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DLC1 suppresses NF-κB activity in prostate cancer cells due to its stabilizing effect on adherens junctions.

Tripathi V, Popescu NC, Zimonjic DB.

Springerplus. 2014 Jan 14;3:27. doi: 10.1186/2193-1801-3-27. eCollection 2014.


Deleted in liver cancer-1 (DLC1): an emerging metastasis suppressor gene.

Popescu NC, Goodison S.

Mol Diagn Ther. 2014 Jun;18(3):293-302. doi: 10.1007/s40291-014-0086-3. Review.


Isolation of Mouse Embryo Fibroblasts.

Durkin ME, Qian X, Popescu NC, Lowy DR.

Bio Protoc. 2013 Sep 20;3(18). pii: e908.


In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells.

Zimonjic DB, Chan LN, Tripathi V, Lu J, Kwon O, Popescu NC, Lowy DR, Tamanoi F.

BMC Cancer. 2013 Apr 22;13:198. doi: 10.1186/1471-2407-13-198.


DLC1 induces expression of E-cadherin in prostate cancer cells through Rho pathway and suppresses invasion.

Tripathi V, Popescu NC, Zimonjic DB.

Oncogene. 2014 Feb 6;33(6):724-33. doi: 10.1038/onc.2013.7. Epub 2013 Feb 4.


Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer.

Qian X, Durkin ME, Wang D, Tripathi BK, Olson L, Yang XY, Vass WC, Popescu NC, Lowy DR.

Cancer Res. 2012 Nov 15;72(22):5900-11. doi: 10.1158/0008-5472.CAN-12-2368. Epub 2012 Sep 25.


DLC1 interaction with α-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activity.

Tripathi V, Popescu NC, Zimonjic DB.

Mol Cell Biol. 2012 Jun;32(11):2145-59. doi: 10.1128/MCB.06580-11. Epub 2012 Apr 2.


Preclinical evaluation of combined antineoplastic effect of DLC1 tumor suppressor protein and suberoylanilide hydroxamic acid on prostate cancer cells.

Zhou X, Yang XY, Popescu NC.

Biochem Biophys Res Commun. 2012 Apr 6;420(2):325-30. doi: 10.1016/j.bbrc.2012.02.158. Epub 2012 Mar 7.


Restoration of senescence in breast and ovarian cancer cells following the transfer of the YAC carrying SEN6A gene located at 6q16.3.

Rane NS, Sandhu AK, Zhawar VS, Kaur G, Popescu NC, Kandpal RP, Jhanwar-Uniyal M, Athwal RS.

Cancer Genomics Proteomics. 2011 Sep-Oct;8(5):227-33.


DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanism.

Yang X, Popescu NC, Zimonjic DB.

Cancer Res. 2011 Apr 15;71(8):2916-25. doi: 10.1158/0008-5472.CAN-10-2158. Epub 2011 Mar 3.


A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors.

Low JS, Tao Q, Ng KM, Goh HK, Shu XS, Woo WL, Ambinder RF, Srivastava G, Shamay M, Chan AT, Popescu NC, Hsieh WS.

Oncogene. 2011 Apr 21;30(16):1923-35. doi: 10.1038/onc.2010.576. Epub 2011 Jan 10.


Role of SV40 integration site at chromosomal interval 1q21.1 in immortalized CRL2504 cells.

Liu J, Kaur G, Zhawar VK, Zimonjic DB, Popescu NC, Kandpal RP, Athwal RS.

Cancer Res. 2009 Oct 1;69(19):7819-25. doi: 10.1158/0008-5472.CAN-09-1003. Epub 2009 Sep 29.


Acquired genetic and functional alterations associated with transforming growth factor beta type I resistance in Hep3B human hepatocellular carcinoma cell line.

Zimonjic DB, Zhou X, Lee JS, Ullmannova-Benson V, Tripathi V, Thorgeirsson SS, Popescu NC.

J Cell Mol Med. 2009 Sep;13(9B):3985-92. doi: 10.1111/j.1582-4934.2009.00769.x. Epub 2009 May 1.


Recurrent and nonrandom DNA copy number and chromosome alterations in Myc transgenic mouse model for hepatocellular carcinogenesis: implications for human disease.

Zimonjic DB, Ullmannova-Benson V, Factor VM, Thorgeirsson SS, Popescu NC.

Cancer Genet Cytogenet. 2009 May;191(1):17-26. doi: 10.1016/j.cancergencyto.2008.12.014.


p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities.

Yang XY, Guan M, Vigil D, Der CJ, Lowy DR, Popescu NC.

Oncogene. 2009 Mar 19;28(11):1401-9. doi: 10.1038/onc.2008.498. Epub 2009 Jan 19.


DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway.

Ullmannova-Benson V, Guan M, Zhou X, Tripathi V, Yang XY, Zimonjic DB, Popescu NC.

Leukemia. 2009 Feb;23(2):383-90. doi: 10.1038/leu.2008.285. Epub 2008 Oct 16.


Delayed kinetics of DNA double-strand break processing in normal and pathological aging.

Sedelnikova OA, Horikawa I, Redon C, Nakamura A, Zimonjic DB, Popescu NC, Bonner WM.

Aging Cell. 2008 Jan;7(1):89-100. Epub 2007 Dec 19.


DLC-1:a Rho GTPase-activating protein and tumour suppressor.

Durkin ME, Yuan BZ, Zhou X, Zimonjic DB, Lowy DR, Thorgeirsson SS, Popescu NC.

J Cell Mol Med. 2007 Sep-Oct;11(5):1185-207. Review.


Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells.

Yuan BZ, Jefferson AM, Millecchia L, Popescu NC, Reynolds SH.

Exp Cell Res. 2007 Nov 1;313(18):3868-80. Epub 2007 Aug 21.


Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses.

Miao ZH, Player A, Shankavaram U, Wang YH, Zimonjic DB, Lorenzi PL, Liao ZY, Liu H, Shimura T, Zhang HL, Meng LH, Zhang YW, Kawasaki ES, Popescu NC, Aladjem MI, Goldstein DJ, Weinstein JN, Pommier Y.

Cancer Res. 2007 Sep 15;67(18):8752-61.


Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity.

Liao MJ, Zhang CC, Zhou B, Zimonjic DB, Mani SA, Kaba M, Gifford A, Reinhardt F, Popescu NC, Guo W, Eaton EN, Lodish HF, Weinberg RA.

Cancer Res. 2007 Sep 1;67(17):8131-8.


Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities.

Qian X, Li G, Asmussen HK, Asnaghi L, Vass WC, Braverman R, Yamada KM, Popescu NC, Papageorge AG, Lowy DR.

Proc Natl Acad Sci U S A. 2007 May 22;104(21):9012-7. Epub 2007 May 15.


Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth.

Durkin ME, Ullmannova V, Guan M, Popescu NC.

Oncogene. 2007 Jul 5;26(31):4580-9. Epub 2007 Feb 5.


Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors.

Ullmannova V, Popescu NC.

Int J Oncol. 2006 Nov;29(5):1127-32.


Effect of hepatitis C virus core protein on the molecular profiling of human B lymphocytes.

Wu CG, Budhu A, Chen S, Zhou X, Popescu NC, Valerie K, Wang XW.

Mol Med. 2006 Jan-Mar;12(1-3):47-53.


Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications.

Guan M, Zhou X, Soulitzis N, Spandidos DA, Popescu NC.

Clin Cancer Res. 2006 Mar 1;12(5):1412-9.


POTE paralogs are induced and differentially expressed in many cancers.

Bera TK, Saint Fleur A, Lee Y, Kydd A, Hahn Y, Popescu NC, Zimonjic DB, Lee B, Pastan I.

Cancer Res. 2006 Jan 1;66(1):52-6.


GTF2IRD1 in craniofacial development of humans and mice.

Tassabehji M, Hammond P, Karmiloff-Smith A, Thompson P, Thorgeirsson SS, Durkin ME, Popescu NC, Hutton T, Metcalfe K, Rucka A, Stewart H, Read AP, Maconochie M, Donnai D.

Science. 2005 Nov 18;310(5751):1184-7. Epub 2005 Nov 3.


Chromosomal aberrations in cell lines derived from thyroid tumors spontaneously developed in TRbetaPV/PV mice.

Zimonjic DB, Kato Y, Ying H, Popescu NC, Cheng SY.

Cancer Genet Cytogenet. 2005 Sep;161(2):104-9.


Assignment of murine placental cathepsin R to mouse chromosome bands 13B2-B3 by fluorescence in situ hybridization.

Zimonjic DB, Liu J, Xu WH, Zhou X, Popescu NC, Shi GP.

Cytogenet Genome Res. 2005;111(1):96. No abstract available.


The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells.

Goodison S, Yuan J, Sloan D, Kim R, Li C, Popescu NC, Urquidi V.

Cancer Res. 2005 Jul 15;65(14):6042-53.


The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation.

Sims-Mourtada JC, Bruce S, McKeller MR, Rangel R, Guzman-Rojas L, Cain K, Lopez C, Zimonjic DB, Popescu NC, Gordon J, Wilkinson MF, Martinez-Valdez H.

DNA Cell Biol. 2005 May;24(5):325-38.


DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development.

Durkin ME, Avner MR, Huh CG, Yuan BZ, Thorgeirsson SS, Popescu NC.

FEBS Lett. 2005 Feb 14;579(5):1191-6. Epub 2005 Jan 19.


Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma.

Park SW, Ludes-Meyers J, Zimonjic DB, Durkin ME, Popescu NC, Aldaz CM.

Br J Cancer. 2004 Aug 16;91(4):753-9.


Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerases.

Zhang H, Meng LH, Zimonjic DB, Popescu NC, Pommier Y.

Nucleic Acids Res. 2004 Apr 19;32(7):2087-92. Print 2004.


Rho GTPase activating protein cDNA on chromosome 13q12 is the deleted in liver cancer (DLC2) gene.

Popescu NC, Durkin ME.

Biochem Biophys Res Commun. 2004 Mar 19;315(4):781. No abstract available.


Fragile sites and cancer genes on the short arm of chromosome 8.

Popescu NC.

Lancet Oncol. 2004 Feb;5(2):77; discussion 77. No abstract available.


Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks.

Sedelnikova OA, Horikawa I, Zimonjic DB, Popescu NC, Bonner WM, Barrett JC.

Nat Cell Biol. 2004 Feb;6(2):168-70.


SMAD5 gene expression, rearrangements, copy number, and amplification at fragile site FRA5C in human hepatocellular carcinoma.

Zimonjic DB, Durkin ME, Keck-Waggoner CL, Park SW, Thorgeirsson SS, Popescu NC.

Neoplasia. 2003 Sep-Oct;5(5):390-6.


DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas.

Yuan BZ, Jefferson AM, Baldwin KT, Thorgeirsson SS, Popescu NC, Reynolds SH.

Oncogene. 2004 Feb 19;23(7):1405-11.


WWOX, the common chromosomal fragile site, FRA16D, cancer gene.

Ludes-Meyers JH, Bednarek AK, Popescu NC, Bedford M, Aldaz CM.

Cytogenet Genome Res. 2003;100(1-4):101-10.

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