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Items: 23

1.

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq.

Wienert B, Wyman SK, Richardson CD, Yeh CD, Akcakaya P, Porritt MJ, Morlock M, Vu JT, Kazane KR, Watry HL, Judge LM, Conklin BR, Maresca M, Corn JE.

Science. 2019 Apr 19;364(6437):286-289. doi: 10.1126/science.aav9023. Epub 2019 Apr 18.

2.

In vivo CRISPR editing with no detectable genome-wide off-target mutations.

Akcakaya P, Bobbin ML, Guo JA, Malagon-Lopez J, Clement K, Garcia SP, Fellows MD, Porritt MJ, Firth MA, Carreras A, Baccega T, Seeliger F, Bjursell M, Tsai SQ, Nguyen NT, Nitsch R, Mayr LM, Pinello L, Bohlooly-Y M, Aryee MJ, Maresca M, Joung JK.

Nature. 2018 Sep;561(7723):416-419. doi: 10.1038/s41586-018-0500-9. Epub 2018 Sep 12.

3.

Therapeutic Genome Editing With CRISPR/Cas9 in a Humanized Mouse Model Ameliorates α1-antitrypsin Deficiency Phenotype.

Bjursell M, Porritt MJ, Ericson E, Taheri-Ghahfarokhi A, Clausen M, Magnusson L, Admyre T, Nitsch R, Mayr L, Aasehaug L, Seeliger F, Maresca M, Bohlooly-Y M, Wiseman J.

EBioMedicine. 2018 Mar;29:104-111. doi: 10.1016/j.ebiom.2018.02.015. Epub 2018 Feb 19.

4.

Photothrombosis-induced infarction of the mouse cerebral cortex is not affected by the Nrf2-activator sulforaphane.

Porritt MJ, Andersson HC, Hou L, Nilsson Å, Pekna M, Pekny M, Nilsson M.

PLoS One. 2012;7(7):e41090. doi: 10.1371/journal.pone.0041090. Epub 2012 Jul 23.

5.

Long-term stimulation of neural progenitor cell migration after cortical ischemia in mice.

Osman AM, Porritt MJ, Nilsson M, Kuhn HG.

Stroke. 2011 Dec;42(12):3559-65. doi: 10.1161/STROKEAHA.111.627802. Epub 2011 Oct 6.

PMID:
21980195
6.

Trauma-induced reactive gliosis is reduced after treatment with octanol and carbenoxolone.

Andersson HC, Anderson MF, Porritt MJ, Nodin C, Blomstrand F, Nilsson M.

Neurol Res. 2011 Jul;33(6):614-24. doi: 10.1179/1743132810Y.0000000020.

PMID:
21708071
7.

Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia.

Howells DW, Porritt MJ, Rewell SS, O'Collins V, Sena ES, van der Worp HB, Traystman RJ, Macleod MR.

J Cereb Blood Flow Metab. 2010 Aug;30(8):1412-31. doi: 10.1038/jcbfm.2010.66. Epub 2010 May 19. Review.

8.

ACE inhibition reduces infarction in normotensive but not hypertensive rats: correlation with cortical ACE activity.

Porritt MJ, Chen M, Rewell SS, Dean RG, Burrell LM, Howells DW.

J Cereb Blood Flow Metab. 2010 Aug;30(8):1520-6. doi: 10.1038/jcbfm.2010.57. Epub 2010 Apr 21.

9.

Can animal models of disease reliably inform human studies?

van der Worp HB, Howells DW, Sena ES, Porritt MJ, Rewell S, O'Collins V, Macleod MR.

PLoS Med. 2010 Mar 30;7(3):e1000245. doi: 10.1371/journal.pmed.1000245.

10.

Comparison of inflammation in the brain and spinal cord following mechanical injury.

Batchelor PE, Tan S, Wills TE, Porritt MJ, Howells DW.

J Neurotrauma. 2008 Oct;25(10):1217-25. doi: 10.1089/neu.2007.0308.

PMID:
18986223
11.

Stimulation of axonal sprouting by trophic factors immobilized within the wound core.

Batchelor PE, Wills TE, Hewa AP, Porritt MJ, Howells DW.

Brain Res. 2008 May 13;1209:49-56. doi: 10.1016/j.brainres.2008.02.098. Epub 2008 Mar 10.

PMID:
18396265
12.

Striatal dopaminergic neurons are lost with Parkinson's disease progression.

Porritt MJ, Kingsbury AE, Hughes AJ, Howells DW.

Mov Disord. 2006 Dec;21(12):2208-11.

PMID:
17029264
13.

Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons.

Porritt MJ, Batchelor PE, Howells DW.

Exp Neurol. 2005 Mar;192(1):226-34.

PMID:
15698637
14.

Imaging the ischemic penumbra with 18F-fluoromisonidazole in a rat model of ischemic stroke.

Saita K, Chen M, Spratt NJ, Porritt MJ, Liberatore GT, Read SJ, Levi CR, Donnan GA, Ackermann U, Tochon-Danguy HJ, Sachinidis JI, Howells DW.

Stroke. 2004 Apr;35(4):975-80. Epub 2004 Mar 11.

PMID:
15017016
15.

Macrophages and Microglia Produce Local Trophic Gradients That Stimulate Axonal Sprouting Toward but Not beyond the Wound Edge.

Batchelor PE, Porritt MJ, Martinello P, Parish CL, Liberatore GT, Donnan GA, Howells DW.

Mol Cell Neurosci. 2002 Nov;21(3):436-53.

PMID:
12498785
16.

Periwound dopaminergic sprouting is dependent on numbers of wound macrophages.

Batchelor PE, Porritt MJ, Nilsson SK, Bertoncello I, Donnan GA, Howells DW.

Eur J Neurosci. 2002 Mar;15(5):826-32.

PMID:
11906524
17.

Reduced BDNF mRNA expression in the Parkinson's disease substantia nigra.

Howells DW, Porritt MJ, Wong JY, Batchelor PE, Kalnins R, Hughes AJ, Donnan GA.

Exp Neurol. 2000 Nov;166(1):127-35.

PMID:
11031089
18.
19.

New dopaminergic neurons in Parkinson's disease striatum.

Porritt MJ, Batchelor PE, Hughes AJ, Kalnins R, Donnan GA, Howells DW.

Lancet. 2000 Jul 1;356(9223):44-5.

PMID:
10892768
20.

Sprouting of dopaminergic axons after striatal injury: confirmation by markers not dependent on dopamine metabolism.

Liberatore GT, Finkelstein DI, Wong JY, Horne MK, Porritt MJ, Donnan GA, Howells DW.

Exp Neurol. 1999 Oct;159(2):565-73.

PMID:
10506529
21.

Tissue fixation prevents contamination of tritium-sensitive storage phosphor imaging plates.

Liberatore GT, Wong JY, Krenus D, Jeffreys BJ, Porritt MJ, Howells DW.

Biotechniques. 1999 Mar;26(3):432-4. No abstract available.

22.
23.

Expression of glial cell line-derived neurotrophic factor (GDNF) mRNA following mechanical injury to mouse striatum.

Liberatore GT, Wong JY, Porritt MJ, Donnan GA, Howells DW.

Neuroreport. 1997 Sep 29;8(14):3097-101.

PMID:
9331921

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