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Items: 1 to 20 of 218


Pre-clinical development of a cryopreservable megakaryocytic cell product capable of sustained platelet production in mice.

Patel A, Clementelli CM, Jarocha D, Mosoyan G, Else C, Kintali M, Fong H, Tong J, Gordon R, Gillespie V, Keyzner A, Poncz M, Hoffman R, Iancu-Rubin C.

Transfusion. 2019 Dec;59(12):3698-3713. doi: 10.1111/trf.15546. Epub 2019 Nov 5.


Understanding how Fc-modification transforms a pathogenic HIT-like monoclonal antibody into a novel treatment for sepsis.

Gollomp K, Sarkar A, Harikumar S, Seeholzer SH, Arepally GM, Hudock KM, Rauova L, Kowalska MA, Poncz M.

Blood. 2019 Nov 13. pii: blood.2019002329. doi: 10.1182/blood.2019002329. [Epub ahead of print]


Infused factor VIII-expressing platelets or megakaryocytes as a novel therapeutic strategy for hemophilia A.

Lyde RB, Ahn HS, Vo KK, Jarocha DJ, Tkaczynski J, Treffeisen E, Sullivan SK, Camire RM, Sabatino DE, French DL, Poncz M.

Blood Adv. 2019 May 14;3(9):1368-1378. doi: 10.1182/bloodadvances.2017007914.


Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot Stability.

Scanlon VM, Teixeira AM, Tyagi T, Zou S, Zhang PX, Booth CJ, Kowalska MA, Bao J, Hwa J, Hayes V, Marks MS, Poncz M, Krause DS.

Thromb Haemost. 2019 May;119(5):744-757. doi: 10.1055/s-0039-1679908. Epub 2019 Mar 12.


Gp1ba-Cre or Pf4-Cre: pick your poison.

Gollomp K, Poncz M.

Blood. 2019 Jan 24;133(4):287-288. doi: 10.1182/blood-2018-11-887513. No abstract available.


Platelets Can Soak It Up and Then Spit It Out.

Gollomp K, Friedman DF, Poncz M.

Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2544-2545. doi: 10.1161/ATVBAHA.118.311863. No abstract available.


Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway.

Khandelwal S, Ravi J, Rauova L, Johnson A, Lee GM, Gilner JB, Gunti S, Notkins AL, Kuchibhatla M, Frank M, Poncz M, Cines DB, Arepally GM.

Blood. 2018 Dec 6;132(23):2431-2440. doi: 10.1182/blood-2018-03-834598. Epub 2018 Oct 11.


Neutrophil accumulation and NET release contribute to thrombosis in HIT.

Gollomp K, Kim M, Johnston I, Hayes V, Welsh J, Arepally GM, Kahn M, Lambert MP, Cuker A, Cines DB, Rauova L, Kowalska MA, Poncz M.

JCI Insight. 2018 Sep 20;3(18). pii: 99445. doi: 10.1172/jci.insight.99445. eCollection 2018 Sep 20.


GNE variants causing autosomal recessive macrothrombocytopenia without associated muscle wasting.

Revel-Vilk S, Shai E, Turro E, Jahshan N, Hi-Am E, Spectre G, Daum H, Kalish Y, Althaus K, Greinacher A, Kaplinsky C, Izraeli S, Mapeta R, Deevi SVV, Jarocha D, Ouwehand WH, Downes K, Poncz M, Varon D, Lambert MP.

Blood. 2018 Oct 25;132(17):1851-1854. doi: 10.1182/blood-2018-04-845545. Epub 2018 Aug 31. No abstract available.


Molecular and cellular pathogenesis of heparin-induced thrombocytopenia (HIT).

Rauova L, Arepally G, Poncz M, Cines DB.

Autoimmun Rev. 2018 Oct;17(10):1046-1052. doi: 10.1016/j.autrev.2018.05.003. Epub 2018 Aug 10. Review. No abstract available.


Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia.

Dai J, Madeeva D, Hayes V, Ahn HS, Tutwiler V, Arepally GM, Cines DB, Poncz M, Rauova L.

Blood. 2018 Aug 16;132(7):727-734. doi: 10.1182/blood-2018-02-830737. Epub 2018 Jun 18.


Serpin functions in host-pathogen interactions.

Bao J, Pan G, Poncz M, Wei J, Ran M, Zhou Z.

PeerJ. 2018 Apr 5;6:e4557. doi: 10.7717/peerj.4557. eCollection 2018.


2-O, 3-O desulfated heparin mitigates murine chemotherapy- and radiation-induced thrombocytopenia.

Tkaczynski E, Arulselvan A, Tkaczynski J, Avery S, Xiao L, Torok-Storb B, Abrams K, Rao NV, Johnson G, Kennedy TP, Poncz M, Lambert MP.

Blood Adv. 2018 Apr 10;2(7):754-761. doi: 10.1182/bloodadvances.2017013672. Erratum in: Blood Adv. 2018 May 22;2(10 ):1129.


Enhancing functional platelet release in vivo from in vitro-grown megakaryocytes using small molecule inhibitors.

Jarocha D, Vo KK, Lyde RB, Hayes V, Camire RM, Poncz M.

Blood Adv. 2018 Mar 27;2(6):597-606. doi: 10.1182/bloodadvances.2017010975.


Biocompatible coupling of therapeutic fusion proteins to human erythrocytes.

Villa CH, Pan DC, Johnston IH, Greineder CF, Walsh LR, Hood ED, Cines DB, Poncz M, Siegel DL, Muzykantov VR.

Blood Adv. 2018 Feb 13;2(3):165-176. doi: 10.1182/bloodadvances.2017011734.


ICAM-1-targeted thrombomodulin mitigates tissue factor-driven inflammatory thrombosis in a human endothelialized microfluidic model.

Greineder CF, Johnston IH, Villa CH, Gollomp K, Esmon CT, Cines DB, Poncz M, Muzykantov VR.

Blood Adv. 2017 Aug 8;1(18):1452-1465. doi: 10.1182/bloodadvances.2017007229. eCollection 2017 Aug 8.


Current status of blood 'pharming': megakaryoctye transfusions as a source of platelets.

Gollomp K, Lambert MP, Poncz M.

Curr Opin Hematol. 2017 Nov;24(6):565-571. doi: 10.1097/MOH.0000000000000378. Review.


Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications.

Borst S, Sim X, Poncz M, French DL, Gadue P.

Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2007-2013. doi: 10.1161/ATVBAHA.117.309197. Epub 2017 Oct 5. Review.


Platelet dense granules begin to selectively accumulate mepacrine during proplatelet formation.

Hanby HA, Bao J, Noh JY, Jarocha D, Poncz M, Weiss MJ, Marks MS.

Blood Adv. 2017 Aug 22;1(19):1478-1490. doi: 10.1182/bloodadvances.2017006726.


Defective acid hydrolase secretion in RUNX1 haplodeficiency: Evidence for a global platelet secretory defect.

Rao AK, Poncz M.

Haemophilia. 2017 Sep;23(5):784-792. doi: 10.1111/hae.13280. Epub 2017 Jun 29.

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