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Salivary mir-27b expression in oral lichen planus patients: a series of cases and a narrative review of litterature.

Stasio DD, Mosca L, Lucchese A, Cave DD, Kawasaki H, Lombardi A, Porcelli M, Caraglia M.

Curr Top Med Chem. 2019 Nov 21. doi: 10.2174/1568026619666191121144407. [Epub ahead of print]


Annurca apple polyphenol extract selectively kills MDA-MB-231 cells through ROS generation, sustained JNK activation and cell growth and survival inhibition.

Martino E, Vuoso DC, D'Angelo S, Mele L, D'Onofrio N, Porcelli M, Cacciapuoti G.

Sci Rep. 2019 Sep 10;9(1):13045. doi: 10.1038/s41598-019-49631-x.


Long Non-coding RNAs as Important Biomarkers in Laryngeal Cancer and Other Head and Neck Tumours.

Cossu AM, Mosca L, Zappavigna S, Misso G, Bocchetti M, De Micco F, Quagliuolo L, Porcelli M, Caraglia M, Boccellino M.

Int J Mol Sci. 2019 Jul 12;20(14). pii: E3444. doi: 10.3390/ijms20143444. Review.


AdoMet triggers apoptosis in head and neck squamous cancer by inducing ER stress and potentiates cell sensitivity to cisplatin.

Mosca L, Pagano M, Ilisso CP, Cave DD, Desiderio V, Mele L, Caraglia M, Cacciapuoti G, Porcelli M.

J Cell Physiol. 2019 Aug;234(8):13277-13291. doi: 10.1002/jcp.28000. Epub 2018 Dec 21.


S-Adenosylmethionine regulates apoptosis and autophagy in MCF-7 breast cancer cells through the modulation of specific microRNAs.

Ilisso CP, Delle Cave D, Mosca L, Pagano M, Coppola A, Mele L, Caraglia M, Cacciapuoti G, Porcelli M.

Cancer Cell Int. 2018 Dec 4;18:197. doi: 10.1186/s12935-018-0697-6. eCollection 2018.


Salivary microRNAs as new molecular markers in cleft lip and palate: a new frontier in molecular medicine.

Grassia V, Lombardi A, Kawasaki H, Ferri C, Perillo L, Mosca L, Delle Cave D, Nucci L, Porcelli M, Caraglia M.

Oncotarget. 2018 Apr 10;9(27):18929-18938. doi: 10.18632/oncotarget.24838. eCollection 2018 Apr 10.


Complete response in a patient with liver metastases from breast cancer employing hepatic arterial infusion 5-fluorouracil based chemotherapy plus systemic nab-paclitaxel.

Ranieri G, Marech I, Porcelli M, Giotta F, Palmiotti G, Laricchia G, Fazio V, Gadaleta CD.

Oncotarget. 2017 Dec 31;9(8):8197-8203. doi: 10.18632/oncotarget.23793. eCollection 2018 Jan 30.


C-Kit receptor and tryptase expressing mast cells correlate with angiogenesis in breast cancer patients.

Marech I, Ammendola M, Leporini C, Patruno R, Luposella M, Zizzo N, Passantino G, Sacco R, Farooqi AA, Zuccalà V, Leo S, Dentamaro R, Porcelli M, Gadaleta P, De Sarro G, Gadaleta CD, Ranieri G.

Oncotarget. 2017 Dec 22;9(8):7918-7927. doi: 10.18632/oncotarget.23722. eCollection 2018 Jan 30.


Spatial and temporal variations in the atmospheric concentrations of "Stockholm Convention" organochlorine pesticides in Kuwait.

Gevao B, Porcelli M, Rajagopalan S, Krishnan D, Martinez-Guijarro K, Alshemmari H, Bahloul M, Zafar J.

Sci Total Environ. 2018 May 1;622-623:1621-1629. doi: 10.1016/j.scitotenv.2017.10.036. Epub 2017 Oct 18.


Seasonal variations in the atmospheric concentrations of polychlorinated biphenyls in Kuwait.

Gevao B, Porcelli M, Rajagopalan S, Krishnan D, Martinez-Guijarro K, Alshemmari H, Bahloul M, Zafar J.

Chemosphere. 2017 Dec;189:652-660. doi: 10.1016/j.chemosphere.2017.09.063. Epub 2017 Sep 15.


Tyrosine-Kinase Inhibitors Therapies with Mainly Anti-Angiogenic Activity in Advanced Renal Cell Carcinoma: Value of PET/CT in Response Evaluation.

Ranieri G, Marech I, Niccoli Asabella A, Di Palo A, Porcelli M, Lavelli V, Rubini G, Ferrari C, Gadaleta CD.

Int J Mol Sci. 2017 Sep 9;18(9). pii: E1937. doi: 10.3390/ijms18091937. Review.


Pro-oxidant and pro-apoptotic activity of polyphenol extract from Annurca apple and its underlying mechanisms in human breast cancer cells.

D'Angelo S, Martino E, Ilisso CP, Bagarolo ML, Porcelli M, Cacciapuoti G.

Int J Oncol. 2017 Sep;51(3):939-948. doi: 10.3892/ijo.2017.4088. Epub 2017 Jul 31.


Bevacizumab-Based Chemotherapy Combined with Regional Deep Capacitive Hyperthermia in Metastatic Cancer Patients: A Pilot Study.

Ranieri G, Ferrari C, Di Palo A, Marech I, Porcelli M, Falagario G, Ritrovato F, Ramunni L, Fanelli M, Rubini G, Gadaleta CD.

Int J Mol Sci. 2017 Jul 6;18(7). pii: E1458. doi: 10.3390/ijms18071458.


Zika virus evolution and spread in the Americas.

Metsky HC, Matranga CB, Wohl S, Schaffner SF, Freije CA, Winnicki SM, West K, Qu J, Baniecki ML, Gladden-Young A, Lin AE, Tomkins-Tinch CH, Ye SH, Park DJ, Luo CY, Barnes KG, Shah RR, Chak B, Barbosa-Lima G, Delatorre E, Vieira YR, Paul LM, Tan AL, Barcellona CM, Porcelli MC, Vasquez C, Cannons AC, Cone MR, Hogan KN, Kopp EW, Anzinger JJ, Garcia KF, Parham LA, Ramírez RMG, Montoya MCM, Rojas DP, Brown CM, Hennigan S, Sabina B, Scotland S, Gangavarapu K, Grubaugh ND, Oliveira G, Robles-Sikisaka R, Rambaut A, Gehrke L, Smole S, Halloran ME, Villar L, Mattar S, Lorenzana I, Cerbino-Neto J, Valim C, Degrave W, Bozza PT, Gnirke A, Andersen KG, Isern S, Michael SF, Bozza FA, Souza TML, Bosch I, Yozwiak NL, MacInnis BL, Sabeti PC.

Nature. 2017 Jun 15;546(7658):411-415. doi: 10.1038/nature22402. Epub 2017 May 24.


Genomic epidemiology reveals multiple introductions of Zika virus into the United States.

Grubaugh ND, Ladner JT, Kraemer MUG, Dudas G, Tan AL, Gangavarapu K, Wiley MR, White S, Thézé J, Magnani DM, Prieto K, Reyes D, Bingham AM, Paul LM, Robles-Sikisaka R, Oliveira G, Pronty D, Barcellona CM, Metsky HC, Baniecki ML, Barnes KG, Chak B, Freije CA, Gladden-Young A, Gnirke A, Luo C, MacInnis B, Matranga CB, Park DJ, Qu J, Schaffner SF, Tomkins-Tinch C, West KL, Winnicki SM, Wohl S, Yozwiak NL, Quick J, Fauver JR, Khan K, Brent SE, Reiner RC Jr, Lichtenberger PN, Ricciardi MJ, Bailey VK, Watkins DI, Cone MR, Kopp EW 4th, Hogan KN, Cannons AC, Jean R, Monaghan AJ, Garry RF, Loman NJ, Faria NR, Porcelli MC, Vasquez C, Nagle ER, Cummings DAT, Stanek D, Rambaut A, Sanchez-Lockhart M, Sabeti PC, Gillis LD, Michael SF, Bedford T, Pybus OG, Isern S, Palacios G, Andersen KG.

Nature. 2017 Jun 15;546(7658):401-405. doi: 10.1038/nature22400. Epub 2017 May 24.


S-Adenosylmethionine-mediated apoptosis is potentiated by autophagy inhibition induced by chloroquine in human breast cancer cells.

Cave DD, Desiderio V, Mosca L, Ilisso CP, Mele L, Caraglia M, Cacciapuoti G, Porcelli M.

J Cell Physiol. 2018 Feb;233(2):1370-1383. doi: 10.1002/jcp.26015. Epub 2017 Jun 22.


Erratum to: The methyl donor S-adenosylmethionine potentiates doxorubicin effects on apoptosis of hormone-dependent breast cancer cell lines.

Ilisso CP, Castellano M, Zappavigna S, Lombardi A, Vitale G, Dicitore A, Cacciapuoti G, Caraglia M, Porcelli M.

Endocrine. 2016 Sep;53(3):875. No abstract available.


Protective Effect of Tyrosol and S-Adenosylmethionine against Ethanol-Induced Oxidative Stress of Hepg2 Cells Involves Sirtuin 1, P53 and Erk1/2 Signaling.

Stiuso P, Bagarolo ML, Ilisso CP, Vanacore D, Martino E, Caraglia M, Porcelli M, Cacciapuoti G.

Int J Mol Sci. 2016 Apr 26;17(5). pii: E622. doi: 10.3390/ijms17050622.


Tumour-associated macrophages correlate with microvascular bed extension in colorectal cancer patients.

Marech I, Ammendola M, Sacco R, Sammarco G, Zuccalà V, Zizzo N, Leporini C, Luposella M, Patruno R, Filippelli G, Russo E, Porcelli M, Gadaleta CD, De Sarro G, Ranieri G.

J Cell Mol Med. 2016 Jul;20(7):1373-80. doi: 10.1111/jcmm.12826. Epub 2016 Apr 22.


Mast cells positive to tryptase and tumour-associated macrophages correlate with angiogenesis in locally advanced colorectal cancer patients undergone to surgery.

Ammendola M, Patruno R, Sacco R, Marech I, Sammarco G, Zuccalà V, Luposella M, Zizzo N, Gadaleta C, Porcelli M, Gadaleta CD, Ribatti D, Ranieri G.

Expert Opin Ther Targets. 2016;20(5):533-40. doi: 10.1517/14728222.2016.1158811. Epub 2016 Mar 16.


Efficient Fludarabine-Activating PNP From Archaea as a Guidance for Redesign the Active Site of E. Coli PNP.

Cacciapuoti G, Bagarolo ML, Martino E, Scafuri B, Marabotti A, Porcelli M.

J Cell Biochem. 2016 May;117(5):1126-35. doi: 10.1002/jcb.25396. Epub 2015 Oct 18.


Classical and non-classical proangiogenic factors as a target of antiangiogenic therapy in tumor microenvironment.

Marech I, Leporini C, Ammendola M, Porcelli M, Gadaleta CD, Russo E, De Sarro G, Ranieri G.

Cancer Lett. 2016 Sep 28;380(1):216-26. doi: 10.1016/j.canlet.2015.07.028. Epub 2015 Jul 31. Review.


S-Adenosylmethionine Affects ERK1/2 and Stat3 Pathways and Induces Apotosis in Osteosarcoma Cells.

Ilisso CP, Sapio L, Delle Cave D, Illiano M, Spina A, Cacciapuoti G, Naviglio S, Porcelli M.

J Cell Physiol. 2016 Feb;231(2):428-35. doi: 10.1002/jcp.25089.


Multiple disulfide bridges modulate conformational stability and flexibility in hyperthermophilic archaeal purine nucleoside phosphorylase.

Bagarolo ML, Porcelli M, Martino E, Feller G, Cacciapuoti G.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt A):1458-65. doi: 10.1016/j.bbapap.2015.06.010. Epub 2015 Jun 24.


A thermostable archaeal S-adenosylmethionine synthetase: a promising tool to improve the synthesis of adenosylmethionine analogs of biotechnological interest.

Porcelli M, Ilisso CP, Mosca L, Cacciapuoti G.

Bioengineered. 2015;6(3):184-6. doi: 10.1080/21655979.2015.1045170.


Biochemical characterization of a thermostable adenosylmethionine synthetase from the archaeon Pyrococcus furiosus with high catalytic power.

Porcelli M, Ilisso CP, De Leo E, Cacciapuoti G.

Appl Biochem Biotechnol. 2015 Mar;175(6):2916-33. doi: 10.1007/s12010-015-1476-7. Epub 2015 Jan 11.


The methyl donor S-adenosylmethionine potentiates doxorubicin effects on apoptosis of hormone-dependent breast cancer cell lines.

Ilisso CP, Castellano M, Zappavigna S, Lombardi A, Vitale G, Dicitore A, Cacciapuoti G, Caraglia M, Porcelli M.

Endocrine. 2015 Sep;50(1):212-22. doi: 10.1007/s12020-014-0484-7. Epub 2015 Jan 11. Erratum in: Endocrine. 2016 Sep;53(3):875.


From Protein Synthesis to Molecular Biology: The Appealing Tale of eIF-5A.

Caraglia M, Alaia C, Porcelli M.

Mol Ther Nucleic Acids. 2014 Oct 7;3:e199. doi: 10.1038/mtna.2014.53. No abstract available.


Use of polycaprolactone (PCL) as scaffolds for the regeneration of nerve tissue.

Barbarisi M, Marino G, Armenia E, Vincenzo Q, Rosso F, Porcelli M, Barbarisi A.

J Biomed Mater Res A. 2015 May;103(5):1755-60. doi: 10.1002/jbm.a.35318. Epub 2014 Sep 15.


Short-term diet and moderate exercise in young overweight men modulate cardiocyte and hepatocarcinoma survival by oxidative stress.

Monda M, Messina G, Scognamiglio I, Lombardi A, Martin GA, Sperlongano P, Porcelli M, Caraglia M, Stiuso P.

Oxid Med Cell Longev. 2014;2014:131024. doi: 10.1155/2014/131024. Epub 2014 Aug 13.


Seasonal variations in the atmospheric concentrations of polybrominated diphenyl ethers in Kuwait.

Gevao B, Ghadban AN, Porcelli M, Ali L, Rashdan A, Al-Bahloul M, Matrouk K, Zafar J.

Sci Total Environ. 2013 Jun 1;454-455:534-41. doi: 10.1016/j.scitotenv.2013.02.073. Epub 2013 Apr 9.


Role of disulfide bonds in conformational stability and folding of 5'-deoxy-5'-methylthioadenosine phosphorylase II from the hyperthermophilic archaeon Sulfolobus solfataricus.

Cacciapuoti G, Fuccio F, Petraccone L, Del Vecchio P, Porcelli M.

Biochim Biophys Acta. 2012 Oct;1824(10):1136-43. doi: 10.1016/j.bbapap.2012.06.014. Epub 2012 Jun 29.


New determinants in the catalytic mechanism of nucleoside hydrolases from the structures of two isozymes from Sulfolobus solfataricus.

Minici C, Cacciapuoti G, De Leo E, Porcelli M, Degano M.

Biochemistry. 2012 Jun 5;51(22):4590-9. Epub 2012 May 21.


Penile degloving injury in an adolescent with congenital hypothyroid.

Kiffin C, Porcelli M, Prychyna O, Pazmino B, Pust D, Decostanza J.

Case Rep Med. 2012;2012:464670. doi: 10.1155/2012/464670. Epub 2012 Mar 25.


Thermal unfolding of nucleoside hydrolases from the hyperthermophilic archaeon Sulfolobus solfataricus: role of disulfide bonds.

Porcelli M, De Leo E, Del Vecchio P, Fuccio F, Cacciapuoti G.

Protein Pept Lett. 2012 Mar;19(3):369-74.


Unraveling the structural and functional differences between purine nucleoside phosphorylase and 5'-deoxy-5'-methylthioadenosine phosphorylase from the archaeon Pyrococcus furiosus.

Cacciapuoti G, Marabotti A, Fuccio F, Porcelli M.

Biochim Biophys Acta. 2011 Oct;1814(10):1358-66. doi: 10.1016/j.bbapap.2011.06.001. Epub 2011 Jun 13.


Hepatothorax: a rare outcome of high-speed trauma.

Porcelli M, Prychyna O, Rosenthal A, Decostanza J.

Case Rep Emerg Med. 2011;2011:905641. doi: 10.1155/2011/905641. Epub 2011 Nov 24.


High activity of sequential low dose chemo-modulating Temozolomide in combination with Fotemustine in metastatic melanoma. A feasibility study.

Guida M, Cramarossa A, Fistola E, Porcelli M, Giudice G, Lubello K, Colucci G.

J Transl Med. 2010 Nov 10;8:115. doi: 10.1186/1479-5876-8-115. No abstract available.


Increased carotid IMT in overweight and obese women affected by Hashimoto's thyroiditis: an adiposity and autoimmune linkage?

Ciccone MM, De Pergola G, Porcelli MT, Scicchitano P, Caldarola P, Iacoviello M, Pietro G, Giorgino F, Favale S.

BMC Cardiovasc Disord. 2010 May 28;10:22. doi: 10.1186/1471-2261-10-22.


Purine nucleoside phosphorylases from hyperthermophilic Archaea require a CXC motif for stability and folding.

Cacciapuoti G, Peluso I, Fuccio F, Porcelli M.

FEBS J. 2009 Oct;276(20):5799-805. doi: 10.1111/j.1742-4658.2009.07247.x. Epub 2009 Sep 9.


Olive oil phenolic compounds inhibit homocysteine-induced endothelial cell adhesion regardless of their different antioxidant activity.

Manna C, Napoli D, Cacciapuoti G, Porcelli M, Zappia V.

J Agric Food Chem. 2009 May 13;57(9):3478-82. doi: 10.1021/jf8037659.


Biochemical characterization and homology modeling of a purine-specific ribonucleoside hydrolase from the archaeon Sulfolobus solfataricus: insights into mechanisms of protein stabilization.

Porcelli M, Peluso I, Marabotti A, Facchiano A, Cacciapuoti G.

Arch Biochem Biophys. 2009 Mar 1;483(1):55-65. doi: 10.1016/ Epub 2008 Dec 24.


Election year's first shot over the bow: reforms needed.

Porcelli MJ.

J Am Osteopath Assoc. 2008 Aug;108(8):461-4. No abstract available.


Pyrimidine-specific ribonucleoside hydrolase from the archaeon Sulfolobus solfataricus--biochemical characterization and homology modeling.

Porcelli M, Concilio L, Peluso I, Marabotti A, Facchiano A, Cacciapuoti G.

FEBS J. 2008 Apr;275(8):1900-14. doi: 10.1111/j.1742-4658.2008.06348.x. Epub 2008 Mar 18.


Homocysteine-induced endothelial cell adhesion is related to adenosine lowering and is not mediated by S-adenosylhomocysteine.

Cacciapuoti G, Manna C, Napoli D, Zappia V, Porcelli M.

FEBS Lett. 2007 Oct 2;581(24):4567-70. Epub 2007 Aug 29.


The first agmatine/cadaverine aminopropyl transferase: biochemical and structural characterization of an enzyme involved in polyamine biosynthesis in the hyperthermophilic archaeon Pyrococcus furiosus.

Cacciapuoti G, Porcelli M, Moretti MA, Sorrentino F, Concilio L, Zappia V, Liu ZJ, Tempel W, Schubot F, Rose JP, Wang BC, Brereton PS, Jenney FE, Adams MW.

J Bacteriol. 2007 Aug;189(16):6057-67. Epub 2007 Jun 1.


Biochemical and structural characterization of mammalian-like purine nucleoside phosphorylase from the Archaeon Pyrococcus furiosus.

Cacciapuoti G, Gorassini S, Mazzeo MF, Siciliano RA, Carbone V, Zappia V, Porcelli M.

FEBS J. 2007 May;274(10):2482-95. Epub 2007 Apr 10.


A novel hyperthermostable 5'-deoxy-5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus.

Cacciapuoti G, Forte S, Moretti MA, Brio A, Zappia V, Porcelli M.

FEBS J. 2005 Apr;272(8):1886-99.


S-adenosylhomocysteine hydrolase from the archaeon Pyrococcus furiosus: biochemical characterization and analysis of protein structure by comparative molecular modeling.

Porcelli M, Moretti MA, Concilio L, Forte S, Merlino A, Graziano G, Cacciapuoti G.

Proteins. 2005 Mar 1;58(4):815-25.


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