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Items: 37

1.

Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein.

Kumar S, Kwei GY, Poon GK, Iliff SA, Wang Y, Chen Q, Franklin RB, Didolkar V, Wang RW, Yamazaki M, Chiu SH, Lin JH, Pearson PG, Baillie TA.

J Pharmacol Exp Ther. 2003 Mar;304(3):1161-71.

PMID:
12604693
2.

Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma.

Hop CE, Wang Y, Kumar S, Elipe MV, Raab CE, Dean DC, Poon GK, Keohane CA, Strauss J, Chiu SH, Curtis N, Elliott J, Gerhard U, Locker K, Morrison D, Mortishire-Smith R, Thomas S, Watt AP, Evans DC.

Drug Metab Dispos. 2002 Aug;30(8):937-43.

PMID:
12124313
3.

Bioactivation of diclofenac via benzoquinone imine intermediates-identification of urinary mercapturic acid derivatives in rats and humans.

Poon GK, Chen Q, Teffera Y, Ngui JS, Griffin PR, Braun MP, Doss GA, Freeden C, Stearns RA, Evans DC, Baillie TA, Tang W.

Drug Metab Dispos. 2001 Dec;29(12):1608-13.

PMID:
11717180
4.

Analysis of cyanobacterial toxins by physicochemical and biochemical methods.

Codd GA, Metcalf JS, Ward CJ, Beattie KA, Bell SG, Kaya K, Poon GK.

J AOAC Int. 2001 Sep-Oct;84(5):1626-35. Review.

PMID:
11601485
5.

Direct analysis of microcystins by microbore liquid chromatography electrospray ionization ion-trap tandem mass spectrometry.

Zweigenbaum JA, Henion JD, Beattie KA, Codd GA, Poon GK.

J Pharm Biomed Anal. 2000 Sep;23(4):723-33.

PMID:
10975248
6.

Integrating qualitative and quantitative liquid chromatography/tandem mass spectrometric analysis to support drug discovery.

Poon GK, Kwei G, Wang R, Lyons K, Chen Q, Didolkar V, Hop CE.

Rapid Commun Mass Spectrom. 1999;13(19):1943-50.

PMID:
10487941
7.

Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil.

Pouria S, de Andrade A, Barbosa J, Cavalcanti RL, Barreto VT, Ward CJ, Preiser W, Poon GK, Neild GH, Codd GA.

Lancet. 1998 Jul 4;352(9121):21-6.

PMID:
9800741
8.

Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee.

Vigushin DM, Poon GK, Boddy A, English J, Halbert GW, Pagonis C, Jarman M, Coombes RC.

Cancer Chemother Pharmacol. 1998;42(2):111-7.

PMID:
9654110
9.

Antibody-directed enzyme prodrug therapy: pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial.

Martin J, Stribbling SM, Poon GK, Begent RH, Napier M, Sharma SK, Springer CJ.

Cancer Chemother Pharmacol. 1997;40(3):189-201.

PMID:
9219501
10.

Identification and characterization of limonene metabolites in patients with advanced cancer by liquid chromatography/mass spectrometry.

Poon GK, Vigushin D, Griggs LJ, Rowlands MG, Coombes RC, Jarman M.

Drug Metab Dispos. 1996 May;24(5):565-71.

PMID:
8723738
11.

Tamoxifen does not form detectable DNA adducts in white blood cells of breast cancer patients.

Phillips DH, Hewer A, Grover PL, Poon GK, Carmichael PL.

Carcinogenesis. 1996 May;17(5):1149-52.

PMID:
8640926
12.

Lack of genotoxicity of tamoxifen in human endometrium.

Carmichael PL, Ugwumadu AH, Neven P, Hewer AJ, Poon GK, Phillips DH.

Cancer Res. 1996 Apr 1;56(7):1475-9.

14.

Rapid screening of taxol metabolites in human microsomes by liquid chromatography/electrospray ionization-mass spectrometry.

Poon GK, Wade J, Bloomer J, Clarke SE, Maltas J.

Rapid Commun Mass Spectrom. 1996;10(10):1165-8.

PMID:
8759326
15.

Biotransformation of the platinum drug JM216 following oral administration to cancer patients.

Raynaud FI, Mistry P, Donaghue A, Poon GK, Kelland LR, Barnard CF, Murrer BA, Harrap KR.

Cancer Chemother Pharmacol. 1996;38(2):155-62.

PMID:
8616906
16.

Activation of tamoxifen and its metabolite alpha-hydroxytamoxifen to DNA-binding products: comparisons between human, rat and mouse hepatocytes.

Phillips DH, Carmichael PL, Hewer A, Cole KJ, Hardcastle IR, Poon GK, Keogh A, Strain AJ.

Carcinogenesis. 1996 Jan;17(1):89-94.

PMID:
8565142
17.

Determination of metabolites of a novel platinum anticancer drug JM216 in human plasma ultrafiltrates.

Poon GK, Mistry P, Raynaud FI, Harrap KR, Murrer BA, Barnard CF.

J Pharm Biomed Anal. 1995 Nov;13(12):1493-8.

PMID:
8788134
18.

Metabolic studies of an orally active platinum anticancer drug by liquid chromatography-electrospray ionization mass spectrometry.

Poon GK, Raynaud FI, Mistry P, Odell DE, Kelland LR, Harrap KR, Barnard CF, Murrer BA.

J Chromatogr A. 1995 Sep 29;712(1):61-6.

PMID:
8556156
19.

The deuterium isotope effect for the alpha-hydroxylation of tamoxifen by rat liver microsomes accounts for the reduced genotoxicity of [D5-ethyl]tamoxifen.

Jarman M, Poon GK, Rowlands MG, Grimshaw RM, Horton MN, Potter GA, McCague R.

Carcinogenesis. 1995 Apr;16(4):683-8.

PMID:
7728943
20.

Identification of tamoxifen metabolites in human Hep G2 cell line, human liver homogenate, and patients on long-term therapy for breast cancer.

Poon GK, Walter B, Lønning PE, Horton MN, McCague R.

Drug Metab Dispos. 1995 Mar;23(3):377-82.

PMID:
7628304
21.

alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes.

Phillips DH, Carmichael PL, Hewer A, Cole KJ, Poon GK.

Cancer Res. 1994 Nov 1;54(21):5518-22.

22.

Analysis of antibody-enzyme conjugate clearance by investigation of prodrug and active drug in an ADEPT clinical study.

Springer CJ, Poon GK, Sharma SK, Bagshawe KD.

Cell Biophys. 1994;24-25:193-207.

PMID:
7736524
23.

Analysis of phase I and phase II metabolites of tamoxifen in breast cancer patients.

Poon GK, Chui YC, McCague R, Lłnning PE, Feng R, Rowlands MG, Jarman M.

Drug Metab Dispos. 1993 Nov-Dec;21(6):1119-24.

PMID:
7905393
24.

Electrospray ionization mass spectrometry for analysis of low-molecular-weight anticancer drugs and their analogues.

Poon GK, Bisset GM, Mistry P.

J Am Soc Mass Spectrom. 1993 Jul;4(7):588-95. doi: 10.1016/1044-0305(93)85020-X.

PMID:
24227645
25.

Identification of prodrug, active drug, and metabolites in an ADEPT clinical study.

Springer CJ, Poon GK, Sharma SK, Bagshawe KD.

Cell Biophys. 1993 Jan-Jun;22(1-3):9-26.

PMID:
7889545
26.

Investigation of conjugated metabolites of 4-hydroxyandrost-4-ene-3,17-dione in patient urine by liquid chromatography-atmospheric pressure ionization mass spectrometry.

Poon GK, Chui YC, Jarman M, Rowlands MG, Kokkonen PS, Niessen WM, van der Greef J.

Drug Metab Dispos. 1992 Nov-Dec;20(6):941-7.

PMID:
1362950
27.

On-line continuous-flow dialysis thermospray tandem mass spectrometry for quantitative screening of drugs in plasma: rogletimide.

van Bakergem E, van der Hoeven RA, Niessen WM, Tjaden UR, van der Greef J, Poon GK, McCague R.

J Chromatogr. 1992 May 15;598(2):189-94.

PMID:
1618979
28.

Identification of 4-hydroxyandrost-4-ene-3,17-dione metabolites in prostatic cancer patients by liquid chromatography-mass spectrometry.

Poon GK, Jarman M, McCague R, Davies JH, Heeremans CE, van der Hoeven RA, Niessen WM, van der Greef J.

J Chromatogr. 1992 May 8;576(2):235-44.

PMID:
1400711
29.

Effects of 4-hydroxyandrost-4-ene-3,17-dione and its metabolites on 5 alpha-reductase activity and the androgen receptor.

Davies JH, Shearer RJ, Rowlands MG, Poon GK, Houghton J, Jarman M, Dowsett M.

J Enzyme Inhib. 1992;6(2):141-7.

PMID:
1284430
30.

Characterisation of metabolites of 3-ethyl-3-(4-pyridyl)-piperidine-2,6-dione, a potential breast cancer drug.

Poon GK, McCague R, Griggs LJ, Jarman M, Lewis IA.

J Chromatogr. 1991 Dec 6;572(1-2):143-57.

PMID:
1818050
31.

Electrospray ionization mass spectrometry of platinum anticancer agents.

Poon GK, Mistry P, Lewis S.

Biol Mass Spectrom. 1991 Nov;20(11):687-92.

PMID:
1799578
32.
33.

Prevalence, distribution and intensity of soil-transmitted helminthiases among Malaysian children.

Kan SP, Poon GK.

Public Health. 1987 Jul;101(4):243-51. No abstract available.

PMID:
3659238
34.

Purification procedure for peptide toxins from the cyanobacterium Microcystis aeruginosa involving high-performance thin-layer chromatography.

Poon GK, Priestley IM, Hunt SM, Fawell JK, Codd GA.

J Chromatogr. 1987 Jan 30;387:551-5. No abstract available.

PMID:
3104380
35.

Isolation of dengue viruses by intracerebral inoculation of mosquito larvae.

Lam SK, Chew CB, Poon GK, Ramalingam S, Seow SC, Pang T.

J Virol Methods. 1986 Sep;14(2):133-40.

PMID:
2877004
36.

Detection of dengue virus by immunofluorescence following inoculation of mosquito larvae.

Pang T, Lam SK, Chew CB, Poon GK, Ramalingam S.

Lancet. 1983 Jun 4;1(8336):1271. No abstract available.

PMID:
6134055
37.

Prevalence of parasitic infections in Malaysian oil palm estate workers.

Sinniah B, Sinniah D, Singh M, Poon GK.

Southeast Asian J Trop Med Public Health. 1978 Jun;9(2):272-6.

PMID:
725660

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