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Items: 36


Ca2+-Dependent Inactivation of GluN2A and GluN2B NMDA Receptors Occurs by a Common Kinetic Mechanism.

Iacobucci GJ, Popescu GK.

Biophys J. 2019 Sep 13. pii: S0006-3495(19)30778-7. doi: 10.1016/j.bpj.2019.07.057. [Epub ahead of print]


Spatial Coupling Tunes NMDA Receptor Responses via Ca2+ Diffusion.

Iacobucci GJ, Popescu GK.

J Neurosci. 2019 Nov 6;39(45):8831-8844. doi: 10.1523/JNEUROSCI.0901-19.2019. Epub 2019 Sep 13.


Kinetic models for activation and modulation of NMDA receptor subtypes.

Iacobucci GJ, Popescu GK.

Curr Opin Physiol. 2018 Apr;2:114-122. doi: 10.1016/j.cophys.2018.02.002. Epub 2018 Feb 22.


Resident Calmodulin Primes NMDA Receptors for Ca2+-Dependent Inactivation.

Iacobucci GJ, Popescu GK.

Biophys J. 2017 Nov 21;113(10):2236-2248. doi: 10.1016/j.bpj.2017.06.035. Epub 2017 Jul 14.


Probing the Structural Dynamics of the NMDA Receptor Activation by Coarse-Grained Modeling.

Zheng W, Wen H, Iacobucci GJ, Popescu GK.

Biophys J. 2017 Jun 20;112(12):2589-2601. doi: 10.1016/j.bpj.2017.04.043.


Residues in the GluN1 C-terminal domain control kinetics and pharmacology of GluN1/GluN3A N-methyl-d-aspartate receptors.

Cummings KA, Belin S, Popescu GK.

Neuropharmacology. 2017 Jun;119:40-47. doi: 10.1016/j.neuropharm.2017.03.031. Epub 2017 Mar 29.


NMDA receptors: linking physiological output to biophysical operation.

Iacobucci GJ, Popescu GK.

Nat Rev Neurosci. 2017 Mar 17;18(4):236-249. doi: 10.1038/nrn.2017.24. Review.


Reprogramming Postnatal Human Epidermal Keratinocytes Toward Functional Neural Crest Fates.

Bajpai VK, Kerosuo L, Tseropoulos G, Cummings KA, Wang X, Lei P, Liu B, Liu S, Popescu GK, Bronner ME, Andreadis ST.

Stem Cells. 2017 May;35(5):1402-1415. doi: 10.1002/stem.2583. Epub 2017 Mar 5.


Mechanical stress activates NMDA receptors in the absence of agonists.

Maneshi MM, Maki B, Gnanasambandam R, Belin S, Popescu GK, Sachs F, Hua SZ.

Sci Rep. 2017 Jan 3;7:39610. doi: 10.1038/srep39610.


Protons Potentiate GluN1/GluN3A Currents by Attenuating Their Desensitisation.

Cummings KA, Popescu GK.

Sci Rep. 2016 Mar 22;6:23344. doi: 10.1038/srep23344.


Kinetic contributions to gating by interactions unique to N-methyl-D-aspartate (NMDA) receptors.

Borschel WF, Cummings KA, Tindell LK, Popescu GK.

J Biol Chem. 2015 Oct 30;290(44):26846-55. doi: 10.1074/jbc.M115.678656. Epub 2015 Sep 14.


Glycine-dependent activation of NMDA receptors.

Cummings KA, Popescu GK.

J Gen Physiol. 2015 Jun;145(6):513-27. doi: 10.1085/jgp.201411302. Epub 2015 May 11.


Zinc transporter found attached to N-methyl-D-aspartate receptors.

Popescu GK.

J Neurochem. 2015 Jan;132(2):155-8. doi: 10.1111/jnc.13014. No abstract available.


Actions of bupivacaine, a widely used local anesthetic, on NMDA receptor responses.

Paganelli MA, Popescu GK.

J Neurosci. 2015 Jan 14;35(2):831-42. doi: 10.1523/JNEUROSCI.3578-14.2015.


Accessories assist AMPA receptors to close pockets.

Popescu GK.

J Gen Physiol. 2015 Jan;145(1):17-21. doi: 10.1085/jgp.201411320. Epub 2014 Dec 15. No abstract available.


Extracellular Ca(2+) ions reduce NMDA receptor conductance and gating.

Maki BA, Popescu GK.

J Gen Physiol. 2014 Nov;144(5):379-92. doi: 10.1085/jgp.201411244.


One-channel cell-attached patch-clamp recording.

Maki BA, Cummings KA, Paganelli MA, Murthy SE, Popescu GK.

J Vis Exp. 2014 Jun 9;(88). doi: 10.3791/51629.


Separate intramolecular targets for protein kinase A control N-methyl-D-aspartate receptor gating and Ca2+ permeability.

Aman TK, Maki BA, Ruffino TJ, Kasperek EM, Popescu GK.

J Biol Chem. 2014 Jul 4;289(27):18805-17. doi: 10.1074/jbc.M113.537282. Epub 2014 May 20.


Dynamic plasticity of NMDA receptor-mediated calcium entry in neurons exposed to HIV-tat.

Popescu GK.

J Neurochem. 2014 Sep;130(5):609-11. doi: 10.1111/jnc.12737. Epub 2014 Apr 30. No abstract available.


Phosphorylation of Ser1166 on GluN2B by PKA is critical to synaptic NMDA receptor function and Ca2+ signaling in spines.

Murphy JA, Stein IS, Lau CG, Peixoto RT, Aman TK, Kaneko N, Aromolaran K, Saulnier JL, Popescu GK, Sabatini BL, Hell JW, Zukin RS.

J Neurosci. 2014 Jan 15;34(3):869-79. doi: 10.1523/JNEUROSCI.4538-13.2014.


Role of cross-cleft contacts in NMDA receptor gating.

Paganelli MA, Kussius CL, Popescu GK.

PLoS One. 2013 Nov 21;8(11):e80953. doi: 10.1371/journal.pone.0080953. eCollection 2013.


Inhibition of GluN2A-containing N-methyl-D-aspartate receptors by 2-naphthoic acid.

Yu H, Popescu GK.

Mol Pharmacol. 2013 Oct;84(4):541-50. doi: 10.1124/mol.113.087189. Epub 2013 Jul 19.


Two serine residues on GluN2A C-terminal tails control NMDA receptor current decay times.

Maki BA, Cole R, Popescu GK.

Channels (Austin). 2013 Mar-Apr;7(2):126-32. doi: 10.4161/chan.23968. Epub 2013 Mar 1.


Gating reaction mechanism of neuronal NMDA receptors.

Borschel WF, Myers JM, Kasperek EM, Smith TP, Graziane NM, Nowak LM, Popescu GK.

J Neurophysiol. 2012 Dec;108(11):3105-15. doi: 10.1152/jn.00551.2012. Epub 2012 Sep 19.


C-terminal domains of N-methyl-D-aspartic acid receptor modulate unitary channel conductance and gating.

Maki BA, Aman TK, Amico-Ruvio SA, Kussius CL, Popescu GK.

J Biol Chem. 2012 Oct 19;287(43):36071-80. doi: 10.1074/jbc.M112.390013. Epub 2012 Sep 4.


Ifenprodil effects on GluN2B-containing glutamate receptors.

Amico-Ruvio SA, Paganelli MA, Myers JM, Popescu GK.

Mol Pharmacol. 2012 Dec;82(6):1074-81. doi: 10.1124/mol.112.078998. Epub 2012 Aug 30.


Probing the activation sequence of NMDA receptors with lurcher mutations.

Murthy SE, Shogan T, Page JC, Kasperek EM, Popescu GK.

J Gen Physiol. 2012 Sep;140(3):267-77. doi: 10.1085/jgp.201210786. Epub 2012 Aug 13.


Modes of glutamate receptor gating.

Popescu GK.

J Physiol. 2012 Jan 1;590(1):73-91. doi: 10.1113/jphysiol.2011.223750. Epub 2011 Nov 21. Review.


NMDA receptor activation requires remodelling of intersubunit contacts within ligand-binding heterodimers.

Borschel WF, Murthy SE, Kasperek EM, Popescu GK.

Nat Commun. 2011 Oct 11;2:498. doi: 10.1038/ncomms1512.


Zinc effects on NMDA receptor gating kinetics.

Amico-Ruvio SA, Murthy SE, Smith TP, Popescu GK.

Biophys J. 2011 Apr 20;100(8):1910-8. doi: 10.1016/j.bpj.2011.02.042.


NMDA receptors with locked glutamate-binding clefts open with high efficacy.

Kussius CL, Popescu GK.

J Neurosci. 2010 Sep 15;30(37):12474-9. doi: 10.1523/JNEUROSCI.3337-10.2010.


Stationary gating of GluN1/GluN2B receptors in intact membrane patches.

Amico-Ruvio SA, Popescu GK.

Biophys J. 2010 Apr 7;98(7):1160-9. doi: 10.1016/j.bpj.2009.12.4276.


Agonist-specific gating of NMDA receptors.

Kussius CL, Popescu AM, Popescu GK.

Channels (Austin). 2010 Mar-Apr;4(2):78-82. Epub 2010 Mar 30.


Kinetic basis of partial agonism at NMDA receptors.

Kussius CL, Popescu GK.

Nat Neurosci. 2009 Sep;12(9):1114-20. doi: 10.1038/nn.2361. Epub 2009 Aug 2.


Pregnanolone sulfate promotes desensitization of activated NMDA receptors.

Kussius CL, Kaur N, Popescu GK.

J Neurosci. 2009 May 27;29(21):6819-27. doi: 10.1523/JNEUROSCI.0281-09.2009.


Distinct gating modes determine the biphasic relaxation of NMDA receptor currents.

Zhang W, Howe JR, Popescu GK.

Nat Neurosci. 2008 Dec;11(12):1373-5. doi: 10.1038/nn.2214. Epub 2008 Oct 26.

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