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Items: 29


Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.

Mizutani Y, Kobayashi H, Iida T, Asai N, Masamune A, Hara A, Esaki N, Ushida K, Mii S, Shiraki Y, Ando K, Weng L, Ishihara S, Ponik SM, Conklin MW, Haga H, Nagasaka A, Miyata T, Matsuyama M, Kobayashi T, Fujii T, Yamada S, Yamaguchi J, Wang T, Woods SL, Worthley D, Shimamura T, Fujishiro M, Hirooka Y, Enomoto A, Takahashi M.

Cancer Res. 2019 Oct 15;79(20):5367-5381. doi: 10.1158/0008-5472.CAN-19-0454. Epub 2019 Aug 22.


Dynamic interactions between the extracellular matrix and estrogen activity in progression of ER+ breast cancer.

Jallow F, O'Leary KA, Rugowski DE, Guerrero JF, Ponik SM, Schuler LA.

Oncogene. 2019 Aug 12. doi: 10.1038/s41388-019-0941-0. [Epub ahead of print]


Scaffold stiffness influences breast cancer cell invasion via EGFR-linked Mena upregulation and matrix remodeling.

Berger AJ, Renner CM, Hale I, Yang X, Ponik SM, Weisman PS, Masters KS, Kreeger PK.

Matrix Biol. 2019 Jul 16. pii: S0945-053X(19)30104-0. doi: 10.1016/j.matbio.2019.07.006. [Epub ahead of print]


Correction: Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts (doi:10.1242/jcs.180539).

Zhang K, Grither WR, Van Hove S, Biswas H, Ponik SM, Eliceiri KW, Keely PJ, Longmore GD.

J Cell Sci. 2019 May 2;132(9). pii: jcs232348. doi: 10.1242/jcs.232348. No abstract available.


A novel bioreactor for combined magnetic resonance spectroscopy and optical imaging of metabolism in 3D cell cultures.

Cox BL, Erickson-Bhatt S, Szulczewski JM, Squirrell JM, Ludwig KD, Macdonald EB, Swader R, Ponik SM, Eliceiri KW, Fain SB.

Magn Reson Med. 2019 May;81(5):3379-3391. doi: 10.1002/mrm.27644. Epub 2019 Jan 16.


Targeted matrisome analysis identifies thrombospondin-2 and tenascin-C in aligned collagen stroma from invasive breast carcinoma.

Tomko LA, Hill RC, Barrett A, Szulczewski JM, Conklin MW, Eliceiri KW, Keely PJ, Hansen KC, Ponik SM.

Sci Rep. 2018 Aug 28;8(1):12941. doi: 10.1038/s41598-018-31126-w.


The Presence of Cyclooxygenase 2, Tumor-Associated Macrophages, and Collagen Alignment as Prognostic Markers for Invasive Breast Carcinoma Patients.

Esbona K, Yi Y, Saha S, Yu M, Van Doorn RR, Conklin MW, Graham DS, Wisinski KB, Ponik SM, Eliceiri KW, Wilke LG, Keely PJ.

Am J Pathol. 2018 Mar;188(3):559-573. doi: 10.1016/j.ajpath.2017.10.025.


Mesenchymal stem cells in breast cancer: response to chemical and mechanical stimuli.

Ishihara S, Ponik SM, Haga H.

Oncoscience. 2017 Nov 28;4(11-12):158-159. doi: 10.18632/oncoscience.381. eCollection 2017 Nov. No abstract available.


Mechano-Signal Transduction in Mesenchymal Stem Cells Induces Prosaposin Secretion to Drive the Proliferation of Breast Cancer Cells.

Ishihara S, Inman DR, Li WJ, Ponik SM, Keely PJ.

Cancer Res. 2017 Nov 15;77(22):6179-6189. doi: 10.1158/0008-5472.CAN-17-0569. Epub 2017 Sep 28.


Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells.

Morris BA, Burkel B, Ponik SM, Fan J, Condeelis JS, Aguirre-Ghiso JA, Castracane J, Denu JM, Keely PJ.

EBioMedicine. 2016 Nov;13:146-156. doi: 10.1016/j.ebiom.2016.10.012. Epub 2016 Oct 8.


The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis.

Corsa CA, Brenot A, Grither WR, Van Hove S, Loza AJ, Zhang K, Ponik SM, Liu Y, DeNardo DG, Eliceiri KW, Keely PJ, Longmore GD.

Cell Rep. 2016 Jun 14;15(11):2510-23. doi: 10.1016/j.celrep.2016.05.033. Epub 2016 Jun 2.


In Vivo Visualization of Stromal Macrophages via label-free FLIM-based metabolite imaging.

Szulczewski JM, Inman DR, Entenberg D, Ponik SM, Aguirre-Ghiso J, Castracane J, Condeelis J, Eliceiri KW, Keely PJ.

Sci Rep. 2016 May 25;6:25086. doi: 10.1038/srep25086.


Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo.

Burkel B, Morris BA, Ponik SM, Riching KM, Eliceiri KW, Keely PJ.

J Vis Exp. 2016 May 9;(111). doi: 10.3791/53989.


Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment.

GarcĂ­a-Mendoza MG, Inman DR, Ponik SM, Jeffery JJ, Sheerar DS, Van Doorn RR, Keely PJ.

Breast Cancer Res. 2016 May 11;18(1):49. doi: 10.1186/s13058-016-0703-7.


Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts.

Zhang K, Grither WR, Van Hove S, Biswas H, Ponik SM, Eliceiri KW, Keely PJ, Longmore GD.

J Cell Sci. 2016 May 15;129(10):1989-2002. doi: 10.1242/jcs.180539. Epub 2016 Apr 12. Erratum in: J Cell Sci. 2019 May 2;132(9):.


Collagen density regulates xenobiotic and hypoxic response of mammary epithelial cells.

Curran CS, Carrillo ER, Ponik SM, Keely PJ.

Environ Toxicol Pharmacol. 2015 Jan;39(1):114-24. doi: 10.1016/j.etap.2014.10.017. Epub 2014 Nov 1.


3D collagen alignment limits protrusions to enhance breast cancer cell persistence.

Riching KM, Cox BL, Salick MR, Pehlke C, Riching AS, Ponik SM, Bass BR, Crone WC, Jiang Y, Weaver AM, Eliceiri KW, Keely PJ.

Biophys J. 2014 Dec 2;107(11):2546-58. doi: 10.1016/j.bpj.2014.10.035. Epub 2014 Dec 2.


The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis.

Zhang K, Corsa CA, Ponik SM, Prior JL, Piwnica-Worms D, Eliceiri KW, Keely PJ, Longmore GD.

Nat Cell Biol. 2013 Jun;15(6):677-87. doi: 10.1038/ncb2743. Epub 2013 May 5.


Bi-directional signaling: extracellular matrix and integrin regulation of breast tumor progression.

Gehler S, Ponik SM, Riching KM, Keely PJ.

Crit Rev Eukaryot Gene Expr. 2013;23(2):139-57. Review.


RhoA is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis.

Ponik SM, Trier SM, Wozniak MA, Eliceiri KW, Keely PJ.

Mol Biol Cell. 2013 Jun;24(11):1688-99, S1-3. doi: 10.1091/mbc.E12-05-0386. Epub 2013 Apr 3.


Microtubules regulate GEF-H1 in response to extracellular matrix stiffness.

Heck JN, Ponik SM, Garcia-Mendoza MG, Pehlke CA, Inman DR, Eliceiri KW, Keely PJ.

Mol Biol Cell. 2012 Jul;23(13):2583-92. doi: 10.1091/mbc.E11-10-0876. Epub 2012 May 16.


Structural changes in mixed Col I/Col V collagen gels probed by SHG microscopy: implications for probing stromal alterations in human breast cancer.

Ajeti V, Nadiarnykh O, Ponik SM, Keely PJ, Eliceiri KW, Campagnola PJ.

Biomed Opt Express. 2011 Aug 1;2(8):2307-16. doi: 10.1364/BOE.2.002307. Epub 2011 Jul 20.


Nonlinear optical imaging and spectral-lifetime computational analysis of endogenous and exogenous fluorophores in breast cancer.

Provenzano PP, Rueden CT, Trier SM, Yan L, Ponik SM, Inman DR, Keely PJ, Eliceiri KW.

J Biomed Opt. 2008 May-Jun;13(3):031220. doi: 10.1117/1.2940365.


Investigating integrin regulation and signaling events in three-dimensional systems.

Keely PJ, Conklin MW, Gehler S, Ponik SM, Provenzano PP.

Methods Enzymol. 2007;426:27-45. Review.


Osteoblasts and osteocytes respond differently to oscillatory and unidirectional fluid flow profiles.

Ponik SM, Triplett JW, Pavalko FM.

J Cell Biochem. 2007 Feb 15;100(3):794-807.


Fluid shear stress induction of COX-2 protein and prostaglandin release in cultured MC3T3-E1 osteoblasts does not require intact microfilaments or microtubules.

Norvell SM, Ponik SM, Bowen DK, Gerard R, Pavalko FM.

J Appl Physiol (1985). 2004 Mar;96(3):957-66. Epub 2003 Nov 14.


Fluid shear stress inhibits TNF-alpha-induced apoptosis in osteoblasts: a role for fluid shear stress-induced activation of PI3-kinase and inhibition of caspase-3.

Pavalko FM, Gerard RL, Ponik SM, Gallagher PJ, Jin Y, Norvell SM.

J Cell Physiol. 2003 Feb;194(2):194-205.


Regulation of PGE(2) and PGI(2) release from human umbilical vein endothelial cells by actin cytoskeleton.

Sawyer SJ, Norvell SM, Ponik SM, Pavalko FM.

Am J Physiol Cell Physiol. 2001 Sep;281(3):C1038-45.

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