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ATF-2 and Tpl2 regulation of endothelial cell cycle progression and apoptosis.

Fearnley GW, Latham AM, Hollstein M, Odell AF, Ponnambalam S.

Cell Signal. 2020 Feb;66:109481. doi: 10.1016/j.cellsig.2019.109481. Epub 2019 Nov 21.


Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function.

Fearnley GW, Abdul-Zani I, Latham AM, Hollstein MC, Ladbury JE, Wheatcroft SB, Odell AF, Ponnambalam S.

Biol Open. 2019 May 17;8(5). pii: bio034215. doi: 10.1242/bio.034215.


Quantifying the phosphorylation timescales of receptor-ligand complexes: a Markovian matrix-analytic approach.

López-García M, Nowicka M, Bendtsen C, Lythe G, Ponnambalam S, Molina-París C.

Open Biol. 2018 Sep 19;8(9). pii: 180126. doi: 10.1098/rsob.180126.


Postoperative Remote Automated Monitoring: Need for and State of the Science.

McGillion MH, Duceppe E, Allan K, Marcucci M, Yang S, Johnson AP, Ross-Howe S, Peter E, Scott T, Ouellette C, Henry S, Le Manach Y, Paré G, Downey B, Carroll SL, Mills J, Turner A, Clyne W, Dvirnik N, Mierdel S, Poole L, Nelson M, Harvey V, Good A, Pettit S, Sanchez K, Harsha P, Mohajer D, Ponnambalam S, Bhavnani S, Lamy A, Whitlock R, Devereaux PJ; PROTECT Network Investigators.

Can J Cardiol. 2018 Jul;34(7):850-862. doi: 10.1016/j.cjca.2018.04.021. Epub 2018 Apr 25. Review.


Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking.

Critchley WR, Pellet-Many C, Ringham-Terry B, Harrison MA, Zachary IC, Ponnambalam S.

Cells. 2018 Mar 15;7(3). pii: E22. doi: 10.3390/cells7030022. Review.


IL-36γ Is a Strong Inducer of IL-23 in Psoriatic Cells and Activates Angiogenesis.

Bridgewood C, Fearnley GW, Berekmeri A, Laws P, Macleod T, Ponnambalam S, Stacey M, Graham A, Wittmann M.

Front Immunol. 2018 Feb 26;9:200. doi: 10.3389/fimmu.2018.00200. eCollection 2018.


Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function.

Smith GA, Fearnley GW, Abdul-Zani I, Wheatcroft SB, Tomlinson DC, Harrison MA, Ponnambalam S.

Biol Open. 2017 Oct 15;6(10):1404-1415. doi: 10.1242/bio.027896.


Affimer proteins are versatile and renewable affinity reagents.

Tiede C, Bedford R, Heseltine SJ, Smith G, Wijetunga I, Ross R, AlQallaf D, Roberts AP, Balls A, Curd A, Hughes RE, Martin H, Needham SR, Zanetti-Domingues LC, Sadigh Y, Peacock TP, Tang AA, Gibson N, Kyle H, Platt GW, Ingram N, Taylor T, Coletta LP, Manfield I, Knowles M, Bell S, Esteves F, Maqbool A, Prasad RK, Drinkhill M, Bon RS, Patel V, Goodchild SA, Martin-Fernandez M, Owens RJ, Nettleship JE, Webb ME, Harrison M, Lippiat JD, Ponnambalam S, Peckham M, Smith A, Ferrigno PK, Johnson M, McPherson MJ, Tomlinson DC.

Elife. 2017 Jun 27;6. pii: e24903. doi: 10.7554/eLife.24903.


Heuristics-Based Trust Estimation in Multiagent Systems Using Temporal Difference Learning.

Rishwaraj G, Ponnambalam SG, Chu Kiong Loo.

IEEE Trans Cybern. 2017 Aug;47(8):1925-1935. doi: 10.1109/TCYB.2016.2634027. Epub 2016 Dec 20.


Technology-Enabled Remote Monitoring and Self-Management - Vision for Patient Empowerment Following Cardiac and Vascular Surgery: User Testing and Randomized Controlled Trial Protocol.

McGillion M, Yost J, Turner A, Bender D, Scott T, Carroll S, Ritvo P, Peter E, Lamy A, Furze G, Krull K, Dunlop V, Good A, Dvirnik N, Bedini D, Naus F, Pettit S, Henry S, Probst C, Mills J, Gossage E, Travale I, Duquette J, Taberner C, Bhavnani S, Khan JS, Cowan D, Romeril E, Lee J, Colella T, Choinière M, Busse J, Katz J, Victor JC, Hoch J, Isaranuwatchai W, Kaasalainen S, Ladak S, O'Keefe-McCarthy S, Parry M, Sessler DI, Stacey M, Stevens B, Stremler R, Thabane L, Watt-Watson J, Whitlock R, MacDermid JC, Leegaard M, McKelvie R, Hillmer M, Cooper L, Arthur G, Sider K, Oliver S, Boyajian K, Farrow M, Lawton C, Gamble D, Walsh J, Field M, LeFort S, Clyne W, Ricupero M, Poole L, Russell-Wood K, Weber M, McNeil J, Alpert R, Sharpe S, Bhella S, Mohajer D, Ponnambalam S, Lakhani N, Khan R, Liu P, Devereaux PJ.

JMIR Res Protoc. 2016 Aug 1;5(3):e149. doi: 10.2196/resprot.5763.


Chapter Eight - Ubiquitin-Mediated Regulation of Cellular Responses to Vascular Endothelial Growth Factors.

Smith GA, Tomlinson DC, Harrison MA, Ponnambalam S.

Prog Mol Biol Transl Sci. 2016;141:313-38. doi: 10.1016/bs.pmbts.2016.02.006. Epub 2016 Mar 25. Review.


VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis.

Fearnley GW, Smith GA, Abdul-Zani I, Yuldasheva N, Mughal NA, Homer-Vanniasinkam S, Kearney MT, Zachary IC, Tomlinson DC, Harrison MA, Wheatcroft SB, Ponnambalam S.

Biol Open. 2016 May 15;5(5):571-83. doi: 10.1242/bio.017434.


Purinergic and Store-Operated Ca(2+) Signaling Mechanisms in Mesenchymal Stem Cells and Their Roles in ATP-Induced Stimulation of Cell Migration.

Peng H, Hao Y, Mousawi F, Roger S, Li J, Sim JA, Ponnambalam S, Yang X, Jiang LH.

Stem Cells. 2016 Aug;34(8):2102-14. doi: 10.1002/stem.2370. Epub 2016 Apr 14.


Extracellular and Luminal pH Regulation by Vacuolar H+-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes.

Smith GA, Howell GJ, Phillips C, Muench SP, Ponnambalam S, Harrison MA.

J Biol Chem. 2016 Apr 15;291(16):8500-15. doi: 10.1074/jbc.M116.723395. Epub 2016 Feb 24.


Sorting Motifs in the Cytoplasmic Tail of the Immunomodulatory E3/49K Protein of Species D Adenoviruses Modulate Cell Surface Expression and Ectodomain Shedding.

Windheim M, Höning S, Leppard KN, Butler L, Seed C, Ponnambalam S, Burgert HG.

J Biol Chem. 2016 Mar 25;291(13):6796-812. doi: 10.1074/jbc.M115.684787. Epub 2016 Feb 3.


The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the β1-adrenergic signaling pathway.

Yang Z, Kirton HM, MacDougall DA, Boyle JP, Deuchars J, Frater B, Ponnambalam S, Hardy ME, White E, Calaghan SC, Peers C, Steele DS.

Sci Signal. 2015 Oct 13;8(398):ra101. doi: 10.1126/scisignal.aaa7677.


VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8.

Smith GA, Fearnley GW, Abdul-Zani I, Wheatcroft SB, Tomlinson DC, Harrison MA, Ponnambalam S.

Traffic. 2016 Jan;17(1):53-65. doi: 10.1111/tra.12341. Epub 2015 Dec 2.


Clinical and Preclinical Use of LOX-1-Specific Antibodies in Diagnostics and Therapeutics.

De Siqueira J, Abdul Zani I, Russell DA, Wheatcroft SB, Ponnambalam S, Homer-Vanniasinkam S.

J Cardiovasc Transl Res. 2015 Nov;8(8):458-65. doi: 10.1007/s12265-015-9655-z. Epub 2015 Sep 18. Review.


The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysis.

Smith GA, Fearnley GW, Tomlinson DC, Harrison MA, Ponnambalam S.

Biosci Rep. 2015 Aug 18;35(5). pii: e00253. doi: 10.1042/BSR20150171. Review.


Identification of Receptor Tyrosine Kinase Inhibitors Using Cell Surface Biotinylation and Affinity Isolation.

Latham AM, Kankanala J, Fishwick CW, Ponnambalam S.

Methods Mol Biol. 2015;1332:121-31. doi: 10.1007/978-1-4939-2917-7_8.


Detection and Quantification of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases in Primary Human Endothelial Cells.

Fearnley GW, Wheatcroft SB, Ponnambalam S.

Methods Mol Biol. 2015;1332:49-65. doi: 10.1007/978-1-4939-2917-7_4.


Scavenger receptor structure and function in health and disease.

Zani IA, Stephen SL, Mughal NA, Russell D, Homer-Vanniasinkam S, Wheatcroft SB, Ponnambalam S.

Cells. 2015 May 22;4(2):178-201. doi: 10.3390/cells4020178. Review.


VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration.

Fearnley GW, Bruns AF, Wheatcroft SB, Ponnambalam S.

Biol Open. 2015 Apr 24;4(6):731-42. doi: 10.1242/bio.201410884.


Vascular endothelial growth factors: multitasking functionality in metabolism, health and disease.

Smith GA, Fearnley GW, Harrison MA, Tomlinson DC, Wheatcroft SB, Ponnambalam S.

J Inherit Metab Dis. 2015 Jul;38(4):753-63. doi: 10.1007/s10545-015-9838-4. Epub 2015 Apr 14. Review.


In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis.

Latham AM, Kankanala J, Fearnley GW, Gage MC, Kearney MT, Homer-Vanniasinkam S, Wheatcroft SB, Fishwick CW, Ponnambalam S.

PLoS One. 2014 Nov 13;9(11):e110997. doi: 10.1371/journal.pone.0110997. eCollection 2014.


The role of lectin-like oxidised low-density lipoprotein receptor-1 in vascular pathology.

Shaw DJ, Seese R, Ponnambalam S, Ajjan R.

Diab Vasc Dis Res. 2014 Nov;11(6):410-8. doi: 10.1177/1479164114547704. Epub 2014 Sep 12. Review.


VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions.

Fearnley GW, Odell AF, Latham AM, Mughal NA, Bruns AF, Burgoyne NJ, Homer-Vanniasinkam S, Zachary IC, Hollstein MC, Wheatcroft SB, Ponnambalam S.

Mol Biol Cell. 2014 Aug 15;25(16):2509-21. doi: 10.1091/mbc.E14-05-0962. Epub 2014 Jun 25.


Experimental Investigation of the Effect of the Driving Voltage of an Electroadhesion Actuator.

Koh KH, Sreekumar M, Ponnambalam SG.

Materials (Basel). 2014 Jun 25;7(7):4963-4981. doi: 10.3390/ma7074963.


Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential.

Cubbon RM, Yuldasheva NY, Viswambharan H, Mercer BN, Baliga V, Stephen SL, Askham J, Sukumar P, Skromna A, Mughal RS, Walker AM, Bruns A, Bailey MA, Galloway S, Imrie H, Gage MC, Rakobowchuk M, Li J, Porter KE, Ponnambalam S, Wheatcroft SB, Beech DJ, Kearney MT.

Stem Cells. 2014 Oct;32(10):2714-23. doi: 10.1002/stem.1766.


Heuristics for multiobjective optimization of two-sided assembly line systems.

Jawahar N, Ponnambalam SG, Sivakumar K, Thangadurai V.

ScientificWorldJournal. 2014 Mar 20;2014:458959. doi: 10.1155/2014/458959. eCollection 2014.


Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation.

Jopling HM, Odell AF, Pellet-Many C, Latham AM, Frankel P, Sivaprasadarao A, Walker JH, Zachary IC, Ponnambalam S.

Cells. 2014 Apr 29;3(2):363-85. doi: 10.3390/cells3020363.


PCB drill path optimization by combinatorial cuckoo search algorithm.

Lim WC, Kanagaraj G, Ponnambalam SG.

ScientificWorldJournal. 2014 Feb 23;2014:264518. doi: 10.1155/2014/264518. eCollection 2014.


Vascular endothelial growth factor A-stimulated signaling from endosomes in primary endothelial cells.

Fearnley GW, Smith GA, Odell AF, Latham AM, Wheatcroft SB, Harrison MA, Tomlinson DC, Ponnambalam S.

Methods Enzymol. 2014;535:265-92. doi: 10.1016/B978-0-12-397925-4.00016-X.


A novel p53 mutant found in iatrogenic urothelial cancers is dysfunctional and can be rescued by a second-site global suppressor mutation.

Odell AF, Odell LR, Askham JM, Alogheli H, Ponnambalam S, Hollstein M.

J Biol Chem. 2013 Jun 7;288(23):16704-14. doi: 10.1074/jbc.M112.443168. Epub 2013 Apr 23.


Trafficking of the Menkes copper transporter ATP7A is regulated by clathrin-, AP-2-, AP-1-, and Rab22-dependent steps.

Holloway ZG, Velayos-Baeza A, Howell GJ, Levecque C, Ponnambalam S, Sztul E, Monaco AP.

Mol Biol Cell. 2013 Jun;24(11):1735-48, S1-8. doi: 10.1091/mbc.E12-08-0625. Epub 2013 Apr 17.


A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.

Bruns AF, Yuldasheva N, Latham AM, Bao L, Pellet-Many C, Frankel P, Stephen SL, Howell GJ, Wheatcroft SB, Kearney MT, Zachary IC, Ponnambalam S.

PLoS One. 2012;7(11):e48539. doi: 10.1371/journal.pone.0048539. Epub 2012 Nov 6.


The S100A6 calcium-binding protein regulates endothelial cell-cycle progression and senescence.

Bao L, Odell AF, Stephen SL, Wheatcroft SB, Walker JH, Ponnambalam S.

FEBS J. 2012 Dec;279(24):4576-88. doi: 10.1111/febs.12044. Epub 2012 Nov 22.


A biphasic endothelial stress-survival mechanism regulates the cellular response to vascular endothelial growth factor A.

Latham AM, Odell AF, Mughal NA, Issitt T, Ulyatt C, Walker JH, Homer-Vanniasinkam S, Ponnambalam S.

Exp Cell Res. 2012 Nov 1;318(18):2297-311. doi: 10.1016/j.yexcr.2012.06.023. Epub 2012 Jul 11.


The LOX-1 Scavenger Receptor and Its Implications in the Treatment of Vascular Disease.

Twigg MW, Freestone K, Homer-Vanniasinkam S, Ponnambalam S.

Cardiol Res Pract. 2012;2012:632408. doi: 10.1155/2012/632408. Epub 2012 Feb 19.


A VE-cadherin-PAR3-α-catenin complex regulates the Golgi localization and activity of cytosolic phospholipase A(2)α in endothelial cells.

Odell AF, Hollstein M, Ponnambalam S, Walker JH.

Mol Biol Cell. 2012 May;23(9):1783-96. doi: 10.1091/mbc.E11-08-0694. Epub 2012 Mar 7.


A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis.

Kankanala J, Latham AM, Johnson AP, Homer-Vanniasinkam S, Fishwick CW, Ponnambalam S.

Br J Pharmacol. 2012 May;166(2):737-48. doi: 10.1111/j.1476-5381.2011.01801.x.


Gene therapy in the treatment of peripheral arterial disease.

Mughal NA, Russell DA, Ponnambalam S, Homer-Vanniasinkam S.

Br J Surg. 2012 Jan;99(1):6-15. doi: 10.1002/bjs.7743. Epub 2011 Nov 8. Review.


Different sorts for different sprouts.

Ponnambalam S.

Blood. 2011 Jul 21;118(3):490-1. doi: 10.1182/blood-2011-05-356592. No abstract available.


Indolinones and anilinophthalazines differentially target VEGF-A- and basic fibroblast growth factor-mediated responses in primary human endothelial cells.

Latham AM, Bruns AF, Kankanala J, Johnson AP, Fishwick CW, Homer-Vanniasinkam S, Ponnambalam S.

Br J Pharmacol. 2012 Jan;165(1):245-59. doi: 10.1111/j.1476-5381.2011.01545.x.


The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling.

Jopling HM, Howell GJ, Gamper N, Ponnambalam S.

Biochem Biophys Res Commun. 2011 Jul 1;410(2):170-6. doi: 10.1016/j.bbrc.2011.04.093. Epub 2011 Apr 24.


Toward in silico prediction of glass-forming ability from molecular structure alone: a screening tool in early drug development.

Mahlin D, Ponnambalam S, Höckerfelt MH, Bergström CA.

Mol Pharm. 2011 Apr 4;8(2):498-506. doi: 10.1021/mp100339c. Epub 2011 Mar 18.


Evolution of the VEGF-regulated vascular network from a neural guidance system.

Ponnambalam S, Alberghina M.

Mol Neurobiol. 2011 Jun;43(3):192-206. doi: 10.1007/s12035-011-8167-3. Epub 2011 Jan 28.


Hypoxia differentially regulates VEGFR1 and VEGFR2 levels and alters intracellular signaling and cell migration in endothelial cells.

Ulyatt C, Walker J, Ponnambalam S.

Biochem Biophys Res Commun. 2011 Jan 21;404(3):774-9. doi: 10.1016/j.bbrc.2010.12.057. Epub 2010 Dec 17.


Scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular disease.

Stephen SL, Freestone K, Dunn S, Twigg MW, Homer-Vanniasinkam S, Walker JH, Wheatcroft SB, Ponnambalam S.

Int J Hypertens. 2010 Aug 17;2010:646929. doi: 10.4061/2010/646929.


An integrative model for vascular endothelial growth factor A as a tumour biomarker.

Latham AM, Molina-París C, Homer-Vanniasinkam S, Ponnambalam S.

Integr Biol (Camb). 2010 Sep;2(9):397-407. doi: 10.1039/c0ib00008f. Epub 2010 Aug 20. Review.


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