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Long-term intranasal insulin aspart: a profile of gene expression, memory, and insulin receptors in aged F344 rats.

Frazier HN, Ghoweri AO, Sudkamp E, Johnson ES, Anderson KL, Fox G, Vatthanaphone K, Xia M, Lin RL, Hargis-Staggs KE, Porter NM, Pauly JR, Blalock EM, Thibault O.

J Gerontol A Biol Sci Med Sci. 2019 Jun 10. pii: glz105. doi: 10.1093/gerona/glz105. [Epub ahead of print]


Broadening the definition of brain insulin resistance in aging and Alzheimer's disease.

Frazier HN, Ghoweri AO, Anderson KL, Lin RL, Porter NM, Thibault O.

Exp Neurol. 2019 Mar;313:79-87. doi: 10.1016/j.expneurol.2018.12.007. Epub 2018 Dec 18. Review.


Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer's Disease Neurofibrillary Tangles First Appear.

Gant JC, Kadish I, Chen KC, Thibault O, Blalock EM, Porter NM, Landfield PW.

J Alzheimers Dis. 2018;66(4):1371-1378. doi: 10.3233/JAD-180618.


FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca2+], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats.

Gant JC, Blalock EM, Chen KC, Kadish I, Thibault O, Porter NM, Landfield PW.

J Neurosci. 2018 Jan 24;38(4):1030-1041. doi: 10.1523/JNEUROSCI.2234-17.2017. Epub 2017 Dec 18.


Novel calcium-related targets of insulin in hippocampal neurons.

Maimaiti S, Frazier HN, Anderson KL, Ghoweri AO, Brewer LD, Porter NM, Thibault O.

Neuroscience. 2017 Nov 19;364:130-142. doi: 10.1016/j.neuroscience.2017.09.019. Epub 2017 Sep 20.


Calcium's role as nuanced modulator of cellular physiology in the brain.

Frazier HN, Maimaiti S, Anderson KL, Brewer LD, Gant JC, Porter NM, Thibault O.

Biochem Biophys Res Commun. 2017 Feb 19;483(4):981-987. doi: 10.1016/j.bbrc.2016.08.105. Epub 2016 Aug 20. Review.


Impact of Single or Repeated Dose Intranasal Zinc-free Insulin in Young and Aged F344 Rats on Cognition, Signaling, and Brain Metabolism.

Anderson KL, Frazier HN, Maimaiti S, Bakshi VV, Majeed ZR, Brewer LD, Porter NM, Lin AL, Thibault O.

J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):189-197. doi: 10.1093/gerona/glw065. Epub 2016 Apr 10.


Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus.

Gant JC, Chen KC, Kadish I, Blalock EM, Thibault O, Porter NM, Landfield PW.

J Neurosci. 2015 Jul 29;35(30):10878-87. doi: 10.1523/JNEUROSCI.1248-15.2015.


Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging.

Maimaiti S, Anderson KL, DeMoll C, Brewer LD, Rauh BA, Gant JC, Blalock EM, Porter NM, Thibault O.

J Gerontol A Biol Sci Med Sci. 2016 Jan;71(1):30-9. doi: 10.1093/gerona/glu314. Epub 2015 Feb 6.


Short-lived diabetes in the young-adult ZDF rat does not exacerbate neuronal Ca(2+) biomarkers of aging.

Maimaiti S, DeMoll C, Anderson KL, Griggs RB, Taylor BK, Porter NM, Thibault O.

Brain Res. 2015 Sep 24;1621:214-21. doi: 10.1016/j.brainres.2014.10.052. Epub 2014 Nov 6.


Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats.

Latimer CS, Brewer LD, Searcy JL, Chen KC, Popović J, Kraner SD, Thibault O, Blalock EM, Landfield PW, Porter NM.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4359-66. doi: 10.1073/pnas.1404477111. Epub 2014 Sep 29.


Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia.

Niedowicz DM, Reeves VL, Platt TL, Kohler K, Beckett TL, Powell DK, Lee TL, Sexton TR, Song ES, Brewer LD, Latimer CS, Kraner SD, Larson KL, Ozcan S, Norris CM, Hersh LB, Porter NM, Wilcock DM, Murphy MP.

Acta Neuropathol Commun. 2014 Jun 10;2:64. doi: 10.1186/2051-5960-2-64.


FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?

Gant JC, Blalock EM, Chen KC, Kadish I, Porter NM, Norris CM, Thibault O, Landfield PW.

Eur J Pharmacol. 2014 Sep 15;739:74-82. doi: 10.1016/j.ejphar.2013.10.070. Epub 2013 Nov 28. Review.


Hippocampal calcium dysregulation at the nexus of diabetes and brain aging.

Thibault O, Anderson KL, DeMoll C, Brewer LD, Landfield PW, Porter NM.

Eur J Pharmacol. 2013 Nov 5;719(1-3):34-43. doi: 10.1016/j.ejphar.2013.07.024. Epub 2013 Jul 17. Review.


Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: implications for low vitamin D-dependent age-related cognitive decline.

Keeney JTR, Förster S, Sultana R, Brewer LD, Latimer CS, Cai J, Klein JB, Porter NM, Butterfield DA.

Free Radic Biol Med. 2013 Dec;65:324-334. doi: 10.1016/j.freeradbiomed.2013.07.019. Epub 2013 Jul 18.


Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging.

Chen KC, Blalock EM, Curran-Rauhut MA, Kadish I, Blalock SJ, Brewer L, Porter NM, Landfield PW.

Endocrinology. 2013 Aug;154(8):2807-20. doi: 10.1210/en.2013-1139. Epub 2013 Jun 4.


Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats.

Pancani T, Anderson KL, Brewer LD, Kadish I, DeMoll C, Landfield PW, Blalock EM, Porter NM, Thibault O.

Neurobiol Aging. 2013 Aug;34(8):1977-87. doi: 10.1016/j.neurobiolaging.2013.02.019. Epub 2013 Mar 29.


Hippocampal CA1 transcriptional profile of sleep deprivation: relation to aging and stress.

Porter NM, Bohannon JH, Curran-Rauhut M, Buechel HM, Dowling AL, Brewer LD, Popovic J, Thibault V, Kraner SD, Chen KC, Blalock EM.

PLoS One. 2012;7(7):e40128. doi: 10.1371/journal.pone.0040128. Epub 2012 Jul 5.


Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease.

Searcy JL, Phelps JT, Pancani T, Kadish I, Popovic J, Anderson KL, Beckett TL, Murphy MP, Chen KC, Blalock EM, Landfield PW, Porter NM, Thibault O.

J Alzheimers Dis. 2012;30(4):943-61. doi: 10.3233/JAD-2012-111661.


Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice.

Latimer CS, Searcy JL, Bridges MT, Brewer LD, Popović J, Blalock EM, Landfield PW, Thibault O, Porter NM.

PLoS One. 2011;6(10):e26812. doi: 10.1371/journal.pone.0026812. Epub 2011 Oct 25.


Imaging of a glucose analog, calcium and NADH in neurons and astrocytes: dynamic responses to depolarization and sensitivity to pioglitazone.

Pancani T, Anderson KL, Porter NM, Thibault O.

Cell Calcium. 2011 Dec;50(6):548-58. doi: 10.1016/j.ceca.2011.09.002. Epub 2011 Oct 5.


A phase I safety study of enzastaurin plus bortezomib in the treatment of relapsed or refractory multiple myeloma.

Ghobrial IM, Munshi NC, Harris BN, Shi P, Porter NM, Schlossman RL, Laubach JP, Anderson KC, Desaiah D, Myrand SP, Wooldridge JE, Richardson PG, Abonour R.

Am J Hematol. 2011 Jul;86(7):573-8. doi: 10.1002/ajh.22048. Epub 2011 May 31.


Deep sleep and parietal cortex gene expression changes are related to cognitive deficits with age.

Buechel HM, Popovic J, Searcy JL, Porter NM, Thibault O, Blalock EM.

PLoS One. 2011 Apr 4;6(4):e18387. doi: 10.1371/journal.pone.0018387.


Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons.

Gant JC, Chen KC, Norris CM, Kadish I, Thibault O, Blalock EM, Porter NM, Landfield PW.

J Neurosci. 2011 Feb 2;31(5):1693-703. doi: 10.1523/JNEUROSCI.4805-10.2011.


Effects of long-term pioglitazone treatment on peripheral and central markers of aging.

Blalock EM, Phelps JT, Pancani T, Searcy JL, Anderson KL, Gant JC, Popovic J, Avdiushko MG, Cohen DA, Chen KC, Porter NM, Thibault O.

PLoS One. 2010 Apr 29;5(4):e10405. doi: 10.1371/journal.pone.0010405.


Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys.

Blalock EM, Grondin R, Chen KC, Thibault O, Thibault V, Pandya JD, Dowling A, Zhang Z, Sullivan P, Porter NM, Landfield PW.

J Neurosci. 2010 Apr 28;30(17):6058-71. doi: 10.1523/JNEUROSCI.3956-09.2010.


Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons.

Pancani T, Phelps JT, Searcy JL, Kilgore MW, Chen KC, Porter NM, Thibault O.

J Neurochem. 2009 Jun;109(6):1800-11. doi: 10.1111/j.1471-4159.2009.06107.x. Epub 2009 May 11.


Estradiol reverses a calcium-related biomarker of brain aging in female rats.

Brewer LD, Dowling AL, Curran-Rauhut MA, Landfield PW, Porter NM, Blalock EM.

J Neurosci. 2009 May 13;29(19):6058-67. doi: 10.1523/JNEUROSCI.5253-08.2009.


Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment.

Kadish I, Thibault O, Blalock EM, Chen KC, Gant JC, Porter NM, Landfield PW.

J Neurosci. 2009 Feb 11;29(6):1805-16. doi: 10.1523/JNEUROSCI.4599-08.2009.


Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging.

Norris CM, Blalock EM, Chen KC, Porter NM, Thibault O, Kraner SD, Landfield PW.

Neurobiol Aging. 2010 Feb;31(2):328-38. doi: 10.1016/j.neurobiolaging.2008.03.026.


Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels.

Brewer LD, Thibault O, Staton J, Thibault V, Rogers JT, Garcia-Ramos G, Kraner S, Landfield PW, Porter NM.

Brain Res. 2007 Jun 2;1151:20-31. Epub 2007 Mar 12.


A new glucocorticoid hypothesis of brain aging: implications for Alzheimer's disease.

Landfield PW, Blalock EM, Chen KC, Porter NM.

Curr Alzheimer Res. 2007 Apr;4(2):205-12. Review.


Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats.

Rowe WB, Blalock EM, Chen KC, Kadish I, Wang D, Barrett JE, Thibault O, Porter NM, Rose GM, Landfield PW.

J Neurosci. 2007 Mar 21;27(12):3098-110.


Electrophysiological mechanisms of delayed excitotoxicity: positive feedback loop between NMDA receptor current and depolarization-mediated glutamate release.

Norris CM, Blalock EM, Thibault O, Brewer LD, Clodfelter GV, Porter NM, Landfield PW.

J Neurophysiol. 2006 Nov;96(5):2488-500. Epub 2006 Aug 16.


Chronic 1alpha,25-(OH)2 vitamin D3 treatment reduces Ca2+ -mediated hippocampal biomarkers of aging.

Brewer LD, Porter NM, Kerr DS, Landfield PW, Thibault O.

Cell Calcium. 2006 Sep;40(3):277-86. Epub 2006 Jun 14.


Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation.

Blalock EM, Chen KC, Stromberg AJ, Norris CM, Kadish I, Kraner SD, Porter NM, Landfield PW.

Ageing Res Rev. 2005 Nov;4(4):481-512. Epub 2005 Oct 27. Review.


Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models.

Norris CM, Kadish I, Blalock EM, Chen KC, Thibault V, Porter NM, Landfield PW, Kraner SD.

J Neurosci. 2005 May 4;25(18):4649-58.


Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses.

Blalock EM, Geddes JW, Chen KC, Porter NM, Markesbery WR, Landfield PW.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2173-8. Epub 2004 Feb 9.


Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment.

Blalock EM, Chen KC, Sharrow K, Herman JP, Porter NM, Foster TC, Landfield PW.

J Neurosci. 2003 May 1;23(9):3807-19.


Sustained Ca2+-induced Ca2+-release underlies the post-glutamate lethal Ca2+ plateau in older cultured hippocampal neurons.

Clodfelter GV, Porter NM, Landfield PW, Thibault O.

Eur J Pharmacol. 2002 Jul 5;447(2-3):189-200.


Group I metabotropic glutamate receptor inhibition selectively blocks a prolonged Ca(2+) elevation associated with age-dependent excitotoxicity.

Attucci S, Clodfelter GV, Thibault O, Staton J, Moroni F, Landfield PW, Porter NM.

Neuroscience. 2002;112(1):183-94.


Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture.

Norris CM, Blalock EM, Chen KC, Porter NM, Landfield PW.

Neuroscience. 2002;110(2):213-25.


Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons.

Brewer LD, Thibault V, Chen KC, Langub MC, Landfield PW, Porter NM.

J Neurosci. 2001 Jan 1;21(1):98-108.


Stress hormones and brain aging: adding injury to insult?

Porter NM, Landfield PW.

Nat Neurosci. 1998 May;1(1):3-4. No abstract available.


Calcium dysregulation in neuronal aging and Alzheimer's disease: history and new directions.

Thibault O, Porter NM, Chen KC, Blalock EM, Kaminker PG, Clodfelter GV, Brewer LD, Landfield PW.

Cell Calcium. 1998 Nov-Dec;24(5-6):417-33. Review. No abstract available.


Calcium channel density and hippocampal cell death with age in long-term culture.

Porter NM, Thibault O, Thibault V, Chen KC, Landfield PW.

J Neurosci. 1997 Jul 15;17(14):5629-39.


Single-channel and whole-cell studies of calcium currents in young and aged rat hippocampal slice neurons.

Thibault O, Mazzanti ML, Blalock EM, Porter NM, Landfield PW.

J Neurosci Methods. 1995 Jun;59(1):77-83.


Mechanisms of neuronal death in brain aging and Alzheimer's disease: role of endocrine-mediated calcium dyshomeostasis.

Landfield PW, Thibault O, Mazzanti ML, Porter NM, Kerr DS.

J Neurobiol. 1992 Nov;23(9):1247-60. Review.


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