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Items: 20


Same day tools, including Xpert Ultra and unstimulated IFN-γ, for the rapid diagnosis of pleural tuberculosis - a prospective observational study.

Meldau R, Randall P, Pooran A, Limberis J, Makambwa E, Dhansay M, Esmail A, Dheda K.

J Clin Microbiol. 2019 Jul 3. pii: JCM.00614-19. doi: 10.1128/JCM.00614-19. [Epub ahead of print]


Cost of managing severe cutaneous adverse drug reactions to first-line tuberculosis therapy in South Africa.

Knight LK, Lehloenya RJ, Sinanovic E, Pooran A.

Trop Med Int Health. 2019 Aug;24(8):994-1002. doi: 10.1111/tmi.13275. Epub 2019 Jun 24.


IL-4 subverts mycobacterial containment in Mycobacterium tuberculosis-infected human macrophages.

Pooran A, Davids M, Nel A, Shoko A, Blackburn J, Dheda K.

Eur Respir J. 2019 Aug 8;54(2). pii: 1802242. doi: 10.1183/13993003.02242-2018. Print 2019 Aug.


Point of care Xpert MTB/RIF versus smear microscopy for tuberculosis diagnosis in southern African primary care clinics: a multicentre economic evaluation.

Pooran A, Theron G, Zijenah L, Chanda D, Clowes P, Mwenge L, Mutenherwa F, Lecesse P, Metcalfe J, Sohn H, Hoelscher M, Pym A, Peter J, Dowdy D, Dheda K.

Lancet Glob Health. 2019 Jun;7(6):e798-e807. doi: 10.1016/S2214-109X(19)30164-0. Erratum in: Lancet Glob Health. 2019 Sep;7(9):e1179.


Spatial Network Mapping of Pulmonary Multidrug-Resistant Tuberculosis Cavities Using RNA Sequencing.

Dheda K, Lenders L, Srivastava S, Magombedze G, Wainwright H, Raj P, Bush SJ, Pollara G, Steyn R, Davids M, Pooran A, Pennel T, Linegar A, McNerney R, Moodley L, Pasipanodya JG, Turner CT, Noursadeghi M, Warren RM, Wakeland E, Gumbo T.

Am J Respir Crit Care Med. 2019 Aug 1;200(3):370-380. doi: 10.1164/rccm.201807-1361OC.


The Injectable Contraceptive Medroxyprogesterone Acetate Attenuates Mycobacterium tuberculosis-Specific Host Immunity Through the Glucocorticoid Receptor.

Tomasicchio M, Davids M, Pooran A, Theron G, Smith L, Semple L, Meldau R, Hapgood JP, Dheda K.

J Infect Dis. 2019 Apr 8;219(8):1329-1337. doi: 10.1093/infdis/jiy657.


An autologous dendritic cell vaccine polarizes a Th-1 response which is tumoricidal to patient-derived breast cancer cells.

Tomasicchio M, Semple L, Esmail A, Meldau R, Randall P, Pooran A, Davids M, Cairncross L, Anderson D, Downs J, Malherbe F, Novitzky N, Panieri E, Oelofse S, Londt R, Naiker T, Dheda K.

Cancer Immunol Immunother. 2019 Jan;68(1):71-83. doi: 10.1007/s00262-018-2238-5. Epub 2018 Oct 3.


Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis.

Dheda K, Lenders L, Magombedze G, Srivastava S, Raj P, Arning E, Ashcraft P, Bottiglieri T, Wainwright H, Pennel T, Linegar A, Moodley L, Pooran A, Pasipanodya JG, Sirgel FA, van Helden PD, Wakeland E, Warren RM, Gumbo T.

Am J Respir Crit Care Med. 2018 Nov 1;198(9):1208-1219. doi: 10.1164/rccm.201711-2333OC.


Regulatory T Cells Subvert Mycobacterial Containment in Patients Failing Extensively Drug-Resistant Tuberculosis Treatment.

Davids M, Pooran AS, Pietersen E, Wainwright HC, Binder A, Warren R, Dheda K.

Am J Respir Crit Care Med. 2018 Jul 1;198(1):104-116. doi: 10.1164/rccm.201707-1441OC.


Early morning urine collection to improve urinary lateral flow LAM assay sensitivity in hospitalised patients with HIV-TB co-infection.

Gina P, Randall PJ, Muchinga TE, Pooran A, Meldau R, Peter JG, Dheda K.

BMC Infect Dis. 2017 May 12;17(1):339. doi: 10.1186/s12879-017-2313-0.


Burden of tuberculosis in intensive care units in Cape Town, South Africa, and assessment of the accuracy and effect on patient outcomes of the Xpert MTB/RIF test on tracheal aspirate samples for diagnosis of pulmonary tuberculosis: a prospective burden of disease study with a nested randomised controlled trial.

Calligaro GL, Theron G, Khalfey H, Peter J, Meldau R, Matinyenya B, Davids M, Smith L, Pooran A, Lesosky M, Esmail A, Miller MG, Piercy J, Michell L, Dawson R, Raine RI, Joubert I, Dheda K.

Lancet Respir Med. 2015 Aug;3(8):621-30. doi: 10.1016/S2213-2600(15)00198-8. Epub 2015 Jul 22.


Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study.

Theron G, Peter J, Zijenah L, Chanda D, Mangu C, Clowes P, Rachow A, Lesosky M, Hoelscher M, Pym A, Mwaba P, Mason P, Naidoo P, Pooran A, Sohn H, Pai M, Stein DJ, Dheda K.

BMC Infect Dis. 2015 Jul 1;15:253. doi: 10.1186/s12879-015-0964-2.


Long-term outcomes of patients with extensively drug-resistant tuberculosis in South Africa: a cohort study.

Pietersen E, Ignatius E, Streicher EM, Mastrapa B, Padanilam X, Pooran A, Badri M, Lesosky M, van Helden P, Sirgel FA, Warren R, Dheda K.

Lancet. 2014 Apr 5;383(9924):1230-9. doi: 10.1016/S0140-6736(13)62675-6. Epub 2014 Jan 17.


Comparison of two methods for acquisition of sputum samples for diagnosis of suspected tuberculosis in smear-negative or sputum-scarce people: a randomised controlled trial.

Peter JG, Theron G, Pooran A, Thomas J, Pascoe M, Dheda K.

Lancet Respir Med. 2013 Aug;1(6):471-8. doi: 10.1016/S2213-2600(13)70120-6. Epub 2013 Jul 19.


Increased production of IL-4 and IL-12p40 from bronchoalveolar lavage cells are biomarkers of Mycobacterium tuberculosis in the sputum.

Nolan A, Fajardo E, Huie ML, Condos R, Pooran A, Dawson R, Dheda K, Bateman E, Rom WN, Weiden MD.

PLoS One. 2013;8(3):e59461. doi: 10.1371/journal.pone.0059461. Epub 2013 Mar 20.


What is the cost of diagnosis and management of drug resistant tuberculosis in South Africa?

Pooran A, Pieterson E, Davids M, Theron G, Dheda K.

PLoS One. 2013;8(1):e54587. doi: 10.1371/journal.pone.0054587. Epub 2013 Jan 18.


Do adjunct tuberculosis tests, when combined with Xpert MTB/RIF, improve accuracy and the cost of diagnosis in a resource-poor setting?

Theron G, Pooran A, Peter J, van Zyl-Smit R, Kumar Mishra H, Meldau R, Calligaro G, Allwood B, Sharma SK, Dawson R, Dheda K.

Eur Respir J. 2012 Jul;40(1):161-8. doi: 10.1183/09031936.00145511. Epub 2011 Nov 10.


A discussion of molecular biology methods for protein engineering.

Zawaira A, Pooran A, Barichievy S, Chopera D.

Mol Biotechnol. 2012 May;51(1):67-102. doi: 10.1007/s12033-011-9448-9. Review.


Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis.

Pooran A, Booth H, Miller RF, Scott G, Badri M, Huggett JF, Rook G, Zumla A, Dheda K.

BMC Pulm Med. 2010 Feb 22;10:7. doi: 10.1186/1471-2466-10-7.


Interpretation of Mycobacterium tuberculosis antigen-specific IFN-gamma release assays (T-SPOT.TB) and factors that may modulate test results.

Dheda K, Pooran A, Pai M, Miller RF, Lesley K, Booth HL, Scott GM, Akbar AN, Zumla A, Rook GA.

J Infect. 2007 Aug;55(2):169-73. Epub 2007 Apr 19.


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