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Items: 36

1.

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target.

Yuan S, Chu H, Chan JF, Ye ZW, Wen L, Yan B, Lai PM, Tee KM, Huang J, Chen D, Li C, Zhao X, Yang D, Chiu MC, Yip C, Poon VK, Chan CC, Sze KH, Zhou J, Chan IH, Kok KH, To KK, Kao RY, Lau JY, Jin DY, Perlman S, Yuen KY.

Nat Commun. 2019 Jan 10;10(1):120. doi: 10.1038/s41467-018-08015-x.

2.

Identification and characterization of GLDC as host susceptibility gene to severe influenza.

Zhou J, Wang D, Wong BH, Li C, Poon VK, Wen L, Zhao X, Chiu MC, Liu X, Ye Z, Yuan S, Sze KH, Chan JF, Chu H, To KK, Yuen KY.

EMBO Mol Med. 2019 Jan;11(1). pii: e9528. doi: 10.15252/emmm.201809528.

3.

The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy.

Chan JF, Zhu Z, Chu H, Yuan S, Chik KK, Chan CC, Poon VK, Yip CC, Zhang X, Tsang JO, Zou Z, Tee KM, Shuai H, Lu G, Yuen KY.

Antiviral Res. 2018 Dec;160:38-47. doi: 10.1016/j.antiviral.2018.10.007. Epub 2018 Oct 13.

PMID:
30326204
4.

Differentiated human airway organoids to assess infectivity of emerging influenza virus.

Zhou J, Li C, Sachs N, Chiu MC, Wong BH, Chu H, Poon VK, Wang D, Zhao X, Wen L, Song W, Yuan S, Wong KK, Chan JF, To KK, Chen H, Clevers H, Yuen KY.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6822-6827. doi: 10.1073/pnas.1806308115. Epub 2018 Jun 11.

5.

Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells.

Chu H, Chan CM, Zhang X, Wang Y, Yuan S, Zhou J, Au-Yeung RK, Sze KH, Yang D, Shuai H, Hou Y, Li C, Zhao X, Poon VK, Leung SP, Yeung ML, Yan J, Lu G, Jin DY, Gao GF, Chan JF, Yuen KY.

J Biol Chem. 2018 Jul 27;293(30):11709-11726. doi: 10.1074/jbc.RA118.001897. Epub 2018 Jun 10.

6.

Immunization With a Novel Human Type 5 Adenovirus-Vectored Vaccine Expressing the Premembrane and Envelope Proteins of Zika Virus Provides Consistent and Sterilizing Protection in Multiple Immunocompetent and Immunocompromised Animal Models.

Guo Q, Chan JF, Poon VK, Wu S, Chan CC, Hou L, Yip CC, Ren C, Cai JP, Zhao M, Zhang AJ, Song X, Chan KH, Wang B, Kok KH, Wen Y, Yuen KY, Chen W.

J Infect Dis. 2018 Jul 2;218(3):365-377. doi: 10.1093/infdis/jiy187.

PMID:
29617816
7.

Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus.

Zhou J, Li C, Zhao G, Chu H, Wang D, Yan HH, Poon VK, Wen L, Wong BH, Zhao X, Chiu MC, Yang D, Wang Y, Au-Yeung RKH, Chan IH, Sun S, Chan JF, To KK, Memish ZA, Corman VM, Drosten C, Hung IF, Zhou Y, Leung SY, Yuen KY.

Sci Adv. 2017 Nov 15;3(11):eaao4966. doi: 10.1126/sciadv.aao4966. eCollection 2017 Nov.

8.

Structure-based discovery of clinically approved drugs as Zika virus NS2B-NS3 protease inhibitors that potently inhibit Zika virus infection in vitro and in vivo.

Yuan S, Chan JF, den-Haan H, Chik KK, Zhang AJ, Chan CC, Poon VK, Yip CC, Mak WW, Zhu Z, Zou Z, Tee KM, Cai JP, Chan KH, de la Peña J, Pérez-Sánchez H, Cerón-Carrasco JP, Yuen KY.

Antiviral Res. 2017 Sep;145:33-43. doi: 10.1016/j.antiviral.2017.07.007. Epub 2017 Jul 14.

PMID:
28712942
9.

Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus.

Chan JF, Yip CC, Tee KM, Zhu Z, Tsang JO, Chik KK, Tsang TG, Chan CC, Poon VK, Sridhar S, Yin F, Hung IF, Chau SK, Zhang AJ, Chan KH, Yuen KY.

Trop Med Int Health. 2017 May;22(5):594-603. doi: 10.1111/tmi.12857. Epub 2017 Mar 16.

10.

Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor.

Chan JF, Chik KK, Yuan S, Yip CC, Zhu Z, Tee KM, Tsang JO, Chan CC, Poon VK, Lu G, Zhang AJ, Lai KK, Chan KH, Kao RY, Yuen KY.

Antiviral Res. 2017 May;141:29-37. doi: 10.1016/j.antiviral.2017.02.002. Epub 2017 Feb 7.

PMID:
28185815
11.

Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons.

Chan JF, Zhang AJ, Chan CC, Yip CC, Mak WW, Zhu H, Poon VK, Tee KM, Zhu Z, Cai JP, Tsang JO, Chik KK, Yin F, Chan KH, Kok KH, Jin DY, Au-Yeung RK, Yuen KY.

EBioMedicine. 2016 Dec;14:112-122. doi: 10.1016/j.ebiom.2016.11.017. Epub 2016 Nov 12.

12.

MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2.

Yeung ML, Yao Y, Jia L, Chan JF, Chan KH, Cheung KF, Chen H, Poon VK, Tsang AK, To KK, Yiu MK, Teng JL, Chu H, Zhou J, Zhang Q, Deng W, Lau SK, Lau JY, Woo PC, Chan TM, Yung S, Zheng BJ, Jin DY, Mathieson PW, Qin C, Yuen KY.

Nat Microbiol. 2016 Feb 22;1:16004. doi: 10.1038/nmicrobiol.2016.4.

PMID:
27572168
13.

A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses.

Zhao H, Zhou J, Zhang K, Chu H, Liu D, Poon VK, Chan CC, Leung HC, Fai N, Lin YP, Zhang AJ, Jin DY, Yuen KY, Zheng BJ.

Sci Rep. 2016 Feb 25;6:22008. doi: 10.1038/srep22008.

14.

An H5N1-based matrix protein 2 ectodomain tetrameric peptide vaccine provides cross-protection against lethal infection with H7N9 influenza virus.

Leung HC, Chan CC, Poon VK, Zhao HJ, Cheung CY, Ng F, Huang JD, Zheng BJ.

Emerg Microbes Infect. 2015 Apr;4(4):e22. doi: 10.1038/emi.2015.22. Epub 2015 Apr 8.

15.

Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response.

Chu H, Zhou J, Wong BH, Li C, Cheng ZS, Lin X, Poon VK, Sun T, Lau CC, Chan JF, To KK, Chan KH, Lu L, Zheng BJ, Yuen KY.

Virology. 2014 Apr;454-455:197-205. doi: 10.1016/j.virol.2014.02.018. Epub 2014 Mar 7.

16.

Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis.

Zhou J, Chu H, Li C, Wong BH, Cheng ZS, Poon VK, Sun T, Lau CC, Wong KK, Chan JY, Chan JF, To KK, Chan KH, Zheng BJ, Yuen KY.

J Infect Dis. 2014 May 1;209(9):1331-42. doi: 10.1093/infdis/jit504. Epub 2013 Sep 24.

PMID:
24065148
17.

A safe and convenient pseudovirus-based inhibition assay to detect neutralizing antibodies and screen for viral entry inhibitors against the novel human coronavirus MERS-CoV.

Zhao G, Du L, Ma C, Li Y, Li L, Poon VK, Wang L, Yu F, Zheng BJ, Jiang S, Zhou Y.

Virol J. 2013 Aug 26;10:266. doi: 10.1186/1743-422X-10-266.

18.

Identification of a receptor-binding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development.

Du L, Zhao G, Kou Z, Ma C, Sun S, Poon VK, Lu L, Wang L, Debnath AK, Zheng BJ, Zhou Y, Jiang S.

J Virol. 2013 Sep;87(17):9939-42. doi: 10.1128/JVI.01048-13. Epub 2013 Jul 3. Erratum in: J Virol. 2013 Nov;87(21):11963.

19.

Leptin mediates the pathogenesis of severe 2009 pandemic influenza A(H1N1) infection associated with cytokine dysregulation in mice with diet-induced obesity.

Zhang AJ, To KK, Li C, Lau CC, Poon VK, Chan CC, Zheng BJ, Hung IF, Lam KS, Xu A, Yuen KY.

J Infect Dis. 2013 Apr 15;207(8):1270-80. doi: 10.1093/infdis/jit031. Epub 2013 Jan 16.

PMID:
23325916
20.

A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection.

Zhou J, To KK, Dong H, Cheng ZS, Lau CC, Poon VK, Fan YH, Song YQ, Tse H, Chan KH, Zheng BJ, Zhao GP, Yuen KY.

J Infect Dis. 2012 Aug 15;206(4):495-503. doi: 10.1093/infdis/jis378. Epub 2012 Jun 12.

PMID:
22693232
21.

Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development.

Chan TH, Chen L, Liu M, Hu L, Zheng BJ, Poon VK, Huang P, Yuan YF, Huang JD, Yang J, Tsao GS, Guan XY.

Hepatology. 2012 Feb;55(2):491-505. doi: 10.1002/hep.24709.

PMID:
21953552
22.

A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection.

Wang X, Chan CC, Yang M, Deng J, Poon VK, Leung VH, Ko KH, Zhou J, Yuen KY, Zheng BJ, Lu L.

Cell Mol Immunol. 2011 Nov;8(6):462-8. doi: 10.1038/cmi.2011.38. Epub 2011 Sep 26.

23.

CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry.

Liu S, Li R, Zhang R, Chan CC, Xi B, Zhu Z, Yang J, Poon VK, Zhou J, Chen M, Münch J, Kirchhoff F, Pleschka S, Haarmann T, Dietrich U, Pan C, Du L, Jiang S, Zheng B.

Eur J Pharmacol. 2011 Jun 25;660(2-3):460-7. doi: 10.1016/j.ejphar.2011.04.013. Epub 2011 Apr 22.

PMID:
21536025
24.

A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses.

Du L, Leung VH, Zhang X, Zhou J, Chen M, He W, Zhang HY, Chan CC, Poon VK, Zhao G, Sun S, Cai L, Zhou Y, Zheng BJ, Jiang S.

PLoS One. 2011 Jan 27;6(1):e16555. doi: 10.1371/journal.pone.0016555.

25.

Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice.

Chan KH, Zhang AJ, To KK, Chan CC, Poon VK, Guo K, Ng F, Zhang QW, Leung VH, Cheung AN, Lau CC, Woo PC, Tse H, Wu W, Chen H, Zheng BJ, Yuen KY.

PLoS One. 2010 Oct 29;5(10):e13757. doi: 10.1371/journal.pone.0013757.

26.

D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice.

Zheng B, Chan KH, Zhang AJ, Zhou J, Chan CC, Poon VK, Zhang K, Leung VH, Jin DY, Woo PC, Chan JF, To KK, Chen H, Yuen KY.

Exp Biol Med (Maywood). 2010 Aug;235(8):981-8. doi: 10.1258/ebm.2010.010071.

PMID:
20660098
27.

Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection.

Zhou J, Huang JD, Poon VK, Chen DQ, Chan CC, Ng F, Guan XY, Watt RM, Lu L, Yuen KY, Zheng BJ.

J Hepatol. 2009 Aug;51(2):322-32. doi: 10.1016/j.jhep.2009.03.020. Epub 2009 May 3.

PMID:
19501422
28.

A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection.

Zhou J, Chen DQ, Poon VK, Zeng Y, Ng F, Lu L, Huang JD, Yuen KY, Zheng BJ.

Immunogenetics. 2009 Jun;61(6):423-30. doi: 10.1007/s00251-009-0377-8. Epub 2009 Jun 2.

PMID:
19488747
29.

Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKepsilon complex.

Siu KL, Kok KH, Ng MH, Poon VK, Yuen KY, Zheng BJ, Jin DY.

J Biol Chem. 2009 Jun 12;284(24):16202-9. doi: 10.1074/jbc.M109.008227. Epub 2009 Apr 20.

30.

A non-synonymous single nucleotide polymorphism in IFNAR1 affects susceptibility to chronic hepatitis B virus infection.

Zhou J, Smith DK, Lu L, Poon VK, Ng F, Chen DQ, Huang JD, Yuen KY, Cao KY, Zheng BJ.

J Viral Hepat. 2009 Jan;16(1):45-52. doi: 10.1111/j.1365-2893.2008.01040.x. Epub 2008 Aug 28.

PMID:
18761606
31.

Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infection.

Zhou J, Lu L, Yuen MF, Lam TW, Chung CP, Lam CL, Zhang B, Wang S, Chen Y, Wu SH, Poon VK, Ng F, Chan CC, Jiang S, Yuen KY, Zheng BJ.

J Hepatol. 2007 Feb;46(2):198-205. Epub 2006 Oct 17.

PMID:
17125879
32.

Antimicrobial activities of silver dressings: an in vitro comparison.

Ip M, Lui SL, Poon VK, Lung I, Burd A.

J Med Microbiol. 2006 Jan;55(Pt 1):59-63.

PMID:
16388031
33.
34.

A study of Q-switched Nd:YAG laser irradiation and paracrine function in human skin cells.

Burd A, Zhu N, Poon VK.

Photodermatol Photoimmunol Photomed. 2005 Jun;21(3):131-7.

PMID:
15888129
35.

In vitro cytotoxity of silver: implication for clinical wound care.

Poon VK, Burd A.

Burns. 2004 Mar;30(2):140-7.

PMID:
15019121
36.

Phage-displayed La/SS-B antigen as a diagnostic reagent.

Poon VK, Chui YL, Lim PL.

Immunotechnology. 1997 Jun;3(2):155-9.

PMID:
9237100

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