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Protein-protein interactions involving enzymes of the mammalian methionine and homocysteine metabolism.

Portillo F, Vázquez J, Pajares MA.

Biochimie. 2020 Feb 24. pii: S0300-9084(20)30043-2. doi: 10.1016/j.biochi.2020.02.015. [Epub ahead of print] Review.


Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice.

Tashkandi M, Ali F, Alsaqer S, Alhousami T, Cano A, Martin A, Salvador F, Portillo F, C Gerstenfeld L, Goldring MB, Bais MV.

Int J Mol Sci. 2019 Sep 27;20(19). pii: E4798. doi: 10.3390/ijms20194798.


Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1.

García-Morales V, Rodríguez-Bey G, Gómez-Pérez L, Domínguez-Vías G, González-Forero D, Portillo F, Campos-Caro A, Gento-Caro Á, Issaoui N, Soler RM, Garcera A, Moreno-López B.

Nat Commun. 2019 Aug 22;10(1):3784. doi: 10.1038/s41467-019-11637-4.


UPR: An Upstream Signal to EMT Induction in Cancer.

Santamaría PG, Mazón MJ, Eraso P, Portillo F.

J Clin Med. 2019 May 8;8(5). pii: E624. doi: 10.3390/jcm8050624. Review.


Evolutionary history of burrowing asps (Lamprophiidae: Atractaspidinae) with emphasis on fang evolution and prey selection.

Portillo F, Stanley EL, Branch WR, Conradie W, Rödel MO, Penner J, Barej MF, Kusamba C, Muninga WM, Aristote MM, Bauer AM, Trape JF, Nagy ZT, Carlino P, Pauwels OSG, Menegon M, Ineich I, Burger M, Zassi-Boulou AG, Mazuch T, Jackson K, Hughes DF, Behangana M, Greenbaum E.

PLoS One. 2019 Apr 17;14(4):e0214889. doi: 10.1371/journal.pone.0214889. eCollection 2019. Erratum in: PLoS One. 2019 May 13;14(5):e0217035.


Identification of hepatic protein-protein interaction targets for betaine homocysteine S-methyltransferase.

Garrido F, Pacheco M, Vargas-Martínez R, Velasco-García R, Jorge I, Serrano H, Portillo F, Vázquez J, Pajares MÁ.

PLoS One. 2018 Jun 20;13(6):e0199472. doi: 10.1371/journal.pone.0199472. eCollection 2018.


Phylogeny and biogeography of the African burrowing snake subfamily Aparallactinae (Squamata: Lamprophiidae).

Portillo F, Branch WR, Conradie W, Rödel MO, Penner J, Barej MF, Kusamba C, Muninga WM, Aristote MM, Bauer AM, Trape JF, Nagy ZT, Carlino P, Pauwels OSG, Menegon M, Burger M, Mazuch T, Jackson K, Hughes DF, Behangana M, Zassi-Boulou AG, Greenbaum E.

Mol Phylogenet Evol. 2018 Oct;127:288-303. doi: 10.1016/j.ympev.2018.03.019. Epub 2018 Mar 15.


Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability.

Santamaría PG, Floristán A, Fontanals-Cirera B, Vázquez-Naharro A, Santos V, Morales S, Yuste L, Peinado H, García-Gómez A, Portillo F, Hernando E, Cano A.

Cell Death Differ. 2018 May;25(5):935-950. doi: 10.1038/s41418-017-0030-2. Epub 2017 Dec 11.


Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer.

Salvador F, Martin A, López-Menéndez C, Moreno-Bueno G, Santos V, Vázquez-Naharro A, Santamaria PG, Morales S, Dubus PR, Muinelo-Romay L, López-López R, Tung JC, Weaver VM, Portillo F, Cano A.

Cancer Res. 2017 Nov 1;77(21):5846-5859. doi: 10.1158/0008-5472.CAN-16-3152. Epub 2017 Jul 18.


EMT: Present and future in clinical oncology.

Santamaria PG, Moreno-Bueno G, Portillo F, Cano A.

Mol Oncol. 2017 Jul;11(7):718-738. doi: 10.1002/1878-0261.12091. Epub 2017 Jun 27. Review.


LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway.

Cuevas EP, Eraso P, Mazón MJ, Santos V, Moreno-Bueno G, Cano A, Portillo F.

Sci Rep. 2017 Mar 23;7:44988. doi: 10.1038/srep44988.


Correction: The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases.

Pérez C, Pérez-Zúñiga FJ, Garrido F, Reytor E, Portillo F, Pajares MA.

PLoS One. 2016 Sep 22;11(9):e0163761. doi: 10.1371/journal.pone.0163761. eCollection 2016.


The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases.

Pérez C, Pérez-Zúñiga FJ, Garrido F, Reytor E, Portillo F, Pajares MA.

PLoS One. 2016 Aug 22;11(8):e0161672. doi: 10.1371/journal.pone.0161672. eCollection 2016. Erratum in: PLoS One. 2016;11(9):e0163761.


Examining hippocampal function in schizophrenia using a virtual reality spatial navigation task.

Salgado-Pineda P, Landin-Romero R, Portillo F, Bosque C, Pomes A, Spanlang B, Franquelo JC, Teixido C, Sarró S, Salvador R, Slater M, Pomarol-Clotet E, McKenna PJ.

Schizophr Res. 2016 Apr;172(1-3):86-93. doi: 10.1016/j.schres.2016.02.033. Epub 2016 Feb 28.


Specific phosphoantibodies reveal two phosphorylation sites in yeast Pma1 in response to glucose.

Mazón MJ, Eraso P, Portillo F.

FEMS Yeast Res. 2015 Aug;15(5):fov030. doi: 10.1093/femsyr/fov030. Epub 2015 May 27.


Loss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors.

Villarejo A, Molina-Ortiz P, Montenegro Y, Moreno-Bueno G, Morales S, Santos V, Gridley T, Pérez-Moreno MA, Peinado H, Portillo F, Calés C, Cano A.

Carcinogenesis. 2015 May;36(5):585-97. doi: 10.1093/carcin/bgv021. Epub 2015 Mar 16.


Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.

Martin A, Salvador F, Moreno-Bueno G, Floristán A, Ruiz-Herguido C, Cuevas EP, Morales S, Santos V, Csiszar K, Dubus P, Haigh JJ, Bigas A, Portillo F, Cano A.

EMBO J. 2015 Apr 15;34(8):1090-109. doi: 10.15252/embj.201489975. Epub 2015 Mar 10.


Phylogeography and species boundaries of Leptopelis (Anura: Arthroleptidae) from the Albertine Rift.

Portillo F, Greenbaum E, Menegon M, Kusamba C, Maximilian Dehling J.

Mol Phylogenet Evol. 2015 Jan;82 Pt A:75-86. doi: 10.1016/j.ympev.2014.09.024. Epub 2014 Oct 5.


Zeb1 and Snail1 engage miR-200f transcriptional and epigenetic regulation during EMT.

Díaz-López A, Díaz-Martín J, Moreno-Bueno G, Cuevas EP, Santos V, Olmeda D, Portillo F, Palacios J, Cano A.

Int J Cancer. 2015 Feb 15;136(4):E62-73. doi: 10.1002/ijc.29177. Epub 2014 Sep 12.


Sin3b interacts with Myc and decreases Myc levels.

Garcia-Sanz P, Quintanilla A, Lafita MC, Moreno-Bueno G, García-Gutierrez L, Tabor V, Varela I, Shiio Y, Larsson LG, Portillo F, Leon J.

J Biol Chem. 2014 Aug 8;289(32):22221-36. doi: 10.1074/jbc.M113.538744. Epub 2014 Jun 20.


Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization.

Canesin G, Cuevas EP, Santos V, López-Menéndez C, Moreno-Bueno G, Huang Y, Csiszar K, Portillo F, Peinado H, Lyden D, Cano A.

Oncogene. 2015 Feb 19;34(8):951-64. doi: 10.1038/onc.2014.23. Epub 2014 Mar 17.


LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition.

Cuevas EP, Moreno-Bueno G, Canesin G, Santos V, Portillo F, Cano A.

Biol Open. 2014 Feb 15;3(2):129-37. doi: 10.1242/bio.20146841.


Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transition.

Villarejo A, Cortés-Cabrera A, Molina-Ortíz P, Portillo F, Cano A.

J Biol Chem. 2014 Jan 10;289(2):930-41. doi: 10.1074/jbc.M113.528026. Epub 2013 Dec 1.


eEF1A mediates the nuclear export of SNAG-containing proteins via the Exportin5-aminoacyl-tRNA complex.

Mingot JM, Vega S, Cano A, Portillo F, Nieto MA.

Cell Rep. 2013 Nov 14;5(3):727-37. doi: 10.1016/j.celrep.2013.09.030. Epub 2013 Oct 24. Erratum in: Cell Rep. 2014 Aug 7;8(3):922.


Characterization of two second-site mutations preventing wild type protein aggregation caused by a dominant negative PMA1 mutant.

Eraso P, Portillo F, Mazón MJ.

PLoS One. 2013 Jun 25;8(6):e67080. doi: 10.1371/journal.pone.0067080. Print 2013.


E47 and Id1 interplay in epithelial-mesenchymal transition.

Cubillo E, Diaz-Lopez A, Cuevas EP, Moreno-Bueno G, Peinado H, Montes A, Santos V, Portillo F, Cano A.

PLoS One. 2013;8(3):e59948. doi: 10.1371/journal.pone.0059948. Epub 2013 Mar 26.


Characterization of the SNAG and SLUG domains of Snail2 in the repression of E-cadherin and EMT induction: modulation by serine 4 phosphorylation.

Molina-Ortiz P, Villarejo A, MacPherson M, Santos V, Montes A, Souchelnytskyi S, Portillo F, Cano A.

PLoS One. 2012;7(5):e36132. doi: 10.1371/journal.pone.0036132. Epub 2012 May 2.


Systematics of the poorly known treefrog Leptopelis fiziensis (Anura: Arthroleptidae), with a description of its call.

Greenbaum E, Portillo F, Kusamba C.

Afr J Herpetol. 2012;61(2):113-127. Epub 2012 Sep 18.


Screening for mutations in Spanish families with myotonia. Functional analysis of novel mutations in CLCN1 gene.

Mazón MJ, Barros F, De la Peña P, Quesada JF, Escudero A, Cobo AM, Pascual-Pascual SI, Gutiérrez-Rivas E, Guillén E, Arpa J, Eraso P, Portillo F, Molano J.

Neuromuscul Disord. 2012 Mar;22(3):231-43. doi: 10.1016/j.nmd.2011.10.013. Epub 2011 Nov 16.


Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas.

Moreno-Bueno G, Salvador F, Martín A, Floristán A, Cuevas EP, Santos V, Montes A, Morales S, Castilla MA, Rojo-Sebastián A, Martínez A, Hardisson D, Csiszar K, Portillo F, Peinado H, Palacios J, Cano A.

EMBO Mol Med. 2011 Sep;3(9):528-44. doi: 10.1002/emmm.201100156. Epub 2011 Jul 6.


Gene expression profiling of yeasts overexpressing wild type or misfolded Pma1 variants reveals activation of the Hog1 MAPK pathway.

Eraso P, Mazón MJ, Posas F, Portillo F.

Mol Microbiol. 2011 Mar;79(5):1339-52. doi: 10.1111/j.1365-2958.2010.07528.x. Epub 2011 Jan 12.


NOS antagonism using viral vectors as an experimental strategy: implications for in vivo studies of cardiovascular control and peripheral neuropathies.

Liu B, Hewinson J, Xu H, Montero F, Sunico CR, Portillo F, Paton JF, Moreno-López B, Kasparov S.

Methods Mol Biol. 2011;704:197-223. doi: 10.1007/978-1-61737-964-2_15.


New insights into the fructosyltransferase activity of Schwanniomyces occidentalis ß-fructofuranosidase, emerging from nonconventional codon usage and directed mutation.

Alvaro-Benito M, de Abreu M, Portillo F, Sanz-Aparicio J, Fernández-Lobato M.

Appl Environ Microbiol. 2010 Nov;76(22):7491-9. doi: 10.1128/AEM.01614-10. Epub 2010 Sep 17.


Role of tau protein on neocortical and hippocampal oscillatory patterns.

Cantero JL, Moreno-Lopez B, Portillo F, Rubio A, Hita-Yañez E, Avila J.

Hippocampus. 2011 Aug;21(8):827-34. doi: 10.1002/hipo.20798. Epub 2010 May 20.


Tau protein role in sleep-wake cycle.

Cantero JL, Hita-Yañez E, Moreno-Lopez B, Portillo F, Rubio A, Avila J.

J Alzheimers Dis. 2010;21(2):411-21. doi: 10.3233/JAD-2010-100285.


An emerging role for class I bHLH E2-2 proteins in EMT regulation and tumor progression.

Cano A, Portillo F.

Cell Adh Migr. 2010 Jan-Mar;4(1):56-60. Epub 2010 Jan 3.


A dominant negative mutant of PMA1 interferes with the folding of the wild type enzyme.

Eraso P, Mazón MJ, Portillo F.

Traffic. 2010 Jan;11(1):37-47. doi: 10.1111/j.1600-0854.2009.01005.x.


Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A.

MacPherson MR, Molina P, Souchelnytskyi S, Wernstedt C, Martin-Pérez J, Portillo F, Cano A.

Mol Biol Cell. 2010 Jan 15;21(2):244-53. doi: 10.1091/mbc.E09-06-0504. Epub 2009 Nov 18.


Kidins220/ARMS modulates the activity of microtubule-regulating proteins and controls neuronal polarity and development.

Higuero AM, Sánchez-Ruiloba L, Doglio LE, Portillo F, Abad-Rodríguez J, Dotti CG, Iglesias T.

J Biol Chem. 2010 Jan 8;285(2):1343-57. doi: 10.1074/jbc.M109.024703. Epub 2009 Nov 10.


The morphological and molecular features of the epithelial-to-mesenchymal transition.

Moreno-Bueno G, Peinado H, Molina P, Olmeda D, Cubillo E, Santos V, Palacios J, Portillo F, Cano A.

Nat Protoc. 2009;4(11):1591-613. doi: 10.1038/nprot.2009.152. Epub 2009 Oct 15.


Semi-rigid tripeptide agonists of melanocortin receptors.

Ruwe AR, Koikov L, Abdel-Malek Z, Haskell-Luevano C, Dirain ML, Portillo F, Xiang Z, Wortman M, Knittel JJ.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5176-81. doi: 10.1016/j.bmcl.2009.07.025. Epub 2009 Jul 9.


A combination of ligand SAR and receptor site-directed mutagenesis reveals requirements for antagonist activity at the melanocortin-3 receptor.

Proneth B, Portillo FP, Haskell-Luevano C.

Adv Exp Med Biol. 2009;611:319-20. No abstract available.


The class I bHLH factors E2-2A and E2-2B regulate EMT.

Sobrado VR, Moreno-Bueno G, Cubillo E, Holt LJ, Nieto MA, Portillo F, Cano A.

J Cell Sci. 2009 Apr 1;122(Pt 7):1014-24. doi: 10.1242/jcs.028241.


Transcriptional regulation of cell polarity in EMT and cancer.

Moreno-Bueno G, Portillo F, Cano A.

Oncogene. 2008 Nov 24;27(55):6958-69. doi: 10.1038/onc.2008.346. Review.


Evidence for a detrimental role of nitric oxide synthesized by endothelial nitric oxide synthase after peripheral nerve injury.

Sunico CR, Portillo F, González-Forero D, Kasparov S, Moreno-López B.

Neuroscience. 2008 Nov 11;157(1):40-51. doi: 10.1016/j.neuroscience.2008.09.001. Epub 2008 Sep 9.


Structure-activity relationship and metabolic stability studies of backbone cyclization and N-methylation of melanocortin peptides.

Linde Y, Ovadia O, Safrai E, Xiang Z, Portillo FP, Shalev DE, Haskell-Luevano C, Hoffman A, Gilon C.

Biopolymers. 2008;90(5):671-82. doi: 10.1002/bip.21057.


The nitric oxide/cyclic guanosine monophosphate pathway modulates the inspiratory-related activity of hypoglossal motoneurons in the adult rat.

Montero F, Portillo F, González-Forero D, Moreno-López B.

Eur J Neurosci. 2008 Jul;28(1):107-16. doi: 10.1111/j.1460-9568.2008.06312.x.


Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas.

Peinado H, Moreno-Bueno G, Hardisson D, Pérez-Gómez E, Santos V, Mendiola M, de Diego JI, Nistal M, Quintanilla M, Portillo F, Cano A.

Cancer Res. 2008 Jun 15;68(12):4541-50. doi: 10.1158/0008-5472.CAN-07-6345.


Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines.

Olmeda D, Montes A, Moreno-Bueno G, Flores JM, Portillo F, Cano A.

Oncogene. 2008 Aug 7;27(34):4690-701. doi: 10.1038/onc.2008.118. Epub 2008 Apr 14.


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