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Items: 25

1.

Pharmacokinetics, metabolism, and excretion of [14C]axitinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in humans.

Smith BJ, Pithavala Y, Bu HZ, Kang P, Hee B, Deese AJ, Pool WF, Klamerus KJ, Wu EY, Dalvie DK.

Drug Metab Dispos. 2014 May;42(5):918-31. doi: 10.1124/dmd.113.056531. Epub 2014 Mar 7.

PMID:
24608633
2.

Pharmacokinetics, distribution, and metabolism of [14C]sunitinib in rats, monkeys, and humans.

Speed B, Bu HZ, Pool WF, Peng GW, Wu EY, Patyna S, Bello C, Kang P.

Drug Metab Dispos. 2012 Mar;40(3):539-55. doi: 10.1124/dmd.111.042853. Epub 2011 Dec 16.

PMID:
22180047
3.
4.

Evaluation of capravirine as a CYP3A probe substrate: in vitro and in vivo metabolism of capravirine in rats and dogs.

Bu HZ, Zhao P, Kang P, Pool WF, Wu EY, Shetty BV.

Drug Metab Dispos. 2007 Sep;35(9):1593-602. Epub 2007 Jun 13.

PMID:
17567732
5.
6.

Identification of enzymes responsible for primary and sequential oxygenation reactions of capravirine in human liver microsomes.

Bu HZ, Zhao P, Kang P, Pool WF, Wu EY.

Drug Metab Dispos. 2006 Nov;34(11):1798-802. Epub 2006 Aug 16.

PMID:
16914510
7.

Human in vitro glutathionyl and protein adducts of carbamazepine-10,11-epoxide, a stable and pharmacologically active metabolite of carbamazepine.

Bu HZ, Kang P, Deese AJ, Zhao P, Pool WF.

Drug Metab Dispos. 2005 Dec;33(12):1920-4. Epub 2005 Oct 4.

PMID:
16204461
8.

A simple sequential incubation method for deconvoluting the complicated sequential metabolism of capravirine in humans.

Bu HZ, Kang P, Zhao P, Pool WF, Wu EY.

Drug Metab Dispos. 2005 Oct;33(10):1438-45. Epub 2005 Jul 8.

PMID:
16006566
9.
10.

Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.

He K, Talaat RE, Pool WF, Reily MD, Reed JE, Bridges AJ, Woolf TF.

Drug Metab Dispos. 2004 Jun;32(6):639-46.

PMID:
15155556
12.

Metabolic disposition of the cognition activator tacrine in rats, dogs, and humans. Species comparisons.

Pool WF, Reily MD, Bjorge SM, Woolf TF.

Drug Metab Dispos. 1997 May;25(5):590-7.

PMID:
9152598
13.
14.

Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology.

Pool WF, Woolf TF, Reily MD, Caprathe BW, Emmerling MR, Jaen JC.

J Med Chem. 1996 Jul 19;39(15):3014-8.

PMID:
8709135
15.

Distribution of tacrine and metabolites in rat brain and plasma after single- and multiple-dose regimens. Evidence for accumulation of tacrine in brain tissue.

McNally WP, Pool WF, Sinz MW, Dehart P, Ortwine DF, Huang CC, Chang T, Woolf TF.

Drug Metab Dispos. 1996 Jun;24(6):628-33.

PMID:
8781777
16.

Species variation in the bioactivation of tacrine by hepatic microsomes.

Madden S, Spaldin V, Hayes RN, Woolf TF, Pool WF, Park BK.

Xenobiotica. 1995 Jan;25(1):103-16.

PMID:
7604602
17.
18.

Stereoselective hydroxylation of tacrine in rats and humans.

Hooper WD, Pool WF, Woolf TF, Gal J.

Drug Metab Dispos. 1994 Sep-Oct;22(5):719-24.

PMID:
7835223
19.

The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes.

Spaldin V, Madden S, Pool WF, Woolf TF, Park BK.

Br J Clin Pharmacol. 1994 Jul;38(1):15-22.

20.

Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparations. Species difference.

Woolf TF, Pool WF, Bjorge SM, Chang T, Goel OP, Purchase CF 2nd, Schroeder MC, Kunze KL, Trager WF.

Drug Metab Dispos. 1993 Sep-Oct;21(5):874-82.

PMID:
7902251
21.
23.

Stereoselectivity in the N'-oxidation of nicotine isomers by flavin-containing monooxygenase.

Damani LA, Pool WF, Crooks PA, Kaderlik RK, Ziegler DM.

Mol Pharmacol. 1988 Jun;33(6):702-5.

PMID:
3380084
24.

Isolation and characterization of N-methyl-N'-oxonicotinium ion, a new urinary metabolite of R-(+)-nicotine in the guinea pig.

Pool WF, Houdi AA, Damani LA, Layton WJ, Crooks PA.

Drug Metab Dispos. 1986 Sep-Oct;14(5):574-9.

PMID:
2876864
25.

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