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Items: 1 to 50 of 147

1.

A Potent and Effective Suicidal Listeria Vaccine Platform.

Hanson WG, Benanti EL, Lemmens EE, Liu W, Skoble J, Leong ML, Rae CS, Fassò M, Brockstedt DG, Chen C, Portnoy DA, Dubensky TW Jr, Lauer P.

Infect Immun. 2019 Jul 23;87(8). pii: e00144-19. doi: 10.1128/IAI.00144-19. Print 2019 Aug.

2.

Listeriolysin O: A phagosome-specific cytolysin revisited.

Nguyen BN, Peterson BN, Portnoy DA.

Cell Microbiol. 2019 Mar;21(3):e12988. doi: 10.1111/cmi.12988. Epub 2019 Jan 15. Review.

PMID:
30511471
3.

A flavin-based extracellular electron transfer mechanism in diverse Gram-positive bacteria.

Light SH, Su L, Rivera-Lugo R, Cornejo JA, Louie A, Iavarone AT, Ajo-Franklin CM, Portnoy DA.

Nature. 2018 Oct;562(7725):140-144. doi: 10.1038/s41586-018-0498-z. Epub 2018 Sep 12.

4.

An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses.

Penn BH, Netter Z, Johnson JR, Von Dollen J, Jang GM, Johnson T, Ohol YM, Maher C, Bell SL, Geiger K, Golovkine G, Du X, Choi A, Parry T, Mohapatra BC, Storck MD, Band H, Chen C, Jäger S, Shales M, Portnoy DA, Hernandez R, Coscoy L, Cox JS, Krogan NJ.

Mol Cell. 2018 Aug 16;71(4):637-648.e5. doi: 10.1016/j.molcel.2018.07.010.

5.

Recombinant Listeria promotes tumor rejection by CD8+ T cell-dependent remodeling of the tumor microenvironment.

Deng W, Lira V, Hudson TE, Lemmens EE, Hanson WG, Flores R, Barajas G, Katibah GE, Desbien AL, Lauer P, Leong ML, Portnoy DA, Dubensky TW Jr.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8179-8184. doi: 10.1073/pnas.1801910115. Epub 2018 Jul 23.

6.

The Listeriolysin O PEST-like Sequence Co-opts AP-2-Mediated Endocytosis to Prevent Plasma Membrane Damage during Listeria Infection.

Chen C, Nguyen BN, Mitchell G, Margolis SR, Ma D, Portnoy DA.

Cell Host Microbe. 2018 Jun 13;23(6):786-795.e5. doi: 10.1016/j.chom.2018.05.006.

7.

Actin-based motility allows Listeria monocytogenes to avoid autophagy in the macrophage cytosol.

Cheng MI, Chen C, Engström P, Portnoy DA, Mitchell G.

Cell Microbiol. 2018 Sep;20(9):e12854. doi: 10.1111/cmi.12854. Epub 2018 May 30.

8.

STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection.

Van Dis E, Sogi KM, Rae CS, Sivick KE, Surh NH, Leong ML, Kanne DB, Metchette K, Leong JJ, Bruml JR, Chen V, Heydari K, Cadieux N, Evans T, McWhirter SM, Dubensky TW Jr, Portnoy DA, Stanley SA.

Cell Rep. 2018 May 1;23(5):1435-1447. doi: 10.1016/j.celrep.2018.04.003.

9.

Listeria monocytogenes triggers noncanonical autophagy upon phagocytosis, but avoids subsequent growth-restricting xenophagy.

Mitchell G, Cheng MI, Chen C, Nguyen BN, Whiteley AT, Kianian S, Cox JS, Green DR, McDonald KL, Portnoy DA.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E210-E217. doi: 10.1073/pnas.1716055115. Epub 2017 Dec 26.

10.

Activation of the Listeria monocytogenes Virulence Program by a Reducing Environment.

Portman JL, Dubensky SB, Peterson BN, Whiteley AT, Portnoy DA.

MBio. 2017 Oct 17;8(5). pii: e01595-17. doi: 10.1128/mBio.01595-17.

11.

Listening to each other: Infectious disease and cancer immunology.

Vance RE, Eichberg MJ, Portnoy DA, Raulet DH.

Sci Immunol. 2017 Jan 13;2(7). pii: eaai9339. doi: 10.1126/sciimmunol.aai9339. Review.

12.

Activity of the Pore-Forming Virulence Factor Listeriolysin O Is Reversibly Inhibited by Naturally Occurring S-Glutathionylation.

Portman JL, Huang Q, Reniere ML, Iavarone AT, Portnoy DA.

Infect Immun. 2017 Mar 23;85(4). pii: e00959-16. doi: 10.1128/IAI.00959-16. Print 2017 Apr.

13.

c-di-AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance and osmoregulation.

Whiteley AT, Garelis NE, Peterson BN, Choi PH, Tong L, Woodward JJ, Portnoy DA.

Mol Microbiol. 2017 Apr;104(2):212-233. doi: 10.1111/mmi.13622. Epub 2017 Mar 8.

14.

Identification of Coxiella burnetii CD8+ T-Cell Epitopes and Delivery by Attenuated Listeria monocytogenes as a Vaccine Vector in a C57BL/6 Mouse Model.

Xiong X, Jiao J, Gregory AE, Wang P, Bi Y, Wang X, Jiang Y, Wen B, Portnoy DA, Samuel JE, Chen C.

J Infect Dis. 2017 May 15;215(10):1580-1589. doi: 10.1093/infdis/jiw470.

15.

An In Vivo Selection Identifies Listeria monocytogenes Genes Required to Sense the Intracellular Environment and Activate Virulence Factor Expression.

Reniere ML, Whiteley AT, Portnoy DA.

PLoS Pathog. 2016 Jul 14;12(7):e1005741. doi: 10.1371/journal.ppat.1005741. eCollection 2016 Jul.

16.

Strategies Used by Bacteria to Grow in Macrophages.

Mitchell G, Chen C, Portnoy DA.

Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.MCHD-0012-2015. Review.

17.
18.

Ribosome hibernation facilitates tolerance of stationary-phase bacteria to aminoglycosides.

McKay SL, Portnoy DA.

Antimicrob Agents Chemother. 2015 Nov;59(11):6992-9. doi: 10.1128/AAC.01532-15. Epub 2015 Aug 31.

19.

The PAMP c-di-AMP Is Essential for Listeria monocytogenes Growth in Rich but Not Minimal Media due to a Toxic Increase in (p)ppGpp. [corrected].

Whiteley AT, Pollock AJ, Portnoy DA.

Cell Host Microbe. 2015 Jun 10;17(6):788-98. doi: 10.1016/j.chom.2015.05.006. Epub 2015 May 28. Erratum in: Cell Host Microbe. 2015 Jul 8;18(1):132.

20.

RNA-Based Fluorescent Biosensors for Live Cell Imaging of Second Messenger Cyclic di-AMP.

Kellenberger CA, Chen C, Whiteley AT, Portnoy DA, Hammond MC.

J Am Chem Soc. 2015 May 27;137(20):6432-5. doi: 10.1021/jacs.5b00275. Epub 2015 May 15.

21.

Host actin polymerization tunes the cell division cycle of an intracellular pathogen.

Siegrist MS, Aditham AK, Espaillat A, Cameron TA, Whiteside SA, Cava F, Portnoy DA, Bertozzi CR.

Cell Rep. 2015 Apr 28;11(4):499-507. doi: 10.1016/j.celrep.2015.03.046. Epub 2015 Apr 16.

22.

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade.

Fu J, Kanne DB, Leong M, Glickman LH, McWhirter SM, Lemmens E, Mechette K, Leong JJ, Lauer P, Liu W, Sivick KE, Zeng Q, Soares KC, Zheng L, Portnoy DA, Woodward JJ, Pardoll DM, Dubensky TW Jr, Kim Y.

Sci Transl Med. 2015 Apr 15;7(283):283ra52. doi: 10.1126/scitranslmed.aaa4306.

23.

Avoidance of autophagy mediated by PlcA or ActA is required for Listeria monocytogenes growth in macrophages.

Mitchell G, Ge L, Huang Q, Chen C, Kianian S, Roberts MF, Schekman R, Portnoy DA.

Infect Immun. 2015 May;83(5):2175-84. doi: 10.1128/IAI.00110-15. Epub 2015 Mar 16.

24.

Glutathione activates virulence gene expression of an intracellular pathogen.

Reniere ML, Whiteley AT, Hamilton KL, John SM, Lauer P, Brennan RG, Portnoy DA.

Nature. 2015 Jan 8;517(7533):170-3. doi: 10.1038/nature14029.

25.

A prl mutation in SecY suppresses secretion and virulence defects of Listeria monocytogenes secA2 mutants.

Durack J, Burke TP, Portnoy DA.

J Bacteriol. 2015 Mar;197(5):932-42. doi: 10.1128/JB.02284-14. Epub 2014 Dec 22.

26.

The Listeria monocytogenes hibernation-promoting factor is required for the formation of 100S ribosomes, optimal fitness, and pathogenesis.

Kline BC, McKay SL, Tang WW, Portnoy DA.

J Bacteriol. 2015 Feb;197(3):581-91. doi: 10.1128/JB.02223-14. Epub 2014 Nov 24.

27.

Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, of cell wall-modifying enzymes.

Burke TP, Loukitcheva A, Zemansky J, Wheeler R, Boneca IG, Portnoy DA.

J Bacteriol. 2014 Nov;196(21):3756-67. doi: 10.1128/JB.02053-14. Epub 2014 Aug 25.

28.

Comparison of widely used Listeria monocytogenes strains EGD, 10403S, and EGD-e highlights genomic variations underlying differences in pathogenicity.

Bécavin C, Bouchier C, Lechat P, Archambaud C, Creno S, Gouin E, Wu Z, Kühbacher A, Brisse S, Pucciarelli MG, García-del Portillo F, Hain T, Portnoy DA, Chakraborty T, Lecuit M, Pizarro-Cerdá J, Moszer I, Bierne H, Cossart P.

MBio. 2014 Mar 25;5(2):e00969-14. doi: 10.1128/mBio.00969-14.

29.

STING-dependent type I IFN production inhibits cell-mediated immunity to Listeria monocytogenes.

Archer KA, Durack J, Portnoy DA.

PLoS Pathog. 2014 Jan;10(1):e1003861. doi: 10.1371/journal.ppat.1003861. Epub 2014 Jan 2.

30.

Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection.

Witte CE, Whiteley AT, Burke TP, Sauer JD, Portnoy DA, Woodward JJ.

MBio. 2013 May 28;4(3):e00282-13. doi: 10.1128/mBio.00282-13.

31.

Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages.

Manzanillo PS, Shiloh MU, Portnoy DA, Cox JS.

Cell Host Microbe. 2012 May 17;11(5):469-80. doi: 10.1016/j.chom.2012.03.007.

32.

Yogi Berra, Forrest Gump, and the discovery of Listeria actin comet tails.

Portnoy DA.

Mol Biol Cell. 2012 Apr;23(7):1141-5. doi: 10.1091/mbc.E11-10-0894.

33.
34.

Hyperinduction of host beta interferon by a Listeria monocytogenes strain naturally overexpressing the multidrug efflux pump MdrT.

Schwartz KT, Carleton JD, Quillin SJ, Rollins SD, Portnoy DA, Leber JH.

Infect Immun. 2012 Apr;80(4):1537-45. doi: 10.1128/IAI.06286-11. Epub 2012 Jan 30.

35.

Innate immune pathways triggered by Listeria monocytogenes and their role in the induction of cell-mediated immunity.

Witte CE, Archer KA, Rae CS, Sauer JD, Woodward JJ, Portnoy DA.

Adv Immunol. 2012;113:135-56. doi: 10.1016/B978-0-12-394590-7.00002-6. Review.

PMID:
22244582
36.

Oral infection with signature-tagged Listeria monocytogenes reveals organ-specific growth and dissemination routes in guinea pigs.

Melton-Witt JA, Rafelski SM, Portnoy DA, Bakardjiev AI.

Infect Immun. 2012 Feb;80(2):720-32. doi: 10.1128/IAI.05958-11. Epub 2011 Nov 14.

37.

Posttranslocation chaperone PrsA2 regulates the maturation and secretion of Listeria monocytogenes proprotein virulence factors.

Forster BM, Zemansky J, Portnoy DA, Marquis H.

J Bacteriol. 2011 Nov;193(21):5961-70. doi: 10.1128/JB.05307-11. Epub 2011 Sep 9.

38.
39.

Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity.

Sauer JD, Pereyre S, Archer KA, Burke TP, Hanson B, Lauer P, Portnoy DA.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12419-24. doi: 10.1073/pnas.1019041108. Epub 2011 Jul 11.

40.

Dynamic imaging of the effector immune response to listeria infection in vivo.

Waite JC, Leiner I, Lauer P, Rae CS, Barbet G, Zheng H, Portnoy DA, Pamer EG, Dustin ML.

PLoS Pathog. 2011 Mar;7(3):e1001326. doi: 10.1371/journal.ppat.1001326. Epub 2011 Mar 24.

41.

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides.

Sauer JD, Sotelo-Troha K, von Moltke J, Monroe KM, Rae CS, Brubaker SW, Hyodo M, Hayakawa Y, Woodward JJ, Portnoy DA, Vance RE.

Infect Immun. 2011 Feb;79(2):688-94. doi: 10.1128/IAI.00999-10. Epub 2010 Nov 22.

42.

c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response.

Woodward JJ, Iavarone AT, Portnoy DA.

Science. 2010 Jun 25;328(5986):1703-5. doi: 10.1126/science.1189801. Epub 2010 May 27.

43.

Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol.

Sauer JD, Witte CE, Zemansky J, Hanson B, Lauer P, Portnoy DA.

Cell Host Microbe. 2010 May 20;7(5):412-9. doi: 10.1016/j.chom.2010.04.004. Epub 2010 Apr 22.

44.

Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria.

Bahjat KS, Meyer-Morse N, Lemmens EE, Shugart JA, Dubensky TW, Brockstedt DG, Portnoy DA.

PLoS Pathog. 2009 Sep;5(9):e1000568. doi: 10.1371/journal.ppat.1000568. Epub 2009 Sep 4.

45.

Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system.

Vance RE, Isberg RR, Portnoy DA.

Cell Host Microbe. 2009 Jul 23;6(1):10-21. doi: 10.1016/j.chom.2009.06.007. Review.

46.

Listeria monocytogenes 6-Phosphogluconolactonase mutants induce increased activation of a host cytosolic surveillance pathway.

Crimmins GT, Schelle MW, Herskovits AA, Ni PP, Kline BC, Meyer-Morse N, Iavarone AT, Portnoy DA.

Infect Immun. 2009 Jul;77(7):3014-22. doi: 10.1128/IAI.01511-08. Epub 2009 Apr 27.

47.

Development of a mariner-based transposon and identification of Listeria monocytogenes determinants, including the peptidyl-prolyl isomerase PrsA2, that contribute to its hemolytic phenotype.

Zemansky J, Kline BC, Woodward JJ, Leber JH, Marquis H, Portnoy DA.

J Bacteriol. 2009 Jun;191(12):3950-64. doi: 10.1128/JB.00016-09. Epub 2009 Apr 17.

48.

Killed but metabolically active Bacillus anthracis vaccines induce broad and protective immunity against anthrax.

Skoble J, Beaber JW, Gao Y, Lovchik JA, Sower LE, Liu W, Luckett W, Peterson JW, Calendar R, Portnoy DA, Lyons CR, Dubensky TW Jr.

Infect Immun. 2009 Apr;77(4):1649-63. doi: 10.1128/IAI.00530-08. Epub 2009 Jan 21.

49.

Listeria monocytogenes multidrug resistance transporters activate a cytosolic surveillance pathway of innate immunity.

Crimmins GT, Herskovits AA, Rehder K, Sivick KE, Lauer P, Dubensky TW Jr, Portnoy DA.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10191-6. doi: 10.1073/pnas.0804170105. Epub 2008 Jul 16.

50.

Distinct TLR- and NLR-mediated transcriptional responses to an intracellular pathogen.

Leber JH, Crimmins GT, Raghavan S, Meyer-Morse NP, Cox JS, Portnoy DA.

PLoS Pathog. 2008 Jan;4(1):e6. doi: 10.1371/journal.ppat.0040006.

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