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Items: 1 to 50 of 83

1.

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.

Balmus G, Pilger D, Coates J, Demir M, Sczaniecka-Clift M, Barros AC, Woods M, Fu B, Yang F, Chen E, Ostermaier M, Stankovic T, Ponstingl H, Herzog M, Yusa K, Martinez FM, Durant ST, Galanty Y, Beli P, Adams DJ, Bradley A, Metzakopian E, Forment JV, Jackson SP.

Nat Commun. 2019 Jan 8;10(1):87. doi: 10.1038/s41467-018-07729-2.

2.

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.

Tzelepis K, De Braekeleer E, Aspris D, Barbieri I, Vijayabaskar MS, Liu WH, Gozdecka M, Metzakopian E, Toop HD, Dudek M, Robson SC, Hermida-Prado F, Yang YH, Babaei-Jadidi R, Garyfallos DA, Ponstingl H, Dias JML, Gallipoli P, Seiler M, Buonamici S, Vick B, Bannister AJ, Rad R, Prinjha RK, Marioni JC, Huntly B, Batson J, Morris JC, Pina C, Bradley A, Jeremias I, Bates DO, Yusa K, Kouzarides T, Vassiliou GS.

Nat Commun. 2018 Dec 19;9(1):5378. doi: 10.1038/s41467-018-07620-0.

3.

JAK2 V617F hematopoietic clones are present several years prior to MPN diagnosis and follow different expansion kinetics.

McKerrell T, Park N, Chi J, Collord G, Moreno T, Ponstingl H, Dias J, Gerasimou P, Melanthiou K, Prokopiou C, Antoniades M, Varela I, Costeas PA, Vassiliou GS.

Blood Adv. 2017 Jun 12;1(14):968-971. doi: 10.1182/bloodadvances.2017007047. eCollection 2017 Jun 13. No abstract available.

4.

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control.

Barbieri I, Tzelepis K, Pandolfini L, Shi J, Millán-Zambrano G, Robson SC, Aspris D, Migliori V, Bannister AJ, Han N, De Braekeleer E, Ponstingl H, Hendrick A, Vakoc CR, Vassiliou GS, Kouzarides T.

Nature. 2017 Dec 7;552(7683):126-131. doi: 10.1038/nature24678. Epub 2017 Nov 27.

5.

Comprehensive annotation and evolutionary insights into the canine (Canis lupus familiaris) antigen receptor loci.

Martin J, Ponstingl H, Lefranc MP, Archer J, Sargan D, Bradley A.

Immunogenetics. 2018 Apr;70(4):223-236. doi: 10.1007/s00251-017-1028-0. Epub 2017 Sep 19.

6.

A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.

de la Rosa J, Weber J, Friedrich MJ, Li Y, Rad L, Ponstingl H, Liang Q, de Quirós SB, Noorani I, Metzakopian E, Strong A, Li MA, Astudillo A, Fernández-García MT, Fernández-García MS, Hoffman GJ, Fuente R, Vassiliou GS, Rad R, López-Otín C, Bradley A, Cadiñanos J.

Nat Genet. 2017 May;49(5):730-741. doi: 10.1038/ng.3817. Epub 2017 Mar 20.

7.

Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice.

Friedrich MJ, Rad L, Bronner IF, Strong A, Wang W, Weber J, Mayho M, Ponstingl H, Engleitner T, Grove C, Pfaus A, Saur D, Cadiñanos J, Quail MA, Vassiliou GS, Liu P, Bradley A, Rad R.

Nat Protoc. 2017 Feb;12(2):289-309. doi: 10.1038/nprot.2016.164. Epub 2017 Jan 12.

PMID:
28079877
8.

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.

Tzelepis K, Koike-Yusa H, De Braekeleer E, Li Y, Metzakopian E, Dovey OM, Mupo A, Grinkevich V, Li M, Mazan M, Gozdecka M, Ohnishi S, Cooper J, Patel M, McKerrell T, Chen B, Domingues AF, Gallipoli P, Teichmann S, Ponstingl H, McDermott U, Saez-Rodriguez J, Huntly BJP, Iorio F, Pina C, Vassiliou GS, Yusa K.

Cell Rep. 2016 Oct 18;17(4):1193-1205. doi: 10.1016/j.celrep.2016.09.079.

9.

Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies.

McKerrell T, Moreno T, Ponstingl H, Bolli N, Dias JM, Tischler G, Colonna V, Manasse B, Bench A, Bloxham D, Herman B, Fletcher D, Park N, Quail MA, Manes N, Hodkinson C, Baxter J, Sierra J, Foukaneli T, Warren AJ, Chi J, Costeas P, Rad R, Huntly B, Grove C, Ning Z, Tyler-Smith C, Varela I, Scott M, Nomdedeu J, Mustonen V, Vassiliou GS.

Blood. 2016 Jul 7;128(1):e1-9. doi: 10.1182/blood-2015-11-683334. Epub 2016 Apr 27.

10.

Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis.

McKerrell T, Park N, Moreno T, Grove CS, Ponstingl H, Stephens J; Understanding Society Scientific Group, Crawley C, Craig J, Scott MA, Hodkinson C, Baxter J, Rad R, Forsyth DR, Quail MA, Zeggini E, Ouwehand W, Varela I, Vassiliou GS.

Cell Rep. 2015 Mar 3;10(8):1239-45. doi: 10.1016/j.celrep.2015.02.005. Epub 2015 Feb 26.

11.

A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer.

Rad R, Rad L, Wang W, Strong A, Ponstingl H, Bronner IF, Mayho M, Steiger K, Weber J, Hieber M, Veltkamp C, Eser S, Geumann U, Öllinger R, Zukowska M, Barenboim M, Maresch R, Cadiñanos J, Friedrich M, Varela I, Constantino-Casas F, Sarver A, Ten Hoeve J, Prosser H, Seidler B, Bauer J, Heikenwälder M, Metzakopian E, Krug A, Ehmer U, Schneider G, Knösel T, Rümmele P, Aust D, Grützmann R, Pilarsky C, Ning Z, Wessels L, Schmid RM, Quail MA, Vassiliou G, Esposito I, Liu P, Saur D, Bradley A.

Nat Genet. 2015 Jan;47(1):47-56. doi: 10.1038/ng.3164. Epub 2014 Dec 8.

PMID:
25485836
12.

A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.

Rad R, Cadiñanos J, Rad L, Varela I, Strong A, Kriegl L, Constantino-Casas F, Eser S, Hieber M, Seidler B, Price S, Fraga MF, Calvanese V, Hoffman G, Ponstingl H, Schneider G, Yusa K, Grove C, Schmid RM, Wang W, Vassiliou G, Kirchner T, McDermott U, Liu P, Saur D, Bradley A.

Cancer Cell. 2013 Jul 8;24(1):15-29. doi: 10.1016/j.ccr.2013.05.014.

13.

MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity.

Müller T, Hess MW, Schiefermeier N, Pfaller K, Ebner HL, Heinz-Erian P, Ponstingl H, Partsch J, Röllinghoff B, Köhler H, Berger T, Lenhartz H, Schlenck B, Houwen RJ, Taylor CJ, Zoller H, Lechner S, Goulet O, Utermann G, Ruemmele FM, Huber LA, Janecke AR.

Nat Genet. 2008 Oct;40(10):1163-5. doi: 10.1038/ng.225. Epub 2008 Aug 24.

PMID:
18724368
14.

Loss of Drop1 expression already at early tumor stages in a wide range of human carcinomas.

Marmé A, Zimmermann HP, Moldenhauer G, Schorpp-Kistner M, Müller C, Keberlein O, Giersch A, Kretschmer J, Seib B, Spiess E, Hunziker A, Merchán F, Möller P, Hahn U, Kurek R, Marmé F, Bastert G, Wallwiener D, Ponstingl H.

Int J Cancer. 2008 Nov 1;123(9):2048-56. doi: 10.1002/ijc.23763.

15.

Morphological aspects of oligomeric protein structures.

Ponstingl H, Kabir T, Gorse D, Thornton JM.

Prog Biophys Mol Biol. 2005 Sep;89(1):9-35. Review.

PMID:
15895504
16.
17.

A structure-based anatomy of the E.coli metabolome.

Nobeli I, Ponstingl H, Krissinel EB, Thornton JM.

J Mol Biol. 2003 Dec 5;334(4):697-719.

PMID:
14636597
18.
19.

How Ran is regulated.

Bischoff FR, Scheffzek K, Ponstingl H.

Results Probl Cell Differ. 2002;35:49-66. Review. No abstract available.

PMID:
11791408
20.

Discriminating between homodimeric and monomeric proteins in the crystalline state.

Ponstingl H, Henrick K, Thornton JM.

Proteins. 2000 Oct 1;41(1):47-57.

PMID:
10944393
21.
22.
23.

Human RanBP3, a group of nuclear RanGTP binding proteins.

Mueller L, Cordes VC, Bischoff FR, Ponstingl H.

FEBS Lett. 1998 May 15;427(3):330-6.

24.

Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus.

Schlenstedt G, Smirnova E, Deane R, Solsbacher J, Kutay U, Görlich D, Ponstingl H, Bischoff FR.

EMBO J. 1997 Oct 15;16(20):6237-49.

25.

Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1.

Deane R, Schäfer W, Zimmermann HP, Mueller L, Görlich D, Prehn S, Ponstingl H, Bischoff FR.

Mol Cell Biol. 1997 Sep;17(9):5087-96.

26.

Localization of the gene encoding the Ran-binding protein RanBP2 to human chromosome 2q11-q13 by fluorescence in situ hybridization.

Krebber H, Bastians H, Hoheisel J, Lichter P, Ponstingl H, Joos S.

Genomics. 1997 Jul 15;43(2):247-8. No abstract available.

PMID:
9244446
27.

The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (Chr 17) and Zfp161-rs1 (X Chr)

Sobek-Klocke I, Disqué-Kochem C, Ronsiek M, Klocke R, Jockusch H, Breuning A, Ponstingl H, Rojas K, Overhauser J, Eichenlaub-Ritter U.

Genomics. 1997 Jul 15;43(2):156-64. Erratum in: Genomics 1997 Nov 1;45(3):633.

PMID:
9244432
28.

Human Supt5h protein, a putative modulator of chromatin structure, is reversibly phosphorylated in mitosis.

Stachora AA, Schäfer RE, Pohlmeier M, Maier G, Ponstingl H.

FEBS Lett. 1997 Jun 2;409(1):74-8.

29.

Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11-p12 by fluorescence in situ hybridization.

Bastians H, Krebber H, Hoheisel J, Ohl S, Lichter P, Ponstingl H, Joos S.

Genomics. 1997 May 15;42(1):181-2. No abstract available.

PMID:
9177794
30.

Localization of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3.

Bastians H, Krebber H, Vetrie D, Hoheisel J, Lichter P, Ponstingl H, Joos S.

Genomics. 1997 Apr 15;41(2):296-7. No abstract available.

PMID:
9143513
31.
33.
34.

The thermolability of nuclear protein import in tsBN2 cells is suppressed by microinjected Ran-GTP or Ran-GDP, but not by RanQ69L or RanT24N.

Dickmanns A, Bischoff FR, Marshallsay C, Lührmann R, Ponstingl H, Fanning E.

J Cell Sci. 1996 Jun;109 ( Pt 6):1449-57.

35.

In vitro and in vivo evidence that protein and U1 snRNP nuclear import in somatic cells differ in their requirement for GTP-hydrolysis, Ran/TC4 and RCC1.

Marshallsay C, Dickmanns A, Bischoff FR, Ponstingl H, Fanning E, Lührmann R.

Nucleic Acids Res. 1996 May 15;24(10):1829-36. Erratum in: Nucleic Acids Res 1996 Jul 1;24(13):2626.

36.

Glutaredoxin-3 from Escherichia coli. Amino acid sequence, 1H AND 15N NMR assignments, and structural analysis.

Aslund F, Nordstrand K, Berndt KD, Nikkola M, Bergman T, Ponstingl H, Jörnvall H, Otting G, Holmgren A.

J Biol Chem. 1996 Mar 22;271(12):6736-45.

37.
38.

RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae.

Becker J, Melchior F, Gerke V, Bischoff FR, Ponstingl H, Wittinghofer A.

J Biol Chem. 1995 May 19;270(20):11860-5.

39.

Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport.

Bischoff FR, Krebber H, Kempf T, Hermes I, Ponstingl H.

Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1749-53.

40.

Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1.

Bischoff FR, Krebber H, Smirnova E, Dong W, Ponstingl H.

EMBO J. 1995 Feb 15;14(4):705-15.

41.

Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1.

Klebe C, Bischoff FR, Ponstingl H, Wittinghofer A.

Biochemistry. 1995 Jan 17;34(2):639-47.

PMID:
7819259
42.

Catalysis of guanine nucleotide exchange of Ran by RCC1 and stimulation of hydrolysis of Ran-bound GTP by Ran-GAP1.

Bischoff FR, Ponstingl H.

Methods Enzymol. 1995;257:135-44. No abstract available.

PMID:
8583915
43.

Isolation of human NuMA protein.

Kempf T, Bischoff FR, Kalies I, Ponstingl H.

FEBS Lett. 1994 Nov 14;354(3):307-10.

44.

Structure of the pleckstrin homology domain from beta-spectrin.

Macias MJ, Musacchio A, Ponstingl H, Nilges M, Saraste M, Oschkinat H.

Nature. 1994 Jun 23;369(6482):675-7.

PMID:
8208297
45.

RanGAP1 induces GTPase activity of nuclear Ras-related Ran.

Bischoff FR, Klebe C, Kretschmer J, Wittinghofer A, Ponstingl H.

Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2587-91.

47.

Conformational properties of the beta(400-436) and beta(400-445) C-terminal peptides of porcine brain tubulin.

Reed J, Hull WE, Ponstingl H, Himes RH.

Biochemistry. 1992 Dec 1;31(47):11888-95.

PMID:
1445919
48.

Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.

Bischoff FR, Ponstingl H.

Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10830-4.

49.

Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1.

Bischoff FR, Ponstingl H.

Nature. 1991 Nov 7;354(6348):80-2.

PMID:
1944575

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