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Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex.

Gui L, Song K, Tritschler D, Bower R, Yan S, Dai A, Augspurger K, Sakizadeh J, Grzemska M, Ni T, Porter ME, Nicastro D.

Proc Natl Acad Sci U S A. 2019 Oct 28. pii: 201910960. doi: 10.1073/pnas.1910960116. [Epub ahead of print]


FAP57/WDR65 targets assembly of a subset of inner arm dyneins and connects to regulatory hubs in cilia.

Lin J, Le TV, Augspurger K, Tritschler D, Bower R, Fu G, Perrone C, O'Toole ET, Mills KV, Dymek E, Smith E, Nicastro D, Porter ME.

Mol Biol Cell. 2019 Oct 1;30(21):2659-2680. doi: 10.1091/mbc.E19-07-0367. Epub 2019 Sep 4.


Navy Medicine Introduces Value-Based Health Care.

Hernandez A, Kaplan RS, Witkowski ML, Faison Iii CF, Porter ME.

Health Aff (Millwood). 2019 Aug;38(8):1393-1400. doi: 10.1377/hlthaff.2019.00280.


PACRG and FAP20 form the inner junction of axonemal doublet microtubules and regulate ciliary motility.

Dymek EE, Lin J, Fu G, Porter ME, Nicastro D, Smith EF.

Mol Biol Cell. 2019 Jul 15;30(15):1805-1816. doi: 10.1091/mbc.E19-01-0063. Epub 2019 May 22.


Mechanical properties of the venomous spines of Pterois volitans and morphology among lionfish species.

Galloway KA, Porter ME.

J Exp Biol. 2019 Mar 27;222(Pt 6). pii: jeb197905. doi: 10.1242/jeb.197905.


Three-dimensional movements of the pectoral fin during yaw turns in the Pacific spiny dogfish, Squalus suckleyi.

Hoffmann SL, Donatelli CM, Leigh SC, Brainerd EL, Porter ME.

Biol Open. 2019 Jan 17;8(1). pii: bio037291. doi: 10.1242/bio.037291.


Mechanical behavior of shark vertebral centra at biologically relevant strains.

Ingle DI, Natanson LJ, Porter ME.

J Exp Biol. 2018 Dec 12;221(Pt 24). pii: jeb188318. doi: 10.1242/jeb.188318.


Is a driver's license age waiver worth a teen's life?

Porter DM, Miller BK, Mullins SH, Porter ME, Aitken ME.

Inj Epidemiol. 2018 Apr 10;5(Suppl 1):8. doi: 10.1186/s40621-018-0146-y.


Stiff and tough: a comparative study on the tensile properties of shark skin.

Creager SB, Porter ME.

Zoology (Jena). 2018 Feb;126:154-163. doi: 10.1016/j.zool.2017.10.002. Epub 2017 Oct 31.


DRC2/CCDC65 is a central hub for assembly of the nexin-dynein regulatory complex and other regulators of ciliary and flagellar motility.

Bower R, Tritschler D, Mills KV, Heuser T, Nicastro D, Porter ME.

Mol Biol Cell. 2018 Jan 15;29(2):137-153. doi: 10.1091/mbc.E17-08-0510. Epub 2017 Nov 22.


Dynamics of the IFT machinery at the ciliary tip.

Chien A, Shih SM, Bower R, Tritschler D, Porter ME, Yildiz A.

Elife. 2017 Sep 20;6. pii: e28606. doi: 10.7554/eLife.28606.


Ciliary Motility: Regulation of Axonemal Dynein Motors.

Viswanadha R, Sale WS, Porter ME.

Cold Spring Harb Perspect Biol. 2017 Aug 1;9(8). pii: a018325. doi: 10.1101/cshperspect.a018325. Review.


Regional variation in undulatory kinematics of two hammerhead species: the bonnethead (Sphyrna tiburo) and the scalloped hammerhead (Sphyrna lewini).

Hoffmann SL, Warren SM, Porter ME.

J Exp Biol. 2017 Sep 15;220(Pt 18):3336-3343. doi: 10.1242/jeb.157941. Epub 2017 Jul 13.


From Volume to Value in Health Care: The Work Begins.

Porter ME, Lee TH.

JAMA. 2016 Sep 13;316(10):1047-8. doi: 10.1001/jama.2016.11698. No abstract available.


Communicating Value in Health Care Using Radar Charts: A Case Study of Prostate Cancer.

Thaker NG, Ali TN, Porter ME, Feeley TW, Kaplan RS, Frank SJ.

J Oncol Pract. 2016 Sep;12(9):813-20. doi: 10.1200/JOP.2016.011320. Epub 2016 Aug 30.


How to Pay for Health Care.

Porter ME, Kaplan RS.

Harv Bus Rev. 2016 Jul-Aug;94(7-8):88-98, 100, 134.


Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease.

Lewis WR, Malarkey EB, Tritschler D, Bower R, Pasek RC, Porath JD, Birket SE, Saunier S, Antignac C, Knowles MR, Leigh MW, Zariwala MA, Challa AK, Kesterson RA, Rowe SM, Drummond IA, Parant JM, Hildebrandt F, Porter ME, Yoder BK, Berbari NF.

PLoS Genet. 2016 Jul 29;12(7):e1006220. doi: 10.1371/journal.pgen.1006220. eCollection 2016 Jul.


The role of the dynein light intermediate chain in retrograde IFT and flagellar function in Chlamydomonas.

Reck J, Schauer AM, VanderWaal Mills K, Bower R, Tritschler D, Perrone CA, Porter ME.

Mol Biol Cell. 2016 Aug 1;27(15):2404-22. doi: 10.1091/mbc.E16-03-0191. Epub 2016 Jun 1.


The nexin link and B-tubule glutamylation maintain the alignment of outer doublets in the ciliary axoneme.

Alford LM, Stoddard D, Li JH, Hunter EL, Tritschler D, Bower R, Nicastro D, Porter ME, Sale WS.

Cytoskeleton (Hoboken). 2016 Jun;73(7):331-40. doi: 10.1002/cm.21301. Epub 2016 Jun 13.


Standardizing Patient Outcomes Measurement.

Porter ME, Larsson S, Lee TH.

N Engl J Med. 2016 Feb 11;374(6):504-6. doi: 10.1056/NEJMp1511701. No abstract available.


Why strategy matters now.

Porter ME, Lee TH.

N Engl J Med. 2015 Apr 30;372(18):1681-4. doi: 10.1056/NEJMp1502419. No abstract available.


In situ localization of N and C termini of subunits of the flagellar nexin-dynein regulatory complex (N-DRC) using SNAP tag and cryo-electron tomography.

Song K, Awata J, Tritschler D, Bower R, Witman GB, Porter ME, Nicastro D.

J Biol Chem. 2015 Feb 27;290(9):5341-53. doi: 10.1074/jbc.M114.626556. Epub 2015 Jan 6.


Proteomic analysis of Lawsonia intracellularis reveals expression of outer membrane proteins during infection.

Watson E, Alberdi MP, Inglis NF, Lainson A, Porter ME, Manson E, Imrie L, Mclean K, Smith DGE.

Vet Microbiol. 2014 Dec 5;174(3-4):448-455. doi: 10.1016/j.vetmic.2014.10.002. Epub 2014 Nov 8.


Built for speed: strain in the cartilaginous vertebral columns of sharks.

Porter ME, Diaz C Jr, Sturm JJ, Grotmol S, Summers AP, Long JH Jr.

Zoology (Jena). 2014 Feb;117(1):19-27. doi: 10.1016/j.zool.2013.10.007. Epub 2013 Dec 5.


A differential cargo-loading model of ciliary length regulation by IFT.

Wren KN, Craft JM, Tritschler D, Schauer A, Patel DK, Smith EF, Porter ME, Kner P, Lechtreck KF.

Curr Biol. 2013 Dec 16;23(24):2463-71. doi: 10.1016/j.cub.2013.10.044. Epub 2013 Dec 5.


Are you positive? Electric dipole polarity discrimination in the yellow stingray, Urobatis jamaicensis.

Siciliano AM, Kajiura SM, Long JH Jr, Porter ME.

Biol Bull. 2013 Oct;225(2):85-91.


Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia.

Austin-Tse C, Halbritter J, Zariwala MA, Gilberti RM, Gee HY, Hellman N, Pathak N, Liu Y, Panizzi JR, Patel-King RS, Tritschler D, Bower R, O'Toole E, Porath JD, Hurd TW, Chaki M, Diaz KA, Kohl S, Lovric S, Hwang DY, Braun DA, Schueler M, Airik R, Otto EA, Leigh MW, Noone PG, Carson JL, Davis SD, Pittman JE, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Dell SD, Rosenfeld M, Milla CE, Loges NT, Omran H, Porter ME, King SM, Knowles MR, Drummond IA, Hildebrandt F.

Am J Hum Genet. 2013 Oct 3;93(4):672-86. doi: 10.1016/j.ajhg.2013.08.015.


Redefining global health-care delivery.

Kim JY, Farmer P, Porter ME.

Lancet. 2013 Sep 21;382(9897):1060-9. doi: 10.1016/S0140-6736(13)61047-8. Epub 2013 May 20.


Redesigning primary care: a strategic vision to improve value by organizing around patients' needs.

Porter ME, Pabo EA, Lee TH.

Health Aff (Millwood). 2013 Mar;32(3):516-25. doi: 10.1377/hlthaff.2012.0961.


The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes.

Bower R, Tritschler D, Vanderwaal K, Perrone CA, Mueller J, Fox L, Sale WS, Porter ME.

Mol Biol Cell. 2013 Apr;24(8):1134-52. doi: 10.1091/mbc.E12-11-0801. Epub 2013 Feb 20.


The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans.

Wirschell M, Olbrich H, Werner C, Tritschler D, Bower R, Sale WS, Loges NT, Pennekamp P, Lindberg S, Stenram U, Carlén B, Horak E, Köhler G, Nürnberg P, Nürnberg G, Porter ME, Omran H.

Nat Genet. 2013 Mar;45(3):262-8. doi: 10.1038/ng.2533. Epub 2013 Jan 27.


Cryoelectron tomography reveals doublet-specific structures and unique interactions in the I1 dynein.

Heuser T, Barber CF, Lin J, Krell J, Rebesco M, Porter ME, Nicastro D.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):E2067-76. doi: 10.1073/pnas.1120690109. Epub 2012 Jun 25.


Computer-assisted image analysis of human cilia and Chlamydomonas flagella reveals both similarities and differences in axoneme structure.

O'Toole ET, Giddings TH Jr, Porter ME, Ostrowski LE.

Cytoskeleton (Hoboken). 2012 Aug;69(8):577-90. doi: 10.1002/cm.21035. Epub 2012 May 22.


Swimming fundamentals: turning performance of leopard sharks (Triakis semifasciata) is predicted by body shape and postural reconfiguration.

Porter ME, Roque CM, Long JH Jr.

Zoology (Jena). 2011 Dec;114(6):348-59. doi: 10.1016/j.zool.2011.06.001. Epub 2011 Oct 6.


A unified taxonomy for ciliary dyneins.

Hom EF, Witman GB, Harris EH, Dutcher SK, Kamiya R, Mitchell DR, Pazour GJ, Porter ME, Sale WS, Wirschell M, Yagi T, King SM.

Cytoskeleton (Hoboken). 2011 Oct;68(10):555-65. doi: 10.1002/cm.20533.


How to solve the cost crisis in health care.

Kaplan RS, Porter ME.

Harv Bus Rev. 2011 Sep;89(9):46-52, 54, 56-61 passim.


Cryo-electron tomography reveals conserved features of doublet microtubules in flagella.

Nicastro D, Fu X, Heuser T, Tso A, Porter ME, Linck RW.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):E845-53. doi: 10.1073/pnas.1106178108. Epub 2011 Sep 19.


Sink and swim: kinematic evidence for lifting-body mechanisms in negatively buoyant electric rays Narcine brasiliensis.

Rosenblum HG, Long JH Jr, Porter ME.

J Exp Biol. 2011 Sep 1;214(Pt 17):2935-48. doi: 10.1242/jeb.053108.


Building blocks of the nexin-dynein regulatory complex in Chlamydomonas flagella.

Lin J, Tritschler D, Song K, Barber CF, Cobb JS, Porter ME, Nicastro D.

J Biol Chem. 2011 Aug 19;286(33):29175-91. doi: 10.1074/jbc.M111.241760. Epub 2011 Jun 23.


bop5 Mutations reveal new roles for the IC138 phosphoprotein in the regulation of flagellar motility and asymmetric waveforms.

VanderWaal KE, Yamamoto R, Wakabayashi K, Fox L, Kamiya R, Dutcher SK, Bayly PV, Sale WS, Porter ME.

Mol Biol Cell. 2011 Aug 15;22(16):2862-74. doi: 10.1091/mbc.E11-03-0270. Epub 2011 Jun 22.


Testing biomimetic structures in bioinspired robots: how vertebrae control the stiffness of the body and the behavior of fish-like swimmers.

Long JH Jr, Krenitsky NM, Roberts SF, Hirokawa J, de Leeuw J, Porter ME.

Integr Comp Biol. 2011 Jul;51(1):158-75. doi: 10.1093/icb/icr020. Epub 2011 May 15.


Bioinspiration: applying mechanical design to experimental biology.

Flammang BE, Porter ME.

Integr Comp Biol. 2011 Jul;51(1):128-32. doi: 10.1093/icb/icr014. Epub 2011 May 15. Review.


Go reconfigure: how fish change shape as they swim and evolve.

Long JH Jr, Porter ME, Root RG, Liew CW.

Integr Comp Biol. 2010 Dec;50(6):1120-39. doi: 10.1093/icb/icq066. Epub 2010 Jun 24.


Distinct roles of 1alpha and 1beta heavy chains of the inner arm dynein I1 of Chlamydomonas flagella.

Toba S, Fox LA, Sakakibara H, Porter ME, Oiwa K, Sale WS.

Mol Biol Cell. 2011 Feb 1;22(3):342-53. doi: 10.1091/mbc.E10-10-0806. Epub 2010 Dec 9.


What is value in health care?

Porter ME.

N Engl J Med. 2010 Dec 23;363(26):2477-81. doi: 10.1056/NEJMp1011024. Epub 2010 Dec 8. No abstract available.


From a declaration of values to the creation of value in global health: a report from Harvard University's Global Health Delivery Project.

Kim JY, Rhatigan J, Jain SH, Weintraub R, Porter ME.

Glob Public Health. 2010;5(2):181-8. doi: 10.1080/17441690903418993.


The dynein regulatory complex is the nexin link and a major regulatory node in cilia and flagella.

Heuser T, Raytchev M, Krell J, Porter ME, Nicastro D.

J Cell Biol. 2009 Dec 14;187(6):921-33. doi: 10.1083/jcb.200908067.


Vertebrae in compression: Mechanical behavior of arches and centra in the gray smooth-hound shark (Mustelus californicus).

Porter ME, Long JH Jr.

J Morphol. 2010 Mar;271(3):366-75. doi: 10.1002/jmor.10803.


A strategy for health care reform--toward a value-based system.

Porter ME.

N Engl J Med. 2009 Jul 9;361(2):109-12. doi: 10.1056/NEJMp0904131. Epub 2009 Jun 3. No abstract available.


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