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Mitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease.

Ait-Aissa K, Blaszak SC, Beutner G, Tsaih SW, Morgan G, Santos JH, Flister MJ, Joyce DL, Camara AKS, Gutterman DD, Donato AJ, Porter GA Jr, Beyer AM.

Sci Rep. 2019 May 20;9(1):7623. doi: 10.1038/s41598-019-43761-y.


ORE Identifies Extreme Expression Effects Enriched for Rare Variants.

Richter F, Hoffman GE, Manheimer KB, Patel N, Sharp AJ, McKean D, Morton SU, DePalma S, Gorham J, Kitaygorodksy A, Porter GA, Giardini A, Shen Y, Chung WK, Seidman JG, Seidman CE, Schadt EE, Gelb BD.

Bioinformatics. 2019 Mar 23. pii: btz202. doi: 10.1093/bioinformatics/btz202. [Epub ahead of print]


The role of scientific evidence in decisions to adopt complex innovations in cancer care settings: a multiple case study in Nova Scotia, Canada.

Urquhart R, Kendell C, Geldenhuys L, Ross A, Rajaraman M, Folkes A, Madden LL, Sullivan V, Rayson D, Porter GA.

Implement Sci. 2019 Feb 12;14(1):14. doi: 10.1186/s13012-019-0859-5.


Reply to 'Double-outlet right ventricle is not hypoplastic left heart syndrome'.

Lo CW, Liu X, Gabriel GC, Martin LJ, Porter GA, Benson DW.

Nat Genet. 2019 Feb;51(2):198-199. doi: 10.1038/s41588-018-0323-5. No abstract available.


Dual role of inorganic polyphosphate in cardiac myocytes: The importance of polyP chain length for energy metabolism and mPTP activation.

Seidlmayer LK, Gomez-Garcia MR, Shiba T, Porter GA Jr, Pavlov EV, Bers DM, Dedkova EN.

Arch Biochem Biophys. 2019 Feb 15;662:177-189. doi: 10.1016/ Epub 2018 Dec 17.


Cyclophilin D, Somehow a Master Regulator of Mitochondrial Function.

Porter GA Jr, Beutner G.

Biomolecules. 2018 Dec 14;8(4). pii: E176. doi: 10.3390/biom8040176. Review.


Examining the implementation of clinical practice guidelines for the management of adult cancers: A mixed methods study.

Urquhart R, Woodside H, Kendell C, Porter GA.

J Eval Clin Pract. 2019 Aug;25(4):656-663. doi: 10.1111/jep.13073. Epub 2018 Nov 21.


Making It Happen: Middle Managers' Roles in Innovation Implementation in Health Care.

Urquhart R, Kendell C, Folkes A, Reiman T, Grunfeld E, Porter GA.

Worldviews Evid Based Nurs. 2018 Dec;15(6):414-423. doi: 10.1111/wvn.12324. Epub 2018 Oct 6.


Potassium conservation is impaired in mice with reduced renal expression of Kir4.1.

Malik S, Lambert E, Zhang J, Wang T, Clark HL, Cypress M, Goldman BI, Porter GA Jr, Pena S, Nino W, Gray DA.

Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1271-F1282. doi: 10.1152/ajprenal.00022.2018. Epub 2018 Aug 15.


Metabolomics reveals critical adrenergic regulatory checkpoints in glycolysis and pentose-phosphate pathways in embryonic heart.

Peoples JNR, Maxmillian T, Le Q, Nadtochiy SM, Brookes PS, Porter GA Jr, Davidson VL, Ebert SN.

J Biol Chem. 2018 May 4;293(18):6925-6941. doi: 10.1074/jbc.RA118.002566. Epub 2018 Mar 14.


Genetic Variance Partitioning and Genome-Wide Prediction with Allele Dosage Information in Autotetraploid Potato.

Endelman JB, Carley CAS, Bethke PC, Coombs JJ, Clough ME, da Silva WL, De Jong WS, Douches DS, Frederick CM, Haynes KG, Holm DG, Miller JC, Muñoz PR, Navarro FM, Novy RG, Palta JP, Porter GA, Rak KT, Sathuvalli VR, Thompson AL, Yencho GC.

Genetics. 2018 May;209(1):77-87. doi: 10.1534/genetics.118.300685. Epub 2018 Mar 7.


The Congenital Heart Disease Genetic Network Study: Cohort description.

Hoang TT, Goldmuntz E, Roberts AE, Chung WK, Kline JK, Deanfield JE, Giardini A, Aleman A, Gelb BD, Mac Neal M, Porter GA Jr, Kim R, Brueckner M, Lifton RP, Edman S, Woyciechowski S, Mitchell LE, Agopian AJ.

PLoS One. 2018 Jan 19;13(1):e0191319. doi: 10.1371/journal.pone.0191319. eCollection 2018.


Neonatal hyperoxia depletes pulmonary vein cardiomyocytes in adult mice via mitochondrial oxidation.

Yee M, Cohen ED, Domm W, Porter GA Jr, McDavid AN, O'Reilly MA.

Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L846-L859. doi: 10.1152/ajplung.00409.2017. Epub 2018 Jan 18.


Patterns of cancer centre follow-up care for survivors of breast, colorectal, gynecologic, and prostate cancer.

Urquhart R, Lethbridge L, Porter GA.

Curr Oncol. 2017 Dec;24(6):360-366. doi: 10.3747/co.24.3627. Epub 2017 Dec 20.


Cyclophilin D regulates the dynamic assembly of mitochondrial ATP synthase into synthasomes.

Beutner G, Alanzalon RE, Porter GA Jr.

Sci Rep. 2017 Nov 3;7(1):14488. doi: 10.1038/s41598-017-14795-x.


Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.

Jin SC, Homsy J, Zaidi S, Lu Q, Morton S, DePalma SR, Zeng X, Qi H, Chang W, Sierant MC, Hung WC, Haider S, Zhang J, Knight J, Bjornson RD, Castaldi C, Tikhonoa IR, Bilguvar K, Mane SM, Sanders SJ, Mital S, Russell MW, Gaynor JW, Deanfield J, Giardini A, Porter GA Jr, Srivastava D, Lo CW, Shen Y, Watkins WS, Yandell M, Yost HJ, Tristani-Firouzi M, Newburger JW, Roberts AE, Kim R, Zhao H, Kaltman JR, Goldmuntz E, Chung WK, Seidman JG, Gelb BD, Seidman CE, Lifton RP, Brueckner M.

Nat Genet. 2017 Nov;49(11):1593-1601. doi: 10.1038/ng.3970. Epub 2017 Oct 9.


The complex genetics of hypoplastic left heart syndrome.

Liu X, Yagi H, Saeed S, Bais AS, Gabriel GC, Chen Z, Peterson KA, Li Y, Schwartz MC, Reynolds WT, Saydmohammed M, Gibbs B, Wu Y, Devine W, Chatterjee B, Klena NT, Kostka D, de Mesy Bentley KL, Ganapathiraju MK, Dexheimer P, Leatherbury L, Khalifa O, Bhagat A, Zahid M, Pu W, Watkins S, Grossfeld P, Murray SA, Porter GA Jr, Tsang M, Martin LJ, Benson DW, Aronow BJ, Lo CW.

Nat Genet. 2017 Jul;49(7):1152-1159. doi: 10.1038/ng.3870. Epub 2017 May 22.


Preventing permeability transition pore opening increases mitochondrial maturation, myocyte differentiation and cardiac function in the neonatal mouse heart.

Lingan JV, Alanzalon RE, Porter GA Jr.

Pediatr Res. 2017 Jun;81(6):932-941. doi: 10.1038/pr.2017.19. Epub 2017 Jan 31.


Erratum to: The Mitochondrial Permeability Transition Pore and ATP Synthase.

Beutner G, Alavian KN, Jonas EA, Porter GA Jr.

Handb Exp Pharmacol. 2017;240:489. doi: 10.1007/164_2016_87. No abstract available.


The Mitochondrial Permeability Transition Pore and ATP Synthase.

Beutner G, Alavian KN, Jonas EA, Porter GA Jr.

Handb Exp Pharmacol. 2017;240:21-46. doi: 10.1007/164_2016_5. Erratum in: Handb Exp Pharmacol. 2017;240:489.


Decision-making by surgeons about referral for adjuvant therapy for patients with non-small-cell lung, breast or colorectal cancer: a qualitative study.

Urquhart R, Kendell C, Buduhan G, Rayson D, Sargeant J, Johnson P, Grunfeld E, Porter GA.

CMAJ Open. 2016 Jan 12;4(1):E7-E12. doi: 10.9778/cmajo.20150030. eCollection 2016 Jan-Mar.


Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development.

Maruyama EO, Lin H, Chiu SY, Yu HM, Porter GA, Hsu W.

Sci Rep. 2016 Feb 17;6:20999. doi: 10.1038/srep20999.


Physiological roles of the mitochondrial permeability transition pore.

Mnatsakanyan N, Beutner G, Porter GA, Alavian KN, Jonas EA.

J Bioenerg Biomembr. 2017 Feb;49(1):13-25. doi: 10.1007/s10863-016-9652-1. Epub 2016 Feb 11. Review.


De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies.

Homsy J, Zaidi S, Shen Y, Ware JS, Samocha KE, Karczewski KJ, DePalma SR, McKean D, Wakimoto H, Gorham J, Jin SC, Deanfield J, Giardini A, Porter GA Jr, Kim R, Bilguvar K, López-Giráldez F, Tikhonova I, Mane S, Romano-Adesman A, Qi H, Vardarajan B, Ma L, Daly M, Roberts AE, Russell MW, Mital S, Newburger JW, Gaynor JW, Breitbart RE, Iossifov I, Ronemus M, Sanders SJ, Kaltman JR, Seidman JG, Brueckner M, Gelb BD, Goldmuntz E, Lifton RP, Seidman CE, Chung WK.

Science. 2015 Dec 4;350(6265):1262-6. doi: 10.1126/science.aac9396.


Health System-Level Factors Influence the Implementation of Complex Innovations in Cancer Care.

Urquhart R, Jackson L, Sargeant J, Porter GA, Grunfeld E.

Healthc Policy. 2015 Nov;11(2):102-18.


Optical properties and residual stress in Nb-Si composite films prepared by magnetron cosputtering.

Tang CJ, Porter GA, Jaing CC, Tsai FM.

Appl Opt. 2015 Feb 1;54(4):959-65. doi: 10.1364/AO.54.000959.


Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the F(1)F(O) ATP synthase.

Jonas EA, Porter GA Jr, Beutner G, Mnatsakanyan N, Alavian KN.

Pharmacol Res. 2015 Sep;99:382-92. doi: 10.1016/j.phrs.2015.04.013. Epub 2015 May 5. Review.


Patterns of health care utilization preceding a colorectal cancer diagnosis are strong predictors of dying quickly following diagnosis.

Urquhart R, Johnston G, Abdolell M, Porter GA.

BMC Palliat Care. 2015 Jan 20;14:2. doi: 10.1186/1472-684X-14-2. eCollection 2015.


How do administrative data compare with a clinical registry for identifying 30-day postoperative complications?

Kao LS, Dimick JB, Porter GA; Evidence-Based Reviews in Surgery Group.

J Am Coll Surg. 2014 Dec;219(6):1187-91. doi: 10.1016/j.jamcollsurg.2014.09.002. Epub 2014 Nov 18. No abstract available.


Initiation of electron transport chain activity in the embryonic heart coincides with the activation of mitochondrial complex 1 and the formation of supercomplexes.

Beutner G, Eliseev RA, Porter GA Jr.

PLoS One. 2014 Nov 26;9(11):e113330. doi: 10.1371/journal.pone.0113330. eCollection 2014.


Bcl-xL in neuroprotection and plasticity.

Jonas EA, Porter GA, Alavian KN.

Front Physiol. 2014 Sep 17;5:355. doi: 10.3389/fphys.2014.00355. eCollection 2014. Review.


Multi-level factors influence the implementation and use of complex innovations in cancer care: a multiple case study of synoptic reporting.

Urquhart R, Porter GA, Sargeant J, Jackson L, Grunfeld E.

Implement Sci. 2014 Sep 16;9:121. doi: 10.1186/s13012-014-0121-0.


An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore.

Alavian KN, Beutner G, Lazrove E, Sacchetti S, Park HA, Licznerski P, Li H, Nabili P, Hockensmith K, Graham M, Porter GA Jr, Jonas EA.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10580-5. doi: 10.1073/pnas.1401591111. Epub 2014 Jun 16.


SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts.

Porter GA, Urciuoli WR, Brookes PS, Nadtochiy SM.

Am J Physiol Heart Circ Physiol. 2014 Jun 15;306(12):H1602-9. doi: 10.1152/ajpheart.00027.2014. Epub 2014 Apr 18.


Improvement of performance of liquid crystal microlens with polymer surface modification.

Hwang SJ, Liu YX, Porter GA.

Opt Express. 2014 Feb 24;22(4):4620-7. doi: 10.1364/OE.22.004620.


Tunable liquid crystal microlenses with crater polymer prepared by droplet evaporation.

Hwang SJ, Liu YX, Porter GA.

Opt Express. 2013 Dec 16;21(25):30731-8. doi: 10.1364/OE.21.030731.


Cross-disciplinary research in cancer: an opportunity to narrow the knowledge-practice gap.

Urquhart R, Grunfeld E, Jackson L, Sargeant J, Porter GA.

Curr Oncol. 2013 Dec;20(6):e512-21. doi: 10.3747/co.20.1487.


Clinical information available to oncologists in surgically treated rectal cancer: room to improve.

Porter GA, Urquhart RL, Rheaume D, Cwajna S, Cox MA, Grunfeld E.

Curr Oncol. 2013 Jun;20(3):166-72. doi: 10.3747/co.20.1215.


Population-based use of sphincter-preserving surgery in patients with rectal cancer: is there room for improvement?

Richardson DP, Porter GA, Johnson PM.

Dis Colon Rectum. 2013 Jun;56(6):704-10. doi: 10.1097/DCR.0b013e3182758c2b.


How do surgeons decide to refer patients for adjuvant cancer treatment? Protocol for a qualitative study.

Urquhart R, Kendell C, Sargeant J, Buduhan G, Johnson P, Rayson D, Grunfeld E, Porter GA.

Implement Sci. 2012 Oct 25;7:102. doi: 10.1186/1748-5908-7-102.


Mitochondria as a drug target in ischemic heart disease and cardiomyopathy.

Walters AM, Porter GA Jr, Brookes PS.

Circ Res. 2012 Oct 12;111(9):1222-36. doi: 10.1161/CIRCRESAHA.112.265660. Review.


Surgeon knowledge contributes to the relationship between surgeon volume and patient outcomes in rectal cancer.

Richardson DP, Porter GA, Johnson PM.

Ann Surg. 2013 Feb;257(2):295-301. doi: 10.1097/SLA.0b013e31825ffdca.


Examining stage IIB survival in a population-based cohort of patients with colorectal cancer.

Urquhart R, Bu J, Grunfeld E, Dewar R, MacIntyre M, Porter GA.

Cancer. 2012 Dec 1;118(23):5973-81. doi: 10.1002/cncr.27610. Epub 2012 May 30.


Reflections on knowledge brokering within a multidisciplinary research team.

Urquhart R, Porter GA, Grunfeld E.

J Contin Educ Health Prof. 2011 Fall;31(4):283-90. doi: 10.1002/chp.20128.


Evaluating survivorship care plans: results of a randomized, clinical trial of patients with breast cancer.

Grunfeld E, Julian JA, Pond G, Maunsell E, Coyle D, Folkes A, Joy AA, Provencher L, Rayson D, Rheaume DE, Porter GA, Paszat LF, Pritchard KI, Robidoux A, Smith S, Sussman J, Dent S, Sisler J, Wiernikowski J, Levine MN.

J Clin Oncol. 2011 Dec 20;29(36):4755-62. doi: 10.1200/JCO.2011.36.8373. Epub 2011 Oct 31.


Improving nodal harvest in colorectal cancer: so what?

Porter GA, Urquhart R, Bu J, Johnson P, Rayson D, Grunfeld E.

Ann Surg Oncol. 2012 Apr;19(4):1066-73. doi: 10.1245/s10434-011-2073-9. Epub 2011 Oct 4.


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