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Items: 30


Insights into myofibroblasts and their activation in scleroderma: opportunities for therapy?

Gyftaki-Venieri DA, Abraham DJ, Ponticos M.

Curr Opin Rheumatol. 2018 Nov;30(6):581-587. doi: 10.1097/BOR.0000000000000543.


Molecular Basis for Dysregulated Activation of NKX2-5 in the Vascular Remodeling of Systemic Sclerosis.

Dritsoula A, Papaioannou I, Guerra SG, Fonseca C, Martin J, Herrick AL, Abraham DJ, Denton CP, Ponticos M.

Arthritis Rheumatol. 2018 Jun;70(6):920-931. doi: 10.1002/art.40419. Epub 2018 Apr 24.


STAT3 controls COL1A2 enhancer activation cooperatively with JunB, regulates type I collagen synthesis posttranscriptionally, and is essential for lung myofibroblast differentiation.

Papaioannou I, Xu S, Denton CP, Abraham DJ, Ponticos M.

Mol Biol Cell. 2018 Jan 15;29(2):84-95. doi: 10.1091/mbc.E17-06-0342. Epub 2017 Nov 15.


Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring.

Ahadome SD, Abraham DJ, Rayapureddi S, Saw VP, Saban DR, Calder VL, Norman JT, Ponticos M, Daniels JT, Dart JK.

JCI Insight. 2016 Aug 4;1(12):e87001. doi: 10.1172/jci.insight.87001.


Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections.

Ikeda T, Fragiadaki M, Shi-Wen X, Ponticos M, Khan K, Denton C, Garcia P, Bou-Gharios G, Yamakawa A, Morimoto C, Abraham D.

Data Brief. 2016 Aug 10;8:1377-80. doi: 10.1016/j.dib.2016.08.014. eCollection 2016 Sep.


Transforming growth factor-β-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblasts.

Ikeda T, Fragiadaki M, Shi-Wen X, Ponticos M, Khan K, Denton C, Garcia P, Bou-Gharios G, Yamakawa A, Morimoto C, Abraham D.

Biochem Biophys Rep. 2016 Jul 2;7:246-252. doi: 10.1016/j.bbrep.2016.06.022. eCollection 2016 Sep.


Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing.

Heindryckx F, Binet F, Ponticos M, Rombouts K, Lau J, Kreuger J, Gerwins P.

EMBO Mol Med. 2016 Jul 1;8(7):729-44. doi: 10.15252/emmm.201505925. Print 2016 Jul.


A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis.

Shiwen X, Stratton R, Nikitorowicz-Buniak J, Ahmed-Abdi B, Ponticos M, Denton C, Abraham D, Takahashi A, Suki B, Layne MD, Lafyatis R, Smith BD.

PLoS One. 2015 May 8;10(5):e0126015. doi: 10.1371/journal.pone.0126015. eCollection 2015.


Failed degradation of JunB contributes to overproduction of type I collagen and development of dermal fibrosis in patients with systemic sclerosis.

Ponticos M, Papaioannou I, Xu S, Holmes AM, Khan K, Denton CP, Bou-Gharios G, Abraham DJ.

Arthritis Rheumatol. 2015 Jan;67(1):243-53. doi: 10.1002/art.38897.


Extracellular matrix synthesis in vascular disease: hypertension, and atherosclerosis.

Ponticos M, Smith BD.

J Biomed Res. 2014 Jan;28(1):25-39. doi: 10.7555/JBR.27.20130064. Epub 2013 Sep 20. Review.


Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro.

Sonnylal S, Xu S, Jones H, Tam A, Sreeram VR, Ponticos M, Norman J, Agrawal P, Abraham D, de Crombrugghe B.

J Cell Sci. 2013 May 15;126(Pt 10):2164-75. doi: 10.1242/jcs.111302. Epub 2013 Mar 22.


Connective tissue growth factor (CCN2) in blood vessels.

Ponticos M.

Vascul Pharmacol. 2013 Mar;58(3):189-93. doi: 10.1016/j.vph.2013.01.004. Epub 2013 Feb 4. Review.


Elevated CCN2 expression in scleroderma: a putative role for the TGFβ accessory receptors TGFβRIII and endoglin.

Holmes AM, Ponticos M, Shi-Wen X, Denton CP, Abraham DJ.

J Cell Commun Signal. 2011 Aug;5(3):173-7. doi: 10.1007/s12079-011-0140-4. Epub 2011 Jul 19.


Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

Ponticos M, Holmes AM, Shi-wen X, Leoni P, Khan K, Rajkumar VS, Hoyles RK, Bou-Gharios G, Black CM, Denton CP, Abraham DJ, Leask A, Lindahl GE.

Arthritis Rheum. 2009 Jul;60(7):2142-55. doi: 10.1002/art.24620.


JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction.

Ponticos M, Harvey C, Ikeda T, Abraham D, Bou-Gharios G.

Nucleic Acids Res. 2009 Sep;37(16):5378-89. doi: 10.1093/nar/gkp544. Epub 2009 Jun 26.


Neuronal regulators and vascular dysfunction in Raynaud's phenomenon and systemic sclerosis.

Fonseca C, Abraham D, Ponticos M.

Curr Vasc Pharmacol. 2009 Jan;7(1):34-9. Review.


A polymorphism in the CTGF promoter region associated with systemic sclerosis.

Fonseca C, Lindahl GE, Ponticos M, Sestini P, Renzoni EA, Holmes AM, Spagnolo P, Pantelidis P, Leoni P, McHugh N, Stock CJ, Shi-Wen X, Denton CP, Black CM, Welsh KI, du Bois RM, Abraham DJ.

N Engl J Med. 2007 Sep 20;357(12):1210-20.


Increased endogenous angiogenic response and hypoxia-inducible factor-1alpha in human critical limb ischemia.

Ho TK, Rajkumar V, Ponticos M, Leoni P, Black DC, Abraham DJ, Baker DM.

J Vasc Surg. 2006 Jan;43(1):125-33.


Chemokine receptor CCR2 expression by systemic sclerosis fibroblasts: evidence for autocrine regulation of myofibroblast differentiation.

Carulli MT, Ong VH, Ponticos M, Shiwen X, Abraham DJ, Black CM, Denton CP.

Arthritis Rheum. 2005 Dec;52(12):3772-82. Erratum in: Arthritis Rheum. 2015 Oct;67(10):2741.


Connective tissue remodeling: cross-talk between endothelins and matrix metalloproteinases.

Abraham D, Ponticos M, Nagase H.

Curr Vasc Pharmacol. 2005 Oct;3(4):369-79. Review.


Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1.

Ponticos M, Partridge T, Black CM, Abraham DJ, Bou-Gharios G.

Mol Cell Biol. 2004 Jul;24(14):6151-61.


Extra-cellular matrix in vascular networks.

Bou-Gharios G, Ponticos M, Rajkumar V, Abraham D.

Cell Prolif. 2004 Jun;37(3):207-20. Review.


Col1a2 enhancer regulates collagen activity during development and in adult tissue repair.

Ponticos M, Abraham D, Alexakis C, Lu QL, Black C, Partridge T, Bou-Gharios G.

Matrix Biol. 2004 Feb;22(8):619-28.


Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway.

Stratton R, Rajkumar V, Ponticos M, Nichols B, Shiwen X, Black CM, Abraham DJ, Leask A.

FASEB J. 2002 Dec;16(14):1949-51. Epub 2002 Oct 4.


Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts.

Leask A, Abraham DJ, Finlay DR, Holmes A, Pennington D, Shi-Wen X, Chen Y, Venstrom K, Dou X, Ponticos M, Black C, Bernabeu C, Jackman JK, Findell PR, Connolly MK.

Arthritis Rheum. 2002 Jul;46(7):1857-65. Erratum in: Arthritis Rheum 2002 Oct;46(10):2830.


Identification of the key regions within the mouse pro-alpha 2(I) collagen gene far-upstream enhancer.

De Val S, Ponticos M, Antoniv TT, Wells DJ, Abraham D, Partridge T, Bou-Gharios G.

J Biol Chem. 2002 Mar 15;277(11):9286-92. Epub 2001 Dec 27.


Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle.

Ponticos M, Lu QL, Morgan JE, Hardie DG, Partridge TA, Carling D.

EMBO J. 1998 Mar 16;17(6):1688-99.


Molecular characterization of the AMP-activated protein kinase and its role in cellular metabolism.

Carling D, Woods A, Thornton C, Cheung PC, Smith FC, Ponticos M, Stein SC.

Biochem Soc Trans. 1997 Nov;25(4):1224-8. Review. No abstract available.


Acceptor side mechanism of photoinduced proteolysis of the D1 protein in photosystem II reaction centers.

De Las Rivas J, Shipton CA, Ponticos M, Barber J.

Biochemistry. 1993 Jul 13;32(27):6944-50.


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