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Generation of IL-3-Secreting CD4+ T Cells by Microbial Challenge at Skin and Mucosal Barriers.

Kunnath-Velayudhan S, Goldberg MF, Saini NK, Ng TW, Arora P, Johndrow CT, Saavedra-Avila NA, Johnson AJ, Xu J, Kim J, Khajoueinejad N, Petro CD, Herold BC, Lauvau G, Chan J, Jacobs WR Jr, Porcelli SA.

Immunohorizons. 2019 May 16;3(5):161-171. doi: 10.4049/immunohorizons.1900028.


Exacting Edward Jenner's revenge: The quest for a new tuberculosis vaccine.

Porcelli SA, Jacobs WR Jr.

Sci Transl Med. 2019 May 1;11(490). pii: eaax4219. doi: 10.1126/scitranslmed.aax4219. Review.


Promotion or Suppression of Murine Intestinal Polyp Development by iNKT Cell Directed Immunotherapy.

Wang Y, Sedimbi SK, Löfbom L, Besra GS, Porcelli SA, Cardell SL.

Front Immunol. 2019 Mar 1;10:352. doi: 10.3389/fimmu.2019.00352. eCollection 2019.


Immunization of Vγ2Vδ2 T cells programs sustained effector memory responses that control tuberculosis in nonhuman primates.

Shen L, Frencher J, Huang D, Wang W, Yang E, Chen CY, Zhang Z, Wang R, Qaqish A, Larsen MH, Shen H, Porcelli SA, Jacobs WR Jr, Chen ZW.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6371-6378. doi: 10.1073/pnas.1811380116. Epub 2019 Mar 8.


Suppression of Th1 Priming by TLR2 Agonists during Cutaneous Immunization Is Mediated by Recruited CCR2+ Monocytes.

Johndrow CT, Goldberg MF, Johnson AJ, Ng TW, Kunnath-Velayudhan S, Lauvau G, Kaplan DH, Gossel GH, Kadolsky UD, Yates AJ, Chan J, Jacobs WR Jr, Porcelli SA.

J Immunol. 2018 Dec 15;201(12):3604-3616. doi: 10.4049/jimmunol.1801185. Epub 2018 Nov 19.


Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae.

Chandra S, Gray J, Kiosses WB, Khurana A, Hitomi K, Crosby CM, Chawla A, Fu Z, Zhao M, Veerapen N, Richardson SK, Porcelli SA, Besra G, Howell AR, Sharma S, Peters B, Kronenberg M.

Nat Commun. 2018 Oct 15;9(1):4279. doi: 10.1038/s41467-018-06646-8.


Photoactivable Glycolipid Antigens Generate Stable Conjugates with CD1d for Invariant Natural Killer T Cell Activation.

Veerapen N, Kharkwal SS, Jervis P, Bhowruth V, Besra AK, North SJ, Haslam SM, Dell A, Hobrath J, Quaid PJ, Moynihan PJ, Cox LR, Kharkwal H, Zauderer M, Besra GS, Porcelli SA.

Bioconjug Chem. 2018 Sep 19;29(9):3161-3173. doi: 10.1021/acs.bioconjchem.8b00484. Epub 2018 Aug 23.


Rapid ex vivo expansion of highly enriched human invariant natural killer T cells via single antigenic stimulation for cell therapy to prevent graft-versus-host disease.

Trujillo-Ocampo A, Cho HW, Herrmann AC, Ruiz-Vazquez W, Thornton AB, He H, Li D, Qazilbash MA, Ma Q, Porcelli SA, Shpall EJ, Molldrem J, Im JS.

Cytotherapy. 2018 Aug;20(8):1089-1101. doi: 10.1016/j.jcyt.2018.05.007. Epub 2018 Jul 31.


Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity.

Chennamadhavuni D, Saavedra-Avila NA, Carreño LJ, Guberman-Pfeffer MJ, Arora P, Yongqing T, Pryce R, Koay HF, Godfrey DI, Keshipeddy S, Richardson SK, Sundararaj S, Lo JH, Wen X, Gascón JA, Yuan W, Rossjohn J, Le Nours J, Porcelli SA, Howell AR.

Cell Chem Biol. 2018 Jul 19;25(7):925. doi: 10.1016/j.chembiol.2018.06.008. No abstract available.


Identification of Novel Mycobacterial Targets for Murine CD4+ T-Cells by IFNγ ELISPOT.

Johnson AJ, Kennedy SC, Ng TW, Porcelli SA.

Methods Mol Biol. 2018;1808:143-150. doi: 10.1007/978-1-4939-8567-8_12.


Identification of Mycobacterial Ribosomal Proteins as Targets for CD4+ T Cells That Enhance Protective Immunity in Tuberculosis.

Kennedy SC, Johnson AJ, Bharrhan S, Lindestam Arlehamn CS, Xu J, Garforth SJ, Chan J, Jacobs WR Jr, Sette A, Almo SC, Porcelli SA.

Infect Immun. 2018 Aug 22;86(9). pii: e00009-18. doi: 10.1128/IAI.00009-18. Print 2018 Sep.


Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity.

Chennamadhavuni D, Saavedra-Avila NA, Carreño LJ, Guberman-Pfeffer MJ, Arora P, Yongqing T, Pryce R, Koay HF, Godfrey DI, Keshipeddy S, Richardson SK, Sundararaj S, Lo JH, Wen X, Gascón JA, Yuan W, Rossjohn J, Le Nours J, Porcelli SA, Howell AR.

Cell Chem Biol. 2018 May 17;25(5):571-584.e8. doi: 10.1016/j.chembiol.2018.02.009. Epub 2018 Mar 22. Erratum in: Cell Chem Biol. 2018 Jul 19;25(7):925.


Infection by Zika viruses requires the transmembrane protein AXL, endocytosis and low pH.

Persaud M, Martinez-Lopez A, Buffone C, Porcelli SA, Diaz-Griffero F.

Virology. 2018 May;518:301-312. doi: 10.1016/j.virol.2018.03.009. Epub 2018 Mar 22.


Isolation of intact RNA from murine CD4+ T cells after intracellular cytokine staining and fluorescence-activated cell sorting.

Kunnath-Velayudhan S, Porcelli SA.

J Immunol Methods. 2018 May;456:77-80. doi: 10.1016/j.jim.2018.02.008. Epub 2018 Feb 17.


Transcriptome Analysis of Mycobacteria-Specific CD4+ T Cells Identified by Activation-Induced Expression of CD154.

Kunnath-Velayudhan S, Goldberg MF, Saini NK, Johndrow CT, Ng TW, Johnson AJ, Xu J, Chan J, Jacobs WR Jr, Porcelli SA.

J Immunol. 2017 Oct 1;199(7):2596-2606. doi: 10.4049/jimmunol.1700654. Epub 2017 Aug 18.


Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth.

Glass LN, Swapna G, Chavadi SS, Tufariello JM, Mi K, Drumm JE, Lam TT, Zhu G, Zhan C, Vilchéze C, Arcos J, Chen Y, Bi L, Mehta S, Porcelli SA, Almo SC, Yeh SR, Jacobs WR Jr, Torrelles JB, Chan J.

PLoS Pathog. 2017 Jul 28;13(7):e1006515. doi: 10.1371/journal.ppat.1006515. eCollection 2017 Jul.


Co-localization of a CD1d-binding glycolipid with an adenovirus-based malaria vaccine for a potent adjuvant effect.

Li X, Huang J, Kawamura A, Funakoshi R, Porcelli SA, Tsuji M.

Vaccine. 2017 May 31;35(24):3171-3177. doi: 10.1016/j.vaccine.2017.04.077. Epub 2017 May 5.


"The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report.

Boggiano C, Eichelberg K, Ramachandra L, Shea J, Ramakrishnan L, Behar S, Ernst JD, Porcelli SA, Maeurer M, Kornfeld H.

Vaccine. 2017 Jun 14;35(27):3433-3440. doi: 10.1016/j.vaccine.2017.04.007. Epub 2017 May 2.


Unique invariant natural killer T cells promote intestinal polyps by suppressing TH1 immunity and promoting regulatory T cells.

Wang Y, Sedimbi S, Löfbom L, Singh AK, Porcelli SA, Cardell SL.

Mucosal Immunol. 2018 Jan;11(1):131-143. doi: 10.1038/mi.2017.34. Epub 2017 Apr 12.


Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine.

Prados-Rosales R, Carreño L, Cheng T, Blanc C, Weinrick B, Malek A, Lowary TL, Baena A, Joe M, Bai Y, Kalscheuer R, Batista-Gonzalez A, Saavedra NA, Sampedro L, Tomás J, Anguita J, Hung SC, Tripathi A, Xu J, Glatman-Freedman A, Jacobs WR Jr, Chan J, Porcelli SA, Achkar JM, Casadevall A.

PLoS Pathog. 2017 Mar 9;13(3):e1006250. doi: 10.1371/journal.ppat.1006250. eCollection 2017 Mar.


Identification of Mycobacterial RplJ/L10 and RpsA/S1 Proteins as Novel Targets for CD4+ T Cells.

Johnson AJ, Kennedy SC, Lindestam Arlehamn CS, Goldberg MF, Saini NK, Xu J, Paul S, Hegde SS, Blanchard JS, Chan J, Jacobs WR Jr, Sette A, Porcelli SA.

Infect Immun. 2017 Mar 23;85(4). pii: e01023-16. doi: 10.1128/IAI.01023-16. Print 2017 Apr.


A review of the PD-1/PD-L1 checkpoint in bladder cancer: From mediator of immune escape to target for treatment.

Zhou TC, Sankin AI, Porcelli SA, Perlin DS, Schoenberg MP, Zang X.

Urol Oncol. 2017 Jan;35(1):14-20. doi: 10.1016/j.urolonc.2016.10.004. Epub 2016 Nov 3. Review.


Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47.

Saini NK, Baena A, Ng TW, Venkataswamy MM, Kennedy SC, Kunnath-Velayudhan S, Carreño LJ, Xu J, Chan J, Larsen MH, Jacobs WR Jr, Porcelli SA.

Nat Microbiol. 2016 Aug 15;1(9):16133. doi: 10.1038/nmicrobiol.2016.133.


Glycolipid activators of invariant NKT cells as vaccine adjuvants.

Kharkwal SS, Arora P, Porcelli SA.

Immunogenetics. 2016 Aug;68(8):597-610. doi: 10.1007/s00251-016-0925-y. Epub 2016 Jul 5. Review.


Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antituberculous Vaccines.

Olsen A, Chen Y, Ji Q, Zhu G, De Silva AD, Vilchèze C, Weisbrod T, Li W, Xu J, Larsen M, Zhang J, Porcelli SA, Jacobs WR Jr, Chan J.

MBio. 2016 May 31;7(3). pii: e01023-15. doi: 10.1128/mBio.01023-15.


The Type of Growth Medium Affects the Presence of a Mycobacterial Capsule and Is Associated With Differences in Protective Efficacy of BCG Vaccination Against Mycobacterium tuberculosis.

Prados-Rosales R, Carreño LJ, Weinrick B, Batista-Gonzalez A, Glatman-Freedman A, Xu J, Chan J, Jacobs WR Jr, Porcelli SA, Casadevall A.

J Infect Dis. 2016 Aug 1;214(3):426-37. doi: 10.1093/infdis/jiw153. Epub 2016 Apr 18. Erratum in: J Infect Dis. 2017 Feb 1;215(3):496.


Synthetic glycolipid activators of natural killer T cells as immunotherapeutic agents.

Carreño LJ, Saavedra-Ávila NA, Porcelli SA.

Clin Transl Immunology. 2016 Apr 8;5(4):e69. doi: 10.1038/cti.2016.14. eCollection 2016 Apr. Review.


An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets.

Arora P, Porcelli SA.

J Vis Exp. 2016 Apr 18;(110):e53824. doi: 10.3791/53824.


Autoimmune response to transthyretin in juvenile idiopathic arthritis.

Clement CC, Moncrieffe H, Lele A, Janow G, Becerra A, Bauli F, Saad FA, Perino G, Montagna C, Cobelli N, Hardin J, Stern LJ, Ilowite N, Porcelli SA, Santambrogio L.

JCI Insight. 2016 Feb;1(2). pii: 85633. doi: 10.1172/jci.insight.85633. Epub 2016 Feb 25.


Species Specific Differences of CD1d Oligomer Loading In Vitro.

Paletta D, Fichtner AS, Starick L, Porcelli SA, Savage PB, Herrmann T.

PLoS One. 2015 Nov 24;10(11):e0143449. doi: 10.1371/journal.pone.0143449. eCollection 2015.


"Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes".

Arora P, Kharkwal SS, Ng TW, Kunnath-Velayudhan S, Saini NK, Johndrow CT, Chang YT, Besra GS, Porcelli SA.

Chem Phys Lipids. 2016 Jan;194:49-57. doi: 10.1016/j.chemphyslip.2015.10.006. Epub 2015 Nov 6.


Current efforts and future prospects in the development of live mycobacteria as vaccines.

Ng TW, Saavedra-Ávila NA, Kennedy SC, Carreño LJ, Porcelli SA.

Expert Rev Vaccines. 2015;14(11):1493-507. doi: 10.1586/14760584.2015.1089175. Epub 2015 Sep 14. Review.


Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes.

Arora P, Kharkwal SS, Ng TW, Kunnath-Velayudhan S, Saini NK, Johndrow CT, Chang YT, Besra GS, Porcelli SA.

Chem Phys Lipids. 2015 Oct;191:75-83. doi: 10.1016/j.chemphyslip.2015.08.010. Epub 2015 Aug 22.


Colocalization of a CD1d-Binding Glycolipid with a Radiation-Attenuated Sporozoite Vaccine in Lymph Node-Resident Dendritic Cells for a Robust Adjuvant Effect.

Li X, Kawamura A, Andrews CD, Miller JL, Wu D, Tsao T, Zhang M, Oren D, Padte NN, Porcelli SA, Wong CH, Kappe SH, Ho DD, Tsuji M.

J Immunol. 2015 Sep 15;195(6):2710-21. doi: 10.4049/jimmunol.1403017. Epub 2015 Aug 7.


A Subset of CD8αβ+ Invariant NKT Cells in a Humanized Mouse Model.

Wen X, Kim S, Xiong R, Li M, Lawrenczyk A, Huang X, Chen SY, Rao P, Besra GS, Dellabona P, Casorati G, Porcelli SA, Akbari O, Exley MA, Yuan W.

J Immunol. 2015 Aug 15;195(4):1459-69. doi: 10.4049/jimmunol.1500574. Epub 2015 Jul 8.


Evasion of Innate and Adaptive Immunity by Mycobacterium tuberculosis.

Goldberg MF, Saini NK, Porcelli SA.

Microbiol Spectr. 2014 Oct;2(5). doi: 10.1128/microbiolspec.MGM2-0005-2013. Review.


A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-γ Production.

Birkholz AM, Girardi E, Wingender G, Khurana A, Wang J, Zhao M, Zahner S, Illarionov PA, Wen X, Li M, Yuan W, Porcelli SA, Besra GS, Zajonc DM, Kronenberg M.

J Immunol. 2015 Aug 1;195(3):924-33. doi: 10.4049/jimmunol.1500070. Epub 2015 Jun 15.


Correction: Expression Patterns of Bovine CD1 In Vivo and Assessment of the Specificities of the Anti-Bovine CD1 Antibodies.

Nguyen TK, Reinink P, El Messlaki C, Im JS, Ercan A, Porcelli SA, Van Rhijn I.

PLoS One. 2015 Jun 5;10(6):e0129755. doi: 10.1371/journal.pone.0129755. eCollection 2015. No abstract available.


Stable Expression of Lentiviral Antigens by Quality-Controlled Recombinant Mycobacterium bovis BCG Vectors.

Hart BE, Asrican R, Lim SY, Sixsmith JD, Lukose R, Souther SJ, Rayasam SD, Saelens JW, Chen CJ, Seay SA, Berney-Meyer L, Magtanong L, Vermeul K, Pajanirassa P, Jimenez AE, Ng TW, Tobin DM, Porcelli SA, Larsen MH, Schmitz JE, Haynes BF, Jacobs WR Jr, Lee S, Frothingham R.

Clin Vaccine Immunol. 2015 Jul;22(7):726-41. doi: 10.1128/CVI.00075-15. Epub 2015 Apr 29.


Expression patterns of bovine CD1 in vivo and assessment of the specificities of the anti-bovine CD1 antibodies.

Nguyen TK, Reinink P, El Messlaki C, Im JS, Ercan A, Porcelli SA, Van Rhijn I.

PLoS One. 2015 Mar 27;10(3):e0121923. doi: 10.1371/journal.pone.0121923. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0129755.


Direct incorporation of the NKT-cell activator α-galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy.

Singh M, Quispe-Tintaya W, Chandra D, Jahangir A, Venkataswamy MM, Ng TW, Sharma-Kharkwal S, Carreño LJ, Porcelli SA, Gravekamp C.

Br J Cancer. 2014 Nov 11;111(10):1945-54. doi: 10.1038/bjc.2014.486. Epub 2014 Oct 14.


Gene deletions in Mycobacterium bovis BCG stimulate increased CD8+ T cell responses.

Panas MW, Sixsmith JD, White K, Korioth-Schmitz B, Shields ST, Moy BT, Lee S, Schmitz JE, Jacobs WR Jr, Porcelli SA, Haynes BF, Letvin NL, Gillard GO.

Infect Immun. 2014 Dec;82(12):5317-26. doi: 10.1128/IAI.02100-14. Epub 2014 Oct 6.


Mycobacterial membrane vesicles administered systemically in mice induce a protective immune response to surface compartments of Mycobacterium tuberculosis.

Prados-Rosales R, Carreño LJ, Batista-Gonzalez A, Baena A, Venkataswamy MM, Xu J, Yu X, Wallstrom G, Magee DM, LaBaer J, Achkar JM, Jacobs WR Jr, Chan J, Porcelli SA, Casadevall A.

MBio. 2014 Sep 30;5(5):e01921-14. doi: 10.1128/mBio.01921-14.


Improving Mycobacterium bovis bacillus Calmette-Guèrin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells.

Venkataswamy MM, Ng TW, Kharkwal SS, Carreño LJ, Johnson AJ, Kunnath-Velayudhan S, Liu Z, Bittman R, Jervis PJ, Cox LR, Besra GS, Wen X, Yuan W, Tsuji M, Li X, Ho DD, Chan J, Lee S, Frothingham R, Haynes BF, Panas MW, Gillard GO, Sixsmith JD, Korioth-Schmitz B, Schmitz JE, Larsen MH, Jacobs WR Jr, Porcelli SA.

PLoS One. 2014 Sep 25;9(9):e108383. doi: 10.1371/journal.pone.0108383. eCollection 2014.


Recombinant Mycobacterium bovis bacillus Calmette-Guérin vectors prime for strong cellular responses to simian immunodeficiency virus gag in rhesus macaques.

Sixsmith JD, Panas MW, Lee S, Gillard GO, White K, Lifton MA, Balachandran H, Mach L, Miller JP, Lavine C, DeMarco CT, Tomaras GD, Gee C, Porcelli SA, Larsen MH, Frothingham R, Schmitz JE, Jacobs WR Jr, Haynes BF, Letvin NL, Korioth-Schmitz B.

Clin Vaccine Immunol. 2014 Oct;21(10):1385-95. doi: 10.1128/CVI.00324-14. Epub 2014 Jul 30.


T helper type 2-polarized invariant natural killer T cells reduce disease severity in acute intra-abdominal sepsis.

Anantha RV, Mazzuca DM, Xu SX, Porcelli SA, Fraser DD, Martin CM, Welch I, Mele T, Haeryfar SM, McCormick JK.

Clin Exp Immunol. 2014 Nov;178(2):292-309. doi: 10.1111/cei.12404.


Optimizing NKT cell ligands as vaccine adjuvants.

Carreño LJ, Kharkwal SS, Porcelli SA.

Immunotherapy. 2014;6(3):309-20. doi: 10.2217/imt.13.175. Review.


A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens.

Arora P, Baena A, Yu KO, Saini NK, Kharkwal SS, Goldberg MF, Kunnath-Velayudhan S, Carreño LJ, Venkataswamy MM, Kim J, Lazar-Molnar E, Lauvau G, Chang YT, Liu Z, Bittman R, Al-Shamkhani A, Cox LR, Jervis PJ, Veerapen N, Besra GS, Porcelli SA.

Immunity. 2014 Jan 16;40(1):105-16. doi: 10.1016/j.immuni.2013.12.004. Epub 2014 Jan 9.


Isolation and In vivo Transfer of Antigen Presenting Cells.

Arora P, Kharkwal SS, Porcelli SA.

Bio Protoc. 2014;4(19). pii: e1260. Epub 2014 Oct 5.


Recent Advances in Defining the Immunoproteome of Mycobacterium tuberculosis.

Kunnath-Velayudhan S, Porcelli SA.

Front Immunol. 2013 Oct 11;4:335. doi: 10.3389/fimmu.2013.00335. Review.

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