Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 117

1.

Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.

Lindemann L, Porter RH, Scharf SH, Kuennecke B, Bruns A, von Kienlin M, Harrison AC, Paehler A, Funk C, Gloge A, Schneider M, Parrott NJ, Polonchuk L, Niederhauser U, Morairty SR, Kilduff TS, Vieira E, Kolczewski S, Wichmann J, Hartung T, Honer M, Borroni E, Moreau JL, Prinssen E, Spooren W, Wettstein JG, Jaeschke G.

J Pharmacol Exp Ther. 2015 Apr;353(1):213-33. doi: 10.1124/jpet.114.222463. Epub 2015 Feb 9.

PMID:
25665805
2.

Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.

Jaeschke G, Kolczewski S, Spooren W, Vieira E, Bitter-Stoll N, Boissin P, Borroni E, Büttelmann B, Ceccarelli S, Clemann N, David B, Funk C, Guba W, Harrison A, Hartung T, Honer M, Huwyler J, Kuratli M, Niederhauser U, Pähler A, Peters JU, Petersen A, Prinssen E, Ricci A, Rueher D, Rueher M, Schneider M, Spurr P, Stoll T, Tännler D, Wichmann J, Porter RH, Wettstein JG, Lindemann L.

J Med Chem. 2015 Feb 12;58(3):1358-71. doi: 10.1021/jm501642c. Epub 2015 Feb 2.

PMID:
25565255
3.

The effects of olfactory stimulation and gender differences on pain responses in full-term infants.

Romantsik O, Porter RH, Varendi H.

Acta Paediatr. 2014 Nov;103(11):1130-5. doi: 10.1111/apa.12759. Epub 2014 Aug 24.

PMID:
25060331
4.

Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease.

Wallace TL, Porter RH.

Biochem Pharmacol. 2011 Oct 15;82(8):891-903. doi: 10.1016/j.bcp.2011.06.034. Epub 2011 Jul 2. Review.

PMID:
21741954
5.

G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey.

Kratochwil NA, Gatti-McArthur S, Hoener MC, Lindemann L, Christ AD, Green LG, Guba W, Martin RE, Malherbe P, Porter RH, Slack JP, Winnig M, Dehmlow H, Grether U, Hertel C, Narquizian R, Panousis CG, Kolczewski S, Steward L.

Curr Top Med Chem. 2011;11(15):1902-24.

PMID:
21470172
6.

Characterization of RO4583298 as a novel potent, dual antagonist with in vivo activity at tachykinin NK₁ and NK₃ receptors.

Malherbe P, Knoflach F, Hernandez MC, Hoffmann T, Schnider P, Porter RH, Wettstein JG, Ballard TM, Spooren W, Steward L.

Br J Pharmacol. 2011 Feb;162(4):929-46. doi: 10.1111/j.1476-5381.2010.01096.x.

7.

Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series.

Achermann G, Ballard TM, Blasco F, Broutin PE, Büttelmann B, Fischer H, Graf M, Hernandez MC, Hilty P, Knoflach F, Koblet A, Knust H, Kurt A, Martin JR, Masciadri R, Porter RH, Stadler H, Thomas AW, Trube G, Wichmann J.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5746-52. doi: 10.1016/j.bmcl.2009.07.153. Epub 2009 Aug 4.

PMID:
19726184
8.

Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors.

Malherbe P, Masciadri R, Norcross RD, Knoflach F, Kratzeisen C, Zenner MT, Kolb Y, Marcuz A, Huwyler J, Nakagawa T, Porter RH, Thomas AW, Wettstein JG, Sleight AJ, Spooren W, Prinssen EP.

Br J Pharmacol. 2008 Jun;154(4):797-811. doi: 10.1038/bjp.2008.135. Epub 2008 Apr 21.

9.

Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives.

Gillespie RJ, Adams DR, Bebbington D, Benwell K, Cliffe IA, Dawson CE, Dourish CT, Fletcher A, Gaur S, Giles PR, Jordan AM, Knight AR, Knutsen LJ, Lawrence A, Lerpiniere J, Misra A, Porter RH, Pratt RM, Shepherd R, Upton R, Ward SE, Weiss SM, Williamson DS.

Bioorg Med Chem Lett. 2008 May 1;18(9):2916-9. doi: 10.1016/j.bmcl.2008.03.075. Epub 2008 Mar 30.

PMID:
18406614
10.

Metabolite identification via LC-SPE-NMR-MS of the in vitro biooxidation products of a lead mGlu5 allosteric antagonist and impact on the improvement of metabolic stability in the series.

Ceccarelli SM, Schlotterbeck G, Boissin P, Binder M, Buettelmann B, Hanlon S, Jaeschke G, Kolczewski S, Kupfer E, Peters JU, Porter RH, Prinssen EP, Rueher M, Ruf I, Spooren W, Stämpfli A, Vieira E.

ChemMedChem. 2008 Jan;3(1):136-44.

PMID:
17994660
11.

Preliminary evidence of a sensitive period for olfactory learning by human newborns.

Romantshik O, Porter RH, Tillmann V, Varendi H.

Acta Paediatr. 2007 Mar;96(3):372-6.

PMID:
17407459
12.

The effect of the odour of mother's milk on breastfeeding behaviour of premature neonates.

Raimbault C, Saliba E, Porter RH.

Acta Paediatr. 2007 Mar;96(3):368-71.

PMID:
17407458
13.

Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP.

Malherbe P, Kratochwil N, Mühlemann A, Zenner MT, Fischer C, Stahl M, Gerber PR, Jaeschke G, Porter RH.

J Neurochem. 2006 Jul;98(2):601-15.

14.

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.

Büttelmann B, Peters JU, Ceccarelli S, Kolczewski S, Vieira E, Prinssen EP, Spooren W, Schuler F, Huwyler J, Porter RH, Jaeschke G.

Bioorg Med Chem Lett. 2006 Apr 1;16(7):1892-7. Epub 2006 Jan 24.

PMID:
16439120
15.

Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors.

Mühlemann A, Ward NA, Kratochwil N, Diener C, Fischer C, Stucki A, Jaeschke G, Malherbe P, Porter RH.

Eur J Pharmacol. 2006 Jan 4;529(1-3):95-104. Epub 2005 Dec 13.

PMID:
16352303
16.

An experimental study of social attraction and spacing between the sexes in sheep.

Michelena P, Henric K, Angibault JM, Gautrais J, Lapeyronie P, Porter RH, Deneubourg JL, Bon R.

J Exp Biol. 2005 Dec;208(Pt 23):4419-26.

17.

An automated system for the analysis of G protein-coupled receptor transmembrane binding pockets: alignment, receptor-based pharmacophores, and their application.

Kratochwil NA, Malherbe P, Lindemann L, Ebeling M, Hoener MC, Mühlemann A, Porter RH, Stahl M, Gerber PR.

J Chem Inf Model. 2005 Sep-Oct;45(5):1324-36.

PMID:
16180909
18.

Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.

Porter RH, Jaeschke G, Spooren W, Ballard TM, Büttelmann B, Kolczewski S, Peters JU, Prinssen E, Wichmann J, Vieira E, Mühlemann A, Gatti S, Mutel V, Malherbe P.

J Pharmacol Exp Ther. 2005 Nov;315(2):711-21. Epub 2005 Jul 22.

PMID:
16040814
19.

Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists.

Röver S, Adams DR, Bénardeau A, Bentley JM, Bickerdike MJ, Bourson A, Cliffe IA, Coassolo P, Davidson JE, Dourish CT, Hebeisen P, Kennett GA, Knight AR, Malcolm CS, Mattei P, Misra A, Mizrahi J, Muller M, Porter RH, Richter H, Taylor S, Vickers SP.

Bioorg Med Chem Lett. 2005 Aug 1;15(15):3604-8.

PMID:
15975787
20.

The biological significance of skin-to-skin contact and maternal odours.

Porter RH.

Acta Paediatr. 2004 Dec;93(12):1560-2.

PMID:
15841761
21.

Constitutive activity modulation of human metabotropic glutamate 5a receptors in HEK293 cells: a role for key amino-terminal cysteine residues.

Mühlemann A, Diener C, Fischer C, Piussi J, Stucki A, Porter RH.

Br J Pharmacol. 2005 Apr;144(8):1118-25.

22.

Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine.

Malherbe P, Kratochwil N, Zenner MT, Piussi J, Diener C, Kratzeisen C, Fischer C, Porter RH.

Mol Pharmacol. 2003 Oct;64(4):823-32.

PMID:
14500738
24.
25.

Induction of maternal behavior in non-parturient adoptive mares.

Porter RH, Duchamp G, Nowak R, Daels PF.

Physiol Behav. 2002 Sep;77(1):151-4.

PMID:
12213513
26.

The effect of labor on olfactory exposure learning within the first postnatal hour.

Varendi H, Porter RH, Winberg J.

Behav Neurosci. 2002 Apr;116(2):206-11.

PMID:
11996306
27.

Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists.

Vickers SP, Easton N, Malcolm CS, Allen NH, Porter RH, Bickerdike MJ, Kennett GA.

Pharmacol Biochem Behav. 2001 Jul-Aug;69(3-4):643-52.

PMID:
11509227
28.

Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells.

Porter RH, Malcolm CS, Allen NH, Lamb H, Revell DF, Sheardown MJ.

Biochem Pharmacol. 2001 Aug 15;62(4):431-8.

PMID:
11448452
29.

Characterisation of agonist binding on human 5-HT2C receptor isoforms.

Quirk K, Lawrence A, Jones J, Misra A, Harvey V, Lamb H, Revell D, Porter RH, Knight AR.

Eur J Pharmacol. 2001 May 11;419(2-3):107-12.

PMID:
11426831
30.

Breast odour as the only maternal stimulus elicits crawling towards the odour source.

Varendi H, Porter RH.

Acta Paediatr. 2001 Apr;90(4):372-5.

PMID:
11332925
31.

Role of mother-young interactions in the survival of offspring in domestic mammals.

Nowak R, Porter RH, Lévy F, Orgeur P, Schaal B.

Rev Reprod. 2000 Sep;5(3):153-63. Review.

PMID:
11006165
32.

3,5-Disubstituted-4-hydroxyphenyls linked to 3-hydroxy-2-methyl-4(1H)-pyridinone: potent inhibitors of lipid peroxidation and cell toxicity.

Bebbington D, Monck NJ, Gaur S, Palmer AM, Benwell K, Harvey V, Malcolm CS, Porter RH.

J Med Chem. 2000 Jul 27;43(15):2779-82. No abstract available. Erratum in: J Med Chem 2000 Nov 30;43(24):4724.

PMID:
10956184
33.

Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats.

Vickers SP, Benwell KR, Porter RH, Bickerdike MJ, Kennett GA, Dourish CT.

Br J Pharmacol. 2000 Jul;130(6):1305-14.

34.
35.

Characterization of iodoacetate-mediated neurotoxicity in vitro using primary cultures of rat cerebellar granule cells.

Malcolm CS, Benwell KR, Lamb H, Bebbington D, Porter RH.

Free Radic Biol Med. 2000 Jan 1;28(1):102-7.

PMID:
10656296
36.

Discriminative responsiveness by lambs to visual images of conspecifics.

Porter RH, Bouissou MF.

Behav Processes. 1999 Nov;48(1-2):101-10.

PMID:
24897566
37.

Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.

Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, Adams DR, Sheardown MJ.

Br J Pharmacol. 1999 Sep;128(1):13-20.

38.

A simple method for testing odor detection and discrimination in chicks.

Porter RH, Hepper PG, Bouchot C, Picard M.

Physiol Behav. 1999 Sep;67(3):459-62.

PMID:
10497967
39.

Olfaction and human kin recognition.

Porter RH.

Genetica. 1998-1999;104(3):259-63. Review.

PMID:
10386392
40.

Unique salience of maternal breast odors for newborn infants.

Porter RH, Winberg J.

Neurosci Biobehav Rev. 1999;23(3):439-49. Review.

PMID:
9989430
41.

Effects of early odor exposure in domestic chicks.

Porter RH, Picard M.

Reprod Nutr Dev. 1998 Jul-Aug;38(4):441-8.

42.

Soothing effect of amniotic fluid smell in newborn infants.

Varendi H, Christensson K, Porter RH, Winberg J.

Early Hum Dev. 1998 Apr 17;51(1):47-55.

PMID:
9570031
43.

Olfaction and human neonatal behaviour: clinical implications.

Winberg J, Porter RH.

Acta Paediatr. 1998 Jan;87(1):6-10. Review.

PMID:
9510439
44.

Natural odour preferences of newborn infants change over time.

Varendi H, Porter RH, Winberg J.

Acta Paediatr. 1997 Sep;86(9):985-90.

PMID:
9343280
46.

Influence of a conspecific image of own vs. different breed on fear reactions of ewes.

Bouissou MF, Porter RH, Boyle L, Ferreira G.

Behav Processes. 1996 Oct;38(1):37-44.

PMID:
24897628
47.

Attractiveness of amniotic fluid odor: evidence of prenatal olfactory learning?

Varendi H, Porter RH, Winberg J.

Acta Paediatr. 1996 Oct;85(10):1223-7.

PMID:
8922088
49.
50.

Glutamate and Parkinson's disease.

Blandini F, Porter RH, Greenamyre JT.

Mol Neurobiol. 1996 Feb;12(1):73-94. Review.

PMID:
8732541

Supplemental Content

Loading ...
Support Center