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Items: 24

1.

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.

Zammit NW, Siggs OM, Gray PE, Horikawa K, Langley DB, Walters SN, Daley SR, Loetsch C, Warren J, Yap JY, Cultrone D, Russell A, Malle EK, Villanueva JE, Cowley MJ, Gayevskiy V, Dinger ME, Brink R, Zahra D, Chaudhri G, Karupiah G, Whittle B, Roots C, Bertram E, Yamada M, Jeelall Y, Enders A, Clifton BE, Mabbitt PD, Jackson CJ, Watson SR, Jenne CN, Lanier LL, Wiltshire T, Spitzer MH, Nolan GP, Schmitz F, Aderem A, Porebski BT, Buckle AM, Abbott DW, Ziegler JB, Craig ME, Benitez-Aguirre P, Teo J, Tangye SG, King C, Wong M, Cox MP, Phung W, Tang J, Sandoval W, Wertz IE, Christ D, Goodnow CC, Grey ST.

Nat Immunol. 2019 Oct;20(10):1299-1310. doi: 10.1038/s41590-019-0492-0. Epub 2019 Sep 18.

PMID:
31534238
2.

A synthetic genetic polymer with an uncharged backbone chemistry based on alkyl phosphonate nucleic acids.

Arangundy-Franklin S, Taylor AI, Porebski BT, Genna V, Peak-Chew S, Vaisman A, Woodgate R, Orozco M, Holliger P.

Nat Chem. 2019 Jun;11(6):533-542. doi: 10.1038/s41557-019-0255-4. Epub 2019 Apr 22.

3.

Reactive centre loop dynamics and serpin specificity.

Marijanovic EM, Fodor J, Riley BT, Porebski BT, Costa MGS, Kass I, Hoke DE, McGowan S, Buckle AM.

Sci Rep. 2019 Mar 7;9(1):3870. doi: 10.1038/s41598-019-40432-w.

4.

Random-sequence genetic oligomer pools display an innate potential for ligation and recombination.

Mutschler H, Taylor AI, Porebski BT, Lightowlers A, Houlihan G, Abramov M, Herdewijn P, Holliger P.

Elife. 2018 Nov 21;7. pii: e43022. doi: 10.7554/eLife.43022.

5.

Mapping the Pathway and Dynamics of Bestatin Inhibition of the Plasmodium falciparum M1 Aminopeptidase PfA-M1.

Yang W, Riley BT, Lei X, Porebski BT, Kass I, Buckle AM, McGowan S.

ChemMedChem. 2018 Dec 6;13(23):2504-2513. doi: 10.1002/cmdc.201800563. Epub 2018 Nov 9.

PMID:
30318749
6.

Structural Capacitance in Protein Evolution and Human Diseases.

Li C, Clark LVT, Zhang R, Porebski BT, McCoey JM, Borg NA, Webb GI, Kass I, Buckle M, Song J, Woolfson A, Buckle AM.

J Mol Biol. 2018 Sep 14;430(18 Pt B):3200-3217. doi: 10.1016/j.jmb.2018.06.051. Epub 2018 Jul 3.

PMID:
30111491
7.

Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.

Burnett DL, Langley DB, Schofield P, Hermes JR, Chan TD, Jackson J, Bourne K, Reed JH, Patterson K, Porebski BT, Brink R, Christ D, Goodnow CC.

Science. 2018 Apr 13;360(6385):223-226. doi: 10.1126/science.aao3859.

8.

Generation of AMBER force field parameters for zinc centres of M1 and M17 family aminopeptidases.

Yang W, Riley BT, Lei X, Porebski BT, Kass I, Buckle AM, McGowan S.

J Biomol Struct Dyn. 2018 Aug;36(10):2595-2604. doi: 10.1080/07391102.2017.1364669. Epub 2017 Aug 28.

PMID:
28782419
9.

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2.

Huma ZE, Sanchez J, Lim HD, Bridgford JL, Huang C, Parker BJ, Pazhamalil JG, Porebski BT, Pfleger KDG, Lane JR, Canals M, Stone MJ.

Sci Signal. 2017 May 23;10(480). pii: eaai8529. doi: 10.1126/scisignal.aai8529.

PMID:
28536301
10.

Structural reconstruction of protein ancestry.

Rouet R, Langley DB, Schofield P, Christie M, Roome B, Porebski BT, Buckle AM, Clifton BE, Jackson CJ, Stock D, Christ D.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3897-3902. doi: 10.1073/pnas.1613477114. Epub 2017 Mar 29.

11.

Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics.

Riley BT, Ilyichova O, Costa MG, Porebski BT, de Veer SJ, Swedberg JE, Kass I, Harris JM, Hoke DE, Buckle AM.

Sci Rep. 2016 Oct 21;6:35385. doi: 10.1038/srep35385.

12.

The role of protein dynamics in the evolution of new enzyme function.

Campbell E, Kaltenbach M, Correy GJ, Carr PD, Porebski BT, Livingstone EK, Afriat-Jurnou L, Buckle AM, Weik M, Hollfelder F, Tokuriki N, Jackson CJ.

Nat Chem Biol. 2016 Nov;12(11):944-950. doi: 10.1038/nchembio.2175. Epub 2016 Sep 12.

PMID:
27618189
13.

Smoothing a rugged protein folding landscape by sequence-based redesign.

Porebski BT, Keleher S, Hollins JJ, Nickson AA, Marijanovic EM, Borg NA, Costa MG, Pearce MA, Dai W, Zhu L, Irving JA, Hoke DE, Kass I, Whisstock JC, Bottomley SP, Webb GI, McGowan S, Buckle AM.

Sci Rep. 2016 Sep 26;6:33958. doi: 10.1038/srep33958.

14.

Circumventing the stability-function trade-off in an engineered FN3 domain.

Porebski BT, Conroy PJ, Drinkwater N, Schofield P, Vazquez-Lombardi R, Hunter MR, Hoke DE, Christ D, McGowan S, Buckle AM.

Protein Eng Des Sel. 2016 Nov 1;29(11):541-550. doi: 10.1093/protein/gzw046.

15.

Consensus protein design.

Porebski BT, Buckle AM.

Protein Eng Des Sel. 2016 Jul;29(7):245-51. doi: 10.1093/protein/gzw015. Epub 2016 Jun 5. Review.

16.

Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity.

Le SN, Porebski BT, McCoey J, Fodor J, Riley B, Godlewska M, Góra M, Czarnocka B, Banga JP, Hoke DE, Kass I, Buckle AM.

PLoS One. 2015 Dec 1;10(12):e0142615. doi: 10.1371/journal.pone.0142615. eCollection 2015.

17.

Critical evaluation of in silico methods for prediction of coiled-coil domains in proteins.

Li C, Ching Han Chang C, Nagel J, Porebski BT, Hayashida M, Akutsu T, Song J, Buckle AM.

Brief Bioinform. 2016 Mar;17(2):270-82. doi: 10.1093/bib/bbv047. Epub 2015 Jul 15. Review.

18.

Solution structure of a soluble fragment derived from a membrane protein by shotgun proteolysis.

Allen MD, Christie M, Jones P, Porebski BT, Roome B, Freund SM, Buckle AM, Bycroft M, Christ D.

Protein Eng Des Sel. 2015 Oct;28(10):445-50. doi: 10.1093/protein/gzv021. Epub 2015 Apr 15.

19.

Structural and dynamic properties that govern the stability of an engineered fibronectin type III domain.

Porebski BT, Nickson AA, Hoke DE, Hunter MR, Zhu L, McGowan S, Webb GI, Buckle AM.

Protein Eng Des Sel. 2015 Mar;28(3):67-78. doi: 10.1093/protein/gzv002.

20.

Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis.

Kass I, Hoke DE, Costa MG, Reboul CF, Porebski BT, Cowieson NP, Leh H, Pennacchietti E, McCoey J, Kleifeld O, Borri Voltattorni C, Langley D, Roome B, Mackay IR, Christ D, Perahia D, Buckle M, Paiardini A, De Biase D, Buckle AM.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2524-9. doi: 10.1073/pnas.1403182111. Epub 2014 Jun 9.

21.

Interactive visualization tools for the structural biologist.

Porebski BT, Ho BK, Buckle AM.

J Appl Crystallogr. 2013 Oct 1;46(Pt 5):1518-1520. Epub 2013 Aug 3.

22.

A redundant role of human thyroid peroxidase propeptide for cellular, enzymatic, and immunological activity.

Godlewska M, Góra M, Buckle AM, Porebski BT, Kemp EH, Sutton BJ, Czarnocka B, Banga JP.

Thyroid. 2014 Feb;24(2):371-82. doi: 10.1089/thy.2013.0127. Epub 2013 Sep 26.

23.

Structural and dynamic requirements for optimal activity of the essential bacterial enzyme dihydrodipicolinate synthase.

Reboul CF, Porebski BT, Griffin MD, Dobson RC, Perugini MA, Gerrard JA, Buckle AM.

PLoS Comput Biol. 2012;8(6):e1002537. doi: 10.1371/journal.pcbi.1002537. Epub 2012 Jun 7.

24.

Epitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complex.

Reboul CF, Meyer GR, Porebski BT, Borg NA, Buckle AM.

PLoS Comput Biol. 2012;8(3):e1002404. doi: 10.1371/journal.pcbi.1002404. Epub 2012 Mar 8.

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