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Items: 1 to 50 of 327

1.

Abnormal activation of calpain and protein kinase Cα promotes a constitutive release of matrix metalloproteinase 9 in peripheral blood mononuclear cells from cystic fibrosis patients.

Averna M, Bavestrello M, Cresta F, Pedrazzi M, De Tullio R, Minicucci L, Sparatore B, Salamino F, Pontremoli S, Melloni E.

Arch Biochem Biophys. 2016 Aug 15;604:103-12. doi: 10.1016/j.abb.2016.06.015. Epub 2016 Jun 25.

PMID:
27349634
2.

Physiological Roles of Calpain 1 Associated to Multiprotein NMDA Receptor Complex.

Averna M, Pellegrini M, Cervetto C, Pedrazzi M, Bavestrello M, De Tullio R, Salamino F, Pontremoli S, Melloni E.

PLoS One. 2015 Oct 2;10(10):e0139750. doi: 10.1371/journal.pone.0139750. eCollection 2015.

3.

Interaction between calpain-1 and HSP90: new insights into the regulation of localization and activity of the protease.

Averna M, De Tullio R, Pedrazzi M, Bavestrello M, Pellegrini M, Salamino F, Pontremoli S, Melloni E.

PLoS One. 2015 Jan 9;10(1):e0116738. doi: 10.1371/journal.pone.0116738. eCollection 2015.

4.

Role of calpain-1 in the early phase of experimental ALS.

Stifanese R, Averna M, De Tullio R, Pedrazzi M, Milanese M, Bonifacino T, Bonanno G, Salamino F, Pontremoli S, Melloni E.

Arch Biochem Biophys. 2014 Nov 15;562:1-8. doi: 10.1016/j.abb.2014.08.006. Epub 2014 Aug 21.

PMID:
25151305
5.

Differential regulation of the calpain-calpastatin complex by the L-domain of calpastatin.

De Tullio R, Averna M, Pedrazzi M, Sparatore B, Salamino F, Pontremoli S, Melloni E.

Biochim Biophys Acta. 2014 Nov;1843(11):2583-91. doi: 10.1016/j.bbamcr.2014.07.002. Epub 2014 Jul 12.

6.

Calpain inhibition promotes the rescue of F(508)del-CFTR in PBMC from cystic fibrosis patients.

Averna M, Pedrazzi M, Minicucci L, De Tullio R, Cresta F, Salamino F, Pontremoli S, Melloni E.

PLoS One. 2013 Jun 13;8(6):e66089. doi: 10.1371/journal.pone.0066089. Print 2013.

7.

Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein.

Pedrazzi M, Averna M, Sparatore B, Patrone M, Salamino F, Marcoli M, Maura G, Cervetto C, Frattaroli D, Pontremoli S, Melloni E.

PLoS One. 2012;7(8):e44518. doi: 10.1371/journal.pone.0044518. Epub 2012 Aug 31.

8.

Evidence for alteration of calpain/calpastatin system in PBMC of cystic fibrosis patients.

Averna M, Stifanese R, De Tullio R, Minicucci L, Cresta F, Palena S, Salamino F, Pontremoli S, Melloni E.

Biochim Biophys Acta. 2011 Dec;1812(12):1649-57. doi: 10.1016/j.bbadis.2011.09.013. Epub 2011 Sep 29.

9.

Calpain digestion and HSP90-based chaperone protection modulate the level of plasma membrane F508del-CFTR.

Averna M, Stifanese R, Grosso R, Pedrazzi M, De Tullio R, Salamino F, Sparatore B, Pontremoli S, Melloni E.

Biochim Biophys Acta. 2011 Jan;1813(1):50-9. doi: 10.1016/j.bbamcr.2010.11.008. Epub 2010 Nov 24.

10.

Role of calpain in the regulation of CFTR (cystic fibrosis transmembrane conductance regulator) turnover.

Averna M, Stifanese R, Grosso R, Pedrazzi M, De Tullio R, Salamino F, Pontremoli S, Melloni E.

Biochem J. 2010 Sep 1;430(2):255-63. doi: 10.1042/BJ20100344.

PMID:
20557290
11.

Adaptive modifications in the calpain/calpastatin system in brain cells after persistent alteration in Ca2+ homeostasis.

Stifanese R, Averna M, De Tullio R, Pedrazzi M, Beccaria F, Salamino F, Milanese M, Bonanno G, Pontremoli S, Melloni E.

J Biol Chem. 2010 Jan 1;285(1):631-43. doi: 10.1074/jbc.M109.031674. Epub 2009 Oct 30.

12.

Calpain-mediated activation of NO synthase in human neuroblastoma SK-N-BE cells.

Averna M, Stifanese R, De Tullio R, Beccaria F, Salamino F, Pontremoli S, Melloni E.

J Neurochem. 2009 Jul;110(1):412-21. doi: 10.1111/j.1471-4159.2009.06149.x. Epub 2009 May 5.

13.

Involvement of exon 6-mediated calpastatin intracellular movements in the modulation of calpain activation.

De Tullio R, Cantoni C, Broggio C, Prato C, Stifanese R, Averna M, Antolini R, Pontremoli S, Melloni E.

Biochim Biophys Acta. 2009 Mar;1790(3):182-7. doi: 10.1016/j.bbagen.2008.11.002. Epub 2008 Nov 21.

PMID:
19103264
14.

Functional role of the charge at the T538 residue in the control of protein kinase Ctheta.

Passalacqua M, Pedrazzi M, Sparatore B, Patrone M, Pontremoli S, Melloni E.

Arch Biochem Biophys. 2009 Jan 15;481(2):202-9. doi: 10.1016/j.abb.2008.11.013. Epub 2008 Nov 21.

PMID:
19056334
15.

Role of the calpain-calpastatin system in the density-dependent growth arrest.

Stifanese R, Averna M, De Tullio R, Salamino F, Cantoni C, Mingari MC, Prato C, Pontremoli S, Melloni E.

Arch Biochem Biophys. 2008 Nov 15;479(2):145-52. doi: 10.1016/j.abb.2008.09.002. Epub 2008 Sep 13.

PMID:
18809371
16.

Functional role of HSP90 complexes with endothelial nitric-oxide synthase (eNOS) and calpain on nitric oxide generation in endothelial cells.

Averna M, Stifanese R, De Tullio R, Passalacqua M, Salamino F, Pontremoli S, Melloni E.

J Biol Chem. 2008 Oct 24;283(43):29069-76. doi: 10.1074/jbc.M803638200. Epub 2008 Aug 5.

17.

In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS-HSP90 heterocomplex.

Averna M, Stifanese R, De Tullio R, Salamino F, Pontremoli S, Melloni E.

FEBS J. 2008 May;275(10):2501-11. doi: 10.1111/j.1742-4658.2008.06394.x. Epub 2008 Apr 8.

18.

Selective proinflammatory activation of astrocytes by high-mobility group box 1 protein signaling.

Pedrazzi M, Patrone M, Passalacqua M, Ranzato E, Colamassaro D, Sparatore B, Pontremoli S, Melloni E.

J Immunol. 2007 Dec 15;179(12):8525-32.

19.

Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90.

Averna M, Stifanese R, De Tullio R, Salamino F, Bertuccio M, Pontremoli S, Melloni E.

FEBS J. 2007 Dec;274(23):6116-27. Epub 2007 Oct 29.

20.

Multiple rat brain calpastatin forms are produced by distinct starting points and alternative splicing of the N-terminal exons.

De Tullio R, Averna M, Stifanese R, Parr T, Bardsley RG, Pontremoli S, Melloni E.

Arch Biochem Biophys. 2007 Sep 1;465(1):148-56. Epub 2007 May 30.

PMID:
17570336
21.

Regulation of calpain activity in rat brain with altered Ca2+ homeostasis.

Averna M, Stifanese R, De Tullio R, Passalacqua M, Defranchi E, Salamino F, Melloni E, Pontremoli S.

J Biol Chem. 2007 Jan 26;282(4):2656-65. Epub 2006 Nov 29.

22.

Characterization of the calpain/calpastatin system in human hemopoietic cell lines.

Stifanese R, Averna M, Salamino F, Cantoni C, Mingari MC, Prato C, Pontremoli S, Melloni E.

Arch Biochem Biophys. 2006 Dec 1;456(1):48-57. Epub 2006 Nov 3.

PMID:
17084378
23.

Stimulation of excitatory amino acid release from adult mouse brain glia subcellular particles by high mobility group box 1 protein.

Pedrazzi M, Raiteri L, Bonanno G, Patrone M, Ledda S, Passalacqua M, Milanese M, Melloni E, Raiteri M, Pontremoli S, Sparatore B.

J Neurochem. 2006 Nov;99(3):827-38. Epub 2006 Aug 14.

24.

Association of calpastatin with inactive calpain: a novel mechanism to control the activation of the protease?

Melloni E, Averna M, Stifanese R, De Tullio R, Defranchi E, Salamino F, Pontremoli S.

J Biol Chem. 2006 Aug 25;281(34):24945-54. Epub 2006 Jun 27.

25.

Interaction between catalytically inactive calpain and calpastatin. Evidence for its occurrence in stimulated cells.

Averna M, Stifanese R, De Tullio R, Defranchi E, Salamino F, Melloni E, Pontremoli S.

FEBS J. 2006 Apr;273(8):1660-8.

26.

Effect of extremely low frequency magnetic fields on calpain activation.

Salamino F, Minafra R, Grano V, Diano N, Mita DG, Pontremoli S, Melloni E.

Bioelectromagnetics. 2006 Jan;27(1):43-50.

PMID:
16283653
27.

Activation of A431 human carcinoma cell motility by extracellular high-mobility group box 1 protein and epidermal growth factor stimuli.

Sparatore B, Patrone M, Passalacqua M, Pedrazzi M, Ledda S, Pontremoli S, Melloni E.

Biochem J. 2005 Jul 1;389(Pt 1):215-21.

28.

Changes in calpastatin localization and expression during calpain activation: a new mechanism for the regulation of intracellular Ca(2+)-dependent proteolysis.

Averna M, De Tullio R, Capini P, Salamino F, Pontremoli S, Melloni E.

Cell Mol Life Sci. 2003 Dec;60(12):2669-78.

PMID:
14685690
29.

Role of the kinase activation loop on protein kinase C theta activity and intracellular localisation.

Sparatore B, Passalacqua M, Pedrazzi M, Ledda S, Patrone M, Gaggero D, Pontremoli S, Melloni E.

FEBS Lett. 2003 Nov 6;554(1-2):35-40.

30.

Characterization of a new p94-like calpain form in human lymphocytes.

De Tullio R, Stifanese R, Salamino F, Pontremoli S, Melloni E.

Biochem J. 2003 Nov 1;375(Pt 3):689-96.

31.

Stimulation of erythroleukaemia cell differentiation by extracellular high-mobility group-box protein 1 is independent of the receptor for advanced glycation end-products.

Sparatore B, Pedrazzi M, Passalacqua M, Gaggero D, Patrone M, Pontremoli S, Melloni E.

Biochem J. 2002 May 1;363(Pt 3):529-35.

32.

Age-dependent degradation of calpastatin in kidney of hypertensive rats.

Averna M, De Tullio R, Salamino F, Minafra R, Pontremoli S, Melloni E.

J Biol Chem. 2001 Oct 19;276(42):38426-32. Epub 2001 Aug 2.

33.

Extracellular processing of amphoterin generates a peptide active on erythroleukaemia cell differentiation.

Sparatore B, Patrone M, Passalacqua M, Pedrazzi M, Gaggero D, Pontremoli S, Melloni E.

Biochem J. 2001 Jul 15;357(Pt 2):569-74.

34.

Changes in intracellular calpastatin localization are mediated by reversible phosphorylation.

Averna M, de Tullio R, Passalacqua M, Salamino F, Pontremoli S, Melloni E.

Biochem J. 2001 Feb 15;354(Pt 1):25-30.

35.

Human neuroblastoma cell differentiation requires protein kinase C-theta.

Sparatore B, Patrone M, Passalacqua M, Pedrazzi M, Pontremoli S, Melloni E.

Biochem Biophys Res Commun. 2000 Dec 20;279(2):589-94.

PMID:
11118330
36.

Neuronal differentiation of PC12 cells involves changes in protein kinase C-theta distribution and molecular properties.

Sparatore B, Patrone M, Passalacqua M, Pedrazzi M, Pontremoli S, Melloni E.

Biochem Biophys Res Commun. 2000 Aug 18;275(1):149-53.

PMID:
10944456
37.

Differential degradation of calpastatin by mu- and m-calpain in Ca(2+)-enriched human neuroblastoma LAN-5 cells.

De Tullio R, Averna M, Salamino F, Pontremoli S, Melloni E.

FEBS Lett. 2000 Jun 9;475(1):17-21.

38.

Properties and intracellular localization of calpain activator protein.

Melloni E, Minafra R, Salamino F, Pontremoli S.

Biochem Biophys Res Commun. 2000 Jun 7;272(2):472-6.

PMID:
10833437
39.

Isolation and characterization of calpain activator protein from bovine brain.

Melloni E, Michetti M, Salamino F, Minafra R, Sparatore B, Pontremoli S.

Methods Mol Biol. 2000;144:99-105. No abstract available.

PMID:
10818753
40.

Acyl-CoA-binding protein is a potent m-calpain activator.

Melloni E, Averna M, Salamino F, Sparatore B, Minafra R, Pontremoli S.

J Biol Chem. 2000 Jan 7;275(1):82-6.

41.

Changes in intracellular localization of calpastatin during calpain activation.

De Tullio R, Passalacqua M, Averna M, Salamino F, Melloni E, Pontremoli S.

Biochem J. 1999 Oct 15;343 Pt 2:467-72.

42.

Protein kinase C-theta is specifically activated in murine erythroleukaemia cells during mitosis.

Passalacqua M, Patrone M, Sparatore B, Pedrazzi M, Melloni E, Pontremoli S.

FEBS Lett. 1999 Jun 25;453(3):249-53.

43.

Phosphorylation of rat brain calpastatins by protein kinase C.

Averna M, De Tullio R, Salamino F, Melloni E, Pontremoli S.

FEBS Lett. 1999 Apr 30;450(1-2):13-6.

44.

Protein kinase C-theta is specifically localized on centrosomes and kinetochores in mitotic cells.

Passalacqua M, Patrone M, Sparatore B, Melloni E, Pontremoli S.

Biochem J. 1999 Jan 1;337 ( Pt 1):113-8.

45.

Mechanism of action of a new component of the Ca(2+)-dependent proteolytic system in rat brain: the calpain activator.

Melloni E, Michetti M, Salamino F, Sparatore B, Pontremoli S.

Biochem Biophys Res Commun. 1998 Aug 28;249(3):583-8.

PMID:
9731179
46.

Properties of calpastatin forms in rat brain.

Melloni E, De Tullio R, Averna M, Tedesco I, Salamino F, Sparatore B, Pontremoli S.

FEBS Lett. 1998 Jul 10;431(1):55-8.

47.

Molecular and functional properties of a calpain activator protein specific for mu-isoforms.

Melloni E, Michetti M, Salamino F, Pontremoli S.

J Biol Chem. 1998 May 22;273(21):12827-31.

48.

Rat brain contains multiple mRNAs for calpastatin.

De Tullio R, Sparatore B, Salamino F, Melloni E, Pontremoli S.

FEBS Lett. 1998 Jan 23;422(1):113-7.

49.

Stimulated astrocytes release high-mobility group 1 protein, an inducer of LAN-5 neuroblastoma cell differentiation.

Passalacqua M, Patrone M, Picotti GB, Del Rio M, Sparatore B, Melloni E, Pontremoli S.

Neuroscience. 1998 Feb;82(4):1021-8.

PMID:
9466426
50.

Modulation of rat brain calpastatin efficiency by post-translational modifications.

Salamino F, Averna M, Tedesco I, De Tullio R, Melloni E, Pontremoli S.

FEBS Lett. 1997 Aug 4;412(3):433-8.

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