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Characterisation of the Ral GTPase inhibitor RBC8 in human and mouse platelets.

Walsh TG, Wersäll A, Poole AW.

Cell Signal. 2019 Jul;59:34-40. doi: 10.1016/j.cellsig.2019.03.015. Epub 2019 Mar 14.


Platelet-specific deletion of SNAP23 ablates granule secretion, substantially inhibiting arterial and venous thrombosis in mice.

Williams CM, Li Y, Brown E, Poole AW.

Blood Adv. 2018 Dec 26;2(24):3627-3636. doi: 10.1182/bloodadvances.2018023291.


Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vessels.

Brown E, Carlin LM, Nerlov C, Lo Celso C, Poole AW.

Life Sci Alliance. 2018 May 21;1(2). pii: e201800061. doi: 10.26508/lsa.201800061.


Small GTPases in platelet membrane trafficking.

Walsh TG, Li Y, Wersäll A, Poole AW.

Platelets. 2019;30(1):31-40. doi: 10.1080/09537104.2018.1535703. Epub 2018 Oct 26. Review.


Loss of the mitochondrial kinase PINK1 does not alter platelet function.

Walsh TG, van den Bosch MTJ, Lewis KE, Williams CM, Poole AW.

Sci Rep. 2018 Sep 26;8(1):14377. doi: 10.1038/s41598-018-32716-4.


Phosphoinositide 3-kinase p110α negatively regulates thrombopoietin-mediated platelet activation and thrombus formation.

Blair TA, Moore SF, Walsh TG, Hutchinson JL, Durrant TN, Anderson KE, Poole AW, Hers I.

Cell Signal. 2018 Oct;50:111-120. doi: 10.1016/j.cellsig.2018.05.005. Epub 2018 May 21.


Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis.

Agbani EO, Williams CM, Li Y, van den Bosch MT, Moore SF, Mauroux A, Hodgson L, Verkman AS, Hers I, Poole AW.

JCI Insight. 2018 May 17;3(10). pii: 99062. doi: 10.1172/jci.insight.99062. eCollection 2018 May 17.


Do platelets promote cardiac recovery after myocardial infarction: roles beyond occlusive ischemic damage.

Walsh TG, Poole AW.

Am J Physiol Heart Circ Physiol. 2018 May 1;314(5):H1043-H1048. doi: 10.1152/ajpheart.00134.2018. Epub 2018 Mar 16.


Mouse Platelet Ral GTPases Control P-Selectin Surface Expression, Regulating Platelet-Leukocyte Interaction.

Wersäll A, Williams CM, Brown E, Iannitti T, Williams N, Poole AW.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):787-800. doi: 10.1161/ATVBAHA.117.310294. Epub 2018 Feb 8.


Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis.

Lauder SN, Allen-Redpath K, Slatter DA, Aldrovandi M, O'Connor A, Farewell D, Percy CL, Molhoek JE, Rannikko S, Tyrrell VJ, Ferla S, Milne GL, Poole AW, Thomas CP, Obaji S, Taylor PR, Jones SA, de Groot PG, Urbanus RT, Hörkkö S, Uderhardt S, Ackermann J, Vince Jenkins P, Brancale A, Krönke G, Collins PW, O'Donnell VB.

Sci Signal. 2017 Nov 28;10(507). pii: eaan2787. doi: 10.1126/scisignal.aan2787.


Procoagulant platelets: generation, function, and therapeutic targeting in thrombosis.

Agbani EO, Poole AW.

Blood. 2017 Nov 16;130(20):2171-2179. doi: 10.1182/blood-2017-05-787259. Epub 2017 Sep 27. Review.


Temporal contribution of the platelet body and balloon to thrombin generation.

Agbani EO, Hers I, Poole AW.

Haematologica. 2017 Oct;102(10):e379-e381. doi: 10.3324/haematol.2017.166819. Epub 2017 Jul 13. No abstract available.


Platelets Protect Cardiomyocytes from Ischaemic Damage.

Walsh TG, Poole AW.

TH Open. 2017 Jun 28;1(1). pii: e24. doi: 10.1055/s-0037-1603928.


Membrane Ballooning in Aggregated Platelets is Synchronised and Mediates a Surge in Microvesiculation.

Agbani EO, Williams CM, Hers I, Poole AW.

Sci Rep. 2017 Jun 5;7(1):2770. doi: 10.1038/s41598-017-02933-4.


The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling.

Battram AM, Durrant TN, Agbani EO, Heesom KJ, Paul DS, Piatt R, Poole AW, Cullen PJ, Bergmeier W, Moore SF, Hers I.

J Biol Chem. 2017 Feb 3;292(5):1691-1704. doi: 10.1074/jbc.M116.746867. Epub 2016 Nov 30.


Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases.

Crescente M, Pluthero FG, Li L, Lo RW, Walsh TG, Schenk MP, Holbrook LM, Louriero S, Ali MS, Vaiyapuri S, Falet H, Jones IM, Poole AW, Kahr WH, Gibbins JM.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1164-73. doi: 10.1161/ATVBAHA.116.307461. Epub 2016 Apr 14.


Identification of roles for the SNARE-associated protein, SNAP29, in mouse platelets.

Williams CM, Savage JS, Harper MT, Moore SF, Hers I, Poole AW.

Platelets. 2016 Jun;27(4):286-94. doi: 10.3109/09537104.2015.1100282. Epub 2015 Nov 20.


Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage.

Mattheij NJ, Braun A, van Kruchten R, Castoldi E, Pircher J, Baaten CC, Wülling M, Kuijpers MJ, Köhler R, Poole AW, Schreiber R, Vortkamp A, Collins PW, Nieswandt B, Kunzelmann K, Cosemans JM, Heemskerk JW.

FASEB J. 2016 Feb;30(2):727-37. doi: 10.1096/fj.15-280446. Epub 2015 Oct 19.


The role of individual protein kinase C isoforms in mouse mast cell function and their targeting by the immunomodulatory parasitic worm product, ES-62.

Bell KS, Al-Riyami L, Lumb FE, Britton GJ, Poole AW, Williams CM, Braun U, Leitges M, Harnett MM, Harnett W.

Immunol Lett. 2015 Nov;168(1):31-40. doi: 10.1016/j.imlet.2015.09.001. Epub 2015 Sep 3.


Leukemia-associated Rho guanine-nucleotide exchange factor is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice.

Williams CM, Harper MT, Goggs R, Walsh TG, Offermanns S, Poole AW.

J Thromb Haemost. 2015 Nov;13(11):2102-7. doi: 10.1111/jth.13129. Epub 2015 Oct 20.


Coordinated Membrane Ballooning and Procoagulant Spreading in Human Platelets.

Agbani EO, van den Bosch MT, Brown E, Williams CM, Mattheij NJ, Cosemans JM, Collins PW, Heemskerk JW, Hers I, Poole AW.

Circulation. 2015 Oct 13;132(15):1414-24. doi: 10.1161/CIRCULATIONAHA.114.015036. Epub 2015 Sep 1.


Correction: Rapid Microsatellite Identification from Illumina Paired-End Genomic Sequencing in Two Birds and a Snake.

Castoe TA, Poole AW, de Koning AP, Jones KL, Tomback DF, Oyler-McCance SJ, Fike JA, Lance SL, Streicher JW, Smith EN, Pollock DD.

PLoS One. 2015 Aug 20;10(8):e0136465. doi: 10.1371/journal.pone.0136465. eCollection 2015. No abstract available.


Platelet dense granule secretion defects may obscure α-granule secretion mechanisms: evidence from Munc13-4-deficient platelets.

Harper MT, van den Bosch MT, Hers I, Poole AW.

Blood. 2015 May 7;125(19):3034-6. doi: 10.1182/blood-2014-12-618439. No abstract available.


Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling.

Moore SF, Williams CM, Brown E, Blair TA, Harper MT, Coward RJ, Poole AW, Hers I.

Cardiovasc Res. 2015 Jul 1;107(1):9-19. doi: 10.1093/cvr/cvv132. Epub 2015 Apr 22.


Platelet Rho GTPases-a focus on novel players, roles and relationships.

Goggs R, Williams CM, Mellor H, Poole AW.

Biochem J. 2015 Mar 15;466(3):431-42. doi: 10.1042/BJ20141404. Review.


Platelet secretion: From haemostasis to wound healing and beyond.

Golebiewska EM, Poole AW.

Blood Rev. 2015 May;29(3):153-62. doi: 10.1016/j.blre.2014.10.003. Epub 2014 Oct 31. Review.


Syntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability.

Golebiewska EM, Harper MT, Williams CM, Savage JS, Goggs R, Fischer von Mollard G, Poole AW.

J Biol Chem. 2015 Jan 16;290(3):1536-45. doi: 10.1074/jbc.M114.602615. Epub 2014 Nov 17.


SDF-1α is a novel autocrine activator of platelets operating through its receptor CXCR4.

Walsh TG, Harper MT, Poole AW.

Cell Signal. 2015 Jan;27(1):37-46. doi: 10.1016/j.cellsig.2014.09.021. Epub 2014 Oct 5.


Is JAK2V617F finally off the hook?

Hers I, Poole AW.

Blood. 2014 Aug 14;124(7):992-3. doi: 10.1182/blood-2014-07-583856. No abstract available.


Protein kinase Cα (PKCα) regulates bone architecture and osteoblast activity.

Galea GL, Meakin LB, Williams CM, Hulin-Curtis SL, Lanyon LE, Poole AW, Price JS.

J Biol Chem. 2014 Sep 12;289(37):25509-22. doi: 10.1074/jbc.M114.580365. Epub 2014 Jul 28.


Phosphoinositide 3-kinases p110α and p110β have differential roles in insulin-like growth factor-1-mediated Akt phosphorylation and platelet priming.

Blair TA, Moore SF, Williams CM, Poole AW, Vanhaesebroeck B, Hers I.

Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1681-8. doi: 10.1161/ATVBAHA.114.303954. Epub 2014 Jun 5.


Secrets of platelet exocytosis - what do we really know about platelet secretion mechanisms?

Golebiewska EM, Poole AW.

Br J Haematol. 2013 Nov 30. doi: 10.1111/bjh.12682. [Epub ahead of print]


Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.

Harper MT, Poole AW.

Cell Death Dis. 2013 Dec 19;4:e969. doi: 10.1038/cddis.2013.495.


The Burmese python genome reveals the molecular basis for extreme adaptation in snakes.

Castoe TA, de Koning AP, Hall KT, Card DC, Schield DR, Fujita MK, Ruggiero RP, Degner JF, Daza JM, Gu W, Reyes-Velasco J, Shaney KJ, Castoe JM, Fox SE, Poole AW, Polanco D, Dobry J, Vandewege MW, Li Q, Schott RK, Kapusta A, Minx P, Feschotte C, Uetz P, Ray DA, Hoffmann FG, Bogden R, Smith EN, Chang BS, Vonk FJ, Casewell NR, Henkel CV, Richardson MK, Mackessy SP, Bronikowski AM, Yandell M, Warren WC, Secor SM, Pollock DD.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20645-50. doi: 10.1073/pnas.1314475110. Epub 2013 Dec 2. Erratum in: Proc Natl Acad Sci U S A. 2013 Dec 17;110(51). doi:10.1073/pnas.1324133111. Bronikowsi, Anne M [corrected to Bronikowski, Anne M]. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3194.


RhoG protein regulates platelet granule secretion and thrombus formation in mice.

Goggs R, Harper MT, Pope RJ, Savage JS, Williams CM, Mundell SJ, Heesom KJ, Bass M, Mellor H, Poole AW.

J Biol Chem. 2013 Nov 22;288(47):34217-29. doi: 10.1074/jbc.M113.504100. Epub 2013 Oct 8.


Comment on "Platelet-derived nucleotides promote tumor cell transendothelial migration and metastasis via P2Y2 receptor" by Schumacher et al.

Harper MT, Savage JS, Poole AW.

Cancer Cell. 2013 Sep 9;24(3):287. doi: 10.1016/j.ccr.2013.08.016. No abstract available.


Transient receptor potential channels function as a coincidence signal detector mediating phosphatidylserine exposure.

Harper MT, Londoño JE, Quick K, Londoño JC, Flockerzi V, Philipp SE, Birnbaumer L, Freichel M, Poole AW.

Sci Signal. 2013 Jun 25;6(281):ra50. doi: 10.1126/scisignal.2003701.


PKCα negatively regulates in vitro proplatelet formation and in vivo platelet production in mice.

Williams CM, Harper MT, Poole AW.

Platelets. 2014;25(1):62-8. doi: 10.3109/09537104.2012.761686. Epub 2013 Feb 12.


The small GTPase Rif is dispensable for platelet filopodia generation in mice.

Goggs R, Savage JS, Mellor H, Poole AW.

PLoS One. 2013;8(1):e54663. doi: 10.1371/journal.pone.0054663. Epub 2013 Jan 24.


Absence of platelet phenotype in mice lacking the motor protein myosin Va.

Harper MT, van den Bosch MT, Hers I, Poole AW.

PLoS One. 2013;8(1):e53239. doi: 10.1371/journal.pone.0053239. Epub 2013 Jan 18.


Munc13-4 is critical for thrombosis through regulating release of ADP from platelets.

Savage JS, Williams CM, Konopatskaya O, Hers I, Harper MT, Poole AW.

J Thromb Haemost. 2013 Apr;11(4):771-5. doi: 10.1111/jth.12138. No abstract available.


Dysfunction of the PI3 kinase/Rap1/integrin α(IIb)β(3) pathway underlies ex vivo platelet hypoactivity in essential thrombocythemia.

Moore SF, Hunter RW, Harper MT, Savage JS, Siddiq S, Westbury SK, Poole AW, Mumford AD, Hers I.

Blood. 2013 Feb 14;121(7):1209-19. doi: 10.1182/blood-2012-05-431288. Epub 2012 Dec 13.


Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets.

Moore SF, van den Bosch MT, Hunter RW, Sakamoto K, Poole AW, Hers I.

J Biol Chem. 2013 Feb 8;288(6):3918-28. doi: 10.1074/jbc.M112.429936. Epub 2012 Dec 13.


Thousands of microsatellite loci from the venomous coralsnake Micrurus fulvius and variability of select loci across populations and related species.

Castoe TA, Streicher JW, Meik JM, Ingrasci MJ, Poole AW, de Koning AP, Campbell JA, Parkinson CL, Smith EN, Pollock DD.

Mol Ecol Resour. 2012 Nov;12(6):1105-13. doi: 10.1111/1755-0998.12000. Epub 2012 Sep 1.


WNT-3a modulates platelet function by regulating small GTPase activity.

Steele BM, Harper MT, Smolenski AP, Alkazemi N, Poole AW, Fitzgerald DJ, Maguire PB.

FEBS Lett. 2012 Jul 30;586(16):2267-72. doi: 10.1016/j.febslet.2012.05.060. Epub 2012 Jun 13.


Bcl-xL-inhibitory BH3 mimetic ABT-737 depletes platelet calcium stores.

Harper MT, Poole AW.

Blood. 2012 May 3;119(18):4337-8. doi: 10.1182/blood-2012-02-413070. No abstract available.


Rapid microsatellite identification from Illumina paired-end genomic sequencing in two birds and a snake.

Castoe TA, Poole AW, de Koning AP, Jones KL, Tomback DF, Oyler-McCance SJ, Fike JA, Lance SL, Streicher JW, Smith EN, Pollock DD.

PLoS One. 2012;7(2):e30953. doi: 10.1371/journal.pone.0030953. Epub 2012 Feb 14. Erratum in: PLoS One. 2015;10(8):e0136465.


Platelet signaling-a primer.

Goggs R, Poole AW.

J Vet Emerg Crit Care (San Antonio). 2012 Feb;22(1):5-29. doi: 10.1111/j.1476-4431.2011.00704.x. Epub 2012 Feb 3. Review.


Using zebrafish (Danio rerio) to assess gene function in thrombus formation.

Williams CM, Poole AW.

Methods Mol Biol. 2012;788:305-19. doi: 10.1007/978-1-61779-307-3_21.


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