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Items: 49

1.

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Cancer Metabolism.

Avnet S, Baldini N, Brisson L, De Milito A, Otto AM, Pastoreková S, Porporato PE, Szabadkai G, Sonveaux P.

Front Oncol. 2018 Oct 3;8:329. doi: 10.3389/fonc.2018.00329. eCollection 2018.

2.

Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function.

Bettonville M, d'Aria S, Weatherly K, Porporato PE, Zhang J, Bousbata S, Sonveaux P, Braun MY.

Elife. 2018 Jun 18;7. pii: e30938. doi: 10.7554/eLife.30938.

3.

Signaling Pathways Regulating Redox Balance in Cancer Metabolism.

De Santis MC, Porporato PE, Martini M, Morandi A.

Front Oncol. 2018 Apr 23;8:126. doi: 10.3389/fonc.2018.00126. eCollection 2018. Review.

4.

Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting.

Wyart E, Reano S, Hsu MY, Longo DL, Li M, Hirsch E, Filigheddu N, Ghigo A, Riganti C, Porporato PE.

Oxid Med Cell Longev. 2018 Feb 26;2018:6419805. doi: 10.1155/2018/6419805. eCollection 2018.

5.

Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth.

Li M, Sala V, De Santis MC, Cimino J, Cappello P, Pianca N, Di Bona A, Margaria JP, Martini M, Lazzarini E, Pirozzi F, Rossi L, Franco I, Bornbaum J, Heger J, Rohrbach S, Perino A, Tocchetti CG, Lima BHF, Teixeira MM, Porporato PE, Schulz R, Angelini A, Sandri M, Ameri P, Sciarretta S, Lima-Júnior RCP, Mongillo M, Zaglia T, Morello F, Novelli F, Hirsch E, Ghigo A.

Circulation. 2018 Aug 14;138(7):696-711. doi: 10.1161/CIRCULATIONAHA.117.030352.

PMID:
29348263
6.

(+)-Catechin in a 1:2 Complex with Lysine Inhibits Cancer Cell Migration and Metastatic Take in Mice.

Payen VL, Porporato PE, Danhier P, Vazeille T, Blackman MCNM, May BH, Niebes P, Sonveaux P.

Front Pharmacol. 2017 Dec 4;8:869. doi: 10.3389/fphar.2017.00869. eCollection 2017.

7.

Mitochondrial metabolism and cancer.

Porporato PE, Filigheddu N, Pedro JMB, Kroemer G, Galluzzi L.

Cell Res. 2018 Mar;28(3):265-280. doi: 10.1038/cr.2017.155. Epub 2017 Dec 8. Review.

8.

Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology.

Contino S, Porporato PE, Bird M, Marinangeli C, Opsomer R, Sonveaux P, Bontemps F, Dewachter I, Octave JN, Bertrand L, Stanga S, Kienlen-Campard P.

Front Physiol. 2017 Oct 12;8:796. doi: 10.3389/fphys.2017.00796. eCollection 2017.

9.

Ffar2 expression regulates leukaemic cell growth in vivo.

Bindels LB, Porporato PE, Ducastel S, Sboarina M, Neyrinck AM, Dewulf EM, Feron O, Lestavel S, Cani PD, Staels B, Sonveaux P, Delzenne NM.

Br J Cancer. 2017 Oct 24;117(9):1336-1340. doi: 10.1038/bjc.2017.307. Epub 2017 Sep 5.

10.

MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: A new rationale for the pathogenesis of osteolytic bone metastases.

Lemma S, Di Pompo G, Porporato PE, Sboarina M, Russell S, Gillies RJ, Baldini N, Sonveaux P, Avnet S.

Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3254-3264. doi: 10.1016/j.bbadis.2017.08.030. Epub 2017 Sep 1.

11.

Monocarboxylate Transporter MCT1 Promotes Tumor Metastasis Independently of Its Activity as a Lactate Transporter.

Payen VL, Hsu MY, Rädecke KS, Wyart E, Vazeille T, Bouzin C, Porporato PE, Sonveaux P.

Cancer Res. 2017 Oct 15;77(20):5591-5601. doi: 10.1158/0008-5472.CAN-17-0764. Epub 2017 Aug 21.

12.

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Networks in Cancer.

Baldini N, De Milito A, Feron O, Gillies RJ, Michiels C, Otto AM, Pastoreková S, Pedersen SF, Porporato PE, Sonveaux P, Supuran CT, Avnet S.

Front Pharmacol. 2017 Jul 4;8:411. doi: 10.3389/fphar.2017.00411. eCollection 2017.

13.

Cancer metabolism in space and time: Beyond the Warburg effect.

Danhier P, Bański P, Payen VL, Grasso D, Ippolito L, Sonveaux P, Porporato PE.

Biochim Biophys Acta Bioenerg. 2017 Aug;1858(8):556-572. doi: 10.1016/j.bbabio.2017.02.001. Epub 2017 Feb 4. Review.

14.

Multimodality Imaging Identifies Distinct Metabolic Profiles In Vitro and In Vivo.

Neveu MA, De Preter G, Marchand V, Bol A, Brender JR, Saito K, Kishimoto S, Porporato PE, Sonveaux P, Grégoire V, Feron O, Jordan BF, Krishna MC, Gallez B.

Neoplasia. 2016 Dec;18(12):742-752. doi: 10.1016/j.neo.2016.10.010. Epub 2016 Nov 24.

15.

Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer.

Brisson L, Bański P, Sboarina M, Dethier C, Danhier P, Fontenille MJ, Van Hée VF, Vazeille T, Tardy M, Falces J, Bouzin C, Porporato PE, Frédérick R, Michiels C, Copetti T, Sonveaux P.

Cancer Cell. 2016 Sep 12;30(3):418-431. doi: 10.1016/j.ccell.2016.08.005.

16.

Energy metabolism in osteoclast formation and activity.

Lemma S, Sboarina M, Porporato PE, Zini N, Sonveaux P, Di Pompo G, Baldini N, Avnet S.

Int J Biochem Cell Biol. 2016 Oct;79:168-180. doi: 10.1016/j.biocel.2016.08.034. Epub 2016 Aug 30.

PMID:
27590854
17.

Paving the way for therapeutic prevention of tumor metastasis with agents targeting mitochondrial superoxide.

Porporato PE, Sonveaux P.

Mol Cell Oncol. 2014 Oct 29;2(3):e968043. doi: 10.4161/23723548.2014.968043. eCollection 2015 Jul-Sep.

18.

Understanding cachexia as a cancer metabolism syndrome.

Porporato PE.

Oncogenesis. 2016 Feb 22;5:e200. doi: 10.1038/oncsis.2016.3. Review.

19.

Direct Evidence of the Link Between Energetic Metabolism and Proliferation Capacity of Cancer Cells In Vitro.

De Preter G, Danhier P, Porporato PE, Payen VL, Jordan BF, Sonveaux P, Gallez B.

Adv Exp Med Biol. 2016;876:209-214. doi: 10.1007/978-1-4939-3023-4_26.

PMID:
26782214
20.

Application of Electron Paramagnetic Resonance (EPR) Oximetry to Monitor Oxygen in Wounds in Diabetic Models.

Desmet CM, Lafosse A, Vériter S, Porporato PE, Sonveaux P, Dufrane D, Levêque P, Gallez B.

PLoS One. 2015 Dec 14;10(12):e0144914. doi: 10.1371/journal.pone.0144914. eCollection 2015.

21.

Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism.

Porporato PE, Payen VL, Baselet B, Sonveaux P.

Cell Mol Life Sci. 2016 Apr;73(7):1349-63. doi: 10.1007/s00018-015-2100-2. Epub 2015 Dec 8. Review.

PMID:
26646069
22.

Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.

Pérez-Escuredo J, Dadhich RK, Dhup S, Cacace A, Van Hée VF, De Saedeleer CJ, Sboarina M, Rodriguez F, Fontenille MJ, Brisson L, Porporato PE, Sonveaux P.

Cell Cycle. 2016;15(1):72-83. doi: 10.1080/15384101.2015.1120930.

23.

Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway.

Payen VL, Porporato PE, Baselet B, Sonveaux P.

Cell Mol Life Sci. 2016 Apr;73(7):1333-48. doi: 10.1007/s00018-015-2098-5. Epub 2015 Dec 1. Review.

PMID:
26626411
24.

Non-invasive in vivo imaging of early metabolic tumor response to therapies targeting choline metabolism.

Mignion L, Danhier P, Magat J, Porporato PE, Masquelier J, Gregoire V, Muccioli GG, Sonveaux P, Gallez B, Jordan BF.

Int J Cancer. 2016 Apr 15;138(8):2043-9. doi: 10.1002/ijc.29932. Epub 2015 Dec 9.

25.

Inhibition of the pentose phosphate pathway by dichloroacetate unravels a missing link between aerobic glycolysis and cancer cell proliferation.

De Preter G, Neveu MA, Danhier P, Brisson L, Payen VL, Porporato PE, Jordan BF, Sonveaux P, Gallez B.

Oncotarget. 2016 Jan 19;7(3):2910-20. doi: 10.18632/oncotarget.6272.

26.

In vivo visualization and ex vivo quantification of murine breast cancer cells in the mouse brain using MRI cell tracking and electron paramagnetic resonance.

Danhier P, Magat J, Levêque P, De Preter G, Porporato PE, Bouzin C, Jordan BF, Demeur G, Haufroid V, Feron O, Sonveaux P, Gallez B.

NMR Biomed. 2015 Mar;28(3):367-75. doi: 10.1002/nbm.3259. Epub 2015 Jan 22.

PMID:
25611487
27.

PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing.

Chereddy KK, Her CH, Comune M, Moia C, Lopes A, Porporato PE, Vanacker J, Lam MC, Steinstraesser L, Sonveaux P, Zhu H, Ferreira LS, Vandermeulen G, Préat V.

J Control Release. 2014 Nov 28;194:138-47. doi: 10.1016/j.jconrel.2014.08.016. Epub 2014 Aug 27.

PMID:
25173841
28.

A mitochondrial switch promotes tumor metastasis.

Porporato PE, Payen VL, Pérez-Escuredo J, De Saedeleer CJ, Danhier P, Copetti T, Dhup S, Tardy M, Vazeille T, Bouzin C, Feron O, Michiels C, Gallez B, Sonveaux P.

Cell Rep. 2014 Aug 7;8(3):754-66. doi: 10.1016/j.celrep.2014.06.043. Epub 2014 Jul 24.

29.

Reprogramming of tumor metabolism by targeting mitochondria improves tumor response to irradiation.

Bol V, Bol A, Bouzin C, Labar D, Lee JA, Janssens G, Porporato PE, Sonveaux P, Feron O, Grégoire V.

Acta Oncol. 2015 Feb;54(2):266-74. doi: 10.3109/0284186X.2014.932006. Epub 2014 Jul 9.

PMID:
25007226
30.

The diacylglycerol kinase α/atypical PKC/β1 integrin pathway in SDF-1α mammary carcinoma invasiveness.

Rainero E, Cianflone C, Porporato PE, Chianale F, Malacarne V, Bettio V, Ruffo E, Ferrara M, Benecchia F, Capello D, Paster W, Locatelli I, Bertoni A, Filigheddu N, Sinigaglia F, Norman JC, Baldanzi G, Graziani A.

PLoS One. 2014 Jun 2;9(6):e97144. doi: 10.1371/journal.pone.0097144. eCollection 2014.

31.

Multimodal cell tracking of a spontaneous metastasis model: comparison between MRI, electron paramagnetic resonance and bioluminescence.

Danhier P, De Preter G, Magat J, Godechal Q, Porporato PE, Jordan BF, Feron O, Sonveaux P, Gallez B.

Contrast Media Mol Imaging. 2014 Mar-Apr;9(2):143-53. doi: 10.1002/cmmi.1553.

PMID:
24523059
32.

Skin electroporation of a plasmid encoding hCAP-18/LL-37 host defense peptide promotes wound healing.

Steinstraesser L, Lam MC, Jacobsen F, Porporato PE, Chereddy KK, Becerikli M, Stricker I, Hancock RE, Lehnhardt M, Sonveaux P, Préat V, Vandermeulen G.

Mol Ther. 2014 Apr;22(4):734-42. doi: 10.1038/mt.2013.258. Epub 2013 Dec 5.

33.

Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration.

De Saedeleer CJ, Porporato PE, Copetti T, Pérez-Escuredo J, Payen VL, Brisson L, Feron O, Sonveaux P.

Oncogene. 2014 Jul 31;33(31):4060-8. doi: 10.1038/onc.2013.454. Epub 2013 Oct 28.

PMID:
24166504
34.

Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells.

de Meester C, Timmermans AD, Balteau M, Ginion A, Roelants V, Noppe G, Porporato PE, Sonveaux P, Viollet B, Sakamoto K, Feron O, Horman S, Vanoverschelde JL, Beauloye C, Bertrand L.

Cardiovasc Res. 2014 Jan 1;101(1):20-9. doi: 10.1093/cvr/cvt227. Epub 2013 Oct 8.

PMID:
24104879
35.

Optimization of tumor radiotherapy with modulators of cell metabolism: toward clinical applications.

Danhier P, De Saedeleer CJ, Karroum O, De Preter G, Porporato PE, Jordan BF, Gallez B, Sonveaux P.

Semin Radiat Oncol. 2013 Oct;23(4):262-72. doi: 10.1016/j.semradonc.2013.05.008. Review.

PMID:
24012340
36.

Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice.

Porporato PE, Filigheddu N, Reano S, Ferrara M, Angelino E, Gnocchi VF, Prodam F, Ronchi G, Fagoonee S, Fornaro M, Chianale F, Baldanzi G, Surico N, Sinigaglia F, Perroteau I, Smith RG, Sun Y, Geuna S, Graziani A.

J Clin Invest. 2013 Feb;123(2):611-22. doi: 10.1172/JCI39920. Epub 2013 Jan 2.

37.

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells.

De Saedeleer CJ, Copetti T, Porporato PE, Verrax J, Feron O, Sonveaux P.

PLoS One. 2012;7(10):e46571. doi: 10.1371/journal.pone.0046571. Epub 2012 Oct 17.

38.

Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice.

Porporato PE, Payen VL, De Saedeleer CJ, Préat V, Thissen JP, Feron O, Sonveaux P.

Angiogenesis. 2012 Dec;15(4):581-92. doi: 10.1007/s10456-012-9282-0. Epub 2012 Jun 3.

PMID:
22660894
39.

Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis.

Dhup S, Dadhich RK, Porporato PE, Sonveaux P.

Curr Pharm Des. 2012;18(10):1319-30. Review.

PMID:
22360558
40.

SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling.

Baldanzi G, Pighini A, Bettio V, Rainero E, Traini S, Chianale F, Porporato PE, Filigheddu N, Mesturini R, Song S, Schweighoffer T, Patrussi L, Baldari CT, Zhong XP, van Blitterswijk WJ, Sinigaglia F, Nichols KE, Rubio I, Parolini O, Graziani A.

J Immunol. 2011 Dec 1;187(11):5941-51. doi: 10.4049/jimmunol.1002476. Epub 2011 Nov 2.

41.

Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review.

Porporato PE, Dhup S, Dadhich RK, Copetti T, Sonveaux P.

Front Pharmacol. 2011 Aug 25;2:49. doi: 10.3389/fphar.2011.00049. eCollection 2011.

42.

Assessment of melanoma extent and melanoma metastases invasion using electron paramagnetic resonance and bioluminescence imaging.

Godechal Q, Defresne F, Danhier P, Leveque P, Porporato PE, Sonveaux P, Baurain JF, Feron O, Gallez B.

Contrast Media Mol Imaging. 2011 Jul-Aug;6(4):282-8. doi: 10.1002/cmmi.430.

PMID:
21861288
43.

Diacylglycerol kinase α mediates 17-β-estradiol-induced proliferation, motility, and anchorage-independent growth of Hec-1A endometrial cancer cell line through the G protein-coupled estrogen receptor GPR30.

Filigheddu N, Sampietro S, Chianale F, Porporato PE, Gaggianesi M, Gregnanin I, Rainero E, Ferrara M, Perego B, Riboni F, Baldanzi G, Graziani A, Surico N.

Cell Signal. 2011 Dec;23(12):1988-96. doi: 10.1016/j.cellsig.2011.07.009. Epub 2011 Jul 22.

PMID:
21802511
44.

NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment.

Moon EJ, Sonveaux P, Porporato PE, Danhier P, Gallez B, Batinic-Haberle I, Nien YC, Schroeder T, Dewhirst MW.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20477-82. doi: 10.1073/pnas.1006646107. Epub 2010 Nov 8.

45.

Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis.

Filigheddu N, Gregnanin I, Porporato PE, Surico D, Perego B, Galli L, Patrignani C, Graziani A, Surico N.

J Biomed Biotechnol. 2010;2010:369549. doi: 10.1155/2010/369549. Epub 2010 Mar 10.

46.

Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI.

Chianale F, Rainero E, Cianflone C, Bettio V, Pighini A, Porporato PE, Filigheddu N, Serini G, Sinigaglia F, Baldanzi G, Graziani A.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4182-7. doi: 10.1073/pnas.0908326107. Epub 2010 Feb 16.

47.

Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling.

Chianale F, Cutrupi S, Rainero E, Baldanzi G, Porporato PE, Traini S, Filigheddu N, Gnocchi VF, Santoro MM, Parolini O, van Blitterswijk WJ, Sinigaglia F, Graziani A.

Mol Biol Cell. 2007 Dec;18(12):4859-71. Epub 2007 Sep 26.

48.

Diacylglycerol kinase is required for HGF-induced invasiveness and anchorage-independent growth of MDA-MB-231 breast cancer cells.

Filigheddu N, Cutrupi S, Porporato PE, Riboni F, Baldanzi G, Chianale F, Fortina E, Piantanida P, De Bortoli M, Vacca G, Graziani A, Surico N.

Anticancer Res. 2007 May-Jun;27(3B):1489-92.

49.

Ghrelin and des-acyl ghrelin promote differentiation and fusion of C2C12 skeletal muscle cells.

Filigheddu N, Gnocchi VF, Coscia M, Cappelli M, Porporato PE, Taulli R, Traini S, Baldanzi G, Chianale F, Cutrupi S, Arnoletti E, Ghè C, Fubini A, Surico N, Sinigaglia F, Ponzetto C, Muccioli G, Crepaldi T, Graziani A.

Mol Biol Cell. 2007 Mar;18(3):986-94. Epub 2007 Jan 3.

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