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Items: 1 to 50 of 107

1.

Synergism between ATM and PARP1 inhibition involves DNA damage and abrogating the G2 DNA damage checkpoint.

Mak JPY, Ma HT, Poon RYC.

Mol Cancer Ther. 2019 Oct 9. pii: molcanther.0474.2019. doi: 10.1158/1535-7163.MCT-19-0474. [Epub ahead of print]

PMID:
31597711
2.

Imbalance of the spindle-assembly checkpoint promotes spindle poison-mediated cytotoxicity with distinct kinetics.

Zeng X, Xu WK, Lok TM, Ma HT, Poon RYC.

Cell Death Dis. 2019 Apr 5;10(4):314. doi: 10.1038/s41419-019-1539-8.

3.

Conditional gene inactivation by combining tetracycline-mediated transcriptional repression and auxin-inducible degron-mediated degradation.

Ng LY, Ma HT, Liu JCY, Huang X, Lee N, Poon RYC.

Cell Cycle. 2019 Jan;18(2):238-248. doi: 10.1080/15384101.2018.1563395. Epub 2019 Jan 7.

PMID:
30582405
4.

TRIP13 Functions in the Establishment of the Spindle Assembly Checkpoint by Replenishing O-MAD2.

Ma HT, Poon RYC.

Cell Rep. 2018 Feb 6;22(6):1439-1450. doi: 10.1016/j.celrep.2018.01.027.

5.

DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis.

Ye F, Kang E, Yu C, Qian X, Jacob F, Yu C, Mao M, Poon RYC, Kim J, Song H, Ming GL, Zhang M.

Neuron. 2017 Dec 6;96(5):1204. doi: 10.1016/j.neuron.2017.11.034. No abstract available.

6.

DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis.

Ye F, Kang E, Yu C, Qian X, Jacob F, Yu C, Mao M, Poon RYC, Kim J, Song H, Ming GL, Zhang M.

Neuron. 2017 Dec 6;96(5):1041-1054.e5. doi: 10.1016/j.neuron.2017.10.010. Epub 2017 Nov 2. Erratum in: Neuron. 2017 Dec 6;96(5):1204.

7.

Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-β/Smad-regulated liver cancer stem cell-like cells.

Xia W, Lo CM, Poon RYC, Cheung TT, Chan ACY, Chen L, Yang S, Tsao GSW, Wang XQ.

Oncotarget. 2017 Jun 13;8(24):38811-38824. doi: 10.18632/oncotarget.16402.

8.

Synchronization of HeLa Cells.

Ma HT, Poon RY.

Methods Mol Biol. 2017;1524:189-201.

PMID:
27815904
9.

BCL-W is a regulator of microtubule inhibitor-induced mitotic cell death.

Huang S, Tang R, Poon RY.

Oncotarget. 2016 Jun 21;7(25):38718-38730. doi: 10.18632/oncotarget.9586.

10.

CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency.

Wang XQ, Lo CM, Chen L, Ngan ES, Xu A, Poon RY.

Cell Death Differ. 2017 Jan;24(1):38-48. doi: 10.1038/cdd.2016.84. Epub 2016 Sep 16.

11.
12.

TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint.

Ma HT, Poon RYC.

Cell Rep. 2016 Feb 9;14(5):1086-1099. doi: 10.1016/j.celrep.2016.01.001. Epub 2016 Jan 28.

13.

SGO1C is a non-functional isoform of Shugoshin and can disrupt sister chromatid cohesion by interacting with PP2A-B56.

Wong WK, Kelly T, Li J, Ma HT, Poon RY.

Cell Cycle. 2015;14(24):3965-77. doi: 10.1080/15384101.2015.1104439.

14.

Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair.

Xie S, Mortusewicz O, Ma HT, Herr P, Poon RY, Helleday T, Qian C.

Mol Cell. 2015 Oct 1;60(1):163-76. doi: 10.1016/j.molcel.2015.07.031. Epub 2015 Sep 3. Erratum in: Mol Cell. 2016 Jan 7;61(1):181. Poon, Randy R Y [Corrected to Poon, Randy Y C].

15.

Cell Cycle Control: A System of Interlinking Oscillators.

Poon RY.

Methods Mol Biol. 2016;1342:3-19. doi: 10.1007/978-1-4939-2957-3_1. Review.

PMID:
26254915
16.

Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells.

Mak JP, Man WY, Chow JP, Ma HT, Poon RY.

Oncotarget. 2015 Aug 28;6(25):21074-84.

17.

Co-inhibition of polo-like kinase 1 and Aurora kinases promotes mitotic catastrophe.

Li J, Hong MJ, Chow JP, Man WY, Mak JP, Ma HT, Poon RY.

Oncotarget. 2015 Apr 20;6(11):9327-40.

18.
19.

Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15-dependent drug resistance.

Ma HT, Erdal S, Huang S, Poon RY.

Mol Oncol. 2014 Dec;8(8):1404-18. doi: 10.1016/j.molonc.2014.05.007. Epub 2014 Jun 2.

20.

Label-free enumeration of colorectal cancer cells from lymphocytes performed at a high cell-loading density by using interdigitated ring-array microelectrodes.

Xing X, Poon RY, Wong CS, Yobas L.

Biosens Bioelectron. 2014 Nov 15;61:434-42. doi: 10.1016/j.bios.2014.05.054. Epub 2014 Jun 4.

PMID:
24934744
21.

G1 checkpoint establishment in vivo during embryonic liver development.

Wang XQ, Chan KK, Ming X, Lui VC, Poon RY, Lo CM, Norbury C, Poon RT.

BMC Dev Biol. 2014 May 19;14:23. doi: 10.1186/1471-213X-14-23.

22.

Salt-inducible kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death.

Chen H, Huang S, Han X, Zhang J, Shan C, Tsang YH, Ma HT, Poon RY.

Cell Death Dis. 2014 Apr 17;5:e1177. doi: 10.1038/cddis.2014.154.

23.

DNA damage checkpoints in nasopharyngeal carcinoma.

Poon RY.

Oral Oncol. 2014 May;50(5):339-44. doi: 10.1016/j.oraloncology.2014.01.009. Epub 2014 Feb 4.

PMID:
24503238
24.

Dovitinib induces mitotic defects and activates the G2 DNA damage checkpoint.

Man WY, Mak JP, Poon RY.

J Cell Mol Med. 2014 Jan;18(1):143-55. doi: 10.1111/jcmm.12176. Epub 2013 Nov 18.

25.

PARP1 is overexpressed in nasopharyngeal carcinoma and its inhibition enhances radiotherapy.

Chow JP, Man WY, Mao M, Chen H, Cheung F, Nicholls J, Tsao SW, Li Lung M, Poon RY.

Mol Cancer Ther. 2013 Nov;12(11):2517-28. doi: 10.1158/1535-7163.MCT-13-0010. Epub 2013 Aug 26.

26.

p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases.

Marxer M, Ma HT, Man WY, Poon RY.

Oncogene. 2014 Jul 3;33(27):3550-60. doi: 10.1038/onc.2013.325. Epub 2013 Aug 19.

PMID:
23955083
27.

Critical differences between isoforms of securin reveal mechanisms of separase regulation.

Han X, Poon RY.

Mol Cell Biol. 2013 Sep;33(17):3400-15. doi: 10.1128/MCB.00057-13. Epub 2013 Jun 24.

28.

Aurora B: hooking up with cyclin-dependent kinases.

Poon RY.

Cell Cycle. 2013 Apr 1;12(7):1019-20. doi: 10.4161/cc.24307. Epub 2013 Mar 19. No abstract available.

29.

Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints.

Tsang YH, Han X, Man WY, Lee N, Poon RY.

PLoS One. 2012;7(11):e49943. doi: 10.1371/journal.pone.0049943. Epub 2012 Nov 26.

30.

The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery.

Chow JP, Poon RY.

Oncogene. 2013 Oct;32(40):4778-88. doi: 10.1038/onc.2012.504. Epub 2012 Nov 12.

PMID:
23146904
31.

Tetraploidization increases sensitivity to Aurora B kinase inhibition.

Marxer M, Foucar CE, Man WY, Chen Y, Ma HT, Poon RY.

Cell Cycle. 2012 Jul 1;11(13):2567-77. doi: 10.4161/cc.20947. Epub 2012 Jul 1.

PMID:
22722494
32.

Depletion of p31comet protein promotes sensitivity to antimitotic drugs.

Ma HT, Chan YY, Chen X, On KF, Poon RY.

J Biol Chem. 2012 Jun 15;287(25):21561-9. doi: 10.1074/jbc.M112.364356. Epub 2012 Apr 27.

33.

Inhibition of Eg5 acts synergistically with checkpoint abrogation in promoting mitotic catastrophe.

Chen Y, Chow JP, Poon RY.

Mol Cancer Res. 2012 May;10(5):626-35. doi: 10.1158/1541-7786.MCR-11-0491. Epub 2012 Apr 20.

34.

SCFβ(TrCP) mediates stress-activated MAPK-induced Cdc25B degradation.

Uchida S, Watanabe N, Kudo Y, Yoshioka K, Matsunaga T, Ishizaka Y, Nakagama H, Poon RY, Yamashita K.

J Cell Sci. 2011 Aug 15;124(Pt 16):2816-25. doi: 10.1242/jcs.083931.

35.

Synchronization of HeLa cells.

Ma HT, Poon RY.

Methods Mol Biol. 2011;761:151-61. doi: 10.1007/978-1-61779-182-6_10.

PMID:
21755447
36.

Determinants of mitotic catastrophe on abrogation of the G2 DNA damage checkpoint by UCN-01.

On KF, Chen Y, Ma HT, Chow JP, Poon RY.

Mol Cancer Ther. 2011 May;10(5):784-94. doi: 10.1158/1535-7163.MCT-10-0809. Epub 2011 Mar 23.

37.

How protein kinases co-ordinate mitosis in animal cells.

Ma HT, Poon RY.

Biochem J. 2011 Apr 1;435(1):17-31. doi: 10.1042/BJ20100284. Review.

PMID:
21406064
38.

Orderly inactivation of the key checkpoint protein mitotic arrest deficient 2 (MAD2) during mitotic progression.

Ma HT, Poon RY.

J Biol Chem. 2011 Apr 15;286(15):13052-9. doi: 10.1074/jbc.M110.201897. Epub 2011 Feb 18.

39.

The requirement of p53 for maintaining chromosomal stability during tetraploidization.

Ho CC, Hau PM, Marxer M, Poon RY.

Oncotarget. 2010 Nov;1(7):583-95.

40.

Inhibitory phosphorylation of cyclin-dependent kinase 1 as a compensatory mechanism for mitosis exit.

Chow JP, Poon RY, Ma HT.

Mol Cell Biol. 2011 Apr;31(7):1478-91. doi: 10.1128/MCB.00891-10. Epub 2011 Jan 24.

41.

Gene down-regulation with short hairpin RNAs and validation of specificity by inducible rescue in mammalian cells.

Ma HT, Poon RY.

Curr Protoc Cell Biol. 2010 Dec;Chapter 27:Unit 27.2. doi: 10.1002/0471143030.cb2702s49.

PMID:
21154550
42.

DNA damage and polyploidization.

Chow J, Poon RY.

Adv Exp Med Biol. 2010;676:57-71. Review.

PMID:
20687469
43.

Polyploidization and cancer. Preface.

Poon RY.

Adv Exp Med Biol. 2010;676:vii. No abstract available.

PMID:
20687465
44.

Genome reduplication: redeployment of cyclin-CDK complexes and spontaneous oscillation of APC/C.

Ma HT, Poon RY.

Cell Cycle. 2010 Feb 1;9(3):431-2. Epub 2010 Feb 23. No abstract available.

PMID:
20090418
45.
46.

Stress-activated mitogen-activated protein kinases c-Jun NH2-terminal kinase and p38 target Cdc25B for degradation.

Uchida S, Yoshioka K, Kizu R, Nakagama H, Matsunaga T, Ishizaka Y, Poon RY, Yamashita K.

Cancer Res. 2009 Aug 15;69(16):6438-44. doi: 10.1158/0008-5472.CAN-09-0869. Epub 2009 Jul 28.

47.

DNA damage mediated s and g(2) checkpoints in human embryonal carcinoma cells.

Wang X, Lui VC, Poon RT, Lu P, Poon RY.

Stem Cells. 2009 Mar;27(3):568-76. doi: 10.1634/stemcells.2008-0690.

48.

Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastrophe.

Chan YW, Chen Y, Poon RY.

Oncogene. 2009 Jan 15;28(2):170-83. doi: 10.1038/onc.2008.369. Epub 2008 Sep 29.

PMID:
18820706
49.

The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability.

Chen Y, Poon RY.

Front Biosci. 2008 May 1;13:5016-29. Review.

PMID:
18508566
50.

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