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Items: 9

1.

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Shrine N, Portelli MA, John C, Soler Artigas M, Bennett N, Hall R, Lewis J, Henry AP, Billington CK, Ahmad A, Packer RJ, Shaw D, Pogson ZEK, Fogarty A, McKeever TM, Singapuri A, Heaney LG, Mansur AH, Chaudhuri R, Thomson NC, Holloway JW, Lockett GA, Howarth PH, Djukanovic R, Hankinson J, Niven R, Simpson A, Chung KF, Sterk PJ, Blakey JD, Adcock IM, Hu S, Guo Y, Obeidat M, Sin DD, van den Berge M, Nickle DC, Bossé Y, Tobin MD, Hall IP, Brightling CE, Wain LV, Sayers I.

Lancet Respir Med. 2019 Jan;7(1):20-34. doi: 10.1016/S2213-2600(18)30389-8. Epub 2018 Dec 11.

2.

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

Wain LV, Shrine N, Artigas MS, Erzurumluoglu AM, Noyvert B, Bossini-Castillo L, Obeidat M, Henry AP, Portelli MA, Hall RJ, Billington CK, Rimington TL, Fenech AG, John C, Blake T, Jackson VE, Allen RJ, Prins BP; Understanding Society Scientific Group, Campbell A, Porteous DJ, Jarvelin MR, Wielscher M, James AL, Hui J, Wareham NJ, Zhao JH, Wilson JF, Joshi PK, Stubbe B, Rawal R, Schulz H, Imboden M, Probst-Hensch NM, Karrasch S, Gieger C, Deary IJ, Harris SE, Marten J, Rudan I, Enroth S, Gyllensten U, Kerr SM, Polasek O, Kähönen M, Surakka I, Vitart V, Hayward C, Lehtimäki T, Raitakari OT, Evans DM, Henderson AJ, Pennell CE, Wang CA, Sly PD, Wan ES, Busch R, Hobbs BD, Litonjua AA, Sparrow DW, Gulsvik A, Bakke PS, Crapo JD, Beaty TH, Hansel NN, Mathias RA, Ruczinski I, Barnes KC, Bossé Y, Joubert P, van den Berge M, Brandsma CA, Paré PD, Sin DD, Nickle DC, Hao K, Gottesman O, Dewey FE, Bruse SE, Carey DJ, Kirchner HL; Geisinger-Regeneron DiscovEHR Collaboration, Jonsson S, Thorleifsson G, Jonsdottir I, Gislason T, Stefansson K, Schurmann C, Nadkarni G, Bottinger EP, Loos RJ, Walters RG, Chen Z, Millwood IY, Vaucher J, Kurmi OP, Li L, Hansell AL, Brightling C, Zeggini E, Cho MH, Silverman EK, Sayers I, Trynka G, Morris AP, Strachan DP, Hall IP, Tobin MD.

Nat Genet. 2017 Mar;49(3):416-425. doi: 10.1038/ng.3787. Epub 2017 Feb 6.

3.

Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients.

Portelli MA, Moseley C, Stewart CE, Postma DS, Howarth P, Warner JA, Holloway JW, Koppelman GH, Brightling C, Sayers I.

Allergy. 2017 Mar;72(3):473-482. doi: 10.1111/all.13046. Epub 2016 Oct 5.

PMID:
27624865
4.

Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma.

Ierodiakonou D, Portelli MA, Postma DS, Koppelman GH, Gerritsen J, Ten Hacken NH, Timens W, Boezen HM, Vonk JM, Sayers I.

Eur Respir J. 2016 May;47(5):1568-71. doi: 10.1183/13993003.01571-2015. Epub 2016 Feb 11. No abstract available.

5.

Response.

Sayers I, Portelli MA, Siedlinski M.

FASEB J. 2015 Dec;29(12):4759. doi: 10.1096/fj.15-1201LTER. No abstract available. Erratum in: FASEB J. 2016 Jun;30(6):2451.

PMID:
26626708
6.

Cigarette Smoke and the Induction of Urokinase Plasminogen Activator Receptor In Vivo: Selective Contribution of Isoforms to Bronchial Epithelial Phenotype.

Portelli MA, Stewart CE, Hall IP, Brightling CE, Sayers I.

Am J Respir Cell Mol Biol. 2015 Aug;53(2):174-83. doi: 10.1165/rcmb.2014-0296OC.

PMID:
25490122
7.

Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction.

Wain LV, Sayers I, Soler Artigas M, Portelli MA, Zeggini E, Obeidat M, Sin DD, Bossé Y, Nickle D, Brandsma CA, Malarstig A, Vangjeli C, Jelinsky SA, John S, Kilty I, McKeever T, Shrine NR, Cook JP, Patel S, Spector TD, Hollox EJ, Hall IP, Tobin MD.

PLoS Genet. 2014 May 1;10(5):e1004314. doi: 10.1371/journal.pgen.1004314. eCollection 2014 May.

8.

Genetic risk factors for the development of allergic disease identified by genome-wide association.

Portelli MA, Hodge E, Sayers I.

Clin Exp Allergy. 2015 Jan;45(1):21-31. doi: 10.1111/cea.12327. Review.

9.

Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels.

Portelli MA, Siedlinski M, Stewart CE, Postma DS, Nieuwenhuis MA, Vonk JM, Nurnberg P, Altmuller J, Moffatt MF, Wardlaw AJ, Parker SG, Connolly MJ, Koppelman GH, Sayers I.

FASEB J. 2014 Feb;28(2):923-34. doi: 10.1096/fj.13-240879. Epub 2013 Nov 18.

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