-94. doi: 10.1016/j.fct.2011.06.011. Epub 2011 Jul 2. Review.

PMID:
21726592
28.

N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers.

Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5098-103. doi: 10.1073/pnas.1016277108. Epub 2011 Mar 8.

29.

A κ Opioid Pharmacophore Becomes a Spinally Selective κ-δ Agonist When Modified with a Basic Extender Arm.

Tang Y, Yang J, Lunzer MM, Powers MD, Portoghese PS.

ACS Med Chem Lett. 2010 Oct 27;2(1):7-10. doi: 10.1021/ml1001294. eCollection 2011 Jan 13.

30.

Consequences of opioid receptor mutation on actions of univalent and bivalent kappa and delta ligands.

Ansonoff MA, Portoghese PS, Pintar JE.

Psychopharmacology (Berl). 2010 Jun;210(2):161-8. doi: 10.1007/s00213-010-1826-7. Epub 2010 Mar 24.

PMID:
20333506
31.

Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization.

Harikumar KG, Akgün E, Portoghese PS, Miller LJ.

J Med Chem. 2010 Apr 8;53(7):2836-42. doi: 10.1021/jm100135g.

32.

Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonists.

Yekkirala AS, Kalyuzhny AE, Portoghese PS.

ACS Chem Neurosci. 2010 Feb 17;1(2):146-54. doi: 10.1021/cn9000236. Epub 2009 Nov 25.

33.

A bivalent ligand (KMN-21) antagonist for mu/kappa heterodimeric opioid receptors.

Zhang S, Yekkirala A, Tang Y, Portoghese PS.

Bioorg Med Chem Lett. 2009 Dec 15;19(24):6978-80. doi: 10.1016/j.bmcl.2009.10.045. Epub 2009 Nov 4.

34.

Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and type 2 cholecystokinin receptors.

Akgün E, Körner M, Gao F, Harikumar KG, Waser B, Reubi JC, Portoghese PS, Miller LJ.

J Med Chem. 2009 Apr 9;52(7):2138-47. doi: 10.1021/jm801439x.

35.

Revision of purity criteria for tested compounds.

Portoghese PS.

J Med Chem. 2009 Jan 8;52(1):1. doi: 10.1021/jm801525s. No abstract available.

PMID:
19118478
36.

Induced association of mu opioid (MOP) and type 2 cholecystokinin (CCK2) receptors by novel bivalent ligands.

Zheng Y, Akgün E, Harikumar KG, Hopson J, Powers MD, Lunzer MM, Miller LJ, Portoghese PS.

J Med Chem. 2009 Jan 22;52(2):247-58. doi: 10.1021/jm800174p.

37.

The FEMA GRAS assessment of alpha,beta-unsaturated aldehydes and related substances used as flavor ingredients.

Adams TB, Gavin CL, Taylor SV, Waddell WJ, Cohen SM, Feron VJ, Goodman J, Rietjens IM, Marnett LJ, Portoghese PS, Smith RL.

Food Chem Toxicol. 2008 Sep;46(9):2935-67. doi: 10.1016/j.fct.2008.06.082. Epub 2008 Jul 3. Review. Erratum in: Food Chem Toxicol. 2009 Oct;47(10):2686.

PMID:
18644420
38.

o-Naphthalenedicarboxaldehyde derivative of 7'-aminonaltrindole as a selective delta-opioid receptor affinity label.

Haris SP, Zhang Y, Le Bourdonnec B, McCurdy CR, Portoghese PS.

J Med Chem. 2007 Jul 12;50(14):3392-6. Epub 2007 Jun 8.

PMID:
17555306
39.

Selectivity of delta- and kappa-opioid ligands depends on the route of central administration in mice.

Lunzer MM, Portoghese PS.

J Pharmacol Exp Ther. 2007 Jul;322(1):166-71. Epub 2007 Mar 30.

PMID:
17400888
40.

Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia.

Lunzer MM, Yekkirala A, Hebbel RP, Portoghese PS.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):6061-5. Epub 2007 Mar 26.

41.

Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores.

Lenard NR, Daniels DJ, Portoghese PS, Roerig SC.

Eur J Pharmacol. 2007 Jul 2;566(1-3):75-82. Epub 2007 Mar 3.

PMID:
17383633
42.

The FEMA GRAS assessment of aromatic substituted secondary alcohols, ketones, and related esters used as flavor ingredients.

Adams TB, McGowen MM, Williams MC, Cohen SM, Feron VJ, Goodman JI, Marnett LJ, Munro IC, Portoghese PS, Smith RL, Waddell WJ.

Food Chem Toxicol. 2007 Feb;45(2):171-201. Epub 2006 Aug 30. Review.

PMID:
17046133
43.

Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series.

Daniels DJ, Lenard NR, Etienne CL, Law PY, Roerig SC, Portoghese PS.

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19208-13. Epub 2005 Dec 19.

44.

Interaction of bivalent ligand KDN21 with heterodimeric delta-kappa opioid receptors in human embryonic kidney 293 cells.

Xie Z, Bhushan RG, Daniels DJ, Portoghese PS.

Mol Pharmacol. 2005 Oct;68(4):1079-86. Epub 2005 Jul 8.

PMID:
16006595
45.

The FEMA GRAS assessment of hydroxy- and alkoxy-substituted benzyl derivatives used as flavor ingredients.

Adams TB, Cohen SM, Doull J, Feron VJ, Goodman JI, Marnett LJ, Munro IC, Portoghese PS, Smith RL, Waddell WJ, Wagner BM; Expert Panel of the Flavor and Extract Manufacturers Association.

Food Chem Toxicol. 2005 Aug;43(8):1241-71. Epub 2005 Apr 1. Review.

PMID:
15950816
46.

The FEMA GRAS assessment of benzyl derivatives used as flavor ingredients.

Adams TB, Cohen SM, Doull J, Feron VJ, Goodman JI, Marnett LJ, Munro IC, Portoghese PS, Smith RL, Waddell WJ, Wagner BM; Expert Panel of the Flavor and Extract Manufacturers Association.

Food Chem Toxicol. 2005 Aug;43(8):1207-40. Epub 2005 Jan 26. Review.

PMID:
15950815
47.

The FEMA GRAS assessment of phenethyl alcohol, aldehyde, acid, and related acetals and esters used as flavor ingredients.

Adams TB, Cohen SM, Doull J, Feron VJ, Goodman JI, Marnett LJ, Munro IC, Portoghese PS, Smith RL, Waddell WJ, Wagner BM; Expert Panel of the Flavor and Extract Manufacturers Association.

Food Chem Toxicol. 2005 Aug;43(8):1179-206. Epub 2005 Jan 26. Review.

PMID:
15950814
48.

Criteria for the safety evaluation of flavoring substances. The Expert Panel of the Flavor and Extract Manufacturers Association.

Smith RL, Cohen SM, Doull J, Feron VJ, Goodman JI, Marnett LJ, Munro IC, Portoghese PS, Waddell WJ, Wagner BM, Adams TB; Expert Panel of the Flavor and Extract Manufacturers Association.

Food Chem Toxicol. 2005 Aug;43(8):1141-77. Epub 2005 Apr 18. Review.

PMID:
15950813
49.

A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers.

Waldhoer M, Fong J, Jones RM, Lunzer MM, Sharma SK, Kostenis E, Portoghese PS, Whistler JL.

Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):9050-5. Epub 2005 Jun 2.

50.

Homology modeling and molecular dynamics simulations of the mu opioid receptor in a membrane-aqueous system.

Zhang Y, Sham YY, Rajamani R, Gao J, Portoghese PS.

Chembiochem. 2005 May;6(5):853-9.

PMID:
15776407

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