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Items: 1 to 50 of 60

1.

Caffeine and cannabinoid receptors modulate impulsive behavior in an animal model of attentional deficit and hyperactivity disorder.

Leffa DT, Ferreira SG, Machado NJ, Souza CM, Rosa FD, de Carvalho C, Kincheski GC, Takahashi RN, Porciúncula LO, Souza DO, Cunha RA, Pandolfo P.

Eur J Neurosci. 2019 Jun;49(12):1673-1683. doi: 10.1111/ejn.14348. Epub 2019 Feb 8.

PMID:
30667546
2.

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions.

Canas PM, Porciúncula LO, Simões AP, Augusto E, Silva HB, Machado NJ, Gonçalves N, Alfaro TM, Gonçalves FQ, Araújo IM, Real JI, Coelho JE, Andrade GM, Almeida RD, Chen JF, Köfalvi A, Agostinho P, Cunha RA.

eNeuro. 2018 Dec 26;5(6). pii: ENEURO.0385-18.2018. doi: 10.1523/ENEURO.0385-18.2018. eCollection 2018 Nov-Dec.

3.

Guanosine Attenuates Behavioral Deficits After Traumatic Brain Injury by Modulation of Adenosinergic Receptors.

Dobrachinski F, Gerbatin RR, Sartori G, Golombieski RM, Antoniazzi A, Nogueira CW, Royes LF, Fighera MR, Porciúncula LO, Cunha RA, Soares FAA.

Mol Neurobiol. 2019 May;56(5):3145-3158. doi: 10.1007/s12035-018-1296-1. Epub 2018 Aug 13.

PMID:
30105669
4.

Differential Behavioral and Biochemical Responses to Caffeine in Male and Female Rats from a Validated Model of Attention Deficit and Hyperactivity Disorder.

Nunes F, Pochmann D, Almeida AS, Marques DM, Porciúncula LO.

Mol Neurobiol. 2018 Nov;55(11):8486-8498. doi: 10.1007/s12035-018-1000-5. Epub 2018 Mar 20.

PMID:
29557061
5.

Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation.

Simões AP, Silva CG, Marques JM, Pochmann D, Porciúncula LO, Ferreira S, Oses JP, Beleza RO, Real JI, Köfalvi A, Bahr BA, Lerma J, Cunha RA, Rodrigues RJ.

Cell Death Dis. 2018 Feb 20;9(3):297. doi: 10.1038/s41419-018-0351-1.

6.

Different effects of caffeine on behavioral neurophenotypes of two zebrafish populations.

Rosa LV, Ardais AP, Costa FV, Fontana BD, Quadros VA, Porciúncula LO, Rosemberg DB.

Pharmacol Biochem Behav. 2018 Feb;165:1-8. doi: 10.1016/j.pbb.2017.12.002. Epub 2017 Dec 12.

PMID:
29241648
7.

Sex differences in the effects of pre- and postnatal caffeine exposure on behavior and synaptic proteins in pubescent rats.

Sallaberry C, Ardais AP, Rocha A, Borges MF, Fioreze GT, Mioranzza S, Nunes F, Pagnussat N, Botton PHS, Porciúncula LO.

Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 2;81:416-425. doi: 10.1016/j.pnpbp.2017.08.015. Epub 2017 Aug 19.

8.

Aged mice receiving caffeine since adulthood show distinct patterns of anxiety-related behavior.

Botton PH, Pochmann D, Rocha AS, Nunes F, Almeida AS, Marques DM, Porciúncula LO.

Physiol Behav. 2017 Mar 1;170:47-53. doi: 10.1016/j.physbeh.2016.11.030. Epub 2016 Nov 24.

PMID:
27890589
9.

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses.

Machado NJ, Simões AP, Silva HB, Ardais AP, Kaster MP, Garção P, Rodrigues DI, Pochmann D, Santos AI, Araújo IM, Porciúncula LO, Tomé ÂR, Köfalvi A, Vaugeois JM, Agostinho P, El Yacoubi M, Cunha RA, Gomes CA.

Mol Neurobiol. 2017 Mar;54(2):1552-1563. doi: 10.1007/s12035-016-9774-9. Epub 2016 Feb 9.

PMID:
26860412
10.

Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice.

de Oliveira ED, Schallenberger C, Böhmer AE, Hansel G, Fagundes AC, Milman M, Silva MD, Oses JP, Porciúncula LO, Portela LV, Elisabetsky E, Souza DO, Schmidt AP.

Eur J Pharmacol. 2016 Feb 5;772:71-82. doi: 10.1016/j.ejphar.2015.12.034. Epub 2015 Dec 19.

11.

Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress.

Kaster MP, Machado NJ, Silva HB, Nunes A, Ardais AP, Santana M, Baqi Y, Müller CE, Rodrigues AL, Porciúncula LO, Chen JF, Tomé ÂR, Agostinho P, Canas PM, Cunha RA.

Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7833-8. doi: 10.1073/pnas.1423088112. Epub 2015 Jun 8.

12.

Adenosine A(2A) receptors are necessary and sufficient to trigger memory impairment in adult mice.

Pagnussat N, Almeida AS, Marques DM, Nunes F, Chenet GC, Botton PH, Mioranzza S, Loss CM, Cunha RA, Porciúncula LO.

Br J Pharmacol. 2015 Aug;172(15):3831-45. doi: 10.1111/bph.13180. Epub 2015 Jun 26.

13.

Cross-generational trans fat intake facilitates mania-like behavior: oxidative and molecular markers in brain cortex.

Trevizol F, Roversi K, Dias VT, Roversi K, Barcelos RC, Kuhn FT, Pase CS, Golombieski R, Veit JC, Piccolo J, Pochmann D, Porciúncula LO, Emanuelli T, Rocha JB, Bürger ME.

Neuroscience. 2015 Feb 12;286:353-63. doi: 10.1016/j.neuroscience.2014.11.059. Epub 2014 Dec 8.

PMID:
25499313
14.

Prenatal caffeine intake differently affects synaptic proteins during fetal brain development.

Mioranzza S, Nunes F, Marques DM, Fioreze GT, Rocha AS, Botton PH, Costa MS, Porciúncula LO.

Int J Dev Neurosci. 2014 Aug;36:45-52. doi: 10.1016/j.ijdevneu.2014.04.006. Epub 2014 May 24.

PMID:
24862851
15.

Caffeine triggers behavioral and neurochemical alterations in adolescent rats.

Ardais AP, Borges MF, Rocha AS, Sallaberry C, Cunha RA, Porciúncula LO.

Neuroscience. 2014 Jun 13;270:27-39. doi: 10.1016/j.neuroscience.2014.04.003. Epub 2014 Apr 13.

PMID:
24726984
16.

The Janus face of caffeine.

Porciúncula LO, Sallaberry C, Mioranzza S, Botton PH, Rosemberg DB.

Neurochem Int. 2013 Nov;63(6):594-609. doi: 10.1016/j.neuint.2013.09.009. Epub 2013 Sep 19. Review.

PMID:
24055856
17.

Caffeine consumption prevents memory impairment, neuronal damage, and adenosine A2A receptors upregulation in the hippocampus of a rat model of sporadic dementia.

Espinosa J, Rocha A, Nunes F, Costa MS, Schein V, Kazlauckas V, Kalinine E, Souza DO, Cunha RA, Porciúncula LO.

J Alzheimers Dis. 2013;34(2):509-18. doi: 10.3233/JAD-111982.

PMID:
23241554
18.

Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats.

Sallaberry C, Nunes F, Costa MS, Fioreze GT, Ardais AP, Botton PH, Klaudat B, Forte T, Souza DO, Elisabetsky E, Porciúncula LO.

Neuropharmacology. 2013 Jan;64:153-9. doi: 10.1016/j.neuropharm.2012.07.010. Epub 2012 Jul 27.

PMID:
22841916
19.

The impact of the frequency of moderate exercise on memory and brain-derived neurotrophic factor signaling in young adult and middle-aged rats.

Costa MS, Ardais AP, Fioreze GT, Mioranzza S, Botton PH, Souza DO, Rocha JB, Porciúncula LO.

Neuroscience. 2012 Oct 11;222:100-9. doi: 10.1016/j.neuroscience.2012.06.068. Epub 2012 Jul 13.

PMID:
22796076
20.

Evaluation of the neurotoxic/neuroprotective role of organoselenides using differentiated human neuroblastoma SH-SY5Y cell line challenged with 6-hydroxydopamine.

Lopes FM, Londero GF, de Medeiros LM, da Motta LL, Behr GA, de Oliveira VA, Ibrahim M, Moreira JC, Porciúncula LO, da Rocha JB, Klamt F.

Neurotox Res. 2012 Aug;22(2):138-49. doi: 10.1007/s12640-012-9311-1. Epub 2012 Jan 20.

PMID:
22271527
21.

Treadmill running frequency on anxiety and hippocampal adenosine receptors density in adult and middle-aged rats.

Costa MS, Ardais AP, Fioreze GT, Mioranzza S, Botton PH, Portela LV, Souza DO, Porciúncula LO.

Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jan 10;36(1):198-204. doi: 10.1016/j.pnpbp.2011.10.015. Epub 2011 Oct 28.

22.

Short-term alterations in hippocampal glutamate transport system caused by one-single neonatal seizure episode: implications on behavioral performance in adulthood.

Moreira JD, de Siqueira LV, Lague VM, Porciúncula LO, Vinadé L, Souza DO.

Neurochem Int. 2011 Aug;59(2):217-23. doi: 10.1016/j.neuint.2011.05.008. Epub 2011 Jun 12.

23.

Biochemical characterization of an ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP, E.C. 3.1.4.1) from rat cardiac soluble and microsomal fractions.

Pochmann D, Innocente AM, Buffon A, Freitas Sarkis JJ, Porciúncula LO.

J Enzyme Inhib Med Chem. 2012 Feb;27(1):29-36. doi: 10.3109/14756366.2011.574129. Epub 2011 May 3.

PMID:
21534863
24.

Enriched environment effects on behavior, memory and BDNF in low and high exploratory mice.

Kazlauckas V, Pagnussat N, Mioranzza S, Kalinine E, Nunes F, Pettenuzzo L, Souza DO, Portela LV, Porciúncula LO, Lara DR.

Physiol Behav. 2011 Mar 28;102(5):475-80. doi: 10.1016/j.physbeh.2010.12.025. Epub 2011 Jan 13.

25.

Distinctive effects of unpredictable subchronic stress on memory, serum corticosterone and hippocampal BDNF levels in high and low exploratory mice.

Kazlauckas V, Kalinine E, Leke R, Oses JP, Nunes F, Espinosa J, Mioranzza S, Lulhier F, Portela LV, Porciúncula LO, Lara DR.

Behav Brain Res. 2011 Mar 17;218(1):80-6. doi: 10.1016/j.bbr.2010.11.030. Epub 2010 Nov 23.

26.

Blockade of adenosine A(1) receptors prevents methylphenidate-induced impairment of object recognition task in adult mice.

Mioranzza S, Costa MS, Botton PH, Ardais AP, Matte VL, Espinosa J, Souza DO, Porciúncula LO.

Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jan 15;35(1):169-76. doi: 10.1016/j.pnpbp.2010.10.022. Epub 2010 Oct 31.

27.

Acetylcholinesterase inhibition in cognition-relevant brain areas of mice treated with a nootropic Amazonian herbal (Marapuama).

Figueiró M, Ilha J, Pochmann D, Porciúncula LO, Xavier LL, Achaval M, Nunes DS, Elisabetsky E.

Phytomedicine. 2010 Oct;17(12):956-62. doi: 10.1016/j.phymed.2010.03.009.

PMID:
20833520
28.

The Amazonian herbal Marapuama attenuates cognitive impairment and neuroglial degeneration in a mouse Alzheimer model.

Figueiró M, Ilha J, Linck VM, Herrmann AP, Nardin P, Menezes CB, Achaval M, Gonçalves CA, Porciúncula LO, Nunes DS, Elisabetsky E.

Phytomedicine. 2011 Feb 15;18(4):327-33. doi: 10.1016/j.phymed.2010.07.013. Epub 2010 Aug 23.

PMID:
20739160
29.

Adenosine A1 receptors are modified by acute treatment with methylphenidate in adult mice.

Mioranzza S, Botton PH, Costa MS, Espinosa J, Kazlauckas V, Ardais AP, Souza DO, Porciúncula LO.

Brain Res. 2010 Oct 21;1357:62-9. doi: 10.1016/j.brainres.2010.08.004. Epub 2010 Aug 7.

PMID:
20699089
30.

Caffeine prevents disruption of memory consolidation in the inhibitory avoidance and novel object recognition tasks by scopolamine in adult mice.

Botton PH, Costa MS, Ardais AP, Mioranzza S, Souza DO, da Rocha JB, Porciúncula LO.

Behav Brain Res. 2010 Dec 25;214(2):254-9. doi: 10.1016/j.bbr.2010.05.034. Epub 2010 May 27.

PMID:
20553765
31.

Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway.

Canas PM, Porciúncula LO, Cunha GM, Silva CG, Machado NJ, Oliveira JM, Oliveira CR, Cunha RA.

J Neurosci. 2009 Nov 25;29(47):14741-51. doi: 10.1523/JNEUROSCI.3728-09.2009.

32.

Acute treatment with diphenyl diselenide inhibits glutamate uptake into rat hippocampal slices and modifies glutamate transporters, SNAP-25, and GFAP immunocontent.

Ardais AP, Viola GG, Costa MS, Nunes F, Behr GA, Klamt F, Moreira JC, Souza DO, Rocha JB, Porciúncula LO.

Toxicol Sci. 2010 Feb;113(2):434-43. doi: 10.1093/toxsci/kfp282. Epub 2009 Nov 18.

PMID:
19926633
33.

Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors.

Schmidt AP, Böhmer AE, Antunes C, Schallenberger C, Porciúncula LO, Elisabetsky E, Lara DR, Souza DO.

Br J Pharmacol. 2009 Jan;156(1):163-72. doi: 10.1111/j.1476-5381.2008.00025.x.

34.

Caffeine improves adult mice performance in the object recognition task and increases BDNF and TrkB independent on phospho-CREB immunocontent in the hippocampus.

Costa MS, Botton PH, Mioranzza S, Ardais AP, Moreira JD, Souza DO, Porciúncula LO.

Neurochem Int. 2008 Sep;53(3-4):89-94. doi: 10.1016/j.neuint.2008.06.006. Epub 2008 Jun 24.

PMID:
18620014
35.

Diphenyl diselenide exerts anxiolytic-like effect in Wistar rats: putative roles of GABAA and 5HT receptors.

Ghisleni G, Kazlauckas V, Both FL, Pagnussat N, Mioranzza S, Rocha JB, Souza DO, Porciúncula LO.

Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 1;32(6):1508-15. doi: 10.1016/j.pnpbp.2008.05.008. Epub 2008 May 20.

PMID:
18579279
36.

Selenium compounds counteract the stimulation of ecto-nucleotidase activities in rat cultured cerebellar granule cells: putative correlation with neuroprotective effects.

Ghisleni G, Porciúncula LO, Mioranzza S, Boeck CR, Rocha JB, Souza DO.

Brain Res. 2008 Jul 24;1221:134-40. doi: 10.1016/j.brainres.2008.04.033. Epub 2008 Apr 24.

PMID:
18554575
37.

Caffeine prevents age-associated recognition memory decline and changes brain-derived neurotrophic factor and tirosine kinase receptor (TrkB) content in mice.

Costa MS, Botton PH, Mioranzza S, Souza DO, Porciúncula LO.

Neuroscience. 2008 Jun 2;153(4):1071-8. doi: 10.1016/j.neuroscience.2008.03.038. Epub 2008 Mar 22.

PMID:
18436387
38.

Evidence that glutaric acid reduces glutamate uptake by cerebral cortex of infant rats.

Rosa RB, Dalcin KB, Schmidt AL, Gerhardt D, Ribeiro CA, Ferreira GC, Schuck PF, Wyse AT, Porciúncula LO, Wofchuk S, Salbego CG, Souza DO, Wajner M.

Life Sci. 2007 Dec 14;81(25-26):1668-76. Epub 2007 Oct 6.

PMID:
17963786
39.

Age and brain structural related effects of glutaric and 3-hydroxyglutaric acids on glutamate binding to plasma membranes during rat brain development.

Dalcin KB, Rosa RB, Schmidt AL, Winter JS, Leipnitz G, Dutra-Filho CS, Wannmacher CM, Porciúncula LO, Souza DO, Wajner M.

Cell Mol Neurobiol. 2007 Sep;27(6):805-18. Epub 2007 Sep 5.

PMID:
17786551
40.

Blockade of adenosine A(2A) receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons.

Silva CG, Porciúncula LO, Canas PM, Oliveira CR, Cunha RA.

Neurobiol Dis. 2007 Aug;27(2):182-9. Epub 2007 May 26.

PMID:
17596953
41.

Exercise affects glutamate receptors in postsynaptic densities from cortical mice brain.

Dietrich MO, Mantese CE, Porciuncula LO, Ghisleni G, Vinade L, Souza DO, Portela LV.

Brain Res. 2005 Dec 14;1065(1-2):20-5. Epub 2005 Nov 18.

PMID:
16298350
42.

Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex.

Rebola N, Porciúncula LO, Lopes LV, Oliveira CR, Soares-da-Silva P, Cunha RA.

Epilepsia. 2005;46 Suppl 5:159-65.

43.

Methylmercury increases S100B content in rat cerebrospinal fluid.

Farina M, Cereser V, Portela LV, Mendez A, Porciúncula LO, Fornaguera J, Gonçalves CA, Wofchuk ST, Rocha JB, Souza DO.

Environ Toxicol Pharmacol. 2005 Feb;19(2):249-53. doi: 10.1016/j.etap.2004.07.008.

PMID:
21783483
44.

The effects of ebselen on [3H]glutamate uptake by synaptic vesicles from rat brain.

Porciúncula LO, Rocha JB, Ghisleni G, Tavares RG, Souza DO.

Brain Res. 2004 Nov 19;1027(1-2):192-5.

PMID:
15494171
45.

Repeated restraint stress alters hippocampal glutamate uptake and release in the rat.

Fontella FU, Vendite DA, Tabajara AS, Porciúncula LO, da Silva Torres IL, Jardim FM, Martini L, Souza DO, Netto CA, Dalmaz C.

Neurochem Res. 2004 Sep;29(9):1703-9.

PMID:
15453265
46.

Glutaric acid stimulates glutamate binding and astrocytic uptake and inhibits vesicular glutamate uptake in forebrain from young rats.

Porciúncula LO, Emanuelli T, Tavares RG, Schwarzbold C, Frizzo ME, Souza DO, Wajner M.

Neurochem Int. 2004 Dec;45(7):1075-86.

PMID:
15337307
47.

In vitro effects of D-2-hydroxyglutaric acid on glutamate binding, uptake and release in cerebral cortex of rats.

Junqueira D, Brusque AM, Porciúncula LO, Rotta LN, Frizzo ME, Wyse AT, Wannmacher CM, Souza DO, Wajner M.

J Neurol Sci. 2004 Feb 15;217(2):189-94.

PMID:
14706223
48.

3-hydroxyglutaric acid enhances glutamate uptake into astrocytes from cerebral cortex of young rats.

Frizzo ME, Schwarzbold C, Porciúncula LO, Dalcin KB, Rosa RB, Ribeiro CA, Souza DO, Wajner M.

Neurochem Int. 2004 Apr;44(5):345-53.

PMID:
14643752
49.

Effects of L-2-hydroxyglutaric acid on various parameters of the glutamatergic system in cerebral cortex of rats.

Junqueira D, Brusque AM, Porciúncula LO, Rotta LN, Ribeiro CA, Frizzo ME, Dutra Filho CS, Wannmacher CM, Wyse AT, Souza DO, Wajner M.

Metab Brain Dis. 2003 Sep;18(3):233-43.

PMID:
14567473
50.

Diphenyl diselenide protects rat hippocampal slices submitted to oxygen-glucose deprivation and diminishes inducible nitric oxide synthase immunocontent.

Ghisleni G, Porciúncula LO, Cimarosti H, Batista T Rocha J, Salbego CG, Souza DO.

Brain Res. 2003 Oct 3;986(1-2):196-9.

PMID:
12965245

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